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The map label for this gene is glmS

Identifier: 15603596

GI number: 15603596

Start: 1947165

End: 1948997

Strand: Reverse

Name: glmS

Synonym: PM1731

Alternate gene names: 15603596

Gene position: 1948997-1947165 (Counterclockwise)

Preceding gene: 15603597

Following gene: 15603592

Centisome position: 86.33

GC content: 43.15

Gene sequence:

>1833_bases
ATGTGTGGTATTGTTGGTGCAATTGCACAACGTGATGTAGCAGAAATTTTAGTGAATGGTTTACATCGTTTGGAGTATCG
GGGCTATGATTCAGCAGGGATAGCCATTGTCGATCAAGAGAAACGATTGCAACGTGTTCGCTGTTTAGGAAAAGTACAAG
TATTAGCTGAAGCCGTTGCGGCTGAAAAAATAACAGGGGGCACAGGGATCGCTCATACCCGCTGGGCAACACATGGTGCG
CCTTCTGAAGATAATGCACACCCTCATGTATCAGGTCAGTTTGCGGTAGTGCACAATGGAATTATTGAAAACTATGAACA
ATTACGCATTGATTTACAACAGAAAGGTTATCAATTTCTCTCTCAAACCGATACTGAAGTGATTGCTCATTTAGTGCATT
GGGTAATGCGTAACGAAACTTCGTTGTTACGGGCTGTGCAGCAGGTCGTAAAACAGCTAAAAGGGGCTTATGGGATGGTT
GTGATGGACTGTGAACAACCAAATCATCTTGTTGCAGCTCGCTCAGGTAGCCCATTAGTGATTGGTTTAGGGATAGGAGA
AAATTTCCTAGCCTCAGATCAACTTGCTTTGTTAAATGTGACACGTCGTTTTATTTTTTTAGAAGAAGGGGATGTTGCAG
AAATTACTCGACGCACCGTCGATATTTACGATGTGAATGGACATCCCGTTCAACGTGACAGCCAAGACTCTCATCTTACA
CACGATGCAACGGAAAAAGGCACATTTCGTCACTTCATGCAAAAAGAGATTTTTGAACAACCTCGTGCTATCTTAAATAC
CCTTGAGGGCAGATTGCATCAGCATAATGTCTTGGTGGACAGCATCGGTAATGGCGCAGAACGATTATTAGAGCAGGTTG
AACATATTCAGATTGTGGCTTGTGGCACCTCTTACAATGCAGGTATGGTAGCGCGTTATTGGTTTGAACATTTGGCAGGA
ATAAGCTGTGATGTGGAAATCGCTTCAGAGTTTCGTTATCGCAAATTTGTGACGCGTCCTAAGAGTTTATTGATTACCCT
TTCCCAATCAGGTGAAACTGCTGATACGTTAGCCGCATTACGTTTAGCTAAAGAAAAAGGCTATATGGGGGCGATGACGA
TTTGTAATGTAGCGGGCTCTTCACTGGTACGAGAATCAGATCTTGCCTTTATGACTCGCGCGGGAGTAGAAATTGGCGTG
GCATCAACAAAGGCTTTTACCACACAATTGGCAACCTTACTGATGCTAGTGATTGCCATTGGTAAAGTCACAGGGAACAT
TTCTCTGTCGCAGGAAGAAGAACTGGTTAAGGCCCTGCAATCTTTACCTGCTGAGATAGAGAAAGCATTAGCATTTAATC
AACAAATTGAAAGCCTCGCGCAAGATTTTGCGGATAAACACCATGCCTTGTTTTTAGGACGAGGAGAGTATTATCCGATT
GCGATGGAAGGCGCGTTGAAGTTAAAAGAAATCTCTTATATTCATGCAGAAGCCTATGCCGCGGGTGAGCTAAAACATGG
TCCACTTGCGTTAATTGATGCGGATATGCCGGTGATTGTGGTCGCACCAACTAATGATCTTTTAGAAAAAGTAAAATCCA
ATATTGAAGAGGTGCGTTCTCGTGGCGGACAGCTTTACGTATTTGCTGATAAAGAAGCTGGCTTTACTGAAACGGAAGGC
ATGAAAATTATGACTATGCCGAAAGTCAATGAAGTGATTGCCCCGATTTTTTATACCATTCCAATGCAATTGTTGGCTTA
TCACGTTGCCTTAATTAAGGGAACCGACGTGGATCAACCGAGAAACCTTGCAAAAGCCGTTACCGTAGAATAA

Upstream 100 bases:

>100_bases
TATTTGCATAAACTGACCTGCTAACTATAATGAGCCTCATGTTTTAATTTTCTTTAGCGTAAACTTAACACATTAAACTT
TTTATAAAAAGGAGAATACT

Downstream 100 bases:

>100_bases
AAGATGTCTTTATAGAAAGCTAAAGGCAGAGATATTATCTTCTCTGCCTTTTTCGCTATATGAATTGTAGTGATATGGAA
AATTTTCTCAAAATTCACCG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAIAQRDVAEILVNGLHRLEYRGYDSAGIAIVDQEKRLQRVRCLGKVQVLAEAVAAEKITGGTGIAHTRWATHGA
PSEDNAHPHVSGQFAVVHNGIIENYEQLRIDLQQKGYQFLSQTDTEVIAHLVHWVMRNETSLLRAVQQVVKQLKGAYGMV
VMDCEQPNHLVAARSGSPLVIGLGIGENFLASDQLALLNVTRRFIFLEEGDVAEITRRTVDIYDVNGHPVQRDSQDSHLT
HDATEKGTFRHFMQKEIFEQPRAILNTLEGRLHQHNVLVDSIGNGAERLLEQVEHIQIVACGTSYNAGMVARYWFEHLAG
ISCDVEIASEFRYRKFVTRPKSLLITLSQSGETADTLAALRLAKEKGYMGAMTICNVAGSSLVRESDLAFMTRAGVEIGV
ASTKAFTTQLATLLMLVIAIGKVTGNISLSQEEELVKALQSLPAEIEKALAFNQQIESLAQDFADKHHALFLGRGEYYPI
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPTNDLLEKVKSNIEEVRSRGGQLYVFADKEAGFTETEG
MKIMTMPKVNEVIAPIFYTIPMQLLAYHVALIKGTDVDQPRNLAKAVTVE

Sequences:

>Translated_610_residues
MCGIVGAIAQRDVAEILVNGLHRLEYRGYDSAGIAIVDQEKRLQRVRCLGKVQVLAEAVAAEKITGGTGIAHTRWATHGA
PSEDNAHPHVSGQFAVVHNGIIENYEQLRIDLQQKGYQFLSQTDTEVIAHLVHWVMRNETSLLRAVQQVVKQLKGAYGMV
VMDCEQPNHLVAARSGSPLVIGLGIGENFLASDQLALLNVTRRFIFLEEGDVAEITRRTVDIYDVNGHPVQRDSQDSHLT
HDATEKGTFRHFMQKEIFEQPRAILNTLEGRLHQHNVLVDSIGNGAERLLEQVEHIQIVACGTSYNAGMVARYWFEHLAG
ISCDVEIASEFRYRKFVTRPKSLLITLSQSGETADTLAALRLAKEKGYMGAMTICNVAGSSLVRESDLAFMTRAGVEIGV
ASTKAFTTQLATLLMLVIAIGKVTGNISLSQEEELVKALQSLPAEIEKALAFNQQIESLAQDFADKHHALFLGRGEYYPI
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPTNDLLEKVKSNIEEVRSRGGQLYVFADKEAGFTETEG
MKIMTMPKVNEVIAPIFYTIPMQLLAYHVALIKGTDVDQPRNLAKAVTVE
>Mature_610_residues
MCGIVGAIAQRDVAEILVNGLHRLEYRGYDSAGIAIVDQEKRLQRVRCLGKVQVLAEAVAAEKITGGTGIAHTRWATHGA
PSEDNAHPHVSGQFAVVHNGIIENYEQLRIDLQQKGYQFLSQTDTEVIAHLVHWVMRNETSLLRAVQQVVKQLKGAYGMV
VMDCEQPNHLVAARSGSPLVIGLGIGENFLASDQLALLNVTRRFIFLEEGDVAEITRRTVDIYDVNGHPVQRDSQDSHLT
HDATEKGTFRHFMQKEIFEQPRAILNTLEGRLHQHNVLVDSIGNGAERLLEQVEHIQIVACGTSYNAGMVARYWFEHLAG
ISCDVEIASEFRYRKFVTRPKSLLITLSQSGETADTLAALRLAKEKGYMGAMTICNVAGSSLVRESDLAFMTRAGVEIGV
ASTKAFTTQLATLLMLVIAIGKVTGNISLSQEEELVKALQSLPAEIEKALAFNQQIESLAQDFADKHHALFLGRGEYYPI
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPTNDLLEKVKSNIEEVRSRGGQLYVFADKEAGFTETEG
MKIMTMPKVNEVIAPIFYTIPMQLLAYHVALIKGTDVDQPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=691, Percent_Identity=37.3371924746744, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI205277386, Length=686, Percent_Identity=37.7551020408163, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI29570798, Length=266, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=70.327868852459, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=228, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082251, Length=323, Percent_Identity=21.9814241486068, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532897, Length=509, Percent_Identity=34.1846758349705, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=507, Percent_Identity=34.3195266272189, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=37.2685185185185, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=36.5853658536585, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=29.3981481481481, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.0487804878049, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=36.271676300578, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28573187, Length=258, Percent_Identity=27.5193798449612, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24659598, Length=264, Percent_Identity=26.1363636363636, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_PASMU (P57963)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246670.1
- ProteinModelPortal:   P57963
- SMR:   P57963
- GeneID:   1245078
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1731
- NMPDR:   fig|272843.1.peg.1732
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   PMUL272843:PM1731-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67141; Mature: 67141

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIAQRDVAEILVNGLHRLEYRGYDSAGIAIVDQEKRLQRVRCLGKVQVLAEAVA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
AEKITGGTGIAHTRWATHGAPSEDNAHPHVSGQFAVVHNGIIENYEQLRIDLQQKGYQFL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIAHLVHWVMRNETSLLRAVQQVVKQLKGAYGMVVMDCEQPNHLVAARSGSPLV
HCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCEE
IGLGIGENFLASDQLALLNVTRRFIFLEEGDVAEITRRTVDIYDVNGHPVQRDSQDSHLT
EEECCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHCEEEEEECCCCCCCCCCCCCCCC
HDATEKGTFRHFMQKEIFEQPRAILNTLEGRLHQHNVLVDSIGNGAERLLEQVEHIQIVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHEEEEE
CGTSYNAGMVARYWFEHLAGISCDVEIASEFRYRKFVTRPKSLLITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMGAMTICNVAGSSLVRESDLAFMTRAGVEIGVASTKAFTTQLATLLMLVIAI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKVTGNISLSQEEELVKALQSLPAEIEKALAFNQQIESLAQDFADKHHALFLGRGEYYPI
HHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPTNDLLEKVKSNIEEVRS
EECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGQLYVFADKEAGFTETEGMKIMTMPKVNEVIAPIFYTIPMQLLAYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAIAQRDVAEILVNGLHRLEYRGYDSAGIAIVDQEKRLQRVRCLGKVQVLAEAVA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
AEKITGGTGIAHTRWATHGAPSEDNAHPHVSGQFAVVHNGIIENYEQLRIDLQQKGYQFL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
SQTDTEVIAHLVHWVMRNETSLLRAVQQVVKQLKGAYGMVVMDCEQPNHLVAARSGSPLV
HCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCEE
IGLGIGENFLASDQLALLNVTRRFIFLEEGDVAEITRRTVDIYDVNGHPVQRDSQDSHLT
EEECCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHCEEEEEECCCCCCCCCCCCCCCC
HDATEKGTFRHFMQKEIFEQPRAILNTLEGRLHQHNVLVDSIGNGAERLLEQVEHIQIVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHEEEEE
CGTSYNAGMVARYWFEHLAGISCDVEIASEFRYRKFVTRPKSLLITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMGAMTICNVAGSSLVRESDLAFMTRAGVEIGVASTKAFTTQLATLLMLVIAI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
GKVTGNISLSQEEELVKALQSLPAEIEKALAFNQQIESLAQDFADKHHALFLGRGEYYPI
HHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AMEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPTNDLLEKVKSNIEEVRS
EECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHH
RGGQLYVFADKEAGFTETEGMKIMTMPKVNEVIAPIFYTIPMQLLAYHVALIKGTDVDQP
CCCEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100