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The map label for this gene is oadA [H]

Identifier: 15603287

GI number: 15603287

Start: 1604938

End: 1606746

Strand: Direct

Name: oadA [H]

Synonym: PM1422

Alternate gene names: 15603287

Gene position: 1604938-1606746 (Clockwise)

Preceding gene: 15603286

Following gene: 15603288

Centisome position: 71.09

GC content: 44.72

Gene sequence:

>1809_bases
ATGACTACTCAAAACAAAAAAATTGCCATTACTGATGTTGTGTTACGTGACGCTCATCAATCTCTCTTTGCCACGCGTAT
GCGCCTTGATGACATGTTGCCTATTGCACATGAGTTAGATCAAATTGGCTATTGGTCGCTTGAAGCCTGGGGGGGCGCGA
CTTTTGATGCGTGTATTCGTTTTTTAGGGGAAGATCCTTGGGTACGTTTACGTGAATTAAAACAAGCCATGCCAAATACG
CCGTTACAAATGCTGTTGCGCGGTCAAAACCTATTAGGTTATCGTCATTATGCGGATGACGTCGTGGATCGCTTTGTAGA
ACGCTCCGTGAAAAATGGGATGTCCGTTTTCCGTGTCTTCGATGCCATGAACGACCCGCGTAATATGAAACAAGCCTTGC
AAGCCGTAAAACGTAACGGTGGACATGCCCAAGGGACATTAAGTTATACCACTAGCCCAGTACATAACTTAGAAACCTGG
TTAGAGATTACTGAGCAATTATTAGAAATCGGTGTCGATTCCGTGGTGATTAAAGATATGTCCGGGATTCTAACCCCAGT
AGAAGCCTACAAATTAGTCAGTGAAATTAAAAAACGCTACGATGTTCAACTCCATTTACATTGCCACGCCACGACGGGAA
TGGCAGAAATGGCGCTATTAAAAGCCGTAGAAGCGGGTATTGATGGCATTGACACCTCCATTTCCTCTATGAGTGGCACT
TATGGTCACCCGTCAACTGAAGCCTTAGTCGCGACTTTACAAGGTACACAATATGACACCGGCTTAGATATCCATAAATT
AGAACATATTGCTGCCTACTTCCGCGAAGTACGTAAAAAATACGCTAAATTTGAAGGTCAATTACGTGGTTCAGATAGCC
GTATCTTAGTTGCACAAGTACCAGGTGGGATGTTGACGAACCTTGAAAGCCAGCTCAAACAACAAAATGCGTCGGATAAA
TTAGATGAGGTATTGAAAGAAATTCCACGTGTGCGTGAAGATTTAGGCTTTATTCCATTAGTTACCCCTACCTCACAAAT
TGTCGGTACGCAGGCCGTGATTAACGTGTTAATGGGTGAGCGTTATAAAACCATTGCTAAAGAAACAGCGGGTATTTTGA
AAGGTGAGTACGGTCGTACACCTGCCCCGGTCAATGCTGAATTACAAGCCAAAGTGTTAGACGGTGGACAACCTATCACT
GATCGTCCAGCCGATCATATTGCACCAGAAATGGAAAAATTAGCCACAGAAATCAAACAACAAGCCAAAGAAAAAGGCAT
TAAACTGGCTGAAAATGAAATTGATGATGTATTGATTGTGGCGTTATTCCCACAAATCGGTTGGAAATTCTTGGAAAATC
GTGGCAACCCAGATGCCTTTGAACCTGCACCAACCTTAGAAACCGCAAAACCGGCAGAAAAACCAGCTGCACCTGTGGCG
AAAACACCAGTTTCAGGACCTGCCGTTTACACCGTGGAATTAGAGGGCAAATCCTTTGTAGTGAAAGTCACAGACGGGGG
AGAAGTCGGTGAGATTGCCCCTGCAGCACAACCAACTGCACAAACAGCGCCACAACCTGCCCCGGCATCTACGAGTGGTA
CACCTGTCAGCGCCCCAATGTCTGGCAATATCTGGAAAGTGGTAGCAAAAGAAGGGCAAAAAGTGGCAGAAGGGGATGTG
TTACTCATTTTAGAAGCCATGAAAATGGAAACTGAAATTCGTGCAAGCCAAGCAGGTACCGTACAAAGTATTCATGTAAA
AGCCGGCGATACTGTTGCCGTTGGCGATACCTTAATGACATTAAGCTAA

Upstream 100 bases:

>100_bases
GAAAATCATGACTTAGAACGTTTACGTCCCGTTATCGTTGCCGCGATTGCACATCATCGCCGCCAACAAGGGCTAAAATA
ACTCACAAAGGAAATTAGAA

Downstream 100 bases:

>100_bases
CGAGGTCAATATGGAAAGTATTTTGTCATTATTAAGAGGAATGGGCATCATGCATCTGGAGTTGGGTCAAGCTCTCATGA
TGCTAATAAGCCTTGTCCTC

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MTTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNT
PLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETW
LEITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGT
YGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDK
LDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGERYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPIT
DRPADHIAPEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVA
KTPVSGPAVYTVELEGKSFVVKVTDGGEVGEIAPAAQPTAQTAPQPAPASTSGTPVSAPMSGNIWKVVAKEGQKVAEGDV
LLILEAMKMETEIRASQAGTVQSIHVKAGDTVAVGDTLMTLS

Sequences:

>Translated_602_residues
MTTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNT
PLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETW
LEITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGT
YGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDK
LDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGERYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPIT
DRPADHIAPEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVA
KTPVSGPAVYTVELEGKSFVVKVTDGGEVGEIAPAAQPTAQTAPQPAPASTSGTPVSAPMSGNIWKVVAKEGQKVAEGDV
LLILEAMKMETEIRASQAGTVQSIHVKAGDTVAVGDTLMTLS
>Mature_601_residues
TTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNTP
LQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVFDAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETWL
EITEQLLEIGVDSVVIKDMSGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGTY
GHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDKL
DEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGERYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPITD
RPADHIAPEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVAK
TPVSGPAVYTVELEGKSFVVKVTDGGEVGEIAPAAQPTAQTAPQPAPASTSGTPVSAPMSGNIWKVVAKEGQKVAEGDVL
LILEAMKMETEIRASQAGTVQSIHVKAGDTVAVGDTLMTLS

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=640, Percent_Identity=32.1875, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI106049295, Length=640, Percent_Identity=32.1875, Blast_Score=295, Evalue=7e-80,
Organism=Homo sapiens, GI106049292, Length=640, Percent_Identity=32.1875, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17562816, Length=627, Percent_Identity=33.1738437001595, Blast_Score=321, Evalue=9e-88,
Organism=Saccharomyces cerevisiae, GI6319695, Length=635, Percent_Identity=31.9685039370079, Blast_Score=313, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6321376, Length=635, Percent_Identity=31.0236220472441, Blast_Score=299, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652212, Length=642, Percent_Identity=32.398753894081, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652210, Length=642, Percent_Identity=32.398753894081, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652214, Length=642, Percent_Identity=32.398753894081, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI19921944, Length=642, Percent_Identity=32.398753894081, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652216, Length=642, Percent_Identity=32.398753894081, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI281363050, Length=642, Percent_Identity=32.2429906542056, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652224, Length=642, Percent_Identity=32.2429906542056, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652222, Length=642, Percent_Identity=32.2429906542056, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652220, Length=642, Percent_Identity=32.2429906542056, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24652218, Length=642, Percent_Identity=32.2429906542056, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 65584; Mature: 65453

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIR
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
FLGEDPWVRLRELKQAMPNTPLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETWLEITEQLLEIGVDSVVIKDM
HHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
SGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGT
HHHCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHCCCC
YGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQV
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
PGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
RYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPITDRPADHIAPEMEKLATEIKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
QAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVA
HHHHCCCEECCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KTPVSGPAVYTVELEGKSFVVKVTDGGEVGEIAPAAQPTAQTAPQPAPASTSGTPVSAPM
CCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
SGNIWKVVAKEGQKVAEGDVLLILEAMKMETEIRASQAGTVQSIHVKAGDTVAVGDTLMT
CCCEEEEEHHCCCEECCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCEEEE
LS
CC
>Mature Secondary Structure 
TTQNKKIAITDVVLRDAHQSLFATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIR
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
FLGEDPWVRLRELKQAMPNTPLQMLLRGQNLLGYRHYADDVVDRFVERSVKNGMSVFRVF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAMNDPRNMKQALQAVKRNGGHAQGTLSYTTSPVHNLETWLEITEQLLEIGVDSVVIKDM
HHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
SGILTPVEAYKLVSEIKKRYDVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGT
HHHCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHCCCC
YGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQV
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEC
PGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLGFIPLVTPTSQIVGTQAVINVLMGE
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
RYKTIAKETAGILKGEYGRTPAPVNAELQAKVLDGGQPITDRPADHIAPEMEKLATEIKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
QAKEKGIKLAENEIDDVLIVALFPQIGWKFLENRGNPDAFEPAPTLETAKPAEKPAAPVA
HHHHCCCEECCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KTPVSGPAVYTVELEGKSFVVKVTDGGEVGEIAPAAQPTAQTAPQPAPASTSGTPVSAPM
CCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
SGNIWKVVAKEGQKVAEGDVLLILEAMKMETEIRASQAGTVQSIHVKAGDTVAVGDTLMT
CCCEEEEEHHCCCEECCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCEEEE
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]