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The map label for this gene is selA

Identifier: 15603633

GI number: 15603633

Start: 1992896

End: 1994278

Strand: Reverse

Name: selA

Synonym: PM1768

Alternate gene names: 15603633

Gene position: 1994278-1992896 (Counterclockwise)

Preceding gene: 15603649

Following gene: 15603631

Centisome position: 88.34

GC content: 43.02

Gene sequence:

>1383_bases
ATGTCGCTCTACTCTTCTCTTCCTTCCATTGATAAATTGTTAAAAACGCCTGAAGGCGCTAGATTAAGTCATGAATTTGG
GCATACTGCGGTAGTGAATATTTGTCGTCAATTGATTGAACAAGGGCGTGAATACATCAAGAATGAAAATAAACTGCTCC
CCGTTTTTCAAGATATAAGCGACACTTTACGTGAAATTGAACTACAGTTACACGCACAAAGCCAAGTAAAAATACAATCC
GTCCATAATCTGACCGGTACTATTCTACACACCAATCTTGGGCGTGCCTTATGGTCAGATGCGGCCCAACACGCCGCCTT
GACCTCAATGTCGCACAATGTGGCATTAGAATACGATTTGGAGGAAGGCAAACGGAGTCATCGTGATCATTATATTAGCG
ATCTCTTGTGCCAATTAACGGGGGCGGAAGCCGCCTGTATCGTCAATAACAATGCAGCAGCGGTGTTACTTATGCTAGCG
ACCTTTGCACAAGGCAAAGAAGTGATTATTTCTCGTGGTGAATTAATTGAAATTGGCGGTGCTTTTCGCATTCCAGATAT
TATGCAACAAGCCGGTTGCAAATTGGTGGAAGTCGGCACAACCAATCGTACACATTTAAGCGATTATCGTCACGCAATTA
ACGAAAATACTGCCTTTTTAATGAAAGTGCACAGCAGTAATTATCAAATCTGTGGCTTCACAAAGTCAGTGACAGAAGCA
GAACTGGTAACGTTAGCCAGAGAATTTAATCTGCCAGTGATGACTGATTTAGGCAGTGGCGCATTAGTCGATTTAGCACA
ATATGGATTGCCGAAGGAACCGACCGTGCAAGAAAAATGGGCACAAGGTGTAGAGTTGATTTCATTTTCTGGCGATAAAC
TACTGGGCGGGCCACAAGCAGGTATTATTGTGGGCAAAAAAGCCTGGATTGATCGCTTACAAACGCATCCTCTTAAGCGT
GCACTGCGTTGCGATAAAGTCATTCTGGCAGGATTAGAAGCCACGTTGCGTTTATATTTGCAACCAGAGAAATTAAGCCA
ACACTTAACCACACTGCGCCTGTTAACACAACCAGTAGAAGCATTACATGAACAAGCCGAACAGCTCCAATCCGTATTAC
TGACAAAATTAACCACAGATTACAGTGTAGCTATCACCAATAGTGTAGCACAAATTGGCAGTGGCTCACAGCCCATGGCA
ACCATTCCTTCTGTCGCAGTCACCATTTCCACTGAAAAAGCAGGAAAACTGACCGCACTTTTACAACGTTTTAAAGCTCT
TCCACAGCCGATCATTTGCCGAGTAGAGAAAGAAAAAATTTGGTTAGATTTACGTGGTTTAGCGGATATAGATAGTCTCC
TCAAGACAATCATGCAGCTATAA

Upstream 100 bases:

>100_bases
CCGCCTCACAAAATTGGGCTTTCTTTTTGATTGCATACTGAATTTTCAGCGAAAAACGAGTATGATTAATCAATTTTGTG
CGCAATAAAAAGGAATCCGA

Downstream 100 bases:

>100_bases
AAAGCAAAAGGGGCATATGCCCCTTGCTTGATGCGTTAACCAATACGTTGCAAAGCATCGTAAATCAAGCCCCAAAATTT
CGCTTTATCCAGTTGCATTG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDISDTLREIELQLHAQSQVKIQS
VHNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDLEEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLA
TFAQGKEVIISRGELIEIGGAFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEA
ELVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQAGIIVGKKAWIDRLQTHPLKR
ALRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVEALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMA
TIPSVAVTISTEKAGKLTALLQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL

Sequences:

>Translated_460_residues
MSLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDISDTLREIELQLHAQSQVKIQS
VHNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDLEEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLA
TFAQGKEVIISRGELIEIGGAFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEA
ELVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQAGIIVGKKAWIDRLQTHPLKR
ALRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVEALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMA
TIPSVAVTISTEKAGKLTALLQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL
>Mature_459_residues
SLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDISDTLREIELQLHAQSQVKIQSV
HNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDLEEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLAT
FAQGKEVIISRGELIEIGGAFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEAE
LVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQAGIIVGKKAWIDRLQTHPLKRA
LRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVEALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMAT
IPSVAVTISTEKAGKLTALLQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=460, Percent_Identity=56.0869565217391, Blast_Score=488, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_PASMU (Q9CK66)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246707.1
- ProteinModelPortal:   Q9CK66
- GeneID:   1245115
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1768
- NMPDR:   fig|272843.1.peg.1769
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- ProtClustDB:   PRK04311
- BioCyc:   PMUL272843:PM1768-MONOMER
- BRENDA:   2.9.1.1
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 50668; Mature: 50537

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDIS
CCHHHCCCHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
DTLREIELQLHAQSQVKIQSVHNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDL
HHHHHHHHHEECCCHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
EEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIGG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCEEEECC
AFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEA
CCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCHHHH
ELVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQA
HHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCC
GIIVGKKAWIDRLQTHPLKRALRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVE
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHH
ALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMATIPSVAVTISTEKAGKLTAL
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCEECCCEEEEEECCCCHHHHHH
LQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL
HHHHHHCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDIS
CHHHCCCHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
DTLREIELQLHAQSQVKIQSVHNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDL
HHHHHHHHHEECCCHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
EEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIGG
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCEEEECC
AFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEA
CCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCHHHH
ELVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQA
HHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCC
GIIVGKKAWIDRLQTHPLKRALRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVE
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHH
ALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMATIPSVAVTISTEKAGKLTAL
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCEECCCEEEEEECCCCHHHHHH
LQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL
HHHHHHCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100