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The map label for this gene is selB [H]

Identifier: 15603631

GI number: 15603631

Start: 1989826

End: 1991700

Strand: Reverse

Name: selB [H]

Synonym: PM1766

Alternate gene names: 15603631

Gene position: 1991700-1989826 (Counterclockwise)

Preceding gene: 15603633

Following gene: 15603628

Centisome position: 88.23

GC content: 42.19

Gene sequence:

>1875_bases
ATGATTATTGTGACATCAGGCCATGTTGATCATGGTAAAACGGCTTTATTACAAGCTCTCACTGGCACACATACCGCACA
TTTACCCGAAGAAAAAAAGCGCGGTATGACCATTGACTTGGGTTATGCTTACTTGCCTTTAGAAAAAAACGGAAAAATCG
ACCGCACTTTAGGCTTTATTGATGTACCAGGGCATGAAAAGTTTCTCGTTAATATGCTCGCTGGCTTAGGTGGTATTCAT
TATGCGATGCTCATTGTGGCAGCAGATGAAGGTGTGCAAGCACAAACTCTAGAACACTTAGCAATTTTACGTTTATTGCA
ATTAGAGCACATTCTTATCGTTATCACCAAAGCAGATCGCGCAACATTACCGCAAATTGAACAGCTTTCACAACAATTAA
AAGCGAATCATCCCATTTTAGCCAATTCACCTGTTTTTATCACTTCGGCTAAAACCGAACAAGGTATTGATGAATTACGT
AACTATCTTGCTAAGTTACCTAATTTAGCGGATTCCAATAAACCCTTTCGTTATGCTATCGATCGCGTATTTAGCGTAAA
AGGGGTAGGTACCGTCGTAACCGGCACTGCGTTTAGTGGACGTGTACAAATCGATGATGAACTGTTGTTATCCAATGGTC
AGACCGTACGTATTAAAAATATTCATAGCCAAAATCAACAAACCAATGTGGGTAACGCAGGGGAACGCTTAGCATTAAAT
CTGAATGTGGATTTAGATCGTATCACCATTGAGCGCGGAGATTGGTTACTTTCTCAACAACCCTTGCCACCAACATCACG
TATCACCGTGCTGCTCAATGCGGAAACTACCTTACAAGAAAGTCAACCTATCCATCTCTATCATGCCAGTGCGCGAACAA
CGGGTAAGCTAAATTTACTGCAACACAAAACCCTTTTGCCTGCACAACAAGGTTTAGCAGAAATCATTTTAGAAAAGCCA
TTGTTCTTAGCTTATGCTGATAAACTCATTTTACGTAGTGGCGATGCCAAACATCTGGTCGCAGGTGCGAAAGTCATTGA
GATTAATTCGCCCAAGCGCCACAAGCGAACTGAACAACGGTTAAATTTCGTATATGCTTTACAGCAAGCCAAAACTACCA
CTGAACGCACCGCACTTTATCTACAAAATAAAGCTGTTGATGCTCAAACGTTGATGTGGACGGAGCAATTAAATGCAGAG
CAGCTCGCTGAGATCGTCGCGGTCAATCAGCAAGTGCGTTTTCAGGATTGGATCTTTAACGCAGATTATCAACAACAACA
AACCGAGAAATTATTGACCGCACTTGCGCAATATCACCAAAATCATAATGACCAACTGGGTATCAGTAAGGCTCGTTTAT
ATCGGATTGCAACCCTGAACCAACCCGAAAAATTGATGTATCACTTCCTAGAAGCATGTTTGGCTAAGGGGCAATTACAA
CAGACACGCGGCTGGCTACATTTACCTGAACACAAAATCCAATTTTCAGAGGACGAACAAGCACTATGGCAAGCGGTACT
GGCACAATTCGAACAACAGCATGGGCACCCCCTTTGGGTGCGTGATCTCGCCAATGTGTTAGGGCAAGACGAAAGCGCAA
TGCGAAATTTTCTCTATAAAGCAGGGAAATTGGGTTATCTGACACCGATTGTCAAAGATCGTTTTTTCCTCACAGAAACG
CTCTACGCTTATTCACGTTTAGTAAAACAATTCATTGCAGAGCACGGCGCGATTTCAGTCAATCAACTCCGTGATGAGCT
TCAATTCGGACGTAAATTGGTTGTACAGCTGATTGAATATTTCGATCGTTGCGGTTTTTTGCGCCGCAAAGGAAATATTC
ACGTATTACGTGATAGTGACGTATTTGATTTGTAA

Upstream 100 bases:

>100_bases
CGCCTCATGAGGTGGCATAAGAGCGCAACAGAAAAAAGTTATTCATTTAAACGCTAAATGCTAAATGCTAAAATGAAAAC
AAAAGCATTGAGGATAAGAG

Downstream 100 bases:

>100_bases
CAAACGGTGAGTGAAACACTCACCGTTTACTACATAGATGCTGTATCAAGCTCCACCCGTTGTTGCGTTTCAATTGATTT
TTTGGCAGCACAAGCCACAG

Product: hypothetical protein

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MIIVTSGHVDHGKTALLQALTGTHTAHLPEEKKRGMTIDLGYAYLPLEKNGKIDRTLGFIDVPGHEKFLVNMLAGLGGIH
YAMLIVAADEGVQAQTLEHLAILRLLQLEHILIVITKADRATLPQIEQLSQQLKANHPILANSPVFITSAKTEQGIDELR
NYLAKLPNLADSNKPFRYAIDRVFSVKGVGTVVTGTAFSGRVQIDDELLLSNGQTVRIKNIHSQNQQTNVGNAGERLALN
LNVDLDRITIERGDWLLSQQPLPPTSRITVLLNAETTLQESQPIHLYHASARTTGKLNLLQHKTLLPAQQGLAEIILEKP
LFLAYADKLILRSGDAKHLVAGAKVIEINSPKRHKRTEQRLNFVYALQQAKTTTERTALYLQNKAVDAQTLMWTEQLNAE
QLAEIVAVNQQVRFQDWIFNADYQQQQTEKLLTALAQYHQNHNDQLGISKARLYRIATLNQPEKLMYHFLEACLAKGQLQ
QTRGWLHLPEHKIQFSEDEQALWQAVLAQFEQQHGHPLWVRDLANVLGQDESAMRNFLYKAGKLGYLTPIVKDRFFLTET
LYAYSRLVKQFIAEHGAISVNQLRDELQFGRKLVVQLIEYFDRCGFLRRKGNIHVLRDSDVFDL

Sequences:

>Translated_624_residues
MIIVTSGHVDHGKTALLQALTGTHTAHLPEEKKRGMTIDLGYAYLPLEKNGKIDRTLGFIDVPGHEKFLVNMLAGLGGIH
YAMLIVAADEGVQAQTLEHLAILRLLQLEHILIVITKADRATLPQIEQLSQQLKANHPILANSPVFITSAKTEQGIDELR
NYLAKLPNLADSNKPFRYAIDRVFSVKGVGTVVTGTAFSGRVQIDDELLLSNGQTVRIKNIHSQNQQTNVGNAGERLALN
LNVDLDRITIERGDWLLSQQPLPPTSRITVLLNAETTLQESQPIHLYHASARTTGKLNLLQHKTLLPAQQGLAEIILEKP
LFLAYADKLILRSGDAKHLVAGAKVIEINSPKRHKRTEQRLNFVYALQQAKTTTERTALYLQNKAVDAQTLMWTEQLNAE
QLAEIVAVNQQVRFQDWIFNADYQQQQTEKLLTALAQYHQNHNDQLGISKARLYRIATLNQPEKLMYHFLEACLAKGQLQ
QTRGWLHLPEHKIQFSEDEQALWQAVLAQFEQQHGHPLWVRDLANVLGQDESAMRNFLYKAGKLGYLTPIVKDRFFLTET
LYAYSRLVKQFIAEHGAISVNQLRDELQFGRKLVVQLIEYFDRCGFLRRKGNIHVLRDSDVFDL
>Mature_624_residues
MIIVTSGHVDHGKTALLQALTGTHTAHLPEEKKRGMTIDLGYAYLPLEKNGKIDRTLGFIDVPGHEKFLVNMLAGLGGIH
YAMLIVAADEGVQAQTLEHLAILRLLQLEHILIVITKADRATLPQIEQLSQQLKANHPILANSPVFITSAKTEQGIDELR
NYLAKLPNLADSNKPFRYAIDRVFSVKGVGTVVTGTAFSGRVQIDDELLLSNGQTVRIKNIHSQNQQTNVGNAGERLALN
LNVDLDRITIERGDWLLSQQPLPPTSRITVLLNAETTLQESQPIHLYHASARTTGKLNLLQHKTLLPAQQGLAEIILEKP
LFLAYADKLILRSGDAKHLVAGAKVIEINSPKRHKRTEQRLNFVYALQQAKTTTERTALYLQNKAVDAQTLMWTEQLNAE
QLAEIVAVNQQVRFQDWIFNADYQQQQTEKLLTALAQYHQNHNDQLGISKARLYRIATLNQPEKLMYHFLEACLAKGQLQ
QTRGWLHLPEHKIQFSEDEQALWQAVLAQFEQQHGHPLWVRDLANVLGQDESAMRNFLYKAGKLGYLTPIVKDRFFLTET
LYAYSRLVKQFIAEHGAISVNQLRDELQFGRKLVVQLIEYFDRCGFLRRKGNIHVLRDSDVFDL

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=378, Percent_Identity=26.4550264550265, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI54607086, Length=292, Percent_Identity=26.3698630136986, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4503507, Length=257, Percent_Identity=27.6264591439689, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI45593140, Length=408, Percent_Identity=25, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI5729864, Length=373, Percent_Identity=23.5924932975871, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI223555963, Length=373, Percent_Identity=23.5924932975871, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI82546879, Length=425, Percent_Identity=24.4705882352941, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI46094014, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194097354, Length=242, Percent_Identity=26.4462809917355, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI194018520, Length=242, Percent_Identity=26.4462809917355, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194018522, Length=242, Percent_Identity=26.4462809917355, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI53729339, Length=235, Percent_Identity=26.8085106382979, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI53729337, Length=235, Percent_Identity=26.8085106382979, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367247, Length=626, Percent_Identity=42.9712460063898, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1790412, Length=370, Percent_Identity=26.4864864864865, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789737, Length=370, Percent_Identity=26.4864864864865, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789108, Length=342, Percent_Identity=26.0233918128655, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25141371, Length=378, Percent_Identity=26.7195767195767, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17509919, Length=315, Percent_Identity=27.6190476190476, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565438, Length=412, Percent_Identity=24.2718446601942, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=390, Percent_Identity=25.8974358974359, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506081, Length=327, Percent_Identity=25.0764525993884, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324761, Length=236, Percent_Identity=31.3559322033898, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19922690, Length=326, Percent_Identity=28.8343558282209, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921738, Length=289, Percent_Identity=29.0657439446367, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363316, Length=228, Percent_Identity=28.9473684210526, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17864358, Length=228, Percent_Identity=28.9473684210526, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24647046, Length=256, Percent_Identity=28.125, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647048, Length=256, Percent_Identity=28.125, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 70583; Mature: 70583

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTSGHVDHGKTALLQALTGTHTAHLPEEKKRGMTIDLGYAYLPLEKNGKIDRTLGFI
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEEEEECCCCCEEEEEEEE
DVPGHEKFLVNMLAGLGGIHYAMLIVAADEGVQAQTLEHLAILRLLQLEHILIVITKADR
ECCCCHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCC
ATLPQIEQLSQQLKANHPILANSPVFITSAKTEQGIDELRNYLAKLPNLADSNKPFRYAI
CCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
DRVFSVKGVGTVVTGTAFSGRVQIDDELLLSNGQTVRIKNIHSQNQQTNVGNAGERLALN
HHHHHCCCCCEEEECCEECCEEEECHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
LNVDLDRITIERGDWLLSQQPLPPTSRITVLLNAETTLQESQPIHLYHASARTTGKLNLL
EECEEEEEEEECCCEEECCCCCCCCCEEEEEEECCHHHCCCCCEEEEECCCCCCCCEEHH
QHKTLLPAQQGLAEIILEKPLFLAYADKLILRSGDAKHLVAGAKVIEINSPKRHKRTEQR
HHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHH
LNFVYALQQAKTTTERTALYLQNKAVDAQTLMWTEQLNAEQLAEIVAVNQQVRFQDWIFN
HHHHHHHHHHHCHHHHHEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEHHHHEEC
ADYQQQQTEKLLTALAQYHQNHNDQLGISKARLYRIATLNQPEKLMYHFLEACLAKGQLQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHCCCHH
QTRGWLHLPEHKIQFSEDEQALWQAVLAQFEQQHGHPLWVRDLANVLGQDESAMRNFLYK
HHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHH
AGKLGYLTPIVKDRFFLTETLYAYSRLVKQFIAEHGAISVNQLRDELQFGRKLVVQLIEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHH
FDRCGFLRRKGNIHVLRDSDVFDL
HHHCCCEEECCCEEEEECCCCCCC
>Mature Secondary Structure
MIIVTSGHVDHGKTALLQALTGTHTAHLPEEKKRGMTIDLGYAYLPLEKNGKIDRTLGFI
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEEEEECCCCCEEEEEEEE
DVPGHEKFLVNMLAGLGGIHYAMLIVAADEGVQAQTLEHLAILRLLQLEHILIVITKADR
ECCCCHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCC
ATLPQIEQLSQQLKANHPILANSPVFITSAKTEQGIDELRNYLAKLPNLADSNKPFRYAI
CCCHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
DRVFSVKGVGTVVTGTAFSGRVQIDDELLLSNGQTVRIKNIHSQNQQTNVGNAGERLALN
HHHHHCCCCCEEEECCEECCEEEECHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
LNVDLDRITIERGDWLLSQQPLPPTSRITVLLNAETTLQESQPIHLYHASARTTGKLNLL
EECEEEEEEEECCCEEECCCCCCCCCEEEEEEECCHHHCCCCCEEEEECCCCCCCCEEHH
QHKTLLPAQQGLAEIILEKPLFLAYADKLILRSGDAKHLVAGAKVIEINSPKRHKRTEQR
HHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHH
LNFVYALQQAKTTTERTALYLQNKAVDAQTLMWTEQLNAEQLAEIVAVNQQVRFQDWIFN
HHHHHHHHHHHCHHHHHEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCEEHHHHEEC
ADYQQQQTEKLLTALAQYHQNHNDQLGISKARLYRIATLNQPEKLMYHFLEACLAKGQLQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHCCCHH
QTRGWLHLPEHKIQFSEDEQALWQAVLAQFEQQHGHPLWVRDLANVLGQDESAMRNFLYK
HHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHH
AGKLGYLTPIVKDRFFLTETLYAYSRLVKQFIAEHGAISVNQLRDELQFGRKLVVQLIEY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHH
FDRCGFLRRKGNIHVLRDSDVFDL
HHHCCCEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]