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The map label for this gene is aroE

Identifier: 15603136

GI number: 15603136

Start: 1463132

End: 1463941

Strand: Direct

Name: aroE

Synonym: PM1271

Alternate gene names: 15603136

Gene position: 1463132-1463941 (Clockwise)

Preceding gene: 15603135

Following gene: 15603139

Centisome position: 64.81

GC content: 45.56

Gene sequence:

>810_bases
ATGGATAAATACGCGGTATGGGGCAATCCAATCGCCCAAAGTAAATCACCACAAATTCATCAAATCTTTGCCAATCAAAC
TCAGCAACAGATGGAATACGTGGCAATGTTAGGTGATGAACAAGATTTTGAACAGCAATTACGCGTCTTCTTTGAAAAAG
GCGCCAAAGGTTGCAACATTACCGCGCCGTTTAAAGAGCGGGCGTTTCAGTTAGCGGATCTTCACAGCGAGCGTTGTTTG
ACGGCGGAAGCCTGTAATACCTTGAAAAAATTAGACGACGGGCGTCTCTATGGCGATAACACCGATGGAGCAGGTTTAGT
CAGTGATTTACAACGCTTAGGTTGGCTTAAGCCAGAACAAACCATTTTGATTTTGGGCGCAGGTGGCGCGACAAAAGGTG
TGTTGTTACCGTTATTACAAGCCAAGCAACATATTGTGTTGGCTAACCGTACCTTAAGTAAGGCAGAGGATTTGGCACAA
AAATTTGCGCAATATGGGCAAATCCAAGCAGTTGAGCTGGATAATATCCCCGTGCAATCCTTCGATTTAATCATCAACGC
CACCTCATCAGGCTTGCACGGGCAAACGGTACAGATGAACCCTGAAATTTTGCAAAACGCTACCGCACTTTACGATATGC
AATATGCTAAACAAGCCGATACGCCGTTTGTGGCGTTATGCAAACAATTAGGCAAGCAAAACGTCAGCGATGGCTTTGGT
ATGTTGGTGGCACAAGCCGCTCACGCTTTTCATTTATGGCGAGGGGTGATGCCAGAATTTGAGGCGTTGCTAGAACAAGA
GTGGCTTTAA

Upstream 100 bases:

>100_bases
GGCGGATTTTCCGGTATTGGATTTGCCTGTAGGAGAGGCAACCAATCCTTCTGAAATTCGTGATCTTTTTACTCATCAAC
TGTTTAGACAAGGTTAAACC

Downstream 100 bases:

>100_bases
AAAAACTGCAAAAAACACCGCACTTTTATACAAAGGCGGTGGTTTTTTGTTGCCAAGCGGGGATTAGAGACCCGGCGCTT
TCCACAGCGAAGTGGTTAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDKYAVWGNPIAQSKSPQIHQIFANQTQQQMEYVAMLGDEQDFEQQLRVFFEKGAKGCNITAPFKERAFQLADLHSERCL
TAEACNTLKKLDDGRLYGDNTDGAGLVSDLQRLGWLKPEQTILILGAGGATKGVLLPLLQAKQHIVLANRTLSKAEDLAQ
KFAQYGQIQAVELDNIPVQSFDLIINATSSGLHGQTVQMNPEILQNATALYDMQYAKQADTPFVALCKQLGKQNVSDGFG
MLVAQAAHAFHLWRGVMPEFEALLEQEWL

Sequences:

>Translated_269_residues
MDKYAVWGNPIAQSKSPQIHQIFANQTQQQMEYVAMLGDEQDFEQQLRVFFEKGAKGCNITAPFKERAFQLADLHSERCL
TAEACNTLKKLDDGRLYGDNTDGAGLVSDLQRLGWLKPEQTILILGAGGATKGVLLPLLQAKQHIVLANRTLSKAEDLAQ
KFAQYGQIQAVELDNIPVQSFDLIINATSSGLHGQTVQMNPEILQNATALYDMQYAKQADTPFVALCKQLGKQNVSDGFG
MLVAQAAHAFHLWRGVMPEFEALLEQEWL
>Mature_269_residues
MDKYAVWGNPIAQSKSPQIHQIFANQTQQQMEYVAMLGDEQDFEQQLRVFFEKGAKGCNITAPFKERAFQLADLHSERCL
TAEACNTLKKLDDGRLYGDNTDGAGLVSDLQRLGWLKPEQTILILGAGGATKGVLLPLLQAKQHIVLANRTLSKAEDLAQ
KFAQYGQIQAVELDNIPVQSFDLIINATSSGLHGQTVQMNPEILQNATALYDMQYAKQADTPFVALCKQLGKQNVSDGFG
MLVAQAAHAFHLWRGVMPEFEALLEQEWL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=266, Percent_Identity=51.8796992481203, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1787983, Length=260, Percent_Identity=25.7692307692308, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PASMU (P57932)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246208.1
- ProteinModelPortal:   P57932
- SMR:   P57932
- GeneID:   1244618
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1271
- NMPDR:   fig|272843.1.peg.1271
- HOGENOM:   HBG553408
- OMA:   FAAQTGI
- ProtClustDB:   PRK00258
- BioCyc:   PMUL272843:PM1271-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29837; Mature: 29837

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKYAVWGNPIAQSKSPQIHQIFANQTQQQMEYVAMLGDEQDFEQQLRVFFEKGAKGCNI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
TAPFKERAFQLADLHSERCLTAEACNTLKKLDDGRLYGDNTDGAGLVSDLQRLGWLKPEQ
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCC
TILILGAGGATKGVLLPLLQAKQHIVLANRTLSKAEDLAQKFAQYGQIQAVELDNIPVQS
EEEEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
FDLIINATSSGLHGQTVQMNPEILQNATALYDMQYAKQADTPFVALCKQLGKQNVSDGFG
EEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
MLVAQAAHAFHLWRGVMPEFEALLEQEWL
HHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDKYAVWGNPIAQSKSPQIHQIFANQTQQQMEYVAMLGDEQDFEQQLRVFFEKGAKGCNI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
TAPFKERAFQLADLHSERCLTAEACNTLKKLDDGRLYGDNTDGAGLVSDLQRLGWLKPEQ
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCC
TILILGAGGATKGVLLPLLQAKQHIVLANRTLSKAEDLAQKFAQYGQIQAVELDNIPVQS
EEEEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
FDLIINATSSGLHGQTVQMNPEILQNATALYDMQYAKQADTPFVALCKQLGKQNVSDGFG
EEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHH
MLVAQAAHAFHLWRGVMPEFEALLEQEWL
HHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100