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The map label for this gene is pyrG [H]

Identifier: 15603737

GI number: 15603737

Start: 2113667

End: 2115295

Strand: Reverse

Name: pyrG [H]

Synonym: PM1872

Alternate gene names: 15603737

Gene position: 2115295-2113667 (Counterclockwise)

Preceding gene: 15603739

Following gene: 15603736

Centisome position: 93.7

GC content: 42.97

Gene sequence:

>1629_bases
ATGGCAACAAATTATATTTTTGTGACGGGCGGTGTTGTATCTTCGCTGGGTAAAGGTATTGCTGCAGCATCATTAGCAGC
AATTTTAGAAGCGCGTGGTTTAAAGGTCACCATGTTAAAACTGGATCCTTATATCAACGTGGACCCGGGCACCATGAGTC
CAACTCAACATGGTGAAGTTTTTGTCACCCAAGATGGCGCTGAAACCGACTTAGACTTAGGGCATTATGAGCGTTTTATT
CGCACCAAAATGACCAAACGTAACAATTTCACCACAGGCAAAATCTATTCCGAAGTCTTACGCAAAGAGCGTCGTGGTGA
TTATTTAGGTGCAACCATTCAAGTCATTCCTCATATTACAAACGAAATTAAATCTCGCGTCATTGATGGCGCAGCTGGGC
ATGATGTCGCAATTGTCGAAGTAGGGGGAACAGTAGGTGACATTGAATCTTTACCTTTCCTTGAAGCCTTACGTCAACTG
GCGGTGCAAGTCGGTCGTGAACGTACCTTGTTTATGCACTTAACCCTCGTGCCTTATATTCCAACGGCAGGTGAAGTGAA
AACGAAACCAACACAACATTCAGTGAAAGAATTATTATCCATTGGGATTCAACCTGATGTCTTAATTTGTCGTTCTGATC
GCATGGTCCCACCGAATGAGCGAGCAAAAATCGCCTTATTCTGTAATGTGCCAGAAAGAGCGGTCATTTCACTGAAAGAT
GTCAGCTCAATTTACCAAATTCCAGCCTTATTAAAATCACAAGGTTTGGATGATTTCATTTGTCAACGTTTCCACTTAGA
TTGCCCAGAAGCCGATCTGTCTGAATGGGAACAAGTGTTATACCAAGAAGCTAATCCAACAGGTGAAGTGGTGATCGGTA
TGGTGGGTAAATACACGGAATTACCAGATGCCTACAAATCGGTTAATGAGGCCTTAAAACACGCAGGCTTAAAAAACCGT
CTTAGCGTACAAATCAAATATATTGATTCACAAGATGTGGAAACCAAAGGCACAGAAGTGTTAGAAGGCGTTGACGGTAT
TTTAGTACCGGGTGGATTTGGTAATCGTGGTGTAGAAGGTAAAATTCTCACCGCCAAATATGCACGTGAAAATCACATTC
CTTATTTAGGGATCTGCTTAGGAATGCAAGTGGCTTACATTGAATATGCTCGCAATGTTGCCGGTTTAACGGATGCAAAT
TCTACTGAATTTGACCGCACTTGTGACTATCCTGTCGTGGGCTTAATTACCGAATGGCAAGACGCCGAAGGGAATATTGA
AACACGTACCGATGCCTCTGATTTAGGTGGCACCATGCGTTTAGGTGCACAACAATGCCATTTAATGGAAGGTAGCAAAG
CACGTGAACTTTATGGTGCTGAAACCATCGAAGAACGTCATCGTCATCGTTATGAAGTCAATAACGTCTTACGTCCACAA
GTGGAAAAAGCAGGCTTAAAAGTCACGGGCTTATCCGCAGATAAAAAATTAGTGGAAATTATTGAAGTACCAAATCACCC
TTGGTTTGTGGCATGTCAATTCCACCCAGAATTCACCTCCACCCCACGTGATGGTCACCCACTCTTTGCCGGCTTTGTCA
AAGCGGCAAAAGACAATCAAAAGAAATAA

Upstream 100 bases:

>100_bases
CAGCACAATGATTGAGTTAAACGTGCCTTTGCTGTAAACTACTCTCCCGTCTTGATAATTTCATTCAATCCATTTTTTCA
TATCAATAGTTAGGTTTCAT

Downstream 100 bases:

>100_bases
TTTTACCTATCAAGAAACTCAGCCCTACAACAACTTTGTAGGGCTTTTTGATGCTTTCGTTTACCAAGAAAAAACTAGAT
GTAAATCAATTAATCGACAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MATNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPTQHGEVFVTQDGAETDLDLGHYERFI
RTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNEIKSRVIDGAAGHDVAIVEVGGTVGDIESLPFLEALRQL
AVQVGRERTLFMHLTLVPYIPTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMVPPNERAKIALFCNVPERAVISLKD
VSSIYQIPALLKSQGLDDFICQRFHLDCPEADLSEWEQVLYQEANPTGEVVIGMVGKYTELPDAYKSVNEALKHAGLKNR
LSVQIKYIDSQDVETKGTEVLEGVDGILVPGGFGNRGVEGKILTAKYARENHIPYLGICLGMQVAYIEYARNVAGLTDAN
STEFDRTCDYPVVGLITEWQDAEGNIETRTDASDLGGTMRLGAQQCHLMEGSKARELYGAETIEERHRHRYEVNNVLRPQ
VEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAKDNQKK

Sequences:

>Translated_542_residues
MATNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPTQHGEVFVTQDGAETDLDLGHYERFI
RTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNEIKSRVIDGAAGHDVAIVEVGGTVGDIESLPFLEALRQL
AVQVGRERTLFMHLTLVPYIPTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMVPPNERAKIALFCNVPERAVISLKD
VSSIYQIPALLKSQGLDDFICQRFHLDCPEADLSEWEQVLYQEANPTGEVVIGMVGKYTELPDAYKSVNEALKHAGLKNR
LSVQIKYIDSQDVETKGTEVLEGVDGILVPGGFGNRGVEGKILTAKYARENHIPYLGICLGMQVAYIEYARNVAGLTDAN
STEFDRTCDYPVVGLITEWQDAEGNIETRTDASDLGGTMRLGAQQCHLMEGSKARELYGAETIEERHRHRYEVNNVLRPQ
VEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAKDNQKK
>Mature_541_residues
ATNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPTQHGEVFVTQDGAETDLDLGHYERFIR
TKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHITNEIKSRVIDGAAGHDVAIVEVGGTVGDIESLPFLEALRQLA
VQVGRERTLFMHLTLVPYIPTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMVPPNERAKIALFCNVPERAVISLKDV
SSIYQIPALLKSQGLDDFICQRFHLDCPEADLSEWEQVLYQEANPTGEVVIGMVGKYTELPDAYKSVNEALKHAGLKNRL
SVQIKYIDSQDVETKGTEVLEGVDGILVPGGFGNRGVEGKILTAKYARENHIPYLGICLGMQVAYIEYARNVAGLTDANS
TEFDRTCDYPVVGLITEWQDAEGNIETRTDASDLGGTMRLGAQQCHLMEGSKARELYGAETIEERHRHRYEVNNVLRPQV
EKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAKDNQKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=558, Percent_Identity=45.8781362007168, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI28559085, Length=560, Percent_Identity=45.7142857142857, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI28559083, Length=560, Percent_Identity=45.7142857142857, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI221316689, Length=560, Percent_Identity=45.7142857142857, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=79.7047970479705, Blast_Score=896, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=39.5387149917628, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=43.859649122807, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=43.9929328621908, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=44.2652329749104, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=42.8571428571429, Blast_Score=395, Evalue=1e-110,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59802; Mature: 59671

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPTQHGEV
CCCCEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTQDGAETDLDLGHYERFIRTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NEIKSRVIDGAAGHDVAIVEVGGTVGDIESLPFLEALRQLAVQVGRERTLFMHLTLVPYI
HHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMVPPNERAKIALFCNVPERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCHHEEEHHH
VSSIYQIPALLKSQGLDDFICQRFHLDCPEADLSEWEQVLYQEANPTGEVVIGMVGKYTE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCC
LPDAYKSVNEALKHAGLKNRLSVQIKYIDSQDVETKGTEVLEGVDGILVPGGFGNRGVEG
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHCCCCEEECCCCCCCCCCC
KILTAKYARENHIPYLGICLGMQVAYIEYARNVAGLTDANSTEFDRTCDYPVVGLITEWQ
EEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCC
DAEGNIETRTDASDLGGTMRLGAQQCHLMEGSKARELYGAETIEERHRHRYEVNNVLRPQ
CCCCCCCCCCCHHHCCCHHHCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCC
VEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAKDNQ
HHHCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCC
KK
CC
>Mature Secondary Structure 
ATNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMLKLDPYINVDPGTMSPTQHGEV
CCCEEEEECHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FVTQDGAETDLDLGHYERFIRTKMTKRNNFTTGKIYSEVLRKERRGDYLGATIQVIPHIT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NEIKSRVIDGAAGHDVAIVEVGGTVGDIESLPFLEALRQLAVQVGRERTLFMHLTLVPYI
HHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PTAGEVKTKPTQHSVKELLSIGIQPDVLICRSDRMVPPNERAKIALFCNVPERAVISLKD
CCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCHHEEEHHH
VSSIYQIPALLKSQGLDDFICQRFHLDCPEADLSEWEQVLYQEANPTGEVVIGMVGKYTE
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCC
LPDAYKSVNEALKHAGLKNRLSVQIKYIDSQDVETKGTEVLEGVDGILVPGGFGNRGVEG
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHHHCCCCEEECCCCCCCCCCC
KILTAKYARENHIPYLGICLGMQVAYIEYARNVAGLTDANSTEFDRTCDYPVVGLITEWQ
EEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCC
DAEGNIETRTDASDLGGTMRLGAQQCHLMEGSKARELYGAETIEERHRHRYEVNNVLRPQ
CCCCCCCCCCCHHHCCCHHHCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCC
VEKAGLKVTGLSADKKLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAKDNQ
HHHCCCEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCC
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA