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The map label for this gene is deoR [H]

Identifier: 15603209

GI number: 15603209

Start: 1537134

End: 1537886

Strand: Direct

Name: deoR [H]

Synonym: PM1344

Alternate gene names: 15603209

Gene position: 1537134-1537886 (Clockwise)

Preceding gene: 15603208

Following gene: 15603212

Centisome position: 68.09

GC content: 39.18

Gene sequence:

>753_bases
ATGGAAAAAATGACGTCTCGCATTCAGAAATTGGAGTTTCTACTTAAGCAAATGGACAAAATTCATCTGCGAGATGCGGC
AGAAATGTTGAATGTGTCTGAAATGACGATTCGACGGGATCTGGTTTCCTGTGCAAGCTCAGTGATTTTATTAGGTGGGT
ATATCGTTAAAGATCCAAAAACTCATGCGCAGAAAGGTTATCGGATCTTTGAACAACAAGAAAAAAACACCGCGGAGAAA
ATGTATTTAGGAAAGCTCGCTGCTTCTCTGATTGAAGATGGCGATGTTGTTTTTTTTGATTGTGGCTCAACAGTGCCTTT
TATCGCGACACAAATTAATGATGACATCAAATTTACCGCACTGTGTTGCTCAATTAATGCATTTTTAGCCTTACAGGAAA
AACCCAATTGTGATTTGATTCTATGTGGGGGACGGTATTCTCGACATAATGCGTTTTTAAATCGTATTCAGCGTCATAGT
GAATTGGATATGATTTGTACCAATAAAGCCTTCATTTCTGCGGCAGGTGTGGCTATCCAACAAGGCGTGACGTGTTTTAA
TTTTGATGAAGCGAAAGCAAAACAGCGTGTTATGGAGAAAACACAACAAGCCTTTTTAGTAGTGGACCATTCTAAATTTA
ATCGAGTTGAGCAGGCATATATTGCGGATCTTTCTGCTTTTGATACTGTGATTTGTGATAAACCCGCACCAACGGCATTC
ATCGACAAACTACCGACGTTAATTTTCAAGTAA

Upstream 100 bases:

>100_bases
TAATGCGGGGGCTAGCCGTATCGGTGCAAGTGCAGGGATTGCGATTATCCATGGTTTACAGGACGTAAGCAGTACCTATT
AATAAATCACTGAGCTTGCT

Downstream 100 bases:

>100_bases
TCAAGTAGCCCTTCATGTCTTTTATCGTGCTCTAACAGCTAATAGCTCTCTTTGTGATGTGTATATTCTGCCCCTTTAGC
TAACATACGCAATTGTAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MEKMTSRIQKLEFLLKQMDKIHLRDAAEMLNVSEMTIRRDLVSCASSVILLGGYIVKDPKTHAQKGYRIFEQQEKNTAEK
MYLGKLAASLIEDGDVVFFDCGSTVPFIATQINDDIKFTALCCSINAFLALQEKPNCDLILCGGRYSRHNAFLNRIQRHS
ELDMICTNKAFISAAGVAIQQGVTCFNFDEAKAKQRVMEKTQQAFLVVDHSKFNRVEQAYIADLSAFDTVICDKPAPTAF
IDKLPTLIFK

Sequences:

>Translated_250_residues
MEKMTSRIQKLEFLLKQMDKIHLRDAAEMLNVSEMTIRRDLVSCASSVILLGGYIVKDPKTHAQKGYRIFEQQEKNTAEK
MYLGKLAASLIEDGDVVFFDCGSTVPFIATQINDDIKFTALCCSINAFLALQEKPNCDLILCGGRYSRHNAFLNRIQRHS
ELDMICTNKAFISAAGVAIQQGVTCFNFDEAKAKQRVMEKTQQAFLVVDHSKFNRVEQAYIADLSAFDTVICDKPAPTAF
IDKLPTLIFK
>Mature_250_residues
MEKMTSRIQKLEFLLKQMDKIHLRDAAEMLNVSEMTIRRDLVSCASSVILLGGYIVKDPKTHAQKGYRIFEQQEKNTAEK
MYLGKLAASLIEDGDVVFFDCGSTVPFIATQINDDIKFTALCCSINAFLALQEKPNCDLILCGGRYSRHNAFLNRIQRHS
ELDMICTNKAFISAAGVAIQQGVTCFNFDEAKAKQRVMEKTQQAFLVVDHSKFNRVEQAYIADLSAFDTVICDKPAPTAF
IDKLPTLIFK

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=227, Percent_Identity=47.136563876652, Blast_Score=214, Evalue=4e-57,
Organism=Escherichia coli, GI1789519, Length=233, Percent_Identity=27.4678111587983, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI226510968, Length=238, Percent_Identity=26.890756302521, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789829, Length=249, Percent_Identity=25.7028112449799, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790753, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789059, Length=235, Percent_Identity=27.6595744680851, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787540, Length=239, Percent_Identity=26.3598326359833, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082344, Length=250, Percent_Identity=22.8, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28150; Mature: 28150

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKMTSRIQKLEFLLKQMDKIHLRDAAEMLNVSEMTIRRDLVSCASSVILLGGYIVKDPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCH
THAQKGYRIFEQQEKNTAEKMYLGKLAASLIEDGDVVFFDCGSTVPFIATQINDDIKFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LCCSINAFLALQEKPNCDLILCGGRYSRHNAFLNRIQRHSELDMICTNKAFISAAGVAIQ
HEEHHHHHEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
QGVTCFNFDEAKAKQRVMEKTQQAFLVVDHSKFNRVEQAYIADLSAFDTVICDKPAPTAF
HCCEEECCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IDKLPTLIFK
HHHHHHHHCC
>Mature Secondary Structure
MEKMTSRIQKLEFLLKQMDKIHLRDAAEMLNVSEMTIRRDLVSCASSVILLGGYIVKDPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCH
THAQKGYRIFEQQEKNTAEKMYLGKLAASLIEDGDVVFFDCGSTVPFIATQINDDIKFTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCHHH
LCCSINAFLALQEKPNCDLILCGGRYSRHNAFLNRIQRHSELDMICTNKAFISAAGVAIQ
HEEHHHHHEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHH
QGVTCFNFDEAKAKQRVMEKTQQAFLVVDHSKFNRVEQAYIADLSAFDTVICDKPAPTAF
HCCEEECCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IDKLPTLIFK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]