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The map label for this gene is mmgC [H]

Identifier: 13471277

GI number: 13471277

Start: 1009158

End: 1010324

Strand: Direct

Name: mmgC [H]

Synonym: mlr1201

Alternate gene names: 13471277

Gene position: 1009158-1010324 (Clockwise)

Preceding gene: 13471274

Following gene: 13471278

Centisome position: 14.34

GC content: 65.12

Gene sequence:

>1167_bases
ATGGACGCCGCGGTCGATGCGAGCACCAGCCAGTTCGAACTCAACGAGGAACAGCGCGCCATCCAGGAGATGGCGCAGGC
CTTCGCCGCCGACCGCGTCGCGCCGAATGCGCTCGACTGGGATCGCAGGAAGCATTTTCCCGCCGATGTGATCCGCGAGA
CCGGGCCGCTCGGCCTCGGCGGCATCTATGTCAGGGACGACGTCGGCGGCTCCGCCCTCGGCCGCCTCGACGCCGTGCTG
ATCTTCGAGGCGCTGTCGCATGCCGATCCGGGCTTTTCGTCCTTCATCTCGATCCACAATATGGTGGCCTCGATGATCGA
CCGCTTCGGCAACGACGAGCAGCGCCAGCGCTTCCTGCCGAAGCTCACCTCGATGGAATGGCTGGCGAGCTATTGCCTGA
CCGAGCCGGGCTCCGGATCGGATGCCGCGGCGCTCAAGACGCGCGCGGTGAAGAGCGGCGGCGACTATGTCCTCAACGGC
GCCAAACAATTCATCTCGGGCGCCGGCGACAGCGATGTCTATGCTGTCATGGTGCGCACCGGCGCCGACGGGCCGAAAGG
CATTTCCACCATTGTGGTACCGAAGGATGCGCCCGGCCTCTCCTTCGGCGCCAACGAGCACAAGATGGGCTGGCACATGC
AGTCGACCCGCCAGGTCATATTCGAGGACTGCAAGGTGCCGGCGGAAAACCTTCTGTCGGGTGAAGGCGCCGGTTTCGGC
ATCGCCATGGCCGGGCTCGATGGCGGCCGGCTGAACATCGCCGCCTGTTCGCTGGGCGGCGCCCAGTCGGCGCTCGACAA
GGCGCTGTCCTACACCGCCGAACGCAAGGCCTTCGGCTCGAAGATCAACCAGTTCCAGGCGCTGCAGTTCAGGCTGGCGG
ATATGGAGACCGAGCTGCAGGCAGCGCGCATCTTCCTCTATGCCGCCGCCTCCAAGCTCGACCGCAAGGCGCCGGACGCC
GGCAAATGGTCTGCCATGGCCAAGCGCTTCGTCACCGACACCGGCTTCAACGTCGCCAACAATGCGCTGCAGTTGCTCGG
CGGTTACGGCTATCTGCACGACTATGGCATCGAGAAGCTGGTGCGCGACCTGCGCGTCCATCAGATCCTCGAAGGCACCA
ACGAGATCATGCGCGTCATCATCGCGCGTGCCTTGATCGGTCGCTGA

Upstream 100 bases:

>100_bases
GGGTCGGGTTGCGCGGCGGCATCATTGGTCTAGATTGATGCGCGCGCAAAGCCAAAAACGACAGGCCAGCGGGCTAGCTG
GCATATAGGGAGAGAACGCC

Downstream 100 bases:

>100_bases
AGCCAGCAAACTCCGGGAGTGAGACAATGACGACGATCGCCTTCATCGGCCTTGGTAATATGGGCAATCCGATGGCCGCC
AATCTGGTCAAGGCCGGGCA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDAAVDASTSQFELNEEQRAIQEMAQAFAADRVAPNALDWDRRKHFPADVIRETGPLGLGGIYVRDDVGGSALGRLDAVL
IFEALSHADPGFSSFISIHNMVASMIDRFGNDEQRQRFLPKLTSMEWLASYCLTEPGSGSDAAALKTRAVKSGGDYVLNG
AKQFISGAGDSDVYAVMVRTGADGPKGISTIVVPKDAPGLSFGANEHKMGWHMQSTRQVIFEDCKVPAENLLSGEGAGFG
IAMAGLDGGRLNIAACSLGGAQSALDKALSYTAERKAFGSKINQFQALQFRLADMETELQAARIFLYAAASKLDRKAPDA
GKWSAMAKRFVTDTGFNVANNALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARALIGR

Sequences:

