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The map label for this gene is mmsB [H]

Identifier: 13471278

GI number: 13471278

Start: 1010351

End: 1011235

Strand: Direct

Name: mmsB [H]

Synonym: mlr1203

Alternate gene names: 13471278

Gene position: 1010351-1011235 (Clockwise)

Preceding gene: 13471277

Following gene: 13471284

Centisome position: 14.36

GC content: 64.18

Gene sequence:

>885_bases
ATGACGACGATCGCCTTCATCGGCCTTGGTAATATGGGCAATCCGATGGCCGCCAATCTGGTCAAGGCCGGGCATCAAGT
GCACGGCTTCGACCTCATGCCGGAGAATTTGACCGTCGCGCGCGAGCACGGTGTTGTCGTCATGGCCAACGCGCCGGCGG
CGGTGAAGGATGCCGACGTGGTGATCACCATGCTCCCTGCCGGCAAGCACGTGCTCTCGGTTTATGAGGACATCGCGCCC
AAGGCAAAAAAAGACGCGCTGTTCATCGATTCGTCGACGATCGACGTCGAGTCGGCGCGCAAGGCGCATGCGATTGCCGC
TAAACACGGCCTGCTTTCCATCGACGCGCCCGTCTCGGGCGGCACCGGTGGTGCGGCGGCCGGCACGCTGACCTTCATGG
CTGGCGGCTCCAACGACGCCTTCGCCGCCGCCGAGCCAGTCCTGAAGCCGATGGCCGGGCGCATCGTCCATTGCGGCGGC
GACGGTGCCGGCCAGGCGGCGAAGATCTGCAACAACATGATCCTCGGCATTTCGATGATCGGCGTCGCCGAGGCCTTCGT
GCTGGCCGAAAAGCTCGGCCTGTCGCATCAGGCGCTGTTCGACGTCGCCTCGACCTCTTCGGGCCAATGCTGGTCCTTGA
CCACCTATTGCCCGGTGCCCGGCCCGGTGCCCACTTCACCCGCCAACAGGGATTACAGGCCGGGCTTCGCCGCTGCCCTT
ATGCTGAAAGACCTGAAATTGTCCCAGGAAGCCGCACAGAGCGCGGGCGCGGTGACCCCGCTTGGCGCCGAGGCGGCACA
GCTCTATGCCCTGTTCAACGCCCAGGGGCATGGCGGCGCCGATTTCTCCGGCATAATTAATTTTCTCAGGGGTAACCCAG
CGTAA

Upstream 100 bases:

>100_bases
GCGTCCATCAGATCCTCGAAGGCACCAACGAGATCATGCGCGTCATCATCGCGCGTGCCTTGATCGGTCGCTGAAGCCAG
CAAACTCCGGGAGTGAGACA

Downstream 100 bases:

>100_bases
CCAGCGGATTTGATGGGTTTTTTCCGGATCAACCTGGCAGAAGAACCGCAAATTTAGATTTGCTTAAGCTCTCGATAACT
CTGCGGTAACGATGTCGCTA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTTIAFIGLGNMGNPMAANLVKAGHQVHGFDLMPENLTVAREHGVVVMANAPAAVKDADVVITMLPAGKHVLSVYEDIAP
KAKKDALFIDSSTIDVESARKAHAIAAKHGLLSIDAPVSGGTGGAAAGTLTFMAGGSNDAFAAAEPVLKPMAGRIVHCGG
DGAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPTSPANRDYRPGFAAAL
MLKDLKLSQEAAQSAGAVTPLGAEAAQLYALFNAQGHGGADFSGIINFLRGNPA

Sequences:

>Translated_294_residues
MTTIAFIGLGNMGNPMAANLVKAGHQVHGFDLMPENLTVAREHGVVVMANAPAAVKDADVVITMLPAGKHVLSVYEDIAP
KAKKDALFIDSSTIDVESARKAHAIAAKHGLLSIDAPVSGGTGGAAAGTLTFMAGGSNDAFAAAEPVLKPMAGRIVHCGG
DGAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPTSPANRDYRPGFAAAL
MLKDLKLSQEAAQSAGAVTPLGAEAAQLYALFNAQGHGGADFSGIINFLRGNPA
>Mature_293_residues
TTIAFIGLGNMGNPMAANLVKAGHQVHGFDLMPENLTVAREHGVVVMANAPAAVKDADVVITMLPAGKHVLSVYEDIAPK
AKKDALFIDSSTIDVESARKAHAIAAKHGLLSIDAPVSGGTGGAAAGTLTFMAGGSNDAFAAAEPVLKPMAGRIVHCGGD
GAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPTSPANRDYRPGFAAALM
LKDLKLSQEAAQSAGAVTPLGAEAAQLYALFNAQGHGGADFSGIINFLRGNPA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=45.2054794520548, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI40556376, Length=289, Percent_Identity=23.5294117647059, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790315, Length=295, Percent_Identity=34.9152542372881, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=32.9824561403509, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=32.5503355704698, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=29.3515358361775, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=299, Percent_Identity=41.8060200668896, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=43.598615916955, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=43.598615916955, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28574115, Length=298, Percent_Identity=24.1610738255034, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29873; Mature: 29741

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIAFIGLGNMGNPMAANLVKAGHQVHGFDLMPENLTVAREHGVVVMANAPAAVKDADV
CCEEEEEEECCCCCHHHHHHHHCCCEEECEEECCCCEEEEECCCEEEEECCCCCCCCCCE
VITMLPAGKHVLSVYEDIAPKAKKDALFIDSSTIDVESARKAHAIAAKHGLLSIDAPVSG
EEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCC
GTGGAAAGTLTFMAGGSNDAFAAAEPVLKPMAGRIVHCGGDGAGQAAKICNNMILGISMI
CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
GVAEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPTSPANRDYRPGFAAAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
MLKDLKLSQEAAQSAGAVTPLGAEAAQLYALFNAQGHGGADFSGIINFLRGNPA
HHHHHHHHHHHHHHCCCCCCCCHHHHHEEHEEECCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TTIAFIGLGNMGNPMAANLVKAGHQVHGFDLMPENLTVAREHGVVVMANAPAAVKDADV
CEEEEEEECCCCCHHHHHHHHCCCEEECEEECCCCEEEEECCCEEEEECCCCCCCCCCE
VITMLPAGKHVLSVYEDIAPKAKKDALFIDSSTIDVESARKAHAIAAKHGLLSIDAPVSG
EEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCC
GTGGAAAGTLTFMAGGSNDAFAAAEPVLKPMAGRIVHCGGDGAGQAAKICNNMILGISMI
CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
GVAEAFVLAEKLGLSHQALFDVASTSSGQCWSLTTYCPVPGPVPTSPANRDYRPGFAAAL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
MLKDLKLSQEAAQSAGAVTPLGAEAAQLYALFNAQGHGGADFSGIINFLRGNPA
HHHHHHHHHHHHHHCCCCCCCCHHHHHEEHEEECCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]