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The map label for this gene is panF [H]

Identifier: 15602954

GI number: 15602954

Start: 1284927

End: 1286360

Strand: Reverse

Name: panF [H]

Synonym: PM1089

Alternate gene names: 15602954

Gene position: 1286360-1284927 (Counterclockwise)

Preceding gene: 15602955

Following gene: 15602953

Centisome position: 56.98

GC content: 40.03

Gene sequence:

>1434_bases
ATGAACTATAGCATTCTTATTCCTTTATTCCTGTATTTATGCTTTGTGTTTGCAGTGGCTTATTATGCCTATGCTAAACG
ACAAAAGGGGAGCTTTTTAAGTGAATATTATGTTGGAAATCGCTCTATGTCTGGTTTTGTATTGGCGATGACGACGGCTG
CAACTTATGTAGGGGCGAGTTCATTTATTGGTGGACCGGGTGCCGCGTATAAATTTGGTTTAGGCTGGGTTTTATTGGCG
ATGATTCAAGTCCCCGTGGTGCTTTTTACCCTTGGTGTATTGGGGAAAAAATTTGCCATGTGGGCAAGAGAACATAAAAG
TTTAACCATTAATGACATTTTATTTTCTCGCTATAAAAGCCCAACCATTGTGTTGTTAGCCAGTTTATCCTTGTTATTTT
CCTTCTTTATTATGATGGCAGTACAATTCATTGGTGTTGGACGTTTATTAGAAACCACATTGAATATTGACTACCGTCTT
TCTGTACTAATCTTTGCCACAACTGTGGGAATCTATACTTTCATTGGTGGCTTTAGAGCGGTAGTATTAACGGACACGAT
TCAAGGTCTCATCATGATGATCGGTACGTTCCTACTGTTATTTGGTGTGATTTATGCTGGTGGCGGAGTCAGTCAAATCA
TAGATACATTAGAAACGATTGATCCACGTTTGATTACGCCTTATGGCATTGAAGCAAGACCGCTTGATTTTACTTTTATG
GCGTCTTTCTGGGTGTTGGTCTGTTTTGGATTGTTAGGGCTTCCACATACGGTTATCCGCGCGATGTCATATAAAAACAG
TAAAGCATTACATAGTGGAATTGTGATTGGTACTGTGGTGATTGCCTTATTAATGTTAGGGATGCATTTAGCTGGCGCAC
TAGGACGAGCGGTGGTGCCAGAATTATCAGTTACGGATAAAATTATTCCAACTTTGATGATTCAAGTGCTTCCGCCTGTG
GTTGCTGGGATTTTCTTAGCGGCGCCGATGGCAGCCATTATGTCATCTATTGACTCGATGCTTATTCAAGCGTCTTCGAC
GTTAATTAAAGATTTATATCTACGTTTTAAACCTGAGCAAATTCGTAATGAGCGACGGGTCAAAATTTTATCGACAGTTG
CTACATTATTCATGACGATTTTAGTCACTGTCGCGACATTAAATCCACCGGATATGCTGATTTGGTTAAACTTATTTGCC
TTAGGGGGATTAGAAACAACGTTCTTATGGGTGATGTTGCTAGGCTTATATTGGCAGAAAGCAAATGCATATGGTGCGGT
ATGTTCCATGATAGTTGGTTTGGGCTCTTATGTGACCTTAACTGCGGCTTCAATTAAATTATTGGATTTCCATGCGATTG
TGCCTGCTTTATTATTTGGTTTGATCGCTTTCCTAATTGGTAACCAATACGGTGAGCGTAAGATTCAGCACTAA

Upstream 100 bases:

>100_bases
TTTGAATTTTCCTGCTTTTATTTGCCAATCCTCTTCACAGCTATCATTTATATTTGTATTAAATTTGTCTTTTGTGATAT
CGATTTAGAGGACAATGAAA

Downstream 100 bases:

>100_bases
GTGACATTACTATGACATGATTTGAGGGCAGACCTGAGTGTCTGCCCTTATTATTTTGCGTAAAAACCTGCAACAATGTA
TCGTGACACGATACAATACA

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNYSILIPLFLYLCFVFAVAYYAYAKRQKGSFLSEYYVGNRSMSGFVLAMTTAATYVGASSFIGGPGAAYKFGLGWVLLA
MIQVPVVLFTLGVLGKKFAMWAREHKSLTINDILFSRYKSPTIVLLASLSLLFSFFIMMAVQFIGVGRLLETTLNIDYRL
SVLIFATTVGIYTFIGGFRAVVLTDTIQGLIMMIGTFLLLFGVIYAGGGVSQIIDTLETIDPRLITPYGIEARPLDFTFM
ASFWVLVCFGLLGLPHTVIRAMSYKNSKALHSGIVIGTVVIALLMLGMHLAGALGRAVVPELSVTDKIIPTLMIQVLPPV
VAGIFLAAPMAAIMSSIDSMLIQASSTLIKDLYLRFKPEQIRNERRVKILSTVATLFMTILVTVATLNPPDMLIWLNLFA
LGGLETTFLWVMLLGLYWQKANAYGAVCSMIVGLGSYVTLTAASIKLLDFHAIVPALLFGLIAFLIGNQYGERKIQH

Sequences:

>Translated_477_residues
MNYSILIPLFLYLCFVFAVAYYAYAKRQKGSFLSEYYVGNRSMSGFVLAMTTAATYVGASSFIGGPGAAYKFGLGWVLLA
MIQVPVVLFTLGVLGKKFAMWAREHKSLTINDILFSRYKSPTIVLLASLSLLFSFFIMMAVQFIGVGRLLETTLNIDYRL
SVLIFATTVGIYTFIGGFRAVVLTDTIQGLIMMIGTFLLLFGVIYAGGGVSQIIDTLETIDPRLITPYGIEARPLDFTFM
ASFWVLVCFGLLGLPHTVIRAMSYKNSKALHSGIVIGTVVIALLMLGMHLAGALGRAVVPELSVTDKIIPTLMIQVLPPV
VAGIFLAAPMAAIMSSIDSMLIQASSTLIKDLYLRFKPEQIRNERRVKILSTVATLFMTILVTVATLNPPDMLIWLNLFA
LGGLETTFLWVMLLGLYWQKANAYGAVCSMIVGLGSYVTLTAASIKLLDFHAIVPALLFGLIAFLIGNQYGERKIQH
>Mature_477_residues
MNYSILIPLFLYLCFVFAVAYYAYAKRQKGSFLSEYYVGNRSMSGFVLAMTTAATYVGASSFIGGPGAAYKFGLGWVLLA
MIQVPVVLFTLGVLGKKFAMWAREHKSLTINDILFSRYKSPTIVLLASLSLLFSFFIMMAVQFIGVGRLLETTLNIDYRL
SVLIFATTVGIYTFIGGFRAVVLTDTIQGLIMMIGTFLLLFGVIYAGGGVSQIIDTLETIDPRLITPYGIEARPLDFTFM
ASFWVLVCFGLLGLPHTVIRAMSYKNSKALHSGIVIGTVVIALLMLGMHLAGALGRAVVPELSVTDKIIPTLMIQVLPPV
VAGIFLAAPMAAIMSSIDSMLIQASSTLIKDLYLRFKPEQIRNERRVKILSTVATLFMTILVTVATLNPPDMLIWLNLFA
LGGLETTFLWVMLLGLYWQKANAYGAVCSMIVGLGSYVTLTAASIKLLDFHAIVPALLFGLIAFLIGNQYGERKIQH

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=442, Percent_Identity=26.0180995475113, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI14140236, Length=471, Percent_Identity=21.4437367303609, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082237, Length=476, Percent_Identity=58.6134453781513, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1787251, Length=478, Percent_Identity=25.3138075313808, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1790113, Length=479, Percent_Identity=24.8434237995825, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790503, Length=470, Percent_Identity=20.6382978723404, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648033, Length=463, Percent_Identity=23.5421166306695, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356865, Length=463, Percent_Identity=23.5421166306695, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52236; Mature: 52236

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSILIPLFLYLCFVFAVAYYAYAKRQKGSFLSEYYVGNRSMSGFVLAMTTAATYVGAS
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCH
SFIGGPGAAYKFGLGWVLLAMIQVPVVLFTLGVLGKKFAMWAREHKSLTINDILFSRYKS
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PTIVLLASLSLLFSFFIMMAVQFIGVGRLLETTLNIDYRLSVLIFATTVGIYTFIGGFRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLTDTIQGLIMMIGTFLLLFGVIYAGGGVSQIIDTLETIDPRLITPYGIEARPLDFTFM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHH
ASFWVLVCFGLLGLPHTVIRAMSYKNSKALHSGIVIGTVVIALLMLGMHLAGALGRAVVP
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ELSVTDKIIPTLMIQVLPPVVAGIFLAAPMAAIMSSIDSMLIQASSTLIKDLYLRFKPEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IRNERRVKILSTVATLFMTILVTVATLNPPDMLIWLNLFALGGLETTFLWVMLLGLYWQK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANAYGAVCSMIVGLGSYVTLTAASIKLLDFHAIVPALLFGLIAFLIGNQYGERKIQH
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNYSILIPLFLYLCFVFAVAYYAYAKRQKGSFLSEYYVGNRSMSGFVLAMTTAATYVGAS
CCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCH
SFIGGPGAAYKFGLGWVLLAMIQVPVVLFTLGVLGKKFAMWAREHKSLTINDILFSRYKS
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PTIVLLASLSLLFSFFIMMAVQFIGVGRLLETTLNIDYRLSVLIFATTVGIYTFIGGFRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VVLTDTIQGLIMMIGTFLLLFGVIYAGGGVSQIIDTLETIDPRLITPYGIEARPLDFTFM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHH
ASFWVLVCFGLLGLPHTVIRAMSYKNSKALHSGIVIGTVVIALLMLGMHLAGALGRAVVP
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ELSVTDKIIPTLMIQVLPPVVAGIFLAAPMAAIMSSIDSMLIQASSTLIKDLYLRFKPEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IRNERRVKILSTVATLFMTILVTVATLNPPDMLIWLNLFALGGLETTFLWVMLLGLYWQK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANAYGAVCSMIVGLGSYVTLTAASIKLLDFHAIVPALLFGLIAFLIGNQYGERKIQH
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]