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The map label for this gene is ade

Identifier: 13470448

GI number: 13470448

Start: 110644

End: 112461

Strand: Direct

Name: ade

Synonym: mlr0157

Alternate gene names: 13470448

Gene position: 110644-112461 (Clockwise)

Preceding gene: 13470447

Following gene: 13470450

Centisome position: 1.57

GC content: 64.74

Gene sequence:

>1818_bases
ATGGCAAAGAAGCCGGCGGCGCATGCGACGAAACCAAAACCCTGGACCGAGATGGCGACGCATCTGGTCGACGTCGCCAT
GGGCCGCAAGCCCGCCGATCTCGTCATCCGCAACGGCCGCTGGGTGAACGTTCACTCCGGCGAGATCATCGCCGGCACCG
ATATCGCCATTGCCGGCGGCCGCTTCGCCTATTGCGGGCCGAATGCCAGCCACGCCATCGGCCAGGGCACCAAGGTTGTC
GATGCCGGCGGGCGCTATCTGGTGCCAGGCCTCTGCGACGCGCACATGCATGTCGAGAGCGGCATGGTGACGGTGACCGA
GTTCTGCCGTGCCGTCATCCCGCACGGCACCACGTCGATGTTCATCGATCCGCACGAGATCGCCAATGTGCTCGGCTTGC
CGGGCGTGCGGCTGATGCATGACGAGGCGGTGGCGATGCCCATCAACGTGCATGTGCAGATGCCGTCCTGCGTGCCGTCG
GCGCCCGGGTTGGAACATGCCGGCGCCGAGCTGACGGTCGCCGATGTTGCCGAGGCCATGACCTGGGAAAACATCATCGG
GCTCGGCGAAGTGATGAATTTCCCCGGTGTCGCCGCAAACGATCCTGTCATGTCGGGCGAGATCGCGGCGACGGTTCGTG
CTGGCAAGACGGTCGGCGGCCACTATGCCTCGCGCGACCTCGGCCTGCCGTTCCATGGCTACGTCGCCGGCGGACCCGAA
GACGACCACGAAGGCACGCGCGCCGAGGATGCCATCGCACGTGTCCGCCAGGGCATGAAGGCGATGCTGCGGCTGGGCTC
GGCCTGGTACGACGTTGCCTCGCAGATCAAGGCGGTGACCGAAGGCGGCATCGATCCGCGCAACTTCATCCTGTGCACCG
ACGACAGCCATTCCGGCACGCTGGTGCATGAAGGCCACATGGACCGGGTGGTGCGCCACGCCATCCAACAGGGGCTGAAG
CCGGTGACGGCGATCCAGATGGCGACGATCAACACTGCCCAGCATTTCAGGCTGGAACGCGAAATCGGTTCGATCGCACC
GGGACGGTTGGCCGACCTGCTGATTGTCTCCGACCTCGCCGCAATGACCATCGATGAGGTTTATGCGCGCGGTGTCAGGT
TGGCCAAGGGTGGCAAGCTCGACATTGACATTCCGGCCTATGATTACCCGAAGACGGCGAAGAACACCGTCAAGTTGGGC
AAAAAACTCAGGGCCGGCGATTTCGACATCACGGCGCCCAAGGGTGCCAACGAGGTGCGGGTGCGCGTCATCGGCGTCAT
CGAGAACCAGGCGCCGACACGGGCGCTGGAGGCCGATCTGCCGGTCGAGGACGGGCTGGTCGCCATGGACCGCCGCAACG
ACGTCTGCCAGATCGCGCTGGTCGAGCGGCACAGGGGCACGGGCGGCGTCACCAACGCCTTCGTCTCCGGCTTCGGCTAT
ATGGGCGATTGCGCCATGGCCTCGAGCGTGGCGCATGACGCCCATCACATCATCTGCGTCGGCACCAACAAGCAGGACAT
GGCGCTGGCGGTCAACCGGCTGGGCCAAGTCGGCGGCGGCGTCGTGCTGTTCTCCAAGGGCAAGGAACTGGCGCTGGTCG
AAATGCCGATCGCCGGCCTGATGTCGGACGAGCGCGCCGAGATCGTCGCCGCCAAGGCCGAGAAACTGACCGAGGCGATG
CGCAAGATGGGGTGTTCCCTGAACAACGCATACATGCAGCACTCGCTGCTGGCGTTGGTGGTCATTCCGGAGCTGAGGAT
TTCCGACGTCGGGCTGATCGATGTGACGACGTTCCAGAAAGTCGATCTGTTCGTCTAG

Upstream 100 bases:

>100_bases
GGCTGAACAGCCTTTGTGAAGGCTGGGCAGGCCCGTTCGCTGTTTGGCGCTGGTCAAAACCAGGCAGGCTTGGCACAGTC
GCGCAAACAGGAGTCCCTTC

Downstream 100 bases:

>100_bases
ACCAAAGCCGCCGCCGGCGACTCGCTCACCCGCCGGTGACGATGGTCAGCACCTTGAACGGCGTGGTGATGACGACCTCG
GCGACCGATCCGACGGCCTT

Product: adenine deaminase

Products: NA

Alternate protein names: Adenase; Adenine aminase

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MAKKPAAHATKPKPWTEMATHLVDVAMGRKPADLVIRNGRWVNVHSGEIIAGTDIAIAGGRFAYCGPNASHAIGQGTKVV
DAGGRYLVPGLCDAHMHVESGMVTVTEFCRAVIPHGTTSMFIDPHEIANVLGLPGVRLMHDEAVAMPINVHVQMPSCVPS
APGLEHAGAELTVADVAEAMTWENIIGLGEVMNFPGVAANDPVMSGEIAATVRAGKTVGGHYASRDLGLPFHGYVAGGPE
DDHEGTRAEDAIARVRQGMKAMLRLGSAWYDVASQIKAVTEGGIDPRNFILCTDDSHSGTLVHEGHMDRVVRHAIQQGLK
PVTAIQMATINTAQHFRLEREIGSIAPGRLADLLIVSDLAAMTIDEVYARGVRLAKGGKLDIDIPAYDYPKTAKNTVKLG
KKLRAGDFDITAPKGANEVRVRVIGVIENQAPTRALEADLPVEDGLVAMDRRNDVCQIALVERHRGTGGVTNAFVSGFGY
MGDCAMASSVAHDAHHIICVGTNKQDMALAVNRLGQVGGGVVLFSKGKELALVEMPIAGLMSDERAEIVAAKAEKLTEAM
RKMGCSLNNAYMQHSLLALVVIPELRISDVGLIDVTTFQKVDLFV

Sequences:

>Translated_605_residues
MAKKPAAHATKPKPWTEMATHLVDVAMGRKPADLVIRNGRWVNVHSGEIIAGTDIAIAGGRFAYCGPNASHAIGQGTKVV
DAGGRYLVPGLCDAHMHVESGMVTVTEFCRAVIPHGTTSMFIDPHEIANVLGLPGVRLMHDEAVAMPINVHVQMPSCVPS
APGLEHAGAELTVADVAEAMTWENIIGLGEVMNFPGVAANDPVMSGEIAATVRAGKTVGGHYASRDLGLPFHGYVAGGPE
DDHEGTRAEDAIARVRQGMKAMLRLGSAWYDVASQIKAVTEGGIDPRNFILCTDDSHSGTLVHEGHMDRVVRHAIQQGLK
PVTAIQMATINTAQHFRLEREIGSIAPGRLADLLIVSDLAAMTIDEVYARGVRLAKGGKLDIDIPAYDYPKTAKNTVKLG
KKLRAGDFDITAPKGANEVRVRVIGVIENQAPTRALEADLPVEDGLVAMDRRNDVCQIALVERHRGTGGVTNAFVSGFGY
MGDCAMASSVAHDAHHIICVGTNKQDMALAVNRLGQVGGGVVLFSKGKELALVEMPIAGLMSDERAEIVAAKAEKLTEAM
RKMGCSLNNAYMQHSLLALVVIPELRISDVGLIDVTTFQKVDLFV
>Mature_604_residues
AKKPAAHATKPKPWTEMATHLVDVAMGRKPADLVIRNGRWVNVHSGEIIAGTDIAIAGGRFAYCGPNASHAIGQGTKVVD
AGGRYLVPGLCDAHMHVESGMVTVTEFCRAVIPHGTTSMFIDPHEIANVLGLPGVRLMHDEAVAMPINVHVQMPSCVPSA
PGLEHAGAELTVADVAEAMTWENIIGLGEVMNFPGVAANDPVMSGEIAATVRAGKTVGGHYASRDLGLPFHGYVAGGPED
DHEGTRAEDAIARVRQGMKAMLRLGSAWYDVASQIKAVTEGGIDPRNFILCTDDSHSGTLVHEGHMDRVVRHAIQQGLKP
VTAIQMATINTAQHFRLEREIGSIAPGRLADLLIVSDLAAMTIDEVYARGVRLAKGGKLDIDIPAYDYPKTAKNTVKLGK
KLRAGDFDITAPKGANEVRVRVIGVIENQAPTRALEADLPVEDGLVAMDRRNDVCQIALVERHRGTGGVTNAFVSGFGYM
GDCAMASSVAHDAHHIICVGTNKQDMALAVNRLGQVGGGVVLFSKGKELALVEMPIAGLMSDERAEIVAAKAEKLTEAMR
KMGCSLNNAYMQHSLLALVVIPELRISDVGLIDVTTFQKVDLFV

Specific function: Unknown

COG id: COG1001

COG function: function code F; Adenine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenine deaminase family

Homologues:

Organism=Escherichia coli, GI1790098, Length=592, Percent_Identity=31.5878378378378, Blast_Score=261, Evalue=8e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADEC_RHILO (Q98NF9)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102016.1
- ProteinModelPortal:   Q98NF9
- GeneID:   1224679
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0157
- NMPDR:   fig|266835.1.peg.121
- HOGENOM:   HBG725357
- OMA:   VGLGEMM
- ProtClustDB:   CLSK862922
- BRENDA:   3.5.4.2
- HAMAP:   MF_01518
- InterPro:   IPR006679
- InterPro:   IPR006680
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01178

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.2

Molecular weight: Translated: 64403; Mature: 64272

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKPAAHATKPKPWTEMATHLVDVAMGRKPADLVIRNGRWVNVHSGEIIAGTDIAIAGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEECCEEEEEECCCEEECCCEEEECC
RFAYCGPNASHAIGQGTKVVDAGGRYLVPGLCDAHMHVESGMVTVTEFCRAVIPHGTTSM
EEEEECCCCCCCCCCCCEEEECCCCEECCCCCCCCEECCCCCEEHHHHHHHHCCCCCCEE
FIDPHEIANVLGLPGVRLMHDEAVAMPINVHVQMPSCVPSAPGLEHAGAELTVADVAEAM
EECHHHHHHHHCCCCEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHH
TWENIIGLGEVMNFPGVAANDPVMSGEIAATVRAGKTVGGHYASRDLGLPFHGYVAGGPE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCC
DDHEGTRAEDAIARVRQGMKAMLRLGSAWYDVASQIKAVTEGGIDPRNFILCTDDSHSGT
CCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
LVHEGHMDRVVRHAIQQGLKPVTAIQMATINTAQHFRLEREIGSIAPGRLADLLIVSDLA
EEECCHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AMTIDEVYARGVRLAKGGKLDIDIPAYDYPKTAKNTVKLGKKLRAGDFDITAPKGANEVR
HHHHHHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCEE
VRVIGVIENQAPTRALEADLPVEDGLVAMDRRNDVCQIALVERHRGTGGVTNAFVSGFGY
EEEEEEECCCCCCCHHCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCC
MGDCAMASSVAHDAHHIICVGTNKQDMALAVNRLGQVGGGVVLFSKGKELALVEMPIAGL
CCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCHHH
MSDERAEIVAAKAEKLTEAMRKMGCSLNNAYMQHSLLALVVIPELRISDVGLIDVTTFQK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCCEEEEECCCE
VDLFV
EEECC
>Mature Secondary Structure 
AKKPAAHATKPKPWTEMATHLVDVAMGRKPADLVIRNGRWVNVHSGEIIAGTDIAIAGG
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEECCEEEEEECCCEEECCCEEEECC
RFAYCGPNASHAIGQGTKVVDAGGRYLVPGLCDAHMHVESGMVTVTEFCRAVIPHGTTSM
EEEEECCCCCCCCCCCCEEEECCCCEECCCCCCCCEECCCCCEEHHHHHHHHCCCCCCEE
FIDPHEIANVLGLPGVRLMHDEAVAMPINVHVQMPSCVPSAPGLEHAGAELTVADVAEAM
EECHHHHHHHHCCCCEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHH
TWENIIGLGEVMNFPGVAANDPVMSGEIAATVRAGKTVGGHYASRDLGLPFHGYVAGGPE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCC
DDHEGTRAEDAIARVRQGMKAMLRLGSAWYDVASQIKAVTEGGIDPRNFILCTDDSHSGT
CCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
LVHEGHMDRVVRHAIQQGLKPVTAIQMATINTAQHFRLEREIGSIAPGRLADLLIVSDLA
EEECCHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AMTIDEVYARGVRLAKGGKLDIDIPAYDYPKTAKNTVKLGKKLRAGDFDITAPKGANEVR
HHHHHHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCEE
VRVIGVIENQAPTRALEADLPVEDGLVAMDRRNDVCQIALVERHRGTGGVTNAFVSGFGY
EEEEEEECCCCCCCHHCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCHHHHHHHCCCC
MGDCAMASSVAHDAHHIICVGTNKQDMALAVNRLGQVGGGVVLFSKGKELALVEMPIAGL
CCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCHHH
MSDERAEIVAAKAEKLTEAMRKMGCSLNNAYMQHSLLALVVIPELRISDVGLIDVTTFQK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCCEEEEECCCE
VDLFV
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968