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The map label for this gene is gyrB [H]

Identifier: 15603341

GI number: 15603341

Start: 1668610

End: 1671030

Strand: Reverse

Name: gyrB [H]

Synonym: PM1476

Alternate gene names: 15603341

Gene position: 1671030-1668610 (Counterclockwise)

Preceding gene: 15603347

Following gene: 15603340

Centisome position: 74.02

GC content: 41.76

Gene sequence:

>2421_bases
ATGTCAAATAATACCCCTGAAAATTATGGTGCGAATAGTATTAAAGTCTTAAAAGGACTTGATGCCGTGCGTAAACGTCC
TGGTATGTACATTGGGGATACGGATGATGGTACGGGTTTACATCACATGGTGTTCGAAGTGGTGGATAATTCCATTGACG
AAGCTTTAGCGGGCTATGCTAAGGATATAACAGTCACCATTCACACCGACAATTCGGTGTCTGTACAAGATGATGGTCGT
GGTATTCCTGTTGATATTCACCCAGAAGAAGGGGTTTCGGCTGCTGAAGTCATTATGACGGTATTACATGCAGGCGGTAA
ATTTGATGATAATTCGTACAAAGTCTCGGGCGGTTTACATGGTGTGGGGGTGTCAGTAGTTAATGCCCTTTCCGATAAAT
TGCAATTAACCATTCGTCGTCAAGGTAAAGTGCATGAACAAATTTACCATTTAGGTGAACCTCAAGCACCATTAGCCGCG
ATTGGTGAAACGGATCAAACTGGAACTACCGTGCGTTTCTGGCCGAGTCCAACCATTTTCAATAACATCGAATTCGAATA
CGATATTTTGGCAAAACGCTTGCGTGAATTGTCTTTCTTAAATTCAGGTGTGTCGATTAAATTATTTGATAAGCGCAATG
ACAGACAAGATCATTTTCATTATGAAGGTGGCATTCAAGCGTTTGTAGAATACCTAAACCGTAACAAAAACCCAATTCAT
CAAAAACCTTTCTATTTTTCGACAGAAAAAGACGGCATTGGCGTGGAAGTGTCAATGCAGTGGAATGATAGCTTTAACGA
AAACGTGTATTGTTTCACCAATAATATTCCACAACGTGACGGCGGTACGCACTTAGCGGGTTTCCGTGGTGCCTTAACTC
GTAGTTTAAATAACTACATGGATAACGAAGGTCATAATAAAAAATCGAAAGTGGCGACTTCGGGTGATGATGCTCGAGAA
GGTTTGGTAGCGATTATTTCGGTCAAAGTACCTGATCCTAAATTCTCCTCGCAAACGAAAGACAAATTAGTGTCTTCGGA
AGTGAAAAGTGCGGTGGAATCGGTGATGAATGAATATTTACAACAATATTTATTAGAAAACCCGTCCGATGCCAAAATCA
TTGTCGGTAAAATTATTGATGCTGCCCGTGCGCGTGAAGCAGCACGTAAAGCCCGTGAAATGACACGCCGTAAAGGGGCA
TTAGATTTAGGTGGCTTACCGGGTAAACTTGCTGACTGCCAAGAGCGTGATCCTGCATTATCGGAATTATACCTCGTGGA
GGGGGATTCTGCGGGCGGCTCAGCAAAACAAGGGCGTAATCGTAAAAACCAAGCCATTTTACCGTTAAAAGGGAAAATTC
TGAACGTAGAAAAAGCCCGTTTTGACAAAATGCTTTCTTCTGCTGAAGTGGGGACATTAATCACCGCACTGGGTTGTGGA
ATTGGTCGTGATGAATATAATCCAGAAAAATTGCGTTATCACAGCATTATTATCATGACCGATGCGGATGTGGATGGTGC
GCACATTCGAACCTTATTATTAACTTTCTTCTATCGTCAAATGCCAGAGTTGATTGAACGTGGTCATGTGTATATTGCGC
AACCCCCACTTTACAAAGTGAAAAAAGGCAAACAAGAGCAATATATCAAAGACGATGAAGCCATGGTGCAATATGAAGTC
GCACTTGCGTTAGAAAATGCGGCACTGTATGTCAATGAAAACGCCCCTGCTATGAGTGGCTTGGCGTTAGAAAGTTTAGT
ATCAGAATATAATGCAGTACAAAAAATGATAGGTCGCTTAACTCGCTATTATCCAGAAGTGGTGTTAAAAGAATTGATTT
ATCATCCAGAGTTAACCAGTGAATTAATGGCAGATCAAAAAGAAGTGGAAAACTGGATTGCAACCCTCGTCGATAAACTG
GTGGCAAAAGAAAGCAATGGTAACCATTATAGCTATCGTACTGTGTTTAACAGCGAACGTCATTTACATGAGGCGGTGTT
AACGGTTCGCACACATGGGATTGATACGGATTATTTCCTTAACTTCCAATTTGCAACAGGCAGTGAATATGCCCGCATCG
TGAAATTAGGCAAACAATTAACCGGTTTAATTGAAGAAGGCGCTTATATCATGCGTGGTGAGCGTAAACTGGAAGTGAGT
TCATTTGAACAAGCGATTGAATGGTTAGTGAAAGAGTCGCGTCGTGGGTTAATGGTACAGCGCTATAAAGGATTGGGGGA
AATGAATCCAGAACAGCTTTGGGAAACCACAATGGATCCGAATGCACGTCGTATGTTAAAAGTTTCGATTAAAGATGCGG
TGGCGGCAGACTTACTGTTTACCACTTTAATGGGTGATGAAGTCGAGCCACGTCGTGAATTTATCGAAAGCAACGCATTA
CATGCAAATTTAGATATTTAG

Upstream 100 bases:

>100_bases
GAAAAATATCAACCAAAATCGACCGCACTTATTCTTAGCCAATTCGCCAAAAATTTGCTATAATCTCAGCAATTTTTTAT
GGTTTAAAAAGAGAGATACG

Downstream 100 bases:

>100_bases
ACAAAAAATCTGCTTTTCATTTCATCAAGTGCGGTTAAAATAAAGTTCATTTTAACCGCACTTTTTCGTTATAAATCCAT
GATATACCAAATTATTGCAC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSNNTPENYGANSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYAKDITVTIHTDNSVSVQDDGR
GIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGKVHEQIYHLGEPQAPLAA
IGETDQTGTTVRFWPSPTIFNNIEFEYDILAKRLRELSFLNSGVSIKLFDKRNDRQDHFHYEGGIQAFVEYLNRNKNPIH
QKPFYFSTEKDGIGVEVSMQWNDSFNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNNYMDNEGHNKKSKVATSGDDARE
GLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESVMNEYLQQYLLENPSDAKIIVGKIIDAARAREAARKAREMTRRKGA
LDLGGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
IGRDEYNPEKLRYHSIIIMTDADVDGAHIRTLLLTFFYRQMPELIERGHVYIAQPPLYKVKKGKQEQYIKDDEAMVQYEV
ALALENAALYVNENAPAMSGLALESLVSEYNAVQKMIGRLTRYYPEVVLKELIYHPELTSELMADQKEVENWIATLVDKL
VAKESNGNHYSYRTVFNSERHLHEAVLTVRTHGIDTDYFLNFQFATGSEYARIVKLGKQLTGLIEEGAYIMRGERKLEVS
SFEQAIEWLVKESRRGLMVQRYKGLGEMNPEQLWETTMDPNARRMLKVSIKDAVAADLLFTTLMGDEVEPRREFIESNAL
HANLDI

Sequences:

>Translated_806_residues
MSNNTPENYGANSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYAKDITVTIHTDNSVSVQDDGR
GIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGKVHEQIYHLGEPQAPLAA
IGETDQTGTTVRFWPSPTIFNNIEFEYDILAKRLRELSFLNSGVSIKLFDKRNDRQDHFHYEGGIQAFVEYLNRNKNPIH
QKPFYFSTEKDGIGVEVSMQWNDSFNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNNYMDNEGHNKKSKVATSGDDARE
GLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESVMNEYLQQYLLENPSDAKIIVGKIIDAARAREAARKAREMTRRKGA
LDLGGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
IGRDEYNPEKLRYHSIIIMTDADVDGAHIRTLLLTFFYRQMPELIERGHVYIAQPPLYKVKKGKQEQYIKDDEAMVQYEV
ALALENAALYVNENAPAMSGLALESLVSEYNAVQKMIGRLTRYYPEVVLKELIYHPELTSELMADQKEVENWIATLVDKL
VAKESNGNHYSYRTVFNSERHLHEAVLTVRTHGIDTDYFLNFQFATGSEYARIVKLGKQLTGLIEEGAYIMRGERKLEVS
SFEQAIEWLVKESRRGLMVQRYKGLGEMNPEQLWETTMDPNARRMLKVSIKDAVAADLLFTTLMGDEVEPRREFIESNAL
HANLDI
>Mature_805_residues
SNNTPENYGANSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYAKDITVTIHTDNSVSVQDDGRG
IPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGKVHEQIYHLGEPQAPLAAI
GETDQTGTTVRFWPSPTIFNNIEFEYDILAKRLRELSFLNSGVSIKLFDKRNDRQDHFHYEGGIQAFVEYLNRNKNPIHQ
KPFYFSTEKDGIGVEVSMQWNDSFNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNNYMDNEGHNKKSKVATSGDDAREG
LVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESVMNEYLQQYLLENPSDAKIIVGKIIDAARAREAARKAREMTRRKGAL
DLGGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCGI
GRDEYNPEKLRYHSIIIMTDADVDGAHIRTLLLTFFYRQMPELIERGHVYIAQPPLYKVKKGKQEQYIKDDEAMVQYEVA
LALENAALYVNENAPAMSGLALESLVSEYNAVQKMIGRLTRYYPEVVLKELIYHPELTSELMADQKEVENWIATLVDKLV
AKESNGNHYSYRTVFNSERHLHEAVLTVRTHGIDTDYFLNFQFATGSEYARIVKLGKQLTGLIEEGAYIMRGERKLEVSS
FEQAIEWLVKESRRGLMVQRYKGLGEMNPEQLWETTMDPNARRMLKVSIKDAVAADLLFTTLMGDEVEPRREFIESNALH
ANLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=544, Percent_Identity=25.1838235294118, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI19913408, Length=552, Percent_Identity=24.6376811594203, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI48994957, Length=808, Percent_Identity=77.2277227722772, Blast_Score=1283, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=551, Percent_Identity=40.8348457350272, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=537, Percent_Identity=25.8845437616387, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=506, Percent_Identity=24.1106719367589, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI212645657, Length=153, Percent_Identity=33.9869281045752, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=569, Percent_Identity=25.1318101933216, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136538, Length=529, Percent_Identity=25.5198487712665, Blast_Score=129, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90194; Mature: 90063

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNTPENYGANSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KDITVTIHTDNSVSVQDDGRGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSDKLQLTIRRQGKVHEQIYHLGEPQAPLAAIGETDQTGTTVRFWPSPTIF
HHHHHHHHHHHHHHEEEEHHCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCEE
NNIEFEYDILAKRLRELSFLNSGVSIKLFDKRNDRQDHFHYEGGIQAFVEYLNRNKNPIH
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
QKPFYFSTEKDGIGVEVSMQWNDSFNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNNYM
CCCEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
DNEGHNKKSKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESVMNEYL
CCCCCCCHHCCCCCCCCHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQYLLENPSDAKIIVGKIIDAARAREAARKAREMTRRKGALDLGGLPGKLADCQERDPAL
HHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
SELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDEYNPEKLRYHSIIIMTDADVDGAHIRTLLLTFFYRQMPELIERGHVYIAQPPLYKV
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
KKGKQEQYIKDDEAMVQYEVALALENAALYVNENAPAMSGLALESLVSEYNAVQKMIGRL
HCCCHHHHCCCCHHHEEEEEEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TRYYPEVVLKELIYHPELTSELMADQKEVENWIATLVDKLVAKESNGNHYSYRTVFNSER
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHH
HLHEAVLTVRTHGIDTDYFLNFQFATGSEYARIVKLGKQLTGLIEEGAYIMRGERKLEVS
HHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHH
SFEQAIEWLVKESRRGLMVQRYKGLGEMNPEQLWETTMDPNARRMLKVSIKDAVAADLLF
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHCCCCCCHHEEEEHHHHHHHHHHHH
TTLMGDEVEPRREFIESNALHANLDI
HHHHCCCCCHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
SNNTPENYGANSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KDITVTIHTDNSVSVQDDGRGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSDKLQLTIRRQGKVHEQIYHLGEPQAPLAAIGETDQTGTTVRFWPSPTIF
HHHHHHHHHHHHHHEEEEHHCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCEE
NNIEFEYDILAKRLRELSFLNSGVSIKLFDKRNDRQDHFHYEGGIQAFVEYLNRNKNPIH
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
QKPFYFSTEKDGIGVEVSMQWNDSFNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNNYM
CCCEEEECCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
DNEGHNKKSKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESVMNEYL
CCCCCCCHHCCCCCCCCHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QQYLLENPSDAKIIVGKIIDAARAREAARKAREMTRRKGALDLGGLPGKLADCQERDPAL
HHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
SELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
CEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDEYNPEKLRYHSIIIMTDADVDGAHIRTLLLTFFYRQMPELIERGHVYIAQPPLYKV
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
KKGKQEQYIKDDEAMVQYEVALALENAALYVNENAPAMSGLALESLVSEYNAVQKMIGRL
HCCCHHHHCCCCHHHEEEEEEEEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
TRYYPEVVLKELIYHPELTSELMADQKEVENWIATLVDKLVAKESNGNHYSYRTVFNSER
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHH
HLHEAVLTVRTHGIDTDYFLNFQFATGSEYARIVKLGKQLTGLIEEGAYIMRGERKLEVS
HHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHH
SFEQAIEWLVKESRRGLMVQRYKGLGEMNPEQLWETTMDPNARRMLKVSIKDAVAADLLF
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHCCCCCCHHEEEEHHHHHHHHHHHH
TTLMGDEVEPRREFIESNALHANLDI
HHHHCCCCCHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]