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The map label for this gene is glmU

Identifier: 15603671

GI number: 15603671

Start: 2029743

End: 2031119

Strand: Direct

Name: glmU

Synonym: PM1806

Alternate gene names: 15603671

Gene position: 2029743-2031119 (Clockwise)

Preceding gene: 15603669

Following gene: 15603677

Centisome position: 89.91

GC content: 42.92

Gene sequence:

>1377_bases
ATGAAAGAGAAAGCATTAAGTATCGTGATTTTAGCGGCCGGTAAAGGGACGCGGATGTATTCTGATTTACCAAAAGTGCT
ACATAAAATTGCCGGAAAACCGATGGTAAAACATGTGATCGATACGGTGAAATCCATTCATGCAAAAAATATCCATTTAG
TGTATGGACATGGTGGGGAAGTGATGCAAACTCGTTTGCAAGATGAACCTGTGAATTGGGTCTTACAAGCCGAGCAATTA
GGTACGGGGCATGCTATGCAGCAAGCAGCCCCGTTTTTTGCAGATGATGAAAATATTTTGATGCTTTATGGTGATGGACC
ATTAATTACTGCAGAAACTTTACAAACATTAATTGCGGCAAAACCTGAACATGGTATTGCATTATTGACCGTCGTATTAG
ATGACCCAACTGGTTATGGGCGTATTGTGCGTGAAAATGGCAATGTGGTGGCGATTGTGGAACAAAAAGATGCCAATGCA
GAGCAATTAAAAATCCAAGAAATTAACACAGGCTTGTTAGTGGCAGACGGTAAAAGTTTGAAAAAATGGTTATCACAGTT
AACCAACAACAATGCACAGGGAGAATATTATATTACGGATGTGATCGCCTTAGCGAATCAAGACGGTTGCCAAGTGGTGG
CGGTACAAGCCAGTGACTTTATGGAAGTAGAGGGCGTGAATAACCGTCAGCAATTAGCGCGTTTAGAGCGTTATTATCAG
CGCAAACAAGCAGACAATTTATTATTGGCTGGGGTGGCATTAGCGGATCCTGAGCGTTTTGATTTACGCGGGGAACTAAG
CCATGGGAAAGACGTGGAAATTGATGTGAACGTGATTATCGAGGGCAAAGTCAGCTTAGGTCACCGAGTTAAAATTGGAG
CTGGTTGTGTGTTAAAAAATTGCCAGATTGGTGATGATGTAGAAATTAAACCTTATTCTGTGTTGGAAGAGGCGATTGTT
GGACAAGCTGCGCAAATTGGACCCTTCTCTCGTTTGCGTCCGGGGACAGCATTAGCCGACAACACTCATATTGGTAATTT
CGTTGAAATTAAGAAAGCGCATATTGGGACGGGCTCGAAAGTAAACCATTTAAGTTATGTGGGAGATGCCGAAGTCGGGA
TGCAATGTAATATTGGTGCCGGCGTGATCACTTGTAACTATGATGGCGCAAATAAATTTAAGACCATTATTGGTGATAAT
GTGTTTGTAGGGTCTGATGTACAACTCGTGGCACCGGTTACCATCGAAACGGGTGCAACCATTGGGGCGGGGACTACGGT
GACCAAAGATGTGGCTTGTGATGAGTTAGTGATTTCACGTGTTCCTCAACGTCATATTCAAGGTTGGCAACGCCCTACTA
AACAAACGAAAAAGTAA

Upstream 100 bases:

>100_bases
TTTAGCTGGCTTGTTTTGGGTGATGTGCGTTTATTTTTATTGTAAAGTTAGATTATAATTTTGAGCAGTTATTTTTTTAT
TCATCAAACAAGAGAAGATT

Downstream 100 bases:

>100_bases
CCGCATTTACGATCAGTATTTATGTACTTGCTGCCCACCTGTTGGTGGGCGGTTTGTTTAGTTAAACGTGATATCTAATC
CCATTTCATTAAGCACGCGT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKEKALSIVILAAGKGTRMYSDLPKVLHKIAGKPMVKHVIDTVKSIHAKNIHLVYGHGGEVMQTRLQDEPVNWVLQAEQL
GTGHAMQQAAPFFADDENILMLYGDGPLITAETLQTLIAAKPEHGIALLTVVLDDPTGYGRIVRENGNVVAIVEQKDANA
EQLKIQEINTGLLVADGKSLKKWLSQLTNNNAQGEYYITDVIALANQDGCQVVAVQASDFMEVEGVNNRQQLARLERYYQ
RKQADNLLLAGVALADPERFDLRGELSHGKDVEIDVNVIIEGKVSLGHRVKIGAGCVLKNCQIGDDVEIKPYSVLEEAIV
GQAAQIGPFSRLRPGTALADNTHIGNFVEIKKAHIGTGSKVNHLSYVGDAEVGMQCNIGAGVITCNYDGANKFKTIIGDN
VFVGSDVQLVAPVTIETGATIGAGTTVTKDVACDELVISRVPQRHIQGWQRPTKQTKK

Sequences:

>Translated_458_residues
MKEKALSIVILAAGKGTRMYSDLPKVLHKIAGKPMVKHVIDTVKSIHAKNIHLVYGHGGEVMQTRLQDEPVNWVLQAEQL
GTGHAMQQAAPFFADDENILMLYGDGPLITAETLQTLIAAKPEHGIALLTVVLDDPTGYGRIVRENGNVVAIVEQKDANA
EQLKIQEINTGLLVADGKSLKKWLSQLTNNNAQGEYYITDVIALANQDGCQVVAVQASDFMEVEGVNNRQQLARLERYYQ
RKQADNLLLAGVALADPERFDLRGELSHGKDVEIDVNVIIEGKVSLGHRVKIGAGCVLKNCQIGDDVEIKPYSVLEEAIV
GQAAQIGPFSRLRPGTALADNTHIGNFVEIKKAHIGTGSKVNHLSYVGDAEVGMQCNIGAGVITCNYDGANKFKTIIGDN
VFVGSDVQLVAPVTIETGATIGAGTTVTKDVACDELVISRVPQRHIQGWQRPTKQTKK
>Mature_458_residues
MKEKALSIVILAAGKGTRMYSDLPKVLHKIAGKPMVKHVIDTVKSIHAKNIHLVYGHGGEVMQTRLQDEPVNWVLQAEQL
GTGHAMQQAAPFFADDENILMLYGDGPLITAETLQTLIAAKPEHGIALLTVVLDDPTGYGRIVRENGNVVAIVEQKDANA
EQLKIQEINTGLLVADGKSLKKWLSQLTNNNAQGEYYITDVIALANQDGCQVVAVQASDFMEVEGVNNRQQLARLERYYQ
RKQADNLLLAGVALADPERFDLRGELSHGKDVEIDVNVIIEGKVSLGHRVKIGAGCVLKNCQIGDDVEIKPYSVLEEAIV
GQAAQIGPFSRLRPGTALADNTHIGNFVEIKKAHIGTGSKVNHLSYVGDAEVGMQCNIGAGVITCNYDGANKFKTIIGDN
VFVGSDVQLVAPVTIETGATIGAGTTVTKDVACDELVISRVPQRHIQGWQRPTKQTKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=455, Percent_Identity=69.010989010989, Blast_Score=657, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PASMU (Q9CK29)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246745.1
- ProteinModelPortal:   Q9CK29
- SMR:   Q9CK29
- GeneID:   1245153
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1806
- NMPDR:   fig|272843.1.peg.1807
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK09451
- BioCyc:   PMUL272843:PM1806-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49557; Mature: 49557

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 363-363 BINDING 76-76 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 387-387 BINDING 405-405 BINDING 423-423 BINDING 440-440

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKALSIVILAAGKGTRMYSDLPKVLHKIAGKPMVKHVIDTVKSIHAKNIHLVYGHGGE
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
VMQTRLQDEPVNWVLQAEQLGTGHAMQQAAPFFADDENILMLYGDGPLITAETLQTLIAA
HHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCEECCCCEEEEECCCCEEEHHHHHHHHHC
KPEHGIALLTVVLDDPTGYGRIVRENGNVVAIVEQKDANAEQLKIQEINTGLLVADGKSL
CCCCCEEEEEEEEECCCCCCEEEEECCCEEEEEECCCCCHHEEEEEECCCCEEEECCHHH
KKWLSQLTNNNAQGEYYITDVIALANQDGCQVVAVQASDFMEVEGVNNRQQLARLERYYQ
HHHHHHHHCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHH
RKQADNLLLAGVALADPERFDLRGELSHGKDVEIDVNVIIEGKVSLGHRVKIGAGCVLKN
HHCCCCEEEEEEEECCCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEECCCEEEEC
CQIGDDVEIKPYSVLEEAIVGQAAQIGPFSRLRPGTALADNTHIGNFVEIKKAHIGTGSK
CCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCEEEEEEEECCCCCC
VNHLSYVGDAEVGMQCNIGAGVITCNYDGANKFKTIIGDNVFVGSDVQLVAPVTIETGAT
CCEEEECCCCCCCEEEECCCEEEEEECCCCCHHHHHHCCCEEECCCCEEEEEEEEECCCE
IGAGTTVTKDVACDELVISRVPQRHIQGWQRPTKQTKK
ECCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MKEKALSIVILAAGKGTRMYSDLPKVLHKIAGKPMVKHVIDTVKSIHAKNIHLVYGHGGE
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCH
VMQTRLQDEPVNWVLQAEQLGTGHAMQQAAPFFADDENILMLYGDGPLITAETLQTLIAA
HHHHHHCCCCCEEEEEECCCCCCHHHHHCCCCEECCCCEEEEECCCCEEEHHHHHHHHHC
KPEHGIALLTVVLDDPTGYGRIVRENGNVVAIVEQKDANAEQLKIQEINTGLLVADGKSL
CCCCCEEEEEEEEECCCCCCEEEEECCCEEEEEECCCCCHHEEEEEECCCCEEEECCHHH
KKWLSQLTNNNAQGEYYITDVIALANQDGCQVVAVQASDFMEVEGVNNRQQLARLERYYQ
HHHHHHHHCCCCCCCEEEEEEEEECCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHH
RKQADNLLLAGVALADPERFDLRGELSHGKDVEIDVNVIIEGKVSLGHRVKIGAGCVLKN
HHCCCCEEEEEEEECCCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEECCCEEEEC
CQIGDDVEIKPYSVLEEAIVGQAAQIGPFSRLRPGTALADNTHIGNFVEIKKAHIGTGSK
CCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCEEEEEEEECCCCCC
VNHLSYVGDAEVGMQCNIGAGVITCNYDGANKFKTIIGDNVFVGSDVQLVAPVTIETGAT
CCEEEECCCCCCCEEEECCCEEEEEECCCCCHHHHHHCCCEEECCCCEEEEEEEEECCCE
IGAGTTVTKDVACDELVISRVPQRHIQGWQRPTKQTKK
ECCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100