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The map label for this gene is hemN [H]

Identifier: 15603698

GI number: 15603698

Start: 2071193

End: 2072572

Strand: Reverse

Name: hemN [H]

Synonym: PM1833

Alternate gene names: 15603698

Gene position: 2072572-2071193 (Counterclockwise)

Preceding gene: 15603699

Following gene: 15603697

Centisome position: 91.81

GC content: 41.59

Gene sequence:

>1380_bases
TTGGGGGAAATCATGTCCGAGATCGTTTGGGATTTGGCGCTTATTCAAAAATATAACCAGTCTGGTCCACGTTATACGTC
CTATCCAACGGCGTTGGAATTTAATGAAAATTATACCAACCAAGATTTTATTCAGGCGACAAAACGCTATCCAAATCGTC
CCCTTTCACTTTATGTCCATATCCCATTTTGCCATAAGCTGTGCTATTTCTGTGCCTGTAATAAAACCATTACTCGTCAC
CAACACAAAGCGGATATTTATCTCGACTTTTTAGAACGTGAAATAGAACACCGTGCACCGCTATTTAAAGATCGTATCGC
AACCCAAGTGCATTGGGGCGGGGGGACGCCAACCTATTTAACAGAGCAACAGTCCGCACGTTTAATGGCGATGCTACGCA
AACATTTTACCATTGCCCCTGATGCGGAAATCAGCATTGAAATGGATCCGCGTGAAATTGAACTCAATATGCTCGATCAT
TTACGTCGCATTGGTTTTAATCGCATGAGTATGGGTGTGCAAGATTTCAATAAAGACGTGCAAAAAGCCATTAACCGTGT
ACAAGATGAAGACTTTATTGAAGCACTCTTAAAACGTGCACGTGAATTGGGTTTCCAATCCACCAATCTCGATTTAATTT
ACGGTCTGCCACTACAAAACGTCGACAGTTTTATGTTCACTTTGCAAAAAGTCATTGCATTAAACCCCGATCGTTTAAGT
GTGTTCAATTACGCCCACTTACCAAGCCGTTTCGCTGGGCAAGCGAAGATTAAAAATGAACAATTGCCGGCACCAGAAAC
CAAATTAACCATTTTGCAAAAAATGATCGAAACCTTAGGTGACGCAGGTTACAAATTTATTGGCATGGATCATTTCGCCA
AACCAGATGATGAACTGGCGATCGCCCAACAACAAGGTGTATTGCACCGCAATTTCCAAGGCTACACTACACAAGAAGAA
TGTGATTTACTCGGCTTAGGTGTCTCGGCGATCAGCTTGTTAGGCGACACTTACGCACAAAATCAAAAAGAATTAAAACA
TTATTATACGGCGATTGATAACACCGGTATTGCACTGCACAAAGGTTTTGCCATGAGTGAAGAAGATTGCTTACGCCGTG
ATGTGATCAAACAATTAATCTGTAACTTCAAATTAGATTATCAACCGATTGAACAGCAATACGGCATTCAATTTACCTCG
CACTTTGCCGAAGATTTAAAACTGCTTGCGCCATTATCTGAAGACGGTCTATTAGAGATCGGTGAAAAGGCGATTCAAGT
GTCGGCGAAAGGGCGTTTGCTGATTCGCAATATTTGCCTTTGTTTTGATACTTATTCCAGAGAACAGGCGAAACGCCAAC
AGTTCTCCCGAATTATTTAA

Upstream 100 bases:

>100_bases
GTTTAGACTTACAACGTGAAAGCGCCGAAGCGGAATTAGAGCAGAAAATTCGCTTAGAATTACAGCAATTATTAATTGAT
ATGAAGTAAATGGAATCTTA

Downstream 100 bases:

>100_bases
ACAAACTTTTTGAAAAACCACCGCACTTTGGGAGAAAACCATGTCCATTTCAAAAACAGATATCCTCAATGCCTTTCATT
TTCGTCACGCTTGCAAAGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MGEIMSEIVWDLALIQKYNQSGPRYTSYPTALEFNENYTNQDFIQATKRYPNRPLSLYVHIPFCHKLCYFCACNKTITRH
QHKADIYLDFLEREIEHRAPLFKDRIATQVHWGGGTPTYLTEQQSARLMAMLRKHFTIAPDAEISIEMDPREIELNMLDH
LRRIGFNRMSMGVQDFNKDVQKAINRVQDEDFIEALLKRARELGFQSTNLDLIYGLPLQNVDSFMFTLQKVIALNPDRLS
VFNYAHLPSRFAGQAKIKNEQLPAPETKLTILQKMIETLGDAGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEE
CDLLGLGVSAISLLGDTYAQNQKELKHYYTAIDNTGIALHKGFAMSEEDCLRRDVIKQLICNFKLDYQPIEQQYGIQFTS
HFAEDLKLLAPLSEDGLLEIGEKAIQVSAKGRLLIRNICLCFDTYSREQAKRQQFSRII

