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The map label for this gene is hemE

Identifier: 15603599

GI number: 15603599

Start: 1950230

End: 1951294

Strand: Reverse

Name: hemE

Synonym: PM1734

Alternate gene names: 15603599

Gene position: 1951294-1950230 (Counterclockwise)

Preceding gene: 15603600

Following gene: 15603598

Centisome position: 86.44

GC content: 44.41

Gene sequence:

>1065_bases
ATGACTGCATTAAAAAATGATCGCTATTTAAAAGCATTATTACGTGAGCCTGTCGATATGACACCGGTTTGGATGATGCG
TCAAGCGGGGCGCTATTTACCAGAATACCGTGCGACGAGAGCCGTCGCGGGGGACTTCATGTCTTTATGTCGCAATGCAG
AGCTGGCTTGTGAGGTCACGTTACAACCTCTACGTCGTTACCCACTGGATGCCGCCATTTTATTTTCTGATATTTTAACT
ATCCCAGATGCCATGGGGTTAGGCTTAAGTTTTGGGGTGGGCGAAGGACCGAAATTTGCGCATCCAATTGAAACGCAACG
TGCAGTGCAAAATTTACCCATTCCCGATCCTGAAGGTGAATTACAATATGTGATGAATGCAGTACGCACCATTCGCCGTG
AATTAAAAGGGGAAGTGCCGTTGATTGGTTTCTCAGGTAGCCCTTGGACATTAGCAACCTATATGGTAGAAGGTGGCAGC
AGTAAAGCCTTCACTAAAATAAAAAAAATGCTGTATGCCGATCCCCAATTATTGCATCAATTATTAGATAAACTGGCGGA
TGCTGTCATACTCTATTTGAATGCACAAATTAAAGCCGGCGCACAGTCAGTGATGATCTTCGATACATGGGGTGGTGTGT
TAGGGCATCGTGAGTATTTAGATTTTTCATTGCACTATATGCACAAAATTGTCGCAGGATTAATACGAGAAAATGAAGGA
CGTAAAGTGCCGGTAACCTTGTTTACGAAAGGTGGTGGCATGTGGTTAGAAGCCATGGCAGAAACTGGTTGCGATGCGTT
GGGCGTTGATTGGACGGTTAATTTAGCACAAGCCAAAGCCAGAGTCGGACATAAAGTGGCGTTACAAGGCAATATGGATC
CATCGGTACTATATGCCTCACCTGCTCGTATTGAACAAGAAGTGCGGTCCATTTTGGCGGATTTTGGTGAGGGATCTGGT
CATGTGTTCAATCTTGGTCATGGTATTCATCAAGATGTGCCAGAACAAAGCCCAGCGGTGTTTGTTAACGCGATTCATCA
ATTTTCTCAACCTTATCATAAATAA

Upstream 100 bases:

>100_bases
ATAATGCGCCCCTCCCAGAGTTACCACCGAAAGGCACTATCGCGTTAAAATTAATTGAGCATACATTGCAACTGTGTGCT
GAGGAAGAAAGGAAAGCAAC

Downstream 100 bases:

>100_bases
TACGCAGGAGAATTATGCGAAACCCTATTCATAAACGCTTAGAAAATCTTGAAACGTGGCAACATATCACTTTTATGGCG
TGCCTTTGTGAACGTATGTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTALKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYRATRAVAGDFMSLCRNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDPEGELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMLYADPQLLHQLLDKLADAVILYLNAQIKAGAQSVMIFDTWGGVLGHREYLDFSLHYMHKIVAGLIRENEG
RKVPVTLFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKARVGHKVALQGNMDPSVLYASPARIEQEVRSILADFGEGSG
HVFNLGHGIHQDVPEQSPAVFVNAIHQFSQPYHK

Sequences:

>Translated_354_residues
MTALKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYRATRAVAGDFMSLCRNAELACEVTLQPLRRYPLDAAILFSDILT
IPDAMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDPEGELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMLYADPQLLHQLLDKLADAVILYLNAQIKAGAQSVMIFDTWGGVLGHREYLDFSLHYMHKIVAGLIRENEG
RKVPVTLFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKARVGHKVALQGNMDPSVLYASPARIEQEVRSILADFGEGSG
HVFNLGHGIHQDVPEQSPAVFVNAIHQFSQPYHK
>Mature_353_residues
TALKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYRATRAVAGDFMSLCRNAELACEVTLQPLRRYPLDAAILFSDILTI
PDAMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDPEGELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTKIKKMLYADPQLLHQLLDKLADAVILYLNAQIKAGAQSVMIFDTWGGVLGHREYLDFSLHYMHKIVAGLIRENEGR
KVPVTLFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKARVGHKVALQGNMDPSVLYASPARIEQEVRSILADFGEGSGH
VFNLGHGIHQDVPEQSPAVFVNAIHQFSQPYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=47.3087818696884, Blast_Score=318, Evalue=6e-87,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=79.9435028248588, Blast_Score=598, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6320252, Length=354, Percent_Identity=38.7005649717514, Blast_Score=255, Evalue=7e-69,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=42.816091954023, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=42.816091954023, Blast_Score=284, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_PASMU (P57964)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246673.1
- ProteinModelPortal:   P57964
- SMR:   P57964
- GeneID:   1245081
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1734
- NMPDR:   fig|272843.1.peg.1735
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   PMUL272843:PM1734-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39160; Mature: 39029

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYRATRAVAGDFMSLCRNAELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDPEGE
HHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHH
LQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMLYADPQLLHQ
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHH
LLDKLADAVILYLNAQIKAGAQSVMIFDTWGGVLGHREYLDFSLHYMHKIVAGLIRENEG
HHHHHHHHHHHHEECCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCC
RKVPVTLFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKARVGHKVALQGNMDPSVLYAS
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEHHHHHHHHCCCEEEEECCCCCCEEEEC
PARIEQEVRSILADFGEGSGHVFNLGHGIHQDVPEQSPAVFVNAIHQFSQPYHK
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TALKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYRATRAVAGDFMSLCRNAELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYPLDAAILFSDILTIPDAMGLGLSFGVGEGPKFAHPIETQRAVQNLPIPDPEGE
HHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHH
LQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMLYADPQLLHQ
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHH
LLDKLADAVILYLNAQIKAGAQSVMIFDTWGGVLGHREYLDFSLHYMHKIVAGLIRENEG
HHHHHHHHHHHHEECCCCCCCCEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCC
RKVPVTLFTKGGGMWLEAMAETGCDALGVDWTVNLAQAKARVGHKVALQGNMDPSVLYAS
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEHHHHHHHHCCCEEEEECCCCCCEEEEC
PARIEQEVRSILADFGEGSGHVFNLGHGIHQDVPEQSPAVFVNAIHQFSQPYHK
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100