Click here to switch to the map view.

The map label for this gene is ldc [H]

Identifier: 13471573

GI number: 13471573

Start: 1322287

End: 1323507

Strand: Reverse

Name: ldc [H]

Synonym: mll1584

Alternate gene names: 13471573

Gene position: 1323507-1322287 (Counterclockwise)

Preceding gene: 13471575

Following gene: 13471571

Centisome position: 18.81

GC content: 63.88

Gene sequence:

>1221_bases
ATGCAGCGATTCGAGAATGCCCGCGAGGCGGCACTGGCGCTTCGTCCTGACGATCCGGTCTATTGCTTTCGCCCGCAGGT
GCTGAAGGCCGATGCCAGGCAGTTCATGGGCATGTTCCCCGGCAAGACCGCCTATGCGGTCAAGACCAATGGCGAGCAGA
TCGTGCTGAAGACCTTGGTCGAGGCCGGCGTCACTGCCTTCGACGTCGCTTCGCCCGGCGAATTCGCTGCCGTGCGCGCG
GTCTCTCCCGATGCCGAGATGCTCTACATGCACCCGGTCAAGGCGCAGTCGGATATCAAACTGGCGCTGGAGAAATACGG
CATCCGCGTCATTTCGCTCGACCATGAGGACGAGATCACCAAGCTGACGCGGGTGGTGCGGGCGCTCGACATCGACCCGG
GCTCGATCAGCGTGTTCGTGCGCATCCAGACGAAAGGGTCGGCGGCCTACGAACTGTCGAAGAAGTTTGGCGCCGGGCCG
GCCTATGCGGTCGAACTCGCCGAGCGGCTGAACCGCACCGGCTACAAGGTCGGCCTGTGTTTCCATGTCGGCAGCCAGAT
CGAGGATCCCGACACGTATGAGCGGGCGCTGGCCTCGGCCGACTGGGTGCGCAACCGGCTGACATTCGACATCGCCGGTC
TCGATGTCGGCGGCGGCTTTCCGGCCGAATACGGCCATGATCCCAACCGCAAGCAGATCGAGATGCCGTCGCTCGGCCAG
ATCATGTCGCGGCTTTCCGGCGACCTGAAGGAATATCAGTTCGACCAGATGCCGCTGGTGGCCGAGCCGGGCAGGGTGAT
CGTGGCGCGCTGCCTGTCGCTGATCGTGCGCGTGCTCCTGCGCAAGGGCAAGCGGCTCTACATCAATGACGGCATCTGGG
CATCGCTGTCGGATTCATGGACCGGCAAGATCACGCTGCCGGCACGCTTCATTCCCGATCCGGCGATCAGGACCCGCAAT
GGCGCTGAAAAGAACGTCGTGCCGTTCAAGGTCTGCGGCGCGACCTGCGATTCCGTCGACATCCTGTCCAGGCCGTTCTG
GCTGCCGGAAACCGTCGACACCGGCGACTGGATCGAGATCGGCCATATCGGCGCCTACTCGCTGTCGCTCCGCACACGCT
TCAACGGCTTCTATCCCGACACATTCGTCGAGGTGACGACGCCGTTCGACGAGGGCGACGCGCCGCAGGGCTTCGCCAGC
CTGGAGACGATGGCGGATTAG

Upstream 100 bases:

>100_bases
CCAAGACTAGCGCGCAGCGTCAGGGGCACGAGACACAGAATTGTTTTCATTAGCCGCTAGCTTGGATTAATTGTGCGCAG
CCGAGATCGAGGATTCGTCA

Downstream 100 bases:

>100_bases
GAGATAGGCAGTGGGGAATAGGGAGTAGGGATCGTTTATTATACTGCCGCTTTGAATGTCACCTTTGCTATTTTCCTGCT
GCCTGCTGCCTGCTGCCTGC

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MQRFENAREAALALRPDDPVYCFRPQVLKADARQFMGMFPGKTAYAVKTNGEQIVLKTLVEAGVTAFDVASPGEFAAVRA
VSPDAEMLYMHPVKAQSDIKLALEKYGIRVISLDHEDEITKLTRVVRALDIDPGSISVFVRIQTKGSAAYELSKKFGAGP
AYAVELAERLNRTGYKVGLCFHVGSQIEDPDTYERALASADWVRNRLTFDIAGLDVGGGFPAEYGHDPNRKQIEMPSLGQ
IMSRLSGDLKEYQFDQMPLVAEPGRVIVARCLSLIVRVLLRKGKRLYINDGIWASLSDSWTGKITLPARFIPDPAIRTRN
GAEKNVVPFKVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSLSLRTRFNGFYPDTFVEVTTPFDEGDAPQGFAS
LETMAD

Sequences:

>Translated_406_residues
MQRFENAREAALALRPDDPVYCFRPQVLKADARQFMGMFPGKTAYAVKTNGEQIVLKTLVEAGVTAFDVASPGEFAAVRA
VSPDAEMLYMHPVKAQSDIKLALEKYGIRVISLDHEDEITKLTRVVRALDIDPGSISVFVRIQTKGSAAYELSKKFGAGP
AYAVELAERLNRTGYKVGLCFHVGSQIEDPDTYERALASADWVRNRLTFDIAGLDVGGGFPAEYGHDPNRKQIEMPSLGQ
IMSRLSGDLKEYQFDQMPLVAEPGRVIVARCLSLIVRVLLRKGKRLYINDGIWASLSDSWTGKITLPARFIPDPAIRTRN
GAEKNVVPFKVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSLSLRTRFNGFYPDTFVEVTTPFDEGDAPQGFAS
LETMAD
>Mature_406_residues
MQRFENAREAALALRPDDPVYCFRPQVLKADARQFMGMFPGKTAYAVKTNGEQIVLKTLVEAGVTAFDVASPGEFAAVRA
VSPDAEMLYMHPVKAQSDIKLALEKYGIRVISLDHEDEITKLTRVVRALDIDPGSISVFVRIQTKGSAAYELSKKFGAGP
AYAVELAERLNRTGYKVGLCFHVGSQIEDPDTYERALASADWVRNRLTFDIAGLDVGGGFPAEYGHDPNRKQIEMPSLGQ
IMSRLSGDLKEYQFDQMPLVAEPGRVIVARCLSLIVRVLLRKGKRLYINDGIWASLSDSWTGKITLPARFIPDPAIRTRN
GAEKNVVPFKVCGATCDSVDILSRPFWLPETVDTGDWIEIGHIGAYSLSLRTRFNGFYPDTFVEVTTPFDEGDAPQGFAS
LETMAD

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=29.7222222222222, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI16506287, Length=355, Percent_Identity=25.6338028169014, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=25.5434782608696, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=25.5434782608696, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562780, Length=358, Percent_Identity=29.0502793296089, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322664, Length=375, Percent_Identity=28.5333333333333, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24586472, Length=356, Percent_Identity=27.247191011236, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24586474, Length=353, Percent_Identity=27.1954674220963, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 44867; Mature: 44867

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFENAREAALALRPDDPVYCFRPQVLKADARQFMGMFPGKTAYAVKTNGEQIVLKTLV
CCCHHCCHHHEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
EAGVTAFDVASPGEFAAVRAVSPDAEMLYMHPVKAQSDIKLALEKYGIRVISLDHEDEIT
HCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHCCEEEEEECCHHHHH
KLTRVVRALDIDPGSISVFVRIQTKGSAAYELSKKFGAGPAYAVELAERLNRTGYKVGLC
HHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEE
FHVGSQIEDPDTYERALASADWVRNRLTFDIAGLDVGGGFPAEYGHDPNRKQIEMPSLGQ
EECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCHHH
IMSRLSGDLKEYQFDQMPLVAEPGRVIVARCLSLIVRVLLRKGKRLYINDGIWASLSDSW
HHHHHCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
TGKITLPARFIPDPAIRTRNGAEKNVVPFKVCGATCDSVDILSRPFWLPETVDTGDWIEI
CEEEEECCEECCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCEEEE
GHIGAYSLSLRTRFNGFYPDTFVEVTTPFDEGDAPQGFASLETMAD
CCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MQRFENAREAALALRPDDPVYCFRPQVLKADARQFMGMFPGKTAYAVKTNGEQIVLKTLV
CCCHHCCHHHEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
EAGVTAFDVASPGEFAAVRAVSPDAEMLYMHPVKAQSDIKLALEKYGIRVISLDHEDEIT
HCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHCCEEEEEECCHHHHH
KLTRVVRALDIDPGSISVFVRIQTKGSAAYELSKKFGAGPAYAVELAERLNRTGYKVGLC
HHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEE
FHVGSQIEDPDTYERALASADWVRNRLTFDIAGLDVGGGFPAEYGHDPNRKQIEMPSLGQ
EECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCEECCCCHHH
IMSRLSGDLKEYQFDQMPLVAEPGRVIVARCLSLIVRVLLRKGKRLYINDGIWASLSDSW
HHHHHCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCC
TGKITLPARFIPDPAIRTRNGAEKNVVPFKVCGATCDSVDILSRPFWLPETVDTGDWIEI
CEEEEECCEECCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCEEEE
GHIGAYSLSLRTRFNGFYPDTFVEVTTPFDEGDAPQGFASLETMAD
CCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]