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The map label for this gene is hisC

Identifier: 15603064

GI number: 15603064

Start: 1393410

End: 1394465

Strand: Direct

Name: hisC

Synonym: PM1199

Alternate gene names: 15603064

Gene position: 1393410-1394465 (Clockwise)

Preceding gene: 15603063

Following gene: 15603065

Centisome position: 61.72

GC content: 46.02

Gene sequence:

>1056_bases
ATGTCAATTTCATCACTTTCACGCAAAAATATTCAAGCCTTAACGCCGTATCAATCGGCTCGGCGATTAGGCGGCAAGGG
CGATATTTGGTTAAATGCCAATGAATACCCAACCTCGCCTGATTTTAATTTAACCCATCGTACCTTTAACCGTTATCCCG
AGCCACAACCACAAGCTGTGATTGAAGGCTATGCCAATTATGTGGGGGTAACGCCTGAAAATGTCTTGGTCAGCCGTGGC
GGTGATGAAAGTATTGAGCTGATTATCCGTGCCTTTTGTGAAGCGGAAGACAGCATACTTTACTGCCCACCAACCTATGG
GATGTATGCGGTCAGTGCCGAAACCTGTGGGATTGCCCTCAAAACGGTGCCGTTGACAGCCGATTTCCAACTGAATTTGC
CTGAAATTGAACGCCAGCTTACCGGTGTCAAAGTGGTGTTTGTGTGTAGCCCGAATAACCCAACAGGGACGTTAGTCAAT
CGCACGGACTTGCTCGCGTTATTAGAGATGACCAGAAATAAAGCCATTGTGGTGGTGGATGAAGCCTACATTGAGTTTTG
TCCACAAGCGACGATGGTCACAGAACTAAAAAACTACCCGCACTTAGCCATTATCCGCACCCTGTCCAAAGCCTTTGCTT
TAGCGGGGCTACGTTGTGGTTTTACTTTGGCGAATAAAGACTTAATCGAGGTGCTACAAAAAGTGATTGCGCCTTATCCT
TTGCCAGTGCCTGTGGCGGATCTTGCTGCGCAAGCCTTACAACCTGCGGGTTTACAAGCAATGCAACAACGGGTACAAGA
AATTCTGCAAAATCGCACCGCACTTGAGGCAGATTTACGCAGCTTGCCTTGTGTAGAAAACGTCTTTCAAAGCGACGGCA
ACTATCTTTTAGTGAAATTCAAAGACGGACAAAAAATCTTCAAAACCCTTTGGGATCAAGGCATTATCTTGCGTAATCAA
CACAGCGCATTGATGTTAGAAAACTGTATTCGTATTACCATTGGCACGGCAGAGGAAAATCGTCGTGTCATTGAAGCAAT
CCGTAAAATTGCCTAA

Upstream 100 bases:

>100_bases
TCTCGCGAACACGGTGATGTTAATGGCAGAAGCAGAACAATTAGAAGCGCATAAGCAAGCAGTGGCAATTCGTTTAGAGA
AATTAACTCAGGAGTAAGTC

Downstream 100 bases:

>100_bases
GATACAAACGAAAAACCAACAGATTAAAATGAAAAACAGGATAACTCTATGACACAACAATCTATTCTTTTTATCGACCG
TGACGGGACTTTAATTGATG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSISSLSRKNIQALTPYQSARRLGGKGDIWLNANEYPTSPDFNLTHRTFNRYPEPQPQAVIEGYANYVGVTPENVLVSRG
GDESIELIIRAFCEAEDSILYCPPTYGMYAVSAETCGIALKTVPLTADFQLNLPEIERQLTGVKVVFVCSPNNPTGTLVN
RTDLLALLEMTRNKAIVVVDEAYIEFCPQATMVTELKNYPHLAIIRTLSKAFALAGLRCGFTLANKDLIEVLQKVIAPYP
LPVPVADLAAQALQPAGLQAMQQRVQEILQNRTALEADLRSLPCVENVFQSDGNYLLVKFKDGQKIFKTLWDQGIILRNQ
HSALMLENCIRITIGTAEENRRVIEAIRKIA

Sequences:

>Translated_351_residues
MSISSLSRKNIQALTPYQSARRLGGKGDIWLNANEYPTSPDFNLTHRTFNRYPEPQPQAVIEGYANYVGVTPENVLVSRG
GDESIELIIRAFCEAEDSILYCPPTYGMYAVSAETCGIALKTVPLTADFQLNLPEIERQLTGVKVVFVCSPNNPTGTLVN
RTDLLALLEMTRNKAIVVVDEAYIEFCPQATMVTELKNYPHLAIIRTLSKAFALAGLRCGFTLANKDLIEVLQKVIAPYP
LPVPVADLAAQALQPAGLQAMQQRVQEILQNRTALEADLRSLPCVENVFQSDGNYLLVKFKDGQKIFKTLWDQGIILRNQ
HSALMLENCIRITIGTAEENRRVIEAIRKIA
>Mature_350_residues
SISSLSRKNIQALTPYQSARRLGGKGDIWLNANEYPTSPDFNLTHRTFNRYPEPQPQAVIEGYANYVGVTPENVLVSRGG
DESIELIIRAFCEAEDSILYCPPTYGMYAVSAETCGIALKTVPLTADFQLNLPEIERQLTGVKVVFVCSPNNPTGTLVNR
TDLLALLEMTRNKAIVVVDEAYIEFCPQATMVTELKNYPHLAIIRTLSKAFALAGLRCGFTLANKDLIEVLQKVIAPYPL
PVPVADLAAQALQPAGLQAMQQRVQEILQNRTALEADLRSLPCVENVFQSDGNYLLVKFKDGQKIFKTLWDQGIILRNQH
SALMLENCIRITIGTAEENRRVIEAIRKIA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=64.4699140401146, Blast_Score=476, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=33.1578947368421, Blast_Score=179, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_PASMU (Q9CLM3)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_246136.1
- ProteinModelPortal:   Q9CLM3
- SMR:   Q9CLM3
- GeneID:   1244546
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1199
- NMPDR:   fig|272843.1.peg.1199
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK01688
- BioCyc:   PMUL272843:PM1199-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38982; Mature: 38850

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISSLSRKNIQALTPYQSARRLGGKGDIWLNANEYPTSPDFNLTHRTFNRYPEPQPQAV
CCCCHHCCCCCEEECCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHH
IEGYANYVGVTPENVLVSRGGDESIELIIRAFCEAEDSILYCPPTYGMYAVSAETCGIAL
HHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCCEEE
KTVPLTADFQLNLPEIERQLTGVKVVFVCSPNNPTGTLVNRTDLLALLEMTRNKAIVVVD
EEEEEEECEEECCHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHHHHCCCEEEEEE
EAYIEFCPQATMVTELKNYPHLAIIRTLSKAFALAGLRCGFTLANKDLIEVLQKVIAPYP
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCC
LPVPVADLAAQALQPAGLQAMQQRVQEILQNRTALEADLRSLPCVENVFQSDGNYLLVKF
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEEEE
KDGQKIFKTLWDQGIILRNQHSALMLENCIRITIGTAEENRRVIEAIRKIA
CCCHHHHHHHHCCCCEEECCCCHHHHCCCEEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SISSLSRKNIQALTPYQSARRLGGKGDIWLNANEYPTSPDFNLTHRTFNRYPEPQPQAV
CCCHHCCCCCEEECCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHH
IEGYANYVGVTPENVLVSRGGDESIELIIRAFCEAEDSILYCPPTYGMYAVSAETCGIAL
HHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCCEEE
KTVPLTADFQLNLPEIERQLTGVKVVFVCSPNNPTGTLVNRTDLLALLEMTRNKAIVVVD
EEEEEEECEEECCHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHHHHCCCEEEEEE
EAYIEFCPQATMVTELKNYPHLAIIRTLSKAFALAGLRCGFTLANKDLIEVLQKVIAPYP
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCC
LPVPVADLAAQALQPAGLQAMQQRVQEILQNRTALEADLRSLPCVENVFQSDGNYLLVKF
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCEEEEEE
KDGQKIFKTLWDQGIILRNQHSALMLENCIRITIGTAEENRRVIEAIRKIA
CCCHHHHHHHHCCCCEEECCCCHHHHCCCEEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100