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The map label for this gene is luxS

Identifier: 15602919

GI number: 15602919

Start: 1243341

End: 1243847

Strand: Reverse

Name: luxS

Synonym: PM1054

Alternate gene names: 15602919

Gene position: 1243847-1243341 (Counterclockwise)

Preceding gene: 15602920

Following gene: 15602918

Centisome position: 55.1

GC content: 40.63

Gene sequence:

>507_bases
ATGCCATTACTTGATAGCTTTAAAGTTGACCATACCCGTATGAAAGCGCCAGCAGTACGCATTGCGAAAACCATGACTAC
CCCAAAGGGCGATAACATTACTGTATTTGATTTACGTTTTTGCATACCAAATAAAGAGATTCTTTCCCCAAAAGGGATTC
ATACTTTAGAACATCTTTTTGCGGGTTTTATGCGCGATCATTTAAATGGGACAGAAGTAGAAATTATTGATATTTCCCCT
ATGGGCTGTCGTACAGGGTTTTACATGTCATTAATTGGCACACCCAATGAGCAACAGGTGGCAGACGCTTGGTTAGCCTC
AATGCGAGATGTGTTATTGGTAAAAGATCAAGCACAGATCCCGGAATTAAATGCCTTCCAGTGCGGGACTTACACCGAGC
ACTCATTAGCCGAAGCACAACAAATCGCACACAATGTACTTGAGCGTGGTGTGAGTGTGAATAAAAATGAAGATTTATTA
CTCGACGAACAATTATTATCTCTTTAA

Upstream 100 bases:

>100_bases
AACAACTGCAAGTTGCTGTATCCTAAGACTGATACGTTTAAAAAAAGTTCAAAAAAATTTACCTGCATTTTGCGAAAACT
TGAAAATTTAAGGACATATT

Downstream 100 bases:

>100_bases
GCATTTATAAAACACAACTGTCCAGAAGGAAATCCATATGACAACAATTGGTACCCCACTTACGCCGAAAGCCACAAAAG
TGATGATGCTAGGTTCAGGC

Product: S-ribosylhomocysteinase

Products: NA

Alternate protein names: AI-2 synthesis protein; Autoinducer-2 production protein luxS

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MPLLDSFKVDHTRMKAPAVRIAKTMTTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGTEVEIIDISP
MGCRTGFYMSLIGTPNEQQVADAWLASMRDVLLVKDQAQIPELNAFQCGTYTEHSLAEAQQIAHNVLERGVSVNKNEDLL
LDEQLLSL

Sequences:

>Translated_168_residues
MPLLDSFKVDHTRMKAPAVRIAKTMTTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGTEVEIIDISP
MGCRTGFYMSLIGTPNEQQVADAWