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The map label for this gene is lpxC [H]

Identifier: 13471542

GI number: 13471542

Start: 1284689

End: 1285639

Strand: Reverse

Name: lpxC [H]

Synonym: mll1545

Alternate gene names: 13471542

Gene position: 1285639-1284689 (Counterclockwise)

Preceding gene: 13471543

Following gene: 13471541

Centisome position: 18.27

GC content: 63.41

Gene sequence:

>951_bases
ATGGGGATTGTCTTGCACGACTACCAGACGACAGTGAAGACGCGCGCGTCGCTTACGGGCACCGGCGTTCACAGCGGCAA
AGAAGTTTCCATCAGTTTCCTGCCGGCGGATGCCGATACCGGCATCGTGTTTCAGCTGGTCAGCGCCGAAGGGCAGGGCC
GCGAGTTCCGCGCGCTGTTTTCCGAGATCGGCGCCACCGATCTGTGCACCATGCTTGGCGATCCCTCGGGCGAGCATATC
GCCACGGTCGAGCACATCATGGCCGCGTTGTTCGGGCTCGGCATCGACAATGTTCTCATCGAGATCGACGGCCACGAGGT
TCCCATCCTCGATGGCAGCGCAATGGCCTTCGTGGAGGCCATCGACCAGGCGGGCATCGAGACGCTGCCGGTCAAGCGGC
GCTATATCAGGGTCGTCAAGCCGGTTCGCATCGAGAACGGTGCTTCCTGGGCGGAGTTCAGGCCCTATGACGGCACCCGC
TTCGAGGTCGAGATCGATTTCGAAAGCCCGGCCATCGGCCGTCAGCTCTTTGCGTCGGACATCAATGCCGACATTTTTCG
CCGCGATATTGCGCGCGCCCGCACCTTCGGCTTCATGAAGGATGTCGAGCGGTTGTGGGCGGCCGGCTATGCGCTTGGCT
CTTCGCTCGAGAATTCCCTGGTGATCGGTGACGACAACCGCGTCATCAATATGGGCGGCCTGCGTTATCCCAACGAATTC
GTGCGCCACAAGACGCTTGACGCCATGGGCGACCTCGCTCTGGCCGGCGCCCGCTTCATCGGCTGTTTCCGTTCCTATCG
CGGTGGCCACAGGCTGAACGCGGCGGCGCTGCGGCGTCTGCTGTCGGACCGCACGGCCTTCGAGATCGTCGAGACGACCC
GCCGCGAGCGTGGCCGCGCGGCAGAGATGAGCGCCGTCAATGCGCCTCTCTACGCGCCCTGGATGATCTGA

Upstream 100 bases:

>100_bases
ATAGTCGGTCTGCCGGGATTTCGGGGAAGTGGCCCTGCCTGCCGATTTAACAAGAGCCGCGCCCTCGGGCTGGAGAAGCG
GACTTAGGCATATCGGGCTT

Downstream 100 bases:

>100_bases
ACTCCGCACTGTTTTCGCACCCTGCAGCGGGATGCCAACTGTTGCAGGAATGCATCAGCGCTCGACGAAATTACAGCGAT
GCGCCAGCGTCGCCGCGCCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MGIVLHDYQTTVKTRASLTGTGVHSGKEVSISFLPADADTGIVFQLVSAEGQGREFRALFSEIGATDLCTMLGDPSGEHI
ATVEHIMAALFGLGIDNVLIEIDGHEVPILDGSAMAFVEAIDQAGIETLPVKRRYIRVVKPVRIENGASWAEFRPYDGTR
FEVEIDFESPAIGRQLFASDINADIFRRDIARARTFGFMKDVERLWAAGYALGSSLENSLVIGDDNRVINMGGLRYPNEF
VRHKTLDAMGDLALAGARFIGCFRSYRGGHRLNAAALRRLLSDRTAFEIVETTRRERGRAAEMSAVNAPLYAPWMI

Sequences:

>Translated_316_residues
MGIVLHDYQTTVKTRASLTGTGVHSGKEVSISFLPADADTGIVFQLVSAEGQGREFRALFSEIGATDLCTMLGDPSGEHI
ATVEHIMAALFGLGIDNVLIEIDGHEVPILDGSAMAFVEAIDQAGIETLPVKRRYIRVVKPVRIENGASWAEFRPYDGTR
FEVEIDFESPAIGRQLFASDINADIFRRDIARARTFGFMKDVERLWAAGYALGSSLENSLVIGDDNRVINMGGLRYPNEF
VRHKTLDAMGDLALAGARFIGCFRSYRGGHRLNAAALRRLLSDRTAFEIVETTRRERGRAAEMSAVNAPLYAPWMI
>Mature_315_residues
GIVLHDYQTTVKTRASLTGTGVHSGKEVSISFLPADADTGIVFQLVSAEGQGREFRALFSEIGATDLCTMLGDPSGEHIA
TVEHIMAALFGLGIDNVLIEIDGHEVPILDGSAMAFVEAIDQAGIETLPVKRRYIRVVKPVRIENGASWAEFRPYDGTRF
EVEIDFESPAIGRQLFASDINADIFRRDIARARTFGFMKDVERLWAAGYALGSSLENSLVIGDDNRVINMGGLRYPNEFV
RHKTLDAMGDLALAGARFIGCFRSYRGGHRLNAAALRRLLSDRTAFEIVETTRRERGRAAEMSAVNAPLYAPWMI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=284, Percent_Identity=44.3661971830986, Blast_Score=247, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34756; Mature: 34625

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVLHDYQTTVKTRASLTGTGVHSGKEVSISFLPADADTGIVFQLVSAEGQGREFRALF
CCEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
SEIGATDLCTMLGDPSGEHIATVEHIMAALFGLGIDNVLIEIDGHEVPILDGSAMAFVEA
HHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHH
IDQAGIETLPVKRRYIRVVKPVRIENGASWAEFRPYDGTRFEVEIDFESPAIGRQLFASD
HHHCCCCCCCHHHHHHHHHCCEEECCCCCCCEECCCCCCEEEEEEECCCCCHHHHHHHHH
INADIFRRDIARARTFGFMKDVERLWAAGYALGSSLENSLVIGDDNRVINMGGLRYPNEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCHHH
VRHKTLDAMGDLALAGARFIGCFRSYRGGHRLNAAALRRLLSDRTAFEIVETTRRERGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCH
AEMSAVNAPLYAPWMI
HHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GIVLHDYQTTVKTRASLTGTGVHSGKEVSISFLPADADTGIVFQLVSAEGQGREFRALF
CEEEECHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
SEIGATDLCTMLGDPSGEHIATVEHIMAALFGLGIDNVLIEIDGHEVPILDGSAMAFVEA
HHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHH
IDQAGIETLPVKRRYIRVVKPVRIENGASWAEFRPYDGTRFEVEIDFESPAIGRQLFASD
HHHCCCCCCCHHHHHHHHHCCEEECCCCCCCEECCCCCCEEEEEEECCCCCHHHHHHHHH
INADIFRRDIARARTFGFMKDVERLWAAGYALGSSLENSLVIGDDNRVINMGGLRYPNEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEECCCCCCCHHH
VRHKTLDAMGDLALAGARFIGCFRSYRGGHRLNAAALRRLLSDRTAFEIVETTRRERGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCH
AEMSAVNAPLYAPWMI
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA