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The map label for this gene is ffh [H]

Identifier: 15603048

GI number: 15603048

Start: 1378451

End: 1379827

Strand: Reverse

Name: ffh [H]

Synonym: PM1183

Alternate gene names: 15603048

Gene position: 1379827-1378451 (Counterclockwise)

Preceding gene: 15603055

Following gene: 15603046

Centisome position: 61.12

GC content: 44.59

Gene sequence:

>1377_bases
ATGTTTGAGAATTTGTCGGATCGCTTGTCAAAAACGCTACGTAACATTAGTGGGCGTGGACGTTTAACTGAGGACAATAT
TAAGGAAACGCTACGTGAAGTCCGCATGGCATTATTAGAAGCGGATGTGGCGTTACCAGTGGTACGTGACTTTATTAATA
AAGTGAAAGAACGCGCAATTGGAGTGGAAGTCAATAAAAGCCTCACACCAGGTCAAGAATTCGTTAAGATCGTGCAAGCG
GAACTTGAAGCGGCAATGGGAGAGGCGAATGAAAGTTTACATCTTTCGACCCAACCACCTGCAGTGATTTTAATGGCGGG
TTTACAAGGGGCGGGTAAAACCACCAGTGTGGGTAAACTGGCAAAATTTTTAAAAGAGCGGCATAAGAAAAAAGTATTAG
TGGTGTCTGCTGACGTATATCGCCCTGCTGCGATCAAGCAATTAGAAACGCTTGCGCAAGCCGTCGGTGCCGATTTCTTT
CCTTCCGATGTCTCACAAAACCCAGTGCAAATTGCCCAAGCAGCATTAAGTGAAGCAAAATTAAAATTCTACGATGTGTT
AATTGTGGATACCGCAGGTCGCCTACACGTCGACGGCGAAATGATGGACGAAATTAAGCAAATTCATGCCGCACTTAACC
CAATTGAAACGCTCTTTACTGTGGATGCGATGACGGGGCAAGATGCTGCAAATACGGCAAAATCCTTTAATGAAGCGTTG
CCTTTAACAGGGGTGGTATTAACGAAAGTGGATGGTGACGCGCGTGGTGGTGCTGCCTTATCAATTCGTCAGATTACTGG
TAAACCGATTAAATTCTTAGGGGTGGGCGAAAAAACCGATGCACTAGAACCCTTCCATCCAGAACGTGTGGCATCACGTA
TCTTGGGCATGGGTGATGTGCTGTCGTTAATTGAAGATCTTGAACGTTCTGTCGATCGCGAAAAAGCGGAGAAAATGGCG
CAGAAGTTCAAAAAAGGTGATAATTTTACCCTTGAGGATTTCCGTGAGCAGCTTATCCAAATGAAAAACATGGGTGGGAT
GATGTCGATGTTAGATAAATTGCCTGGTGCCAAAAATCTACCGGATCACATCAAGAATAAAGTAGATGACAAAATGTTCA
GTAAAATGGAAGCCATGATTAATTCCATGACGTTGAAAGAGCGCGCAAATCCAGAAATTATCAAAGGTTCTCGCCGTCGT
CGTATTGCAATGGGTTCAGGTACGCAAGTGCAAGATGTGAATAAATTACTCAAACAGTTCGATGAAATGCAACGTATGAT
GAAAAAAATGCGCAAAGGTGGCATGGCAAAAATGATGCGCGGCATGCAAGGCATGATGGGCGGACTCGGCGGTTTAGGCG
GGATGTTTAGACGCTAA

Upstream 100 bases:

>100_bases
TCTCACTGTGAAATCGCTATAAATTTATTACAAAGGATGAAAATCTATGGGATTTCAGTATAATTAGGGCAATTTTTTCG
AGATTAAATAGGAAGATTGC

Downstream 100 bases:

>100_bases
TGTAAAAGTATAGAAAAAGGGAAAATGTGTATTTTCCCTTTTTATCAGAAACCCGCGGTTTCATGGGCAATGAGAGGAAT
ACTAAAGTGCGGTCAAAATT

Product: hypothetical protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFENLSDRLSKTLRNISGRGRLTEDNIKETLREVRMALLEADVALPVVRDFINKVKERAIGVEVNKSLTPGQEFVKIVQA
ELEAAMGEANESLHLSTQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLETLAQAVGADFF
PSDVSQNPVQIAQAALSEAKLKFYDVLIVDTAGRLHVDGEMMDEIKQIHAALNPIETLFTVDAMTGQDAANTAKSFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPERVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDNFTLEDFREQLIQMKNMGGMMSMLDKLPGAKNLPDHIKNKVDDKMFSKMEAMINSMTLKERANPEIIKGSRRR
RIAMGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGMMGGLGGLGGMFRR

Sequences:

>Translated_458_residues
MFENLSDRLSKTLRNISGRGRLTEDNIKETLREVRMALLEADVALPVVRDFINKVKERAIGVEVNKSLTPGQEFVKIVQA
ELEAAMGEANESLHLSTQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLETLAQAVGADFF
PSDVSQNPVQIAQAALSEAKLKFYDVLIVDTAGRLHVDGEMMDEIKQIHAALNPIETLFTVDAMTGQDAANTAKSFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPERVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDNFTLEDFREQLIQMKNMGGMMSMLDKLPGAKNLPDHIKNKVDDKMFSKMEAMINSMTLKERANPEIIKGSRRR
RIAMGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGMMGGLGGLGGMFRR
>Mature_458_residues
MFENLSDRLSKTLRNISGRGRLTEDNIKETLREVRMALLEADVALPVVRDFINKVKERAIGVEVNKSLTPGQEFVKIVQA
ELEAAMGEANESLHLSTQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLETLAQAVGADFF
PSDVSQNPVQIAQAALSEAKLKFYDVLIVDTAGRLHVDGEMMDEIKQIHAALNPIETLFTVDAMTGQDAANTAKSFNEAL
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPERVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDNFTLEDFREQLIQMKNMGGMMSMLDKLPGAKNLPDHIKNKVDDKMFSKMEAMINSMTLKERANPEIIKGSRRR
RIAMGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGMMGGLGGLGGMFRR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=501, Percent_Identity=30.7385229540918, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226371618, Length=392, Percent_Identity=31.8877551020408, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=35, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=26.3492063492064, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=26.3492063492064, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788963, Length=446, Percent_Identity=80.4932735426009, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=35.8565737051793, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=491, Percent_Identity=28.7169042769857, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=34.1584158415842, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=445, Percent_Identity=31.9101123595506, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17647949, Length=495, Percent_Identity=28.4848484848485, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.6363636363636, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50489; Mature: 50489

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSKTLRNISGRGRLTEDNIKETLREVRMALLEADVALPVVRDFINKVKERAI
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVEVNKSLTPGQEFVKIVQAELEAAMGEANESLHLSTQPPAVILMAGLQGAGKTTSVGKL
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHH
AKFLKERHKKKVLVVSADVYRPAAIKQLETLAQAVGADFFPSDVSQNPVQIAQAALSEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDGEMMDEIKQIHAALNPIETLFTVDAMTGQDAANTAKSFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPERVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDNFTLEDFREQLIQMKNMGGMMSMLDKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PDHIKNKVDDKMFSKMEAMINSMTLKERANPEIIKGSRRRRIAMGSGTQVQDVNKLLKQF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGMMGGLGGLGGMFRR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFENLSDRLSKTLRNISGRGRLTEDNIKETLREVRMALLEADVALPVVRDFINKVKERAI
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVEVNKSLTPGQEFVKIVQAELEAAMGEANESLHLSTQPPAVILMAGLQGAGKTTSVGKL
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHH
AKFLKERHKKKVLVVSADVYRPAAIKQLETLAQAVGADFFPSDVSQNPVQIAQAALSEAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDGEMMDEIKQIHAALNPIETLFTVDAMTGQDAANTAKSFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
PLTGVVLTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPERVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDNFTLEDFREQLIQMKNMGGMMSMLDKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PDHIKNKVDDKMFSKMEAMINSMTLKERANPEIIKGSRRRRIAMGSGTQVQDVNKLLKQF
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGMMGGLGGLGGMFRR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]