>Translated_388_residues
MDAAVDASTSQFELNEEQRAIQEMAQAFAADRVAPNALDWDRRKHFPADVIRETGPLGLGGIYVRDDVGGSALGRLDAVL
IFEALSHADPGFSSFISIHNMVASMIDRFGNDEQRQRFLPKLTSMEWLASYCLTEPGSGSDAAALKTRAVKSGGDYVLNG
AKQFISGAGDSDVYAVMVRTGADGPKGISTIVVPKDAPGLSFGANEHKMGWHMQSTRQVIFEDCKVPAENLLSGEGAGFG
IAMAGLDGGRLNIAACSLGGAQSALDKALSYTAERKAFGSKINQFQALQFRLADMETELQAARIFLYAAASKLDRKAPDA
GKWSAMAKRFVTDTGFNVANNALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARALIGR
>Mature_388_residues
MDAAVDASTSQFELNEEQRAIQEMAQAFAADRVAPNALDWDRRKHFPADVIRETGPLGLGGIYVRDDVGGSALGRLDAVL
IFEALSHADPGFSSFISIHNMVASMIDRFGNDEQRQRFLPKLTSMEWLASYCLTEPGSGSDAAALKTRAVKSGGDYVLNG
AKQFISGAGDSDVYAVMVRTGADGPKGISTIVVPKDAPGLSFGANEHKMGWHMQSTRQVIFEDCKVPAENLLSGEGAGFG
IAMAGLDGGRLNIAACSLGGAQSALDKALSYTAERKAFGSKINQFQALQFRLADMETELQAARIFLYAAASKLDRKAPDA
GKWSAMAKRFVTDTGFNVANNALQLLGGYGYLHDYGIEKLVRDLRVHQILEGTNEIMRVIIARALIGR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=386, Percent_Identity=54.6632124352332, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=37.5328083989501, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=37.5328083989501, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=37.7659574468085, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.6310160427808, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=35.7142857142857, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI226958414, Length=356, Percent_Identity=35.9550561797753, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=32.8947368421053, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557235, Length=335, Percent_Identity=34.6268656716418, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=33.0729166666667, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI21361497, Length=382, Percent_Identity=32.1989528795811, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=29.4736842105263, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI7669494, Length=350, Percent_Identity=29.4285714285714, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=27.3972602739726, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=27.1477663230241, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=27.1477663230241, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786223, Length=389, Percent_Identity=28.2776349614396, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081958, Length=349, Percent_Identity=28.9398280802292, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082384, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=46.9496021220159, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=38.4020618556701, Blast_Score=284, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.3202099737533, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.6456692913386, Blast_Score=247, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=36.71875, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=34.5844504021448, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=32.8877005347594, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=33.4285714285714, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=390, Percent_Identity=30, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=30.6666666666667, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=33.9222614840989, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=35.2173913043478, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.021897810219, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562446, Length=252, Percent_Identity=30.1587301587302, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=26.8595041322314, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=314, Percent_Identity=26.1146496815287, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=314, Percent_Identity=26.1146496815287, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=36.6233766233766, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.5, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=36.5333333333333, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=35.2941176470588, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=34.8958333333333, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281363737, Length=340, Percent_Identity=34.7058823529412, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=28.3464566929134, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41774; Mature: 41774

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAAVDASTSQFELNEEQRAIQEMAQAFAADRVAPNALDWDRRKHFPADVIRETGPLGLG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCC
GIYVRDDVGGSALGRLDAVLIFEALSHADPGFSSFISIHNMVASMIDRFGNDEQRQRFLP
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KLTSMEWLASYCLTEPGSGSDAAALKTRAVKSGGDYVLNGAKQFISGAGDSDVYAVMVRT
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCEEEEEEEE
GADGPKGISTIVVPKDAPGLSFGANEHKMGWHMQSTRQVIFEDCKVPAENLLSGEGAGFG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCE
IAMAGLDGGRLNIAACSLGGAQSALDKALSYTAERKAFGSKINQFQALQFRLADMETELQ
EEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARIFLYAAASKLDRKAPDAGKWSAMAKRFVTDTGFNVANNALQLLGGYGYLHDYGIEKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VRDLRVHQILEGTNEIMRVIIARALIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDAAVDASTSQFELNEEQRAIQEMAQAFAADRVAPNALDWDRRKHFPADVIRETGPLGLG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCC
GIYVRDDVGGSALGRLDAVLIFEALSHADPGFSSFISIHNMVASMIDRFGNDEQRQRFLP
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KLTSMEWLASYCLTEPGSGSDAAALKTRAVKSGGDYVLNGAKQFISGAGDSDVYAVMVRT
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCEEEEEEEE
GADGPKGISTIVVPKDAPGLSFGANEHKMGWHMQSTRQVIFEDCKVPAENLLSGEGAGFG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCE
IAMAGLDGGRLNIAACSLGGAQSALDKALSYTAERKAFGSKINQFQALQFRLADMETELQ
EEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARIFLYAAASKLDRKAPDAGKWSAMAKRFVTDTGFNVANNALQLLGGYGYLHDYGIEKL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHH
VRDLRVHQILEGTNEIMRVIIARALIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]