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The map label for this gene is qor [C]

Identifier: 15603805

GI number: 15603805

Start: 2176582

End: 2177292

Strand: Direct

Name: qor [C]

Synonym: PM1940

Alternate gene names: 15603805

Gene position: 2176582-2177292 (Clockwise)

Preceding gene: 15603802

Following gene: 15603807

Centisome position: 96.42

GC content: 42.33

Gene sequence:

>711_bases
ATGTCCTTATTTTTATTGAGATGGAATGGCGCAATGTTAAAGCTTGACCTAGGGTTAAGGTCAAGTAATCTGAAAAAATT
CTATCATTTGAAAATTTTTCTCAAAATCCTACTGCTTGTAGTAGAGATATGCCAACGTACCATTACAGTGCAAAAAGGCG
ATTTTGTTGTATTGGGCGGAGCGACCAGCTCGGTAGGCATTGCCACCATTCAAATCGCCAAAATGCAAGGGGCAAACGTG
ATTGCTCTGTCTCGCACGCACGCCAAAGGCGATGTGCTTTTACAGAAAGGGGCGGATTTTGTGATTGCCACCAAAGAAGA
TGACGTTACGGCTAAATTACTAGAAATTACAAACGGCAAAGGCGTGAATTTGGTGTTCGACCCTGTGGGTGGCAAAGAAG
CAGCAAAAATTATCAACGCAATGACACAAGACGGCAAATACATCATCTACGGTGCATTAAGCCACGATGATATCGCCGTG
CCTGTGTTCCCAATTTTAGGCAAACACTTAACCGTGCGAGGCTATGAATTGTTTGAAATCACTACCGTACCAGAAAAACT
CGCTCAAGCGAAAAAATTCGTGTTTGACGGCTTAGCAAGCGGTCAATTAAAACCAGAAATTGACAAAGTTTTTGCTTTTG
ATGAAATGGCGGAAGCTCACCGTTATATGGAAAGCAATGCACAGATTGGGAAGATTTTGGTAAAGGTTTGA

Upstream 100 bases:

>100_bases
TTTTCCACACTTCCATAGAAAGTGTTTGTGCTTGAGCACAAGCGGTTATCCCTAAACTTAAAAGCAACAATGAGCGGGTG
AATTTATGTAATTTCATAAG

Downstream 100 bases:

>100_bases
TTGTTTTAAGGTAAATATGCCGTCTGAAAAATAAGTTTCAGACGGCACATCGTTATTTTACCTGCCGATTAAGCCACCAC
ACTAGCGAGAGCATCACAGG

Product: hypothetical protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: Alcohol Dehydrogenase; NAD(P)H Quinone Oxidoreductase PIG3 Family; Oxidoreductase; Zinc-Containing Alcohol Dehydrogenase Superfamily Protein; PIG3 Family NAD(P)H Quinone Oxidoreductase; Alcohol Dehydrogenase Zinc-Containing; Zinc-Containing Alcohol Dehydrogenase Superfamily; NAD(P)H Quinone Oxidoreductase; Zinc-Containing Alcohol Dehydrogenase; Oxidoreductase Zinc-Containing Alcohol Dehydrogenase; Quinone Reductase; NADPHQuinone Reductase; NAD(P)H Quinone Oxidoreductase Pig3 Family; NADPH Quinone Oxidoreductase; Oxidoreductase Protein; NAD-Dependent Alcohol Dehydrogenase; Glucose Dehydrogenase; NADPH2Quinone Reductase; Zinc-Dependent NADPHQuinone Oxidoreductase; Alcohol Dehydrogenase And Quinone Oxidoreductase; Trans-2-Enoyl-CoA Reductase; NADPHQuinone Oxidoreductase; Alcohol Dehydrogenase GroES Domain Protein; Zn-Dependent Oxidoreductase NADphQuinone Reductase; Polyketide Synthase Aufe; Oxydoreductase Protein Zinc-Containing; NADPH-Quinone Reductase; NADphQuinone Reductase; Quinone Oxidoreductase Protein; Alcohol Dehydrogenase Superfamily Protein Zinc-Containing; Dehydrogenase/Reductase; Polyketide Synthase; Zn-Dependent Oxidoreductase NADPHQuinone Reductase

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSLFLLRWNGAMLKLDLGLRSSNLKKFYHLKIFLKILLLVVEICQRTITVQKGDFVVLGGATSSVGIATIQIAKMQGANV
IALSRTHAKGDVLLQKGADFVIATKEDDVTAKLLEITNGKGVNLVFDPVGGKEAAKIINAMTQDGKYIIYGALSHDDIAV
PVFPILGKHLTVRGYELFEITTVPEKLAQAKKFVFDGLASGQLKPEIDKVFAFDEMAEAHRYMESNAQIGKILVKV

Sequences:

>Translated_236_residues
MSLFLLRWNGAMLKLDLGLRSSNLKKFYHLKIFLKILLLVVEICQRTITVQKGDFVVLGGATSSVGIATIQIAKMQGANV
IALSRTHAKGDVLLQKGADFVIATKEDDVTAKLLEITNGKGVNLVFDPVGGKEAAKIINAMTQDGKYIIYGALSHDDIAV
PVFPILGKHLTVRGYELFEITTVPEKLAQAKKFVFDGLASGQLKPEIDKVFAFDEMAEAHRYMESNAQIGKILVKV
>Mature_235_residues
SLFLLRWNGAMLKLDLGLRSSNLKKFYHLKIFLKILLLVVEICQRTITVQKGDFVVLGGATSSVGIATIQIAKMQGANVI
ALSRTHAKGDVLLQKGADFVIATKEDDVTAKLLEITNGKGVNLVFDPVGGKEAAKIINAMTQDGKYIIYGALSHDDIAVP
VFPILGKHLTVRGYELFEITTVPEKLAQAKKFVFDGLASGQLKPEIDKVFAFDEMAEAHRYMESNAQIGKILVKV

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI22538446, Length=201, Percent_Identity=30.8457711442786, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI22538444, Length=201, Percent_Identity=30.8457711442786, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI197927207, Length=175, Percent_Identity=25.1428571428571, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790485, Length=205, Percent_Identity=28.780487804878, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=164, Percent_Identity=27.4390243902439, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=231, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 25817; Mature: 25686

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFLLRWNGAMLKLDLGLRSSNLKKFYHLKIFLKILLLVVEICQRTITVQKGDFVVLGG
CEEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEECC
ATSSVGIATIQIAKMQGANVIALSRTHAKGDVLLQKGADFVIATKEDDVTAKLLEITNGK
CCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEECCCCEEEEECCCCCEEEEEEECCCC
GVNLVFDPVGGKEAAKIINAMTQDGKYIIYGALSHDDIAVPVFPILGKHLTVRGYELFEI
CCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHCCCEEEEECEEEEEE
TTVPEKLAQAKKFVFDGLASGQLKPEIDKVFAFDEMAEAHRYMESNAQIGKILVKV
ECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure 
SLFLLRWNGAMLKLDLGLRSSNLKKFYHLKIFLKILLLVVEICQRTITVQKGDFVVLGG
EEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEECC
ATSSVGIATIQIAKMQGANVIALSRTHAKGDVLLQKGADFVIATKEDDVTAKLLEITNGK
CCCCCCEEEEEEEEECCCEEEEEEECCCCCCEEEECCCCEEEEECCCCCEEEEEEECCCC
GVNLVFDPVGGKEAAKIINAMTQDGKYIIYGALSHDDIAVPVFPILGKHLTVRGYELFEI
CCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHCCCEEEEECEEEEEE
TTVPEKLAQAKKFVFDGLASGQLKPEIDKVFAFDEMAEAHRYMESNAQIGKILVKV
ECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA