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The map label for this gene is pbpC [H]

Identifier: 13471634

GI number: 13471634

Start: 1394500

End: 1396590

Strand: Direct

Name: pbpC [H]

Synonym: mlr1664

Alternate gene names: 13471634

Gene position: 1394500-1396590 (Clockwise)

Preceding gene: 13471633

Following gene: 13471635

Centisome position: 19.82

GC content: 68.34

Gene sequence:

>2091_bases
ATGCTTTCAAGAAAGTCCCTTCGACGAGCGGCCATAACTCTAGCTTCCTGTGCGGCCATTCTCGCGGTCTCCGTCGCCAC
CCTGTGGGAGCTCGACCGCGCCTTCCCGCCCCCCTTGCCGGCGGAACTCACGGTCTCGACCGAAGTCCAGGACCGCGATG
GCCAGCTGTTGCGCGCCTTCGCCACGCCGGACGGCTACTGGCGGCTCGAAACCCGGCTCGACCAGGTCGACAAGCAGTTC
GTCGACATGCTGGTCACCTATGAGGACAAGCGCTTCTGGGACCATCAAGGCATCGACGTGCTGGCGCTTGGCCGCGCCGC
CGGCCAGTTCGCCACCAGCGGCCACATCGTCTCCGGCGGCTCGACGCTTTCGATGCAGCTCGCCCGCCTGATCGAGCCGC
GCGAAAGCCGAAGCCTCGGCTCCAAGATCAAGCAGATGCTGCGCGCCATCCAGATCGAGCGGCGGCTGTCCAAGCGCGAG
ATCCTCGAACGCTATCTGACGCTGGCGCCCTATGGCGGCAATCTGGAAGGCGTGCGCGCCGCTTCGCTTGCCTATTTCGG
CAAGGAGCCGAAGCGGCTCACCGTCTCCGAAGCCGCCCTGCTCGTCGCCTTGCCCCAATTGCCGGAAAAGCGCCGGCCCG
ACCGCAATCTCGCAATCGCCCACGCCGCCCGTGACCGTGTGCTGACCCGCATGGTCTCGTCGGGCCTGATCGGCGAACGC
GAGGCCGCGCGCGCCGCCCTTGACGATGTGTCGGGCCTGCGCCGAACGTTGCCGGCGCTCGCCCCGCACGCCGCCTATGC
GATGCTGCCCAAGGCTGTTCCCGGCGAGCCGCTCAAACTGACAATTCGAAAAAGTGTCCAGGAAGGGCTTGAGCAGGTCG
CGCGCGATGCCGCCACAAAGCTTGGCCCGCGCCTGTCCGTCGCCATGGTGCTGGCCGATTCCCGCACCGGCGACATTCTG
GGCGAAGTCGGCTCGGCCAATTTCTTCGACGCCAGCCGCTCCGGCTGGATCGACATGACCAAGATCGTGCGCTCGCCCGG
CTCGACGCTGAAGCCGTTCATCTATGGCCTTGCCTTCGAGCAGGGACTGGTGGCGCAGGAAACGCTGATCGAGGACAGCC
CGGTCGATTTCGGCGGCTACCGGCCCAAGAATTTCGACATGGGCTACCAGGGCGATGTCAGCGTCCGCCAGGCGCTGCAA
TTGTCGCTCAACGTGCCGGCGATCCGCGTGCTCGACGCCGTCGGTCCAGCGCGGCTGACCGCGCGCTTCCGCCAGGCCGG
CGTCAACCCGATCCTGCCGGTCAACGAGGCGCCGGGCCTGGCCATCGGCCTCGGCGGCGTTGGCGTCACGCTGCGCGACC
TCGTCCAGCTCTATACGGGGCTCGCCAATGGCGGCAAGACGCACACGCTGCATGACGGCACCGAGCCGGCCAATGCCGAG
CGCACCACCGCCACCATCCTCAACGACCAGGCGAACTGGCAGATCATCGACATCTTGTCGGGGGTCAAGCCGCCGGAGGG
CGCCTTGCAGCGCGGCATCGCCTACAAGACCGGCACGTCCTACGGCTACCGCGACGCCTGGTCGGTCGGCTTCGACGGCC
GCTATGTCTTGGGTGTCTGGGTCGGGCGTCCCGATGCCAGCGCCGTGCCGGGCCTTTCCGGCTATGTCTCGGCCGCCCCC
ATCCTGTTCGAGGGCTTTGTCCGCTCGGGCCTAGCCACCGTGCCGCTGCCGGGCAGGCCGCCCGGCGCCTTCACTCCCAA
GCGCGAGGACCTGCCGGTGACGCTCGCCCGCTTCGGCGCCGGCGCGGATGGCCTGGTGCAGGCGACGCCGACCGAGCCCG
CACCGACAATCATCTTCCCGCCGGACGGCGCCCGCGTCGACCTCGCCACGAATTCCGCCGACGCCACGCCGCTGGTGCTG
AAACTGCAGGGCGGCCGTGCGCCGTTCCGCTGGCTGGCCAATGGCAAGCCGCTCACCGGCATCGATCGCCGCCGCACCGC
GACGTGGTTGCCCGACGGCGCTGGTTATTCGACCCTGACCGTGATCGACGCGGCCGGGCGAGCGGCCAGCGTGAAAGTGT
TCGTTGAATAG

Upstream 100 bases:

>100_bases
GCCGTGGTCCGCGCAGCGGGCGAAAAGCCAATTGCTTGGCTTTTCGAACGGTGAACGCCCGAAGGGCCGTGGCGCCGGCA
GCCGGATGAGGGGCGCCGCC

Downstream 100 bases:

>100_bases
AGCGCGCCAGGCGATTCTGCGCGTTGGCTTTTACGCGCTGACGGTTGCCGTTGCCGTTCTGCCGGCACATGCCGACCCTC
TCCCCGCCGGCTTCGTCCGC

Product: penicillin binding protein

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MLSRKSLRRAAITLASCAAILAVSVATLWELDRAFPPPLPAELTVSTEVQDRDGQLLRAFATPDGYWRLETRLDQVDKQF
VDMLVTYEDKRFWDHQGIDVLALGRAAGQFATSGHIVSGGSTLSMQLARLIEPRESRSLGSKIKQMLRAIQIERRLSKRE
ILERYLTLAPYGGNLEGVRAASLAYFGKEPKRLTVSEAALLVALPQLPEKRRPDRNLAIAHAARDRVLTRMVSSGLIGER
EAARAALDDVSGLRRTLPALAPHAAYAMLPKAVPGEPLKLTIRKSVQEGLEQVARDAATKLGPRLSVAMVLADSRTGDIL
GEVGSANFFDASRSGWIDMTKIVRSPGSTLKPFIYGLAFEQGLVAQETLIEDSPVDFGGYRPKNFDMGYQGDVSVRQALQ
LSLNVPAIRVLDAVGPARLTARFRQAGVNPILPVNEAPGLAIGLGGVGVTLRDLVQLYTGLANGGKTHTLHDGTEPANAE
RTTATILNDQANWQIIDILSGVKPPEGALQRGIAYKTGTSYGYRDAWSVGFDGRYVLGVWVGRPDASAVPGLSGYVSAAP
ILFEGFVRSGLATVPLPGRPPGAFTPKREDLPVTLARFGAGADGLVQATPTEPAPTIIFPPDGARVDLATNSADATPLVL
KLQGGRAPFRWLANGKPLTGIDRRRTATWLPDGAGYSTLTVIDAAGRAASVKVFVE

Sequences:

>Translated_696_residues
MLSRKSLRRAAITLASCAAILAVSVATLWELDRAFPPPLPAELTVSTEVQDRDGQLLRAFATPDGYWRLETRLDQVDKQF
VDMLVTYEDKRFWDHQGIDVLALGRAAGQFATSGHIVSGGSTLSMQLARLIEPRESRSLGSKIKQMLRAIQIERRLSKRE
ILERYLTLAPYGGNLEGVRAASLAYFGKEPKRLTVSEAALLVALPQLPEKRRPDRNLAIAHAARDRVLTRMVSSGLIGER
EAARAALDDVSGLRRTLPALAPHAAYAMLPKAVPGEPLKLTIRKSVQEGLEQVARDAATKLGPRLSVAMVLADSRTGDIL
GEVGSANFFDASRSGWIDMTKIVRSPGSTLKPFIYGLAFEQGLVAQETLIEDSPVDFGGYRPKNFDMGYQGDVSVRQALQ
LSLNVPAIRVLDAVGPARLTARFRQAGVNPILPVNEAPGLAIGLGGVGVTLRDLVQLYTGLANGGKTHTLHDGTEPANAE
RTTATILNDQANWQIIDILSGVKPPEGALQRGIAYKTGTSYGYRDAWSVGFDGRYVLGVWVGRPDASAVPGLSGYVSAAP
ILFEGFVRSGLATVPLPGRPPGAFTPKREDLPVTLARFGAGADGLVQATPTEPAPTIIFPPDGARVDLATNSADATPLVL
KLQGGRAPFRWLANGKPLTGIDRRRTATWLPDGAGYSTLTVIDAAGRAASVKVFVE
>Mature_696_residues
MLSRKSLRRAAITLASCAAILAVSVATLWELDRAFPPPLPAELTVSTEVQDRDGQLLRAFATPDGYWRLETRLDQVDKQF
VDMLVTYEDKRFWDHQGIDVLALGRAAGQFATSGHIVSGGSTLSMQLARLIEPRESRSLGSKIKQMLRAIQIERRLSKRE
ILERYLTLAPYGGNLEGVRAASLAYFGKEPKRLTVSEAALLVALPQLPEKRRPDRNLAIAHAARDRVLTRMVSSGLIGER
EAARAALDDVSGLRRTLPALAPHAAYAMLPKAVPGEPLKLTIRKSVQEGLEQVARDAATKLGPRLSVAMVLADSRTGDIL
GEVGSANFFDASRSGWIDMTKIVRSPGSTLKPFIYGLAFEQGLVAQETLIEDSPVDFGGYRPKNFDMGYQGDVSVRQALQ
LSLNVPAIRVLDAVGPARLTARFRQAGVNPILPVNEAPGLAIGLGGVGVTLRDLVQLYTGLANGGKTHTLHDGTEPANAE
RTTATILNDQANWQIIDILSGVKPPEGALQRGIAYKTGTSYGYRDAWSVGFDGRYVLGVWVGRPDASAVPGLSGYVSAAP
ILFEGFVRSGLATVPLPGRPPGAFTPKREDLPVTLARFGAGADGLVQATPTEPAPTIIFPPDGARVDLATNSADATPLVL
KLQGGRAPFRWLANGKPLTGIDRRRTATWLPDGAGYSTLTVIDAAGRAASVKVFVE

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=579, Percent_Identity=41.6234887737478, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI87082258, Length=304, Percent_Identity=30.5921052631579, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786343, Length=559, Percent_Identity=27.3703041144902, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1789601, Length=132, Percent_Identity=34.0909090909091, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 74689; Mature: 74689

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRKSLRRAAITLASCAAILAVSVATLWELDRAFPPPLPAELTVSTEVQDRDGQLLRAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEE
ATPDGYWRLETRLDQVDKQFVDMLVTYEDKRFWDHQGIDVLALGRAAGQFATSGHIVSGG
ECCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCCCCEEEECC
STLSMQLARLIEPRESRSLGSKIKQMLRAIQIERRLSKREILERYLTLAPYGGNLEGVRA
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ASLAYFGKEPKRLTVSEAALLVALPQLPEKRRPDRNLAIAHAARDRVLTRMVSSGLIGER
HHHHHHCCCCCEEEHHHHHHEEECCCCCHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCH
EAARAALDDVSGLRRTLPALAPHAAYAMLPKAVPGEPLKLTIRKSVQEGLEQVARDAATK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LGPRLSVAMVLADSRTGDILGEVGSANFFDASRSGWIDMTKIVRSPGSTLKPFIYGLAFE
CCCCEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
QGLVAQETLIEDSPVDFGGYRPKNFDMGYQGDVSVRQALQLSLNVPAIRVLDAVGPARLT
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCHHHHH
ARFRQAGVNPILPVNEAPGLAIGLGGVGVTLRDLVQLYTGLANGGKTHTLHDGTEPANAE
HHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
RTTATILNDQANWQIIDILSGVKPPEGALQRGIAYKTGTSYGYRDAWSVGFDGRYVLGVW
CCEEEEECCCCCEEEEEHHHCCCCCHHHHHCCCEEECCCCCCCCCCEECCCCCEEEEEEE
VGRPDASAVPGLSGYVSAAPILFEGFVRSGLATVPLPGRPPGAFTPKREDLPVTLARFGA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEHHHHCC
GADGLVQATPTEPAPTIIFPPDGARVDLATNSADATPLVLKLQGGRAPFRWLANGKPLTG
CCCCCEEECCCCCCCEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCC
IDRRRTATWLPDGAGYSTLTVIDAAGRAASVKVFVE
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure
MLSRKSLRRAAITLASCAAILAVSVATLWELDRAFPPPLPAELTVSTEVQDRDGQLLRAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEE
ATPDGYWRLETRLDQVDKQFVDMLVTYEDKRFWDHQGIDVLALGRAAGQFATSGHIVSGG
ECCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCCCCEEEECC
STLSMQLARLIEPRESRSLGSKIKQMLRAIQIERRLSKREILERYLTLAPYGGNLEGVRA
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ASLAYFGKEPKRLTVSEAALLVALPQLPEKRRPDRNLAIAHAARDRVLTRMVSSGLIGER
HHHHHHCCCCCEEEHHHHHHEEECCCCCHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCH
EAARAALDDVSGLRRTLPALAPHAAYAMLPKAVPGEPLKLTIRKSVQEGLEQVARDAATK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
LGPRLSVAMVLADSRTGDILGEVGSANFFDASRSGWIDMTKIVRSPGSTLKPFIYGLAFE
CCCCEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
QGLVAQETLIEDSPVDFGGYRPKNFDMGYQGDVSVRQALQLSLNVPAIRVLDAVGPARLT
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCHHHHH
ARFRQAGVNPILPVNEAPGLAIGLGGVGVTLRDLVQLYTGLANGGKTHTLHDGTEPANAE
HHHHHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
RTTATILNDQANWQIIDILSGVKPPEGALQRGIAYKTGTSYGYRDAWSVGFDGRYVLGVW
CCEEEEECCCCCEEEEEHHHCCCCCHHHHHCCCEEECCCCCCCCCCEECCCCCEEEEEEE
VGRPDASAVPGLSGYVSAAPILFEGFVRSGLATVPLPGRPPGAFTPKREDLPVTLARFGA
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEHHHHCC
GADGLVQATPTEPAPTIIFPPDGARVDLATNSADATPLVLKLQGGRAPFRWLANGKPLTG
CCCCCEEECCCCCCCEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCC
IDRRRTATWLPDGAGYSTLTVIDAAGRAASVKVFVE
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]