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The map label for this gene is hsrA [H]

Identifier: 15603649

GI number: 15603649

Start: 2009018

End: 2010403

Strand: Reverse

Name: hsrA [H]

Synonym: PM1784

Alternate gene names: 15603649

Gene position: 2010403-2009018 (Counterclockwise)

Preceding gene: 15603650

Following gene: 15603633

Centisome position: 89.05

GC content: 44.3

Gene sequence:

>1386_bases
ATGACCGAACGTGAAAGTTATCGGGGGTTAGCTTGGATTGCGGCAATGGCACTTTTCATGCAAACCCTTGATGCAACCAT
TCTCAACACTGCCTTACCCGCCATTTCACGCGATTTAAATGAATCGCCGTTAGAAATGCAACTTGCGATTATCAGCTATG
CACTCAGTGTGGCATTGTTTATCCCTCTCAGTGGTTGGCTCGCGGATAAATATGGCACCTTAAAAATTTTTCGCATTGCT
GTCAGCATTTTTGTTATCGGATCTGTTGCCTGCGCCATCTCTAACACGCTTGATACCCTTGTCCTGGCGCGTGTATTACA
AGGTTTTGGCGGTGCCTTAATGATGCCCGTAGCACGGCTTGCCATTATTCGCACCGTGCCTAAACAGCATTTATTATCCG
TTTGGAATTTAATGGCGATGTCAGGTTTGCTCGGTCCGATTTTAGGTCCGATTTTAGGTGGCTGGTTAGTAACCTATGCG
ACTTGGCATTGGATATTCTTGATTAATATTCCGATTGGTATTATCGGGGTATTGATTGCGGGCAACTACATGCAAAATGT
CACGGCTGAAGTCAATAAACTTGATTGGAAAGGCTTTATGCTCTTTGCTGGTAGTTTAGTCGGACTCACATTGGGCTTAG
ATCTCATCGCTGAACGAAGTAGTCACAAAGGGATTGCGTTTAGCGTATTAATGTTGGGATTACTCTTATTGTGTGCTTAT
TATTTCCACGCGAAAAAATCCCCTATTTCCCTTTTGCCACTGTCCTTATTTAAGATCAGAACCTTTACGATCAGCATTGT
GGCCAACTTATTTATTCGCCTTTGTGGTTCGGGGATTCCTTTTTTATTGCCTTTGATGTTACAAGTTGTTTTTCATTACA
GCGCGGAATTATCTGGCTGGCTCCTCGCTCCGATTGCCATCAGCTCTGTGTTAATGAAACCCTTAATTAGCCCTATTCTC
CACCGTTTAGGCTACAAAACCACCCTTCTTTTAACTGCCATTTGTCTCACACTGGCGATTGCTGTCATGGCGTTGGTCAC
TGTTGACACACCAATTTGGTTATTAGTACTCGCCCTCGCATTTTATGGCGCTTGTATGTCTGTGATTTTCAGTGCCACCA
ACACGTTAGCGGTCAGCGAATTATCCGAACAAAACGCCAGTGCCGGCTCCACTATTTTGAGCGTTGCTCAACAAATGGGG
ATTGGGATCGGCATTGCGGTCTGCTCCGTGATCCTTGGGATTTATCGCGACCACATCGGAGAAGTAGGTGAACAACTTCA
ACAATCATTCAGCTATACCTTTTTAAGTGTTGCCTGTTTTGGTTTTATTTTGATTTGGGTGCTCACTTATTTAAAAGCCC
AAGATGGTCAGAGTCTCCGTCGTTAA

Upstream 100 bases:

>100_bases
ATCAACGGTCCCTGTTTTAGACATCAATGATATCACGCGAATCGCTACCTTCATTCAGCATTGGTATCAACAAAAGTGCG
GTGCAAAATAGGAAAGTTTT

Downstream 100 bases:

>100_bases
AAAACAAGGCGAGAATGGGAGTCCAATTTACCATATAACATATTGATTTATAAAAGACTAAATTTTAACACCCCCAAATA
TAGTACTATTCCTAGTACTA

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTERESYRGLAWIAAMALFMQTLDATILNTALPAISRDLNESPLEMQLAIISYALSVALFIPLSGWLADKYGTLKIFRIA
VSIFVIGSVACAISNTLDTLVLARVLQGFGGALMMPVARLAIIRTVPKQHLLSVWNLMAMSGLLGPILGPILGGWLVTYA
TWHWIFLINIPIGIIGVLIAGNYMQNVTAEVNKLDWKGFMLFAGSLVGLTLGLDLIAERSSHKGIAFSVLMLGLLLLCAY
YFHAKKSPISLLPLSLFKIRTFTISIVANLFIRLCGSGIPFLLPLMLQVVFHYSAELSGWLLAPIAISSVLMKPLISPIL
HRLGYKTTLLLTAICLTLAIAVMALVTVDTPIWLLVLALAFYGACMSVIFSATNTLAVSELSEQNASAGSTILSVAQQMG
IGIGIAVCSVILGIYRDHIGEVGEQLQQSFSYTFLSVACFGFILIWVLTYLKAQDGQSLRR

Sequences:

>Translated_461_residues
MTERESYRGLAWIAAMALFMQTLDATILNTALPAISRDLNESPLEMQLAIISYALSVALFIPLSGWLADKYGTLKIFRIA
VSIFVIGSVACAISNTLDTLVLARVLQGFGGALMMPVARLAIIRTVPKQHLLSVWNLMAMSGLLGPILGPILGGWLVTYA
TWHWIFLINIPIGIIGVLIAGNYMQNVTAEVNKLDWKGFMLFAGSLVGLTLGLDLIAERSSHKGIAFSVLMLGLLLLCAY
YFHAKKSPISLLPLSLFKIRTFTISIVANLFIRLCGSGIPFLLPLMLQVVFHYSAELSGWLLAPIAISSVLMKPLISPIL
HRLGYKTTLLLTAICLTLAIAVMALVTVDTPIWLLVLALAFYGACMSVIFSATNTLAVSELSEQNASAGSTILSVAQQMG
IGIGIAVCSVILGIYRDHIGEVGEQLQQSFSYTFLSVACFGFILIWVLTYLKAQDGQSLRR
>Mature_460_residues
TERESYRGLAWIAAMALFMQTLDATILNTALPAISRDLNESPLEMQLAIISYALSVALFIPLSGWLADKYGTLKIFRIAV
SIFVIGSVACAISNTLDTLVLARVLQGFGGALMMPVARLAIIRTVPKQHLLSVWNLMAMSGLLGPILGPILGGWLVTYAT
WHWIFLINIPIGIIGVLIAGNYMQNVTAEVNKLDWKGFMLFAGSLVGLTLGLDLIAERSSHKGIAFSVLMLGLLLLCAYY
FHAKKSPISLLPLSLFKIRTFTISIVANLFIRLCGSGIPFLLPLMLQVVFHYSAELSGWLLAPIAISSVLMKPLISPILH
RLGYKTTLLLTAICLTLAIAVMALVTVDTPIWLLVLALAFYGACMSVIFSATNTLAVSELSEQNASAGSTILSVAQQMGI
GIGIAVCSVILGIYRDHIGEVGEQLQQSFSYTFLSVACFGFILIWVLTYLKAQDGQSLRR

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=457, Percent_Identity=49.2341356673961, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1788392, Length=445, Percent_Identity=38.6516853932584, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1788710, Length=408, Percent_Identity=30.8823529411765, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789042, Length=331, Percent_Identity=31.7220543806647, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=26.8292682926829, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325455, Length=232, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=379, Percent_Identity=24.2744063324538, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50005; Mature: 49874

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TERESYRGLAWIAAMALFMQTLDATILNTALPAISRDLNESPLEMQLAIISYALSVALF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]