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The map label for this gene is lspA

Identifier: 15603528

GI number: 15603528

Start: 1872200

End: 1872697

Strand: Direct

Name: lspA

Synonym: PM1663

Alternate gene names: 15603528

Gene position: 1872200-1872697 (Clockwise)

Preceding gene: 15603527

Following gene: 15603529

Centisome position: 82.93

GC content: 36.14

Gene sequence:

>498_bases
ATGACAAAATCGAAAAGTGGGCTTTCATTTCTTTGGTTAAGTGCGGTGACATTTTTATTAGATTTAAGCAGCAAATATTT
CGTCGTAAAAAATTTTGAACTGTATGAAAGTATCAATATTCTTCCCGTGTTTAATTTAACTTATGTGCGGAACTATGGCG
CAGCATTTAGCTTCTTAGCCGATCACGATGGTTGGCAAAAATACTTTTTTATTGTGCTTGCCATCGCGATTTCACTGATG
TTGTGTTATTTTCTCGCAAAAAATCAAGCAACACAGAAATTACAGAATATTGCCTACGCACTGATTATTGGTGGGGCATT
AGGTAATATGATTGATCGTTTATATCATGGTTTTGTTGTCGATTTCTTTGATTTTTACTGGGATATTTATCACTACCCAG
TTTTCAATGTTGCCGACATCGCCATTTCCCTTGGTGCAGGATTGATGATTCTTGATGCGTTCAAAAATCGCCATGAACCT
GAACAACGTACAGAATAA

Upstream 100 bases:

>100_bases
AGGCAGTTTATCCTGCCTTTGTTGTGCATGCTCGAATTTATTCTTACAGGCGAACATGAACGTTCGCCTCTTGCAATATT
GAAACGATGTAAAGGTTATT

Downstream 100 bases:

>100_bases
TAGAGGACGATGATGAAAATTATTTTAGCCAATCCACGTGGTTTCTGTGCCGGTGTTGATCGTGCGATTAGTATCGTAGA
ATCTGCGTTAGAGATTCACG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLADHDGWQKYFFIVLAIAISLM
LCYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVVDFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEP
EQRTE

Sequences:

>Translated_165_residues
MTKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLADHDGWQKYFFIVLAIAISLM
LCYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVVDFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEP
EQRTE
>Mature_164_residues
TKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLADHDGWQKYFFIVLAIAISLML
CYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVVDFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEPE
QRTE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=52.4390243902439, Blast_Score=180, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_PASMU (P57959)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246602.1
- MEROPS:   A08.001
- GeneID:   1245010
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1663
- NMPDR:   fig|272843.1.peg.1664
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK00376
- BioCyc:   PMUL272843:PM1663-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18988; Mature: 18857

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 112-112 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

HASH(0xdfcc7e0)-; HASH(0xe647200)-; HASH(0xe2b5edc)-; HASH(0xf440c8c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLA
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEEEHHHHHHHCCHHHHHHH
DHDGWQKYFFIVLAIAISLMLCYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEPEQRTE
HHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCH
>Mature Secondary Structure 
TKSKSGLSFLWLSAVTFLLDLSSKYFVVKNFELYESINILPVFNLTYVRNYGAAFSFLA
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEEEHHHHHHHCCHHHHHHH
DHDGWQKYFFIVLAIAISLMLCYFLAKNQATQKLQNIAYALIIGGALGNMIDRLYHGFVV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFFDFYWDIYHYPVFNVADIAISLGAGLMILDAFKNRHEPEQRTE
HHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100