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The map label for this gene is pyrG

Identifier: 13470808

GI number: 13470808

Start: 472844

End: 474472

Strand: Reverse

Name: pyrG

Synonym: mll0606

Alternate gene names: 13470808

Gene position: 474472-472844 (Counterclockwise)

Preceding gene: 13470809

Following gene: 13470807

Centisome position: 6.74

GC content: 61.69

Gene sequence:

>1629_bases
ATGGCGCGATATGTATTCATCACAGGCGGCGTGGTTTCCTCACTTGGAAAAGGCATAGCCGCAGCGGCCCTTGGGGCTCT
CCTGCAGGCGCGAGGTTATCGCGCACGCATCAAAAAACTCGACCCGTATCTCAATGTCGATCCGGGCACGATGTCGCCGT
ACCAGCATGGCGAGGTGTTCGTCACCGATGACGGTGCGGAGACCGATCTCGATCTTGGCCATTACGAGCGCTTCACCGGC
CGCTCGGCCAATCAGCAAGACAACATCACCACCGGCCGCATTTACAAAAACATCATCGAGCGTGAGCGGCGCGGCGACTA
TCTCGGCGCGACCGTTCAGGTCATTCCGCATGTCACCGACGAGATCAAGAATTTCGTCCTCAACGGCAATGACGACTACG
ATTTCGTGCTGTGCGAGATCGGCGGCACGGTCGGCGACATCGAGGCCATGCCGTTCCTCGAGGCGATCCGCCAGCTCGGC
AACGATCTGCCGCGCAACAATGCCGTCTACGTGCATCTGACCCTGATGCCCTACATCCCGACGGCGGGTGAACTGAAGAC
CAAGCCGACCCAGCATTCGGTCAAGGAACTGCGCGGCATCGGCATCGCGCCCGACATCCTGCTGGTCCGTGCGGACCGCG
CCATTCCCAAGGAAGAGCGCAGAAAGCTGTCGCTGTTCTGCAATGTCAGGGAAAGCGCCGTCATCCAGGCGCTCGATGTG
CCGCACATCTACGACGTGCCGATGGCCTACCACAAGGAAGGGCTCGATTCGGAGGTGCTGGCTGCCTTCGGCATCGATCC
GGCGCCTAAGCCGCGCATGGAGCCCTGGCAGAAAGTGTCGGACCGCATCCACAGCCCGGAAGGCGAGGTGACCATCGCCA
TCGTCGGCAAATACACCGGCCTCAAGGATGCCTACAAATCGCTGATCGAAGCGCTTTCGCATGGCGGCCTGGCCAATCAC
GTCAAGGTCAAGCTCGACTGGATCGAATCGGAGATCTTCGAGAAGGAGGATCCGACGCCGTGGCTGGAAAAGGTGCATGG
CATCCTGGTTCCGGGCGGCTTTGGCGAACGCGGCTCCGAAGGCAAGATCCTGGCGGCGAAATTCGCGCGCGAGCGCAAGG
TGCCGTATTTCGGCATCTGCTTCGGCATGCAGATGGCCTGCATCGAGGCGGCGCGGTCGCTGGCTGGCGTCGAGCATGCC
TCCTCGACCGAGTTCGGCCCGACCGAGGAGCCCGTTGTCGGCCTAATGACCGAATGGCTGAAGGGCAACATGCTGGAGAA
GCGGCGTGAGACCGGCGACCTCGGTGGCACAATGCGTCTCGGTGCCTATCAGGCGGACCTCGCCAAGGGCTCCAAGATCG
CCGAGATCTATGGCGATACGCAGATTTCCGAGCGCCACCGCCACCGCTACGAGGTCAATATCGACTACAAGGAGCGGCTG
GAGGATTGCGGCCTGGTGTTTGCCGGCATGTCGCCCGATGGCGTGCTGCCGGAGACGGTCGAATATCCCGACCATCCGTG
GTTCATCGGCGTGCAGTATCATCCCGAGCTGAAGAGCCGGCCACTCGATCCGCATCCGCTGTTCGCCAGCTTCATCGAAG
CGGCTGTGGAGCAGTCTCGCCTGGTGTAG

Upstream 100 bases:

>100_bases
CACTCTTCGGGATCAAGGTCCGACGCCTTCTTGGGAAAAAACCTTCGCGGTGGTTTTTTCTCTGGCGGAATCAATCCAGC
CGCGTTAAGCGATGACTCCC

Downstream 100 bases:

>100_bases
GCAACCGCCGGGCGGGGCCTCTCATGCAGACCTATGTCGCGCTCCTCTACAGCATCATCCTGGGCGAGGGGCGCCGGGTC
GTCATGGCGGACCTCAAGGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MARYVFITGGVVSSLGKGIAAAALGALLQARGYRARIKKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTG
RSANQQDNITTGRIYKNIIERERRGDYLGATVQVIPHVTDEIKNFVLNGNDDYDFVLCEIGGTVGDIEAMPFLEAIRQLG
NDLPRNNAVYVHLTLMPYIPTAGELKTKPTQHSVKELRGIGIAPDILLVRADRAIPKEERRKLSLFCNVRESAVIQALDV
PHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMEPWQKVSDRIHSPEGEVTIAIVGKYTGLKDAYKSLIEALSHGGLANH
VKVKLDWIESEIFEKEDPTPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGVEHA
SSTEFGPTEEPVVGLMTEWLKGNMLEKRRETGDLGGTMRLGAYQADLAKGSKIAEIYGDTQISERHRHRYEVNIDYKERL
EDCGLVFAGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAAVEQSRLV

Sequences:

>Translated_542_residues
MARYVFITGGVVSSLGKGIAAAALGALLQARGYRARIKKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTG
RSANQQDNITTGRIYKNIIERERRGDYLGATVQVIPHVTDEIKNFVLNGNDDYDFVLCEIGGTVGDIEAMPFLEAIRQLG
NDLPRNNAVYVHLTLMPYIPTAGELKTKPTQHSVKELRGIGIAPDILLVRADRAIPKEERRKLSLFCNVRESAVIQALDV
PHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMEPWQKVSDRIHSPEGEVTIAIVGKYTGLKDAYKSLIEALSHGGLANH
VKVKLDWIESEIFEKEDPTPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGVEHA
SSTEFGPTEEPVVGLMTEWLKGNMLEKRRETGDLGGTMRLGAYQADLAKGSKIAEIYGDTQISERHRHRYEVNIDYKERL
EDCGLVFAGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAAVEQSRLV
>Mature_541_residues
ARYVFITGGVVSSLGKGIAAAALGALLQARGYRARIKKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGR
SANQQDNITTGRIYKNIIERERRGDYLGATVQVIPHVTDEIKNFVLNGNDDYDFVLCEIGGTVGDIEAMPFLEAIRQLGN
DLPRNNAVYVHLTLMPYIPTAGELKTKPTQHSVKELRGIGIAPDILLVRADRAIPKEERRKLSLFCNVRESAVIQALDVP
HIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMEPWQKVSDRIHSPEGEVTIAIVGKYTGLKDAYKSLIEALSHGGLANHV
KVKLDWIESEIFEKEDPTPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGVEHAS
STEFGPTEEPVVGLMTEWLKGNMLEKRRETGDLGGTMRLGAYQADLAKGSKIAEIYGDTQISERHRHRYEVNIDYKERLE
DCGLVFAGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAAVEQSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=43.8061041292639, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI28559085, Length=562, Percent_Identity=43.0604982206406, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=562, Percent_Identity=43.0604982206406, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=562, Percent_Identity=43.0604982206406, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=56.5055762081784, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=36.6174055829228, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=39.5061728395062, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322563, Length=571, Percent_Identity=40.4553415061296, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=44.0071556350626, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.3663366336634, Blast_Score=391, Evalue=1e-109,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_RHILO (Q98MF0)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102377.1
- ProteinModelPortal:   Q98MF0
- SMR:   Q98MF0
- GeneID:   1225040
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0606
- NMPDR:   fig|266835.1.peg.482
- HOGENOM:   HBG597806
- OMA:   TEWLRGN
- ProtClustDB:   PRK05380
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60164; Mature: 60033

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 380-380 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYVFITGGVVSSLGKGIAAAALGALLQARGYRARIKKLDPYLNVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGRSANQQDNITTGRIYKNIIERERRGDYLGATVQVIPHVTD
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIKNFVLNGNDDYDFVLCEIGGTVGDIEAMPFLEAIRQLGNDLPRNNAVYVHLTLMPYIP
HHHHHEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
TAGELKTKPTQHSVKELRGIGIAPDILLVRADRAIPKEERRKLSLFCNVRESAVIQALDV
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCEEEEEEECCHHHHHHHCCC
PHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMEPWQKVSDRIHSPEGEVTIAIVGKYTG
CCEECCCHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCC
LKDAYKSLIEALSHGGLANHVKVKLDWIESEIFEKEDPTPWLEKVHGILVPGGFGERGSE
HHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHCCCCCCHHHHHHCCEEECCCCCCCCCC
GKILAAKFARERKVPYFGICFGMQMACIEAARSLAGVEHASSTEFGPTEEPVVGLMTEWL
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
KGNMLEKRRETGDLGGTMRLGAYQADLAKGSKIAEIYGDTQISERHRHRYEVNIDYKERL
CCCHHHHHHHCCCCCCEEEECCHHHHHHCCCEEEEHHCCCHHHHHHCCEEEEECCHHHHH
EDCGLVFAGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAAVEQSR
HHCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHC
LV
CC
>Mature Secondary Structure 
ARYVFITGGVVSSLGKGIAAAALGALLQARGYRARIKKLDPYLNVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGRSANQQDNITTGRIYKNIIERERRGDYLGATVQVIPHVTD
EECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIKNFVLNGNDDYDFVLCEIGGTVGDIEAMPFLEAIRQLGNDLPRNNAVYVHLTLMPYIP
HHHHHEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCC
TAGELKTKPTQHSVKELRGIGIAPDILLVRADRAIPKEERRKLSLFCNVRESAVIQALDV
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCEEEEEEECCHHHHHHHCCC
PHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMEPWQKVSDRIHSPEGEVTIAIVGKYTG
CCEECCCHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCC
LKDAYKSLIEALSHGGLANHVKVKLDWIESEIFEKEDPTPWLEKVHGILVPGGFGERGSE
HHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHCCCCCCHHHHHHCCEEECCCCCCCCCC
GKILAAKFARERKVPYFGICFGMQMACIEAARSLAGVEHASSTEFGPTEEPVVGLMTEWL
CCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
KGNMLEKRRETGDLGGTMRLGAYQADLAKGSKIAEIYGDTQISERHRHRYEVNIDYKERL
CCCHHHHHHHCCCCCCEEEECCHHHHHHCCCEEEEHHCCCHHHHHHCCEEEEECCHHHHH
EDCGLVFAGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDPHPLFASFIEAAVEQSR
HHCCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968