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The map label for this gene is cpxR [H]

Identifier: 15603752

GI number: 15603752

Start: 2128482

End: 2129183

Strand: Direct

Name: cpxR [H]

Synonym: PM1887

Alternate gene names: 15603752

Gene position: 2128482-2129183 (Clockwise)

Preceding gene: 15603751

Following gene: 15603753

Centisome position: 94.29

GC content: 36.75

Gene sequence:

>702_bases
ATGCCTAAGATTTTATTAGTTGATGATGATGTTGAATTAATAGAGCTTCTTGCTGAGTTATTAACATTGGAAGGCTTTGA
GATTGATATGGCAAATAATGGCTTACAAGCATTACAAAAATTAGATCTAAGTTATGATTTAGTTTTGTTGGATATTATGA
TGCCTGTCCTCAATGGGGTTGAGACGTTAAAGAAAATTCGTCAGGAATTTTCTGTACCCGTGATCATGTTAACTGCACGT
GGTGATGATATTGATCGTATTCTCGGTCTCGAACTTGGGGCAGATGATTACATTCCAAAACCGTTTAATGATCGCGAGCT
TGTAGCGCGTATTAAAGCGATTTTACGTCGTACACAGCCAGCAGCCACATTAAATACAGAAGTGAAAGAAAATCGTAGCG
AATTTGTATTTTGCGATATTACACTTTATCCCGGTCGACAACAGGCATTTCACCATGATAAAGATTTAGAATTAACAGGA
ACAGAATTTGCACTATTACAAAAATTGGTCTTGAATCCCGGTCAAATTCTTTCCAGAGAGTCGTTAAGTATTGAAATTTT
AGGTAAACAATTAACCCCATTTGACCGTGCTATTGATATGCATATGTCAAATTTACGTAAGAAACTTCCACCGCGTACGG
ATGGGTCTCCTTGGTTTAAAACCTTACGTGGACGAGGTTATTTGTTAGTGTCAGAAAAATAA

Upstream 100 bases:

>100_bases
AGCGCCTCAAAAAGCTGGTGGAAATTTTGGCAATAGCAAATAATTTGTCGCGCTGTTGTTTATTGCGTTTTCTTTTTAAT
CAAATGTGAGGAGAGTCTGT

Downstream 100 bases:

>100_bases
CAGTGATGATAAAGGCTATTATCATGCATAATAGCCTTGTGTTTGAGGGCAACTATGCCATTTGCGAAAGAAAGTTTTTT
TAATACTATTTCATTCCGAA

Product: CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MPKILLVDDDVELIELLAELLTLEGFEIDMANNGLQALQKLDLSYDLVLLDIMMPVLNGVETLKKIRQEFSVPVIMLTAR
GDDIDRILGLELGADDYIPKPFNDRELVARIKAILRRTQPAATLNTEVKENRSEFVFCDITLYPGRQQAFHHDKDLELTG
TEFALLQKLVLNPGQILSRESLSIEILGKQLTPFDRAIDMHMSNLRKKLPPRTDGSPWFKTLRGRGYLLVSEK

Sequences:

>Translated_233_residues
MPKILLVDDDVELIELLAELLTLEGFEIDMANNGLQALQKLDLSYDLVLLDIMMPVLNGVETLKKIRQEFSVPVIMLTAR
GDDIDRILGLELGADDYIPKPFNDRELVARIKAILRRTQPAATLNTEVKENRSEFVFCDITLYPGRQQAFHHDKDLELTG
TEFALLQKLVLNPGQILSRESLSIEILGKQLTPFDRAIDMHMSNLRKKLPPRTDGSPWFKTLRGRGYLLVSEK
>Mature_232_residues
PKILLVDDDVELIELLAELLTLEGFEIDMANNGLQALQKLDLSYDLVLLDIMMPVLNGVETLKKIRQEFSVPVIMLTARG
DDIDRILGLELGADDYIPKPFNDRELVARIKAILRRTQPAATLNTEVKENRSEFVFCDITLYPGRQQAFHHDKDLELTGT
EFALLQKLVLNPGQILSRESLSIEILGKQLTPFDRAIDMHMSNLRKKLPPRTDGSPWFKTLRGRGYLLVSEK

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=63.3620689655172, Blast_Score=264, Evalue=4e-72,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=39.5652173913043, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=37.8854625550661, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=37.9912663755458, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=37.3390557939914, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=32.618025751073, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=34.9344978165939, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=34.061135371179, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=34.3478260869565, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=237, Percent_Identity=34.1772151898734, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=31.7391304347826, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082012, Length=236, Percent_Identity=32.6271186440678, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=234, Percent_Identity=28.2051282051282, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=41.1214953271028, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=35.5932203389831, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=33.8983050847458, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=35.6435643564356, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26483; Mature: 26352

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILLVDDDVELIELLAELLTLEGFEIDMANNGLQALQKLDLSYDLVLLDIMMPVLNGV
CCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
ETLKKIRQEFSVPVIMLTARGDDIDRILGLELGADDYIPKPFNDRELVARIKAILRRTQP
HHHHHHHHHHCCCEEEEEECCCCHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
AATLNTEVKENRSEFVFCDITLYPGRQQAFHHDKDLELTGTEFALLQKLVLNPGQILSRE
CHHHCCHHHCCCCCEEEEEEEECCCCHHHCCCCCCCEECCHHHHHHHHHHCCCCHHHCCC
SLSIEILGKQLTPFDRAIDMHMSNLRKKLPPRTDGSPWFKTLRGRGYLLVSEK
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
PKILLVDDDVELIELLAELLTLEGFEIDMANNGLQALQKLDLSYDLVLLDIMMPVLNGV
CEEEEECCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
ETLKKIRQEFSVPVIMLTARGDDIDRILGLELGADDYIPKPFNDRELVARIKAILRRTQP
HHHHHHHHHHCCCEEEEEECCCCHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
AATLNTEVKENRSEFVFCDITLYPGRQQAFHHDKDLELTGTEFALLQKLVLNPGQILSRE
CHHHCCHHHCCCCCEEEEEEEECCCCHHHCCCCCCCEECCHHHHHHHHHHCCCCHHHCCC
SLSIEILGKQLTPFDRAIDMHMSNLRKKLPPRTDGSPWFKTLRGRGYLLVSEK
CCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]