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The map label for this gene is ubiA

Identifier: 15603616

GI number: 15603616

Start: 1973355

End: 1974227

Strand: Reverse

Name: ubiA

Synonym: PM1751

Alternate gene names: 15603616

Gene position: 1974227-1973355 (Counterclockwise)

Preceding gene: 15603624

Following gene: 15603615

Centisome position: 87.45

GC content: 41.35

Gene sequence:

>873_bases
ATGCCAATTTCTAAACAAAAATGGATTGCCTACGCACAGCTGATGCGATTTGATAAGCCAATTGGCACTTTACTCTTACT
TTGGCCAACCCTTTGGGCATTATTTCTATCCGTCAAAGGCATGCCCGACTTGTCGATATTAAGTATTTTTGTCTTAGGCG
TGATTTTTATGCGTGCCGCGGGTTGTGTGATTAATGACTATGCCGATCGTCATATTGATGGTGCCGTCAAACGCACCTCA
AAACGACCGTTAGCAACGGGAGCCGCCACACCTGAAGAAGCAAAATGGCTGTTTGTATTACTGGTCTTCTGTTCATTCAT
ATTAGTACTCTTTTTAAATACTTATGCTATCGTCTTGTCATTTATTGCTGTCTTTTTAGCCTTTATCTACCCCTTTATGA
AACGCTACACCCATTTGCCACAACTGTTTTTAGGCATGGCATTTGGCTGGTCGATTCCCATGGCGTATGGCGCCTCGATT
GAAGCCTTACCGCTCGAATGCTGGCTGTTATTTTTCGCCAATTTAGCGTGGACAGTCGCCTATGACACGCAATACGCCAT
GGTGGATCGCGATGATGATTTACGCATTGGAGTAAAATCCACCGCCATTTTATTTGCCCAATATGACAATAAAATCATCT
CATTATTGCAAATCGTCACGTTGTTTTTCTTAGGGCTAATTGGTTATCTTTCCCAGTTACATACCAGCTATTTTGTGGTG
CTTTTCCTCGCCACTTTGTTATTTGTCTATCAATGCAAGCTCATCAAAGATCGTGAACGAGAATCCTGCTTCAAAGCCTT
TTTAAATAACAACTACTTTGGCGCAATGGTATTTGTGGCGTTTTTGTTTGGGATATTTTTTGATAAATTGTAA

Upstream 100 bases:

>100_bases
AGAAGAAAAGAAATGAAATGTTTTTTGTTAACGATTTTGTCAAGAAATTTAGTAAAATTTGCAGTAAAATGACCGCACTT
TTAACTCGTTTTGGGAAACT

Downstream 100 bases:

>100_bases
TTTTTTAGCAACAACGGGATTAAGATTAAACTTACTTTAATGGAAACGAGTGGATAGTGAGAATTCGATTAGGATGCTGC
TAGAAGGAATAATAGAAAAT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTS
KRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLSFIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASI
EALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVV
LFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL

Sequences:

>Translated_290_residues
MPISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTS
KRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLSFIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASI
EALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVV
LFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL
>Mature_289_residues
PISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAAGCVINDYADRHIDGAVKRTSK
RPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLSFIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASIE
ALPLECWLLFFANLAWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVVL
FLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=280, Percent_Identity=35.7142857142857, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=61.6487455197133, Blast_Score=348, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=34.8591549295775, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI32565247, Length=275, Percent_Identity=35.2727272727273, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17553720, Length=179, Percent_Identity=39.6648044692737, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565245, Length=137, Percent_Identity=43.0656934306569, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=136, Percent_Identity=42.6470588235294, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=237, Percent_Identity=31.2236286919831, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21355567, Length=280, Percent_Identity=36.0714285714286, Blast_Score=180, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_PASMU (P57970)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246690.1
- GeneID:   1245098
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1751
- NMPDR:   fig|272843.1.peg.1752
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12848
- BioCyc:   PMUL272843:PM1751-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33176; Mature: 33045

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf081e60)-; HASH(0xf76850c)-; HASH(0xf638be8)-; HASH(0xf6d6398)-; HASH(0xf0ce178)-; HASH(0xb516f44)-; HASH(0xf072b0c)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAA
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
GCVINDYADRHIDGAVKRTSKRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASIEALPLECWLLFFANLAWTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHEE
YDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVV
ECCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
PISKQKWIAYAQLMRFDKPIGTLLLLWPTLWALFLSVKGMPDLSILSIFVLGVIFMRAA
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
GCVINDYADRHIDGAVKRTSKRPLATGAATPEEAKWLFVLLVFCSFILVLFLNTYAIVLS
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIAVFLAFIYPFMKRYTHLPQLFLGMAFGWSIPMAYGASIEALPLECWLLFFANLAWTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHEE
YDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIISLLQIVTLFFLGLIGYLSQLHTSYFVV
ECCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLATLLFVYQCKLIKDRERESCFKAFLNNNYFGAMVFVAFLFGIFFDKL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100