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The map label for this gene is cpxA [H]

Identifier: 15603753

GI number: 15603753

Start: 2129238

End: 2130641

Strand: Direct

Name: cpxA [H]

Synonym: PM1888

Alternate gene names: 15603753

Gene position: 2129238-2130641 (Clockwise)

Preceding gene: 15603752

Following gene: 15603755

Centisome position: 94.32

GC content: 39.1

Gene sequence:

>1404_bases
ATGCCATTTGCGAAAGAAAGTTTTTTTAATACTATTTCATTCCGAATTTTTGCTTTTTTCTGGTTAACGTTTTCGCTACT
TTCCATTCTGATTTTTTCTATCCCTTATTTTGATTCTCGCATTTATTCTGAATTAAGCGAGAAAGAGCTATCTGCTTATC
AGCAAGAAATTATCACTTCTATTCGTCATAACCAAATTGCACGTATTTTAGCCGGTGTGCCTCTCTCTCACGCAGAACGG
TTTGACGGTATTCGCCCTGTGTTAGTCGATGATGTCGATGACAGCAGTATTTTAGGGGCGACGGCGACAGAAATCCCTTT
ATTAACTCAATTTATGTTTTCTTCTTCAGATCCCACAAGACCTTTGAAAAAAGTGTTTGGGGATGTTCGTATCGTTGGTC
CTTTTTCAATACATTTAGGCGGGGAAGCAAATAAATCTTATACACTTTATTTTATTGATAGAGTGAATGCGCAGAAGGAA
ATTATGAGCTTTGTCTTTGCTAACCCCGCTTTATTAGTCGGTTTGATTATTTTGGTGTCAACCCCGTTATTGTGGTGGCT
TGCGCGCAGTATTGGTAAACCTATTCGAAACTTGCAAATGTCGGCAAAGGCAGTCGCTTTAGGGGACTTTAAAATTAATA
AAGATCTTGAAACCAAAGGCTCGTTAGAATTACGTCAAGTAGGGCAAAGTTTTAACCAAATGACGGAGTCTTTGGAAGAA
TTACTCTCGAGCCAACAAGTGTTACTGTCTTCGATTTCTCATGAATTACGTACACCACTGACCCGTTTGCAATTAGCCTT
GGCGTTATTACGCCGTAGGTTTGGAGAAGATAATACCGAAATTCATCGTATTGAAATTGAGGCACGCCGTTTAGATAAAA
TGATTAATGATCTTTTATTGTTATCAAGACAGCAGTTGCATAGTCATGTTTCACGTGAGATTTTTCCGATTAATGAATTA
TGGGAGGAGGTGCTTGATGATGCAATATTTGAGGCAGAACACCGTAAATTGAATTTTGTTGTAAGACAAAATATTACTCA
GCCTGCCCGATACTATGTGAATGGTAATAAAGCACTTTTGGTCAGTGCGATCGAAAATATTGTTCGAAATGCATTGAAAT
ATACCCAAAGTGAAATCAGGGTGTCGATTTTCTTAAAACGTCAAGAATTGATGATTGTGATTGATGATAATGGTCACGGC
TTAGATGAGGCAGAATACGAGAAAATTTTCCAACCGTTTTACCGTGTAGATGAAACCAGAACCCGCGAAACCGGAGGAAC
GGGATTAGGTTTAGCCATTGTTGCTAACGTCGTTAAAGAGCATCACGGTGCGGTGTGGGCAAATGCTAGTCAGCTTGGGG
GACTTTGTGTCACTTTATGTATTCCGCTTTGGATTACCAGTTAA

Upstream 100 bases:

>100_bases
TAAAACCTTACGTGGACGAGGTTATTTGTTAGTGTCAGAAAAATAACAGTGATGATAAAGGCTATTATCATGCATAATAG
CCTTGTGTTTGAGGGCAACT

Downstream 100 bases:

>100_bases
ATTTAGCATGTTAGAAAAATGCCACAATCGTTGTGGCATTTTTTATACTCCAAGTTAAGCAACTTGTGGCTGTGCATTGA
GCGCTTGGATTTTACGTAAA

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPFAKESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAER
FDGIRPVLVDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKE
IMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEE
LLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPINEL
WEEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHG
LDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS

Sequences:

>Translated_467_residues
MPFAKESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAER
FDGIRPVLVDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKE
IMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEE
LLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPINEL
WEEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHG
LDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS
>Mature_466_residues
PFAKESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAERF
DGIRPVLVDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEI
MSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEEL
LSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPINELW
EEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGL
DEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=467, Percent_Identity=42.1841541755889, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1787894, Length=299, Percent_Identity=29.7658862876254, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=28.5211267605634, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=28.1786941580756, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=25.6797583081571, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=26.8939393939394, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=25.1677852348993, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=26.2295081967213, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=312, Percent_Identity=26.6025641025641, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=24.0802675585284, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787374, Length=279, Percent_Identity=27.9569892473118, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=27.4678111587983, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=27.8225806451613, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=28.5087719298246, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=24.8927038626609, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25.4464285714286, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=339, Percent_Identity=23.598820058997, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=311, Percent_Identity=24.4372990353698, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53080; Mature: 52949

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFAKESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IRHNQIARILAGVPLSHAERFDGIRPVLVDDVDDSSILGATATEIPLLTQFMFSSSDPTR
HHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
PLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVFANPALLVGLIILVS
HHHHHHCCEEEEEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHH
TPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEE
HHHHHHHHHHHCCHHHHHHHHHHEEEEECEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHH
LSRQQLHSHVSREIFPINELWEEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCHH
VSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETR
HHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHH
TRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS
CCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFAKESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IRHNQIARILAGVPLSHAERFDGIRPVLVDDVDDSSILGATATEIPLLTQFMFSSSDPTR
HHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCH
PLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVFANPALLVGLIILVS
HHHHHHCCEEEEEEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHH
TPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEE
HHHHHHHHHHHCCHHHHHHHHHHEEEEECEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHH
LSRQQLHSHVSREIFPINELWEEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCHH
VSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETR
HHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHH
TRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS
CCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]