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The map label for this gene is tpiA [H]

Identifier: 15603176

GI number: 15603176

Start: 1505418

End: 1506203

Strand: Reverse

Name: tpiA [H]

Synonym: PM1311

Alternate gene names: 15603176

Gene position: 1506203-1505418 (Counterclockwise)

Preceding gene: 15603178

Following gene: 15603170

Centisome position: 66.72

GC content: 44.02

Gene sequence:

>786_bases
ATGGCTCGTCGTCCTTTAGTTATGGGTAACTGGAAATTAAACGGTAGCAAAGCATTCACCAAAGCATTAATCGAAGACTT
AAAAACAGAATTAGCGGGTGTTGAAGGCTGCGATGTGGCAATTGCCCCACCGGTGATGTATTTAGCAGAAGCAGAAGCTG
CCTTAAAATGCAGTTGTAGTTGTGGCGGAAAAGCCATTGCCCTTGGTGCACAAAACGTCGATGTGAATGTACAAGGTGCC
TTTACTGGCGATATTTCAACAGAAATGCTGAAAGATTTTGGTGCAAAATATATCATTATCGGTCACTCTGAGCGTCGTAC
TTATCATAAAGAAAGCGATGAATTCATCGCGAAAAAATTCGCAGCATTAAAACAAGCAGGCTTAGTGCCGGTATTGTGTA
TCGGTGAAAGTGAAGCCGAAAATGAAGCGGGCAAAACAGAAGAAGTATGCGCACGCCAAATTGATGCCGTATTAAATACA
TTAGGCGCTGAAGCCTTTAATGGTGCCGTTATCGCTTATGAGCCAATTTGGGCAATCGGTACCGGTAAATCAGCAACCCC
TGCTCAAGCACAAGCAGTTCATGCCTTTATCCGCGGTCATATTGCGAAAAAAGACAACGCGGTAGCAGAACAAGTGATCA
TCCAATACGGTGGTTCAGTTAATGATGCGAATGCGGCTGAATTATTTACTCAACCCGATATCGATGGTGCATTAGTTGGT
GGTGCCTCATTAAAAGCTCCTGCCTTTGCGGTGATCGTCAAAGCCGCAGCAAAAGCAAAAAACTAA

Upstream 100 bases:

>100_bases
ACAAAAAATTTTTTTAAATTTGCCTAAAATCAACAGAATGGATGAAAAAATTTGCTATAGTAATGCGGTTATTTTTTATT
ACTTTAATACGGAGAAAATT

Downstream 100 bases:

>100_bases
TTGATTCGTCAATGTAAAAAGCAGATCAATGATCTGCTTTTTTTATGTTTCAAGTGCGGTAGCTTAGACTATTTTTTCCA
ACTCACAAACGCCCATGTTT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCSCGGKAIALGAQNVDVNVQGA
FTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKFAALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNT
LGAEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVG
GASLKAPAFAVIVKAAAKAKN

Sequences:

>Translated_261_residues
MARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCSCGGKAIALGAQNVDVNVQGA
FTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKFAALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNT
LGAEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVG
GASLKAPAFAVIVKAAAKAKN
>Mature_260_residues
ARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCSCGGKAIALGAQNVDVNVQGAF
TGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKFAALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNTL
GAEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVGG
ASLKAPAFAVIVKAAAKAKN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=255, Percent_Identity=44.7058823529412, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4507645, Length=255, Percent_Identity=44.7058823529412, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1790353, Length=259, Percent_Identity=74.9034749034749, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17536593, Length=256, Percent_Identity=46.484375, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6320255, Length=258, Percent_Identity=45.7364341085271, Blast_Score=198, Evalue=9e-52,
Organism=Drosophila melanogaster, GI28572008, Length=258, Percent_Identity=46.5116279069767, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI28572006, Length=258, Percent_Identity=46.5116279069767, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI28572004, Length=258, Percent_Identity=46.5116279069767, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27248; Mature: 27117

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCS
CCCCCEEEECEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHCCHHEEEECC
CGGKAIALGAQNVDVNVQGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKF
CCCEEEEEECCCCEEEEEEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHH
AALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNTLGAEAFNGAVIAYEPIWAIG
HHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECCEEEEE
TGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVG
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEC
GASLKAPAFAVIVKAAAKAKN
CCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCS
CCCCEEEECEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHCCHHEEEECC
CGGKAIALGAQNVDVNVQGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKF
CCCEEEEEECCCCEEEEEEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHH
AALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNTLGAEAFNGAVIAYEPIWAIG
HHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECCEEEEE
TGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVG
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEC
GASLKAPAFAVIVKAAAKAKN
CCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA