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The map label for this gene is gmhB

Identifier: 15603592

GI number: 15603592

Start: 1943110

End: 1943664

Strand: Reverse

Name: gmhB

Synonym: PM1727

Alternate gene names: 15603592

Gene position: 1943664-1943110 (Counterclockwise)

Preceding gene: 15603596

Following gene: 15603587

Centisome position: 86.1

GC content: 37.48

Gene sequence:

>555_bases
ATGAAAAAAGCAATTTTTTTAGATCGAGATGGCACATTAAATATTGATCATGGCTATGTTCATGAAATTGATCAGTTTCA
ATTTATTGACGGTAGCATTGAAGCGTTACAACAACTGAAAGCGATGGGCTATTTATTGGTACTTGTAACAAATCAGTCAG
GTATTGCGCGTGGATATTTTAGCGAAGATCAATTTTTACAGCTGACAGAATGGATGGATTGGTCTCTTGCAGATCGTGGA
GTGGATTTAGATGGCATCTATTATTGCCCACACCACACAGAAGGAAAAGGTGAGTATTGCCAAGACTGCGATTGCCGTAA
GCCAAAACCTGGTATGTTACTGCAGGCAATTAAGGAACTTAATATAGATCCCAATACCTCTTTTATGGTGGGTGATAAAG
TGGAAGATATGTTAGCAGGTAAAGGTGCCAAAATTAAAAATACTGTTTTAGTGAAAACAGGCAAGCCTATTACGGAGGAT
GGCAAAAAACAGGCAAACTATGTATTAGAGTCCATTGCGGATCTACCAAAACTGATAAAAGGATTAAAAAGTTAA

Upstream 100 bases:

>100_bases
ACAATTTGTTATGAGATAGAAATAATCGCGACTTTATTTGCGAAGCGAGTCAAGAAAAGGGATAATTTAAAGCACATTTA
AATAAAAGGAAGGCTCTCAT

Downstream 100 bases:

>100_bases
CAAAAATCTAACAATATTTATGCATTAAGTTTAAAAAATAATCTTTTAATAAAAAAATTAACTTTTTTTGTAAAAAGGGG
TTGCAAAGGGTTTTAAAATG

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKKAIFLDRDGTLNIDHGYVHEIDQFQFIDGSIEALQQLKAMGYLLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLADRG
VDLDGIYYCPHHTEGKGEYCQDCDCRKPKPGMLLQAIKELNIDPNTSFMVGDKVEDMLAGKGAKIKNTVLVKTGKPITED
GKKQANYVLESIADLPKLIKGLKS

Sequences:

>Translated_184_residues
MKKAIFLDRDGTLNIDHGYVHEIDQFQFIDGSIEALQQLKAMGYLLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLADRG
VDLDGIYYCPHHTEGKGEYCQDCDCRKPKPGMLLQAIKELNIDPNTSFMVGDKVEDMLAGKGAKIKNTVLVKTGKPITED
GKKQANYVLESIADLPKLIKGLKS
>Mature_184_residues
MKKAIFLDRDGTLNIDHGYVHEIDQFQFIDGSIEALQQLKAMGYLLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLADRG
VDLDGIYYCPHHTEGKGEYCQDCDCRKPKPGMLLQAIKELNIDPNTSFMVGDKVEDMLAGKGAKIKNTVLVKTGKPITED
GKKQANYVLESIADLPKLIKGLKS

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family

Homologues:

Organism=Escherichia coli, GI1786399, Length=178, Percent_Identity=66.2921348314607, Blast_Score=250, Evalue=3e-68,
Organism=Escherichia coli, GI87082027, Length=139, Percent_Identity=32.3741007194245, Blast_Score=77, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHB_PASMU (Q9CK98)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246666.1
- ProteinModelPortal:   Q9CK98
- SMR:   Q9CK98
- GeneID:   1245074
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1727
- NMPDR:   fig|272843.1.peg.1728
- HOGENOM:   HBG613347
- OMA:   FSFTNQP
- ProtClustDB:   PRK08942
- BioCyc:   PMUL272843:PM1727-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR00213
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: 3.1.1.-

Molecular weight: Translated: 20618; Mature: 20618

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIFLDRDGTLNIDHGYVHEIDQFQFIDGSIEALQQLKAMGYLLVLVTNQSGIARGYF
CCCEEEEECCCEEECCCCCHHCCCCEEECCHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
SEDQFLQLTEWMDWSLADRGVDLDGIYYCPHHTEGKGEYCQDCDCRKPKPGMLLQAIKEL
CCCHHHHHHHHCCCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
NIDPNTSFMVGDKVEDMLAGKGAKIKNTVLVKTGKPITEDGKKQANYVLESIADLPKLIK
CCCCCCCEEECCHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GLKS
HHCC
>Mature Secondary Structure
MKKAIFLDRDGTLNIDHGYVHEIDQFQFIDGSIEALQQLKAMGYLLVLVTNQSGIARGYF
CCCEEEEECCCEEECCCCCHHCCCCEEECCHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
SEDQFLQLTEWMDWSLADRGVDLDGIYYCPHHTEGKGEYCQDCDCRKPKPGMLLQAIKEL
CCCHHHHHHHHCCCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
NIDPNTSFMVGDKVEDMLAGKGAKIKNTVLVKTGKPITEDGKKQANYVLESIADLPKLIK
CCCCCCCEEECCHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
GLKS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100