Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 15603289

GI number: 15603289

Start: 1608184

End: 1609434

Strand: Reverse

Name: lysA [H]

Synonym: PM1424

Alternate gene names: 15603289

Gene position: 1609434-1608184 (Counterclockwise)

Preceding gene: 15603293

Following gene: 15603285

Centisome position: 71.29

GC content: 43.17

Gene sequence:

>1251_bases
ATGGATTATTTTCAATATCAACAAGCACAACTGATGGCAGAACAAGTGCCGGTAAAACACATTGCACAGCAATATGGTAC
CCCTTTGTATATTTATTCTCGTGCCACGTTAGAACGTCATTGGCATGCCTTTAATAACGCACTTGGCGATCATCCGCATT
TGATTTGCTTTGCGGTGAAATCCAATCCTAACATCGCGATTTTGAATATTATGGCGCGGTTAGGTTCAGGTTTTGATATT
GTGTCCCAAGGTGAATTGGAACGTGTCCTAGCGGCGGGTGGCGAGCCGAGTAAAATAGTGTTTTCTGGTGTGGCGAAAAC
AGAAACAGAAATTGCTCGTGCATTAGAGGTCGGTATTCGCTGTTTTAATGTGGAATCGGTTGCTGAGTTGTATCGCATTA
ATCAGGTAGCGGGTGAAATGGGGAAAACTGCGCCTATTTCATTGCGCGTTAATCCTGATGTGGATGCGCGCACGCATCCT
TATATTTCAACCGGTTTAAAAGAAAATAAATTTGGTATTAGTGTGGCGGAAGCCCGTAACGTTTATCAATTAGCAAATCA
ATTACCTCATATTCAAATCACAGGTATGGATTGCCATATTGGGTCACAATTGACTGAATTACAACCTTTCTTAGATGCCA
CAGATCGTCTAATTGTGTTAATGGAACAGTTGAAACAAGATGGTATTCAGCTTAAACATTTAGATTTAGGCGGTGGTTTG
GGCGTACCTTATACTAATGAAAACCCACCACATCCGAGTGAATATGCCAGTGCATTGTTAGATAAATTAAAAGCCTATCA
TGAACTTGAGATTATTCTTGAGCCGGGTCGTGCAATCACCGCGAATGCAGGGATTTTGGTCACTAAAGTGGAATATCTCA
AACATAATGAAGATCGCCATTTTGCGATTGTTGACGCGGGGATGAATGATATGATTCGCCCAGCATTGTATCAGGCGTAT
ATGAATATTATTGAAGTTGATCGCACGTTAACACGTGATAAAGCGGTTTATGACGTTGTAGGACCAATTTGTGAAACCTC
GGATTTTCTCGGCAAACAACGGGAATTGGCGATTGCGGCTGGTGATTATTTGGCACAACGTTCCGCAGGGGCTTATGGCG
CCAGTATGTCCTCCAACTATAATTCACGTTCGCGTACCGCGGAAGTGATGGTGGATGGGGATCAAGTGCATTTAATCCGC
CGTCGTGAAACACTGGAAGAACTGTGGGCACTGGAACGACTCTTGCCATAA

Upstream 100 bases:

>100_bases
GGGATGGTTTGTGCCTTAAGTGTGGCTTGTGGTGTGAAAGGTCCTTTGTATTTCCCTGAAAATGAGACAGTACAAAAAAC
ACAATAATAGCAGGTAAGAA

Downstream 100 bases:

>100_bases
ATACCATCACCTATCGCCGAGATGTAACATGAAAAGAAAAATCCTCGTTAGTATTATATCTAACGAGGATTTTTTATCGG
AAAAGTGTGTTTTTATACCG

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDYFQYQQAQLMAEQVPVKHIAQQYGTPLYIYSRATLERHWHAFNNALGDHPHLICFAVKSNPNIAILNIMARLGSGFDI
VSQGELERVLAAGGEPSKIVFSGVAKTETEIARALEVGIRCFNVESVAELYRINQVAGEMGKTAPISLRVNPDVDARTHP
YISTGLKENKFGISVAEARNVYQLANQLPHIQITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKQDGIQLKHLDLGGGL
GVPYTNENPPHPSEYASALLDKLKAYHELEIILEPGRAITANAGILVTKVEYLKHNEDRHFAIVDAGMNDMIRPALYQAY
MNIIEVDRTLTRDKAVYDVVGPICETSDFLGKQRELAIAAGDYLAQRSAGAYGASMSSNYNSRSRTAEVMVDGDQVHLIR
RRETLEELWALERLLP

Sequences:

>Translated_416_residues
MDYFQYQQAQLMAEQVPVKHIAQQYGTPLYIYSRATLERHWHAFNNALGDHPHLICFAVKSNPNIAILNIMARLGSGFDI
VSQGELERVLAAGGEPSKIVFSGVAKTETEIARALEVGIRCFNVESVAELYRINQVAGEMGKTAPISLRVNPDVDARTHP
YISTGLKENKFGISVAEARNVYQLANQLPHIQITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKQDGIQLKHLDLGGGL
GVPYTNENPPHPSEYASALLDKLKAYHELEIILEPGRAITANAGILVTKVEYLKHNEDRHFAIVDAGMNDMIRPALYQAY
MNIIEVDRTLTRDKAVYDVVGPICETSDFLGKQRELAIAAGDYLAQRSAGAYGASMSSNYNSRSRTAEVMVDGDQVHLIR
RRETLEELWALERLLP
>Mature_416_residues
MDYFQYQQAQLMAEQVPVKHIAQQYGTPLYIYSRATLERHWHAFNNALGDHPHLICFAVKSNPNIAILNIMARLGSGFDI
VSQGELERVLAAGGEPSKIVFSGVAKTETEIARALEVGIRCFNVESVAELYRINQVAGEMGKTAPISLRVNPDVDARTHP
YISTGLKENKFGISVAEARNVYQLANQLPHIQITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKQDGIQLKHLDLGGGL
GVPYTNENPPHPSEYASALLDKLKAYHELEIILEPGRAITANAGILVTKVEYLKHNEDRHFAIVDAGMNDMIRPALYQAY
MNIIEVDRTLTRDKAVYDVVGPICETSDFLGKQRELAIAAGDYLAQRSAGAYGASMSSNYNSRSRTAEVMVDGDQVHLIR
RRETLEELWALERLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=24, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI22538418, Length=363, Percent_Identity=25.6198347107438, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21361583, Length=363, Percent_Identity=25.6198347107438, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=24.6376811594203, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789203, Length=406, Percent_Identity=34.2364532019704, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562780, Length=355, Percent_Identity=24.2253521126761, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=377, Percent_Identity=24.9336870026525, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24586474, Length=397, Percent_Identity=25.6926952141058, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586472, Length=389, Percent_Identity=24.4215938303342, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46282; Mature: 46282

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFQYQQAQLMAEQVPVKHIAQQYGTPLYIYSRATLERHWHAFNNALGDHPHLICFAVK
CCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEE
SNPNIAILNIMARLGSGFDIVSQGELERVLAAGGEPSKIVFSGVAKTETEIARALEVGIR
CCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHE
CFNVESVAELYRINQVAGEMGKTAPISLRVNPDVDARTHPYISTGLKENKFGISVAEARN
EECHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCCEEHHHHHH
VYQLANQLPHIQITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKQDGIQLKHLDLGGGL
HHHHHHHCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYTNENPPHPSEYASALLDKLKAYHELEIILEPGRAITANAGILVTKVEYLKHNEDRH
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCEEEEEEHHHHCCCCCE
FAIVDAGMNDMIRPALYQAYMNIIEVDRTLTRDKAVYDVVGPICETSDFLGKQRELAIAA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEH
GDYLAQRSAGAYGASMSSNYNSRSRTAEVMVDGDQVHLIRRRETLEELWALERLLP
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDYFQYQQAQLMAEQVPVKHIAQQYGTPLYIYSRATLERHWHAFNNALGDHPHLICFAVK
CCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEE
SNPNIAILNIMARLGSGFDIVSQGELERVLAAGGEPSKIVFSGVAKTETEIARALEVGIR
CCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHE
CFNVESVAELYRINQVAGEMGKTAPISLRVNPDVDARTHPYISTGLKENKFGISVAEARN
EECHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCCCCCCCCEEHHHHHH
VYQLANQLPHIQITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKQDGIQLKHLDLGGGL
HHHHHHHCCCEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYTNENPPHPSEYASALLDKLKAYHELEIILEPGRAITANAGILVTKVEYLKHNEDRH
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEECCCEEEEEEHHHHCCCCCE
FAIVDAGMNDMIRPALYQAYMNIIEVDRTLTRDKAVYDVVGPICETSDFLGKQRELAIAA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEH
GDYLAQRSAGAYGASMSSNYNSRSRTAEVMVDGDQVHLIRRRETLEELWALERLLP
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]