Sequences:

>Translated_459_residues
MGEIMSEIVWDLALIQKYNQSGPRYTSYPTALEFNENYTNQDFIQATKRYPNRPLSLYVHIPFCHKLCYFCACNKTITRH
QHKADIYLDFLEREIEHRAPLFKDRIATQVHWGGGTPTYLTEQQSARLMAMLRKHFTIAPDAEISIEMDPREIELNMLDH
LRRIGFNRMSMGVQDFNKDVQKAINRVQDEDFIEALLKRARELGFQSTNLDLIYGLPLQNVDSFMFTLQKVIALNPDRLS
VFNYAHLPSRFAGQAKIKNEQLPAPETKLTILQKMIETLGDAGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEE
CDLLGLGVSAISLLGDTYAQNQKELKHYYTAIDNTGIALHKGFAMSEEDCLRRDVIKQLICNFKLDYQPIEQQYGIQFTS
HFAEDLKLLAPLSEDGLLEIGEKAIQVSAKGRLLIRNICLCFDTYSREQAKRQQFSRII
>Mature_458_residues
GEIMSEIVWDLALIQKYNQSGPRYTSYPTALEFNENYTNQDFIQATKRYPNRPLSLYVHIPFCHKLCYFCACNKTITRHQ
HKADIYLDFLEREIEHRAPLFKDRIATQVHWGGGTPTYLTEQQSARLMAMLRKHFTIAPDAEISIEMDPREIELNMLDHL
RRIGFNRMSMGVQDFNKDVQKAINRVQDEDFIEALLKRARELGFQSTNLDLIYGLPLQNVDSFMFTLQKVIALNPDRLSV
FNYAHLPSRFAGQAKIKNEQLPAPETKLTILQKMIETLGDAGYKFIGMDHFAKPDDELAIAQQQGVLHRNFQGYTTQEEC
DLLGLGVSAISLLGDTYAQNQKELKHYYTAIDNTGIALHKGFAMSEEDCLRRDVIKQLICNFKLDYQPIEQQYGIQFTSH
FAEDLKLLAPLSEDGLLEIGEKAIQVSAKGRLLIRNICLCFDTYSREQAKRQQFSRII

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=27.3469387755102, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI87082341, Length=455, Percent_Identity=69.2307692307692, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=242, Percent_Identity=30.9917355371901, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52925; Mature: 52794

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEIMSEIVWDLALIQKYNQSGPRYTSYPTALEFNENYTNQDFIQATKRYPNRPLSLYVH
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEE
IPFCHKLCYFCACNKTITRHQHKADIYLDFLEREIEHRAPLFKDRIATQVHWGGGTPTYL
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEECCCCCCCEE
TEQQSARLMAMLRKHFTIAPDAEISIEMDPREIELNMLDHLRRIGFNRMSMGVQDFNKDV
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHH
QKAINRVQDEDFIEALLKRARELGFQSTNLDLIYGLPLQNVDSFMFTLQKVIALNPDRLS
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCEE
VFNYAHLPSRFAGQAKIKNEQLPAPETKLTILQKMIETLGDAGYKFIGMDHFAKPDDELA
HHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHH
IAQQQGVLHRNFQGYTTQEECDLLGLGVSAISLLGDTYAQNQKELKHYYTAIDNTGIALH
HHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
KGFAMSEEDCLRRDVIKQLICNFKLDYQPIEQQYGIQFTSHFAEDLKLLAPLSEDGLLEI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHH
GEKAIQVSAKGRLLIRNICLCFDTYSREQAKRQQFSRII
CHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GEIMSEIVWDLALIQKYNQSGPRYTSYPTALEFNENYTNQDFIQATKRYPNRPLSLYVH
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEE
IPFCHKLCYFCACNKTITRHQHKADIYLDFLEREIEHRAPLFKDRIATQVHWGGGTPTYL
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEECCCCCCCEE
TEQQSARLMAMLRKHFTIAPDAEISIEMDPREIELNMLDHLRRIGFNRMSMGVQDFNKDV
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCHHHHHHHH
QKAINRVQDEDFIEALLKRARELGFQSTNLDLIYGLPLQNVDSFMFTLQKVIALNPDRLS
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCEE
VFNYAHLPSRFAGQAKIKNEQLPAPETKLTILQKMIETLGDAGYKFIGMDHFAKPDDELA
HHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHH
IAQQQGVLHRNFQGYTTQEECDLLGLGVSAISLLGDTYAQNQKELKHYYTAIDNTGIALH
HHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
KGFAMSEEDCLRRDVIKQLICNFKLDYQPIEQQYGIQFTSHFAEDLKLLAPLSEDGLLEI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHH
GEKAIQVSAKGRLLIRNICLCFDTYSREQAKRQQFSRII
CHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]