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The map label for this gene is grxC [C]

Identifier: 15603212

GI number: 15603212

Start: 1539593

End: 1540318

Strand: Direct

Name: grxC [C]

Synonym: PM1347

Alternate gene names: 15603212

Gene position: 1539593-1540318 (Clockwise)

Preceding gene: 15603209

Following gene: 15603214

Centisome position: 68.2

GC content: 40.36

Gene sequence:

>726_bases
ATGACATTAATGGAAGGAAAAAAAGTACCTCAAGTGACATTTCATACTCGTCAGGGCGATCAATGGGTAGATGTAACCAG
TGCGGAATTATTTGATAATAAAACTGTTGTACTTTTCTCATTACCGGGAGCATTTACACCCACTTGTTCTTCCACTCATT
TGCCTCGCTATAATGAATTAGCTTGTGAATTTAAAGCATTAGGGGTAGACAGTATCATTTGTATGTCAGTGAATGATACG
TTCGTCATGAATGCGTGGAAAGCGGATCAGGAATGTGAAAATGTGATTGTCATTCCGGATGGTAATGGTGAATTTACCGA
AGGTATGGGGATGCTCGTCGGTAAGGAAGATTTAGGCTTTGGTAAACGCTCTTGGCGTTATTCGATGTTAGTGCGCAATG
GTATTGTGGAGAAAATGTTTGTTGAGCCACAAGAACCCGGTGATCCATTTAAAGTCTCTGATGCAGACACGATGATTAAA
TATCTTAAACCAGAATGGCAAGCTAAGCCTTCTGTTTCAGTGATCACTAAACCTGGTTGCCCATATTGTGCCAAAGCAAA
AGCGTTGTTAAAAGCGAAAGACTATACCTTTGAAGAAATTGTGTTAGGACGTGATGCCAGTACGATTTCTGTTCGTGCGA
TTACAGGGAAAACAAGCGTACCTCAAGTCTTTATCGGTGGAAAATACATCGGTGGCAGTGAAGAGTTAGAAAAGTATTTT
GCTTAA

Upstream 100 bases:

>100_bases
TTAAATCAATTGCTTAGAACTATATCATAAATTTGACTAGAATTCATAAAGGAGTAAGATAGATTTTATTGTTTATTAAT
TAGTCTAAAGGAGATTTTTT

Downstream 100 bases:

>100_bases
GCTTAAATCAACAGAACAAGTGCGGTAAACTTGACCGCACTTTTTTCTTGTGTGAGTCAATAATGTGGTGGTGGAGTTTC
TTCGGCTTGGCTCGCAATGT

Product: hypothetical protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTLMEGKKVPQVTFHTRQGDQWVDVTSAELFDNKTVVLFSLPGAFTPTCSSTHLPRYNELACEFKALGVDSIICMSVNDT
FVMNAWKADQECENVIVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVRNGIVEKMFVEPQEPGDPFKVSDADTMIK
YLKPEWQAKPSVSVITKPGCPYCAKAKALLKAKDYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSEELEKYF
A

Sequences:

>Translated_241_residues
MTLMEGKKVPQVTFHTRQGDQWVDVTSAELFDNKTVVLFSLPGAFTPTCSSTHLPRYNELACEFKALGVDSIICMSVNDT
FVMNAWKADQECENVIVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVRNGIVEKMFVEPQEPGDPFKVSDADTMIK
YLKPEWQAKPSVSVITKPGCPYCAKAKALLKAKDYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSEELEKYF
A
>Mature_240_residues
TLMEGKKVPQVTFHTRQGDQWVDVTSAELFDNKTVVLFSLPGAFTPTCSSTHLPRYNELACEFKALGVDSIICMSVNDTF
VMNAWKADQECENVIVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVRNGIVEKMFVEPQEPGDPFKVSDADTMIKY
LKPEWQAKPSVSVITKPGCPYCAKAKALLKAKDYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSEELEKYFA

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=145, Percent_Identity=40.6896551724138, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=44.8, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=44.8, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26695; Mature: 26564

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMEGKKVPQVTFHTRQGDQWVDVTSAELFDNKTVVLFSLPGAFTPTCSSTHLPRYNEL
CCCCCCCCCCEEEEEECCCCEEEEEEHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
ACEFKALGVDSIICMSVNDTFVMNAWKADQECENVIVIPDGNGEFTEGMGMLVGKEDLGF
HHEEEECCCCEEEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCC
GKRSWRYSMLVRNGIVEKMFVEPQEPGDPFKVSDADTMIKYLKPEWQAKPSVSVITKPGC
CCCCCEEHHHHHHCCHHHEECCCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCCC
PYCAKAKALLKAKDYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSEELEKYF
CHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEEECCHHHHHHHC
A
C
>Mature Secondary Structure 
TLMEGKKVPQVTFHTRQGDQWVDVTSAELFDNKTVVLFSLPGAFTPTCSSTHLPRYNEL
CCCCCCCCCEEEEEECCCCEEEEEEHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
ACEFKALGVDSIICMSVNDTFVMNAWKADQECENVIVIPDGNGEFTEGMGMLVGKEDLGF
HHEEEECCCCEEEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCC
GKRSWRYSMLVRNGIVEKMFVEPQEPGDPFKVSDADTMIKYLKPEWQAKPSVSVITKPGC
CCCCCEEHHHHHHCCHHHEECCCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCCC
PYCAKAKALLKAKDYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSEELEKYF
CHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEEECCHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]