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The map label for this gene is aphA [H]

Identifier: 13470404

GI number: 13470404

Start: 72065

End: 73093

Strand: Reverse

Name: aphA [H]

Synonym: mll0103

Alternate gene names: 13470404

Gene position: 73093-72065 (Counterclockwise)

Preceding gene: 13470405

Following gene: 13470398

Centisome position: 1.04

GC content: 64.04

Gene sequence:

>1029_bases
ATGAAGGCCTTTTACGCCGAGGAACAGAAACGTCACGACCCCAAGGCCTTTCTTTCCAGTGGTGCGGCGCAGCCCAATCC
GGAAAAGCCCGAGCGCGTCGAGAAATTATTAGCCGGCGCAAAATCTGCAGGCTGCATGATCGAGCAGCCGCGCAATCACG
GGCTCGGCCCGGTCTCGGCAGTGCATACACCGGAATATCTCGACTTCCTCGAACATATTTTCGAGCGCTGGCAGCGGATT
GAGGGCGCTTCGGCGGAAGTGATCCCCAACATCCACCCGATCGCGCGCAACGGCTCCTATCCGGCCTCGGCGGTTGGCCA
GGCCGGCTACCATATGGCCGACACCGCTTGCCCGATCTCAGGCGAAACCTGGCAAAGCGCGCTGTGGAGCGCCTGGAGTG
CGGTCGAAGCGGCGGAAGCAGTGATGGCTGGCGCGCCGGCAGCCTATGCGCTGTGCCGTCCGCCCGGCCACCATGCCTTT
GCCGATGTCGCCGGCGGCTTCTGCTTCATCAACAATTCGGCGGTCGCCGCGCAGGTGCTGCGCAAGCAGGCGGCGCGGGT
GGCTATTCTCGATGTCGACCTGCACCATGGCAACGGCACGCAAGGCATCTTCTATGCCCGGCCCGACGTGTTCACCGTCT
CGCTGCATGCCGATCCGGTGCGGTTCTACCCGTTCTTCTGGGGTCATGCCGACGAGCGCGGCGAAGGCCCCGGCCTCGGC
TATAATTTCAACCTGCCCTTACCGCGCAAATCCGCCGACGCGGCGTTTCTGGAAGCGCTTGGCGTTGCGTTCCAGCGCAT
CCGCGCCTTTTCACCGGATGCGCTGGTGGTGGCACTTGGCCTTGACGCCTTCGAAGGCGATCCGTTCGGCGGGCTCTCGG
TGACGACGCCCGGCTTCTCCCGCATTGGCGAGGCGATTGGCAAACTCGGCCTGCCGAGCGTCGTCGTCCAGGAAGGCGGC
TATCTCTGCGACGCACTCAGCGACAATCTCACCGCCTTCCTCACAGGTTTTGGCGGCAAGGTGCGGTGA

Upstream 100 bases:

>100_bases
TCTATGAAAGGCTGGGCATCGCCTGGTCGAGTTACGAACAGACGCAGAAAATCATCGGCGATGCCTTTTTTGCCTTCGCC
GACGCGCCGGAGGAGCAGGA

Downstream 100 bases:

>100_bases
CGGTTTCTTCTTACGTCAGGAGCGCTGCTGCCTGAGCATGGCGATGACCCGGTGCACGCTCTCCAGCGTCTCGTCGATTT
CGGCCGCCGTGTTGTAGTGC

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKAFYAEEQKRHDPKAFLSSGAAQPNPEKPERVEKLLAGAKSAGCMIEQPRNHGLGPVSAVHTPEYLDFLEHIFERWQRI
EGASAEVIPNIHPIARNGSYPASAVGQAGYHMADTACPISGETWQSALWSAWSAVEAAEAVMAGAPAAYALCRPPGHHAF
ADVAGGFCFINNSAVAAQVLRKQAARVAILDVDLHHGNGTQGIFYARPDVFTVSLHADPVRFYPFFWGHADERGEGPGLG
YNFNLPLPRKSADAAFLEALGVAFQRIRAFSPDALVVALGLDAFEGDPFGGLSVTTPGFSRIGEAIGKLGLPSVVVQEGG
YLCDALSDNLTAFLTGFGGKVR

Sequences:

>Translated_342_residues
MKAFYAEEQKRHDPKAFLSSGAAQPNPEKPERVEKLLAGAKSAGCMIEQPRNHGLGPVSAVHTPEYLDFLEHIFERWQRI
EGASAEVIPNIHPIARNGSYPASAVGQAGYHMADTACPISGETWQSALWSAWSAVEAAEAVMAGAPAAYALCRPPGHHAF
ADVAGGFCFINNSAVAAQVLRKQAARVAILDVDLHHGNGTQGIFYARPDVFTVSLHADPVRFYPFFWGHADERGEGPGLG
YNFNLPLPRKSADAAFLEALGVAFQRIRAFSPDALVVALGLDAFEGDPFGGLSVTTPGFSRIGEAIGKLGLPSVVVQEGG
YLCDALSDNLTAFLTGFGGKVR
>Mature_342_residues
MKAFYAEEQKRHDPKAFLSSGAAQPNPEKPERVEKLLAGAKSAGCMIEQPRNHGLGPVSAVHTPEYLDFLEHIFERWQRI
EGASAEVIPNIHPIARNGSYPASAVGQAGYHMADTACPISGETWQSALWSAWSAVEAAEAVMAGAPAAYALCRPPGHHAF
ADVAGGFCFINNSAVAAQVLRKQAARVAILDVDLHHGNGTQGIFYARPDVFTVSLHADPVRFYPFFWGHADERGEGPGLG
YNFNLPLPRKSADAAFLEALGVAFQRIRAFSPDALVVALGLDAFEGDPFGGLSVTTPGFSRIGEAIGKLGLPSVVVQEGG
YLCDALSDNLTAFLTGFGGKVR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI17158039, Length=216, Percent_Identity=38.4259259259259, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI30795204, Length=216, Percent_Identity=38.4259259259259, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI30795202, Length=216, Percent_Identity=38.4259259259259, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI13128864, Length=327, Percent_Identity=30.5810397553517, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI148539870, Length=225, Percent_Identity=38.2222222222222, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI169234807, Length=225, Percent_Identity=38.2222222222222, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI153085395, Length=201, Percent_Identity=38.3084577114428, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI20070354, Length=328, Percent_Identity=29.8780487804878, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI62750347, Length=206, Percent_Identity=39.3203883495146, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI62750349, Length=206, Percent_Identity=39.3203883495146, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI8923769, Length=300, Percent_Identity=26.3333333333333, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI13128860, Length=169, Percent_Identity=34.9112426035503, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073088, Length=178, Percent_Identity=32.0224719101124, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226529806, Length=228, Percent_Identity=30.2631578947368, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI293336691, Length=153, Percent_Identity=31.3725490196078, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI13128862, Length=166, Percent_Identity=31.3253012048193, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073092, Length=236, Percent_Identity=25.8474576271186, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537347, Length=214, Percent_Identity=35.0467289719626, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17540334, Length=228, Percent_Identity=35.0877192982456, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=228, Percent_Identity=35.0877192982456, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=228, Percent_Identity=35.0877192982456, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193209491, Length=217, Percent_Identity=36.405529953917, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=312, Percent_Identity=26.2820512820513, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534739, Length=308, Percent_Identity=26.6233766233766, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17561978, Length=168, Percent_Identity=31.547619047619, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25154020, Length=196, Percent_Identity=25, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25154022, Length=216, Percent_Identity=23.6111111111111, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324307, Length=345, Percent_Identity=31.5942028985507, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323999, Length=263, Percent_Identity=26.615969581749, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=206, Percent_Identity=26.2135922330097, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=155, Percent_Identity=32.9032258064516, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641720, Length=202, Percent_Identity=39.1089108910891, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281360799, Length=202, Percent_Identity=39.1089108910891, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281360801, Length=202, Percent_Identity=39.1089108910891, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24642142, Length=230, Percent_Identity=35.6521739130435, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642146, Length=230, Percent_Identity=35.6521739130435, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642144, Length=230, Percent_Identity=35.6521739130435, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360899, Length=222, Percent_Identity=36.4864864864865, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24657891, Length=315, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644244, Length=166, Percent_Identity=33.7349397590361, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36442; Mature: 36442

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFYAEEQKRHDPKAFLSSGAAQPNPEKPERVEKLLAGAKSAGCMIEQPRNHGLGPVSA
CCCCCCCHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
VHTPEYLDFLEHIFERWQRIEGASAEVIPNIHPIARNGSYPASAVGQAGYHMADTACPIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHCCCCCEECCCCCCCC
GETWQSALWSAWSAVEAAEAVMAGAPAAYALCRPPGHHAFADVAGGFCFINNSAVAAQVL
CHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHCCCEEEECCCHHHHHHH
RKQAARVAILDVDLHHGNGTQGIFYARPDVFTVSLHADPVRFYPFFWGHADERGEGPGLG
HHHHCEEEEEEEEEECCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCC
YNFNLPLPRKSADAAFLEALGVAFQRIRAFSPDALVVALGLDAFEGDPFGGLSVTTPGFS
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCEECCCCHH
RIGEAIGKLGLPSVVVQEGGYLCDALSDNLTAFLTGFGGKVR
HHHHHHHHCCCCHHHHHCCCEEEHHHHCCCEEEEECCCCCCC
>Mature Secondary Structure
MKAFYAEEQKRHDPKAFLSSGAAQPNPEKPERVEKLLAGAKSAGCMIEQPRNHGLGPVSA
CCCCCCCHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCC
VHTPEYLDFLEHIFERWQRIEGASAEVIPNIHPIARNGSYPASAVGQAGYHMADTACPIS
CCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHCCCCCEECCCCCCCC
GETWQSALWSAWSAVEAAEAVMAGAPAAYALCRPPGHHAFADVAGGFCFINNSAVAAQVL
CHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHCCCEEEECCCHHHHHHH
RKQAARVAILDVDLHHGNGTQGIFYARPDVFTVSLHADPVRFYPFFWGHADERGEGPGLG
HHHHCEEEEEEEEEECCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCC
YNFNLPLPRKSADAAFLEALGVAFQRIRAFSPDALVVALGLDAFEGDPFGGLSVTTPGFS
EECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCCCCEECCCCHH
RIGEAIGKLGLPSVVVQEGGYLCDALSDNLTAFLTGFGGKVR
HHHHHHHHCCCCHHHHHCCCEEEHHHHCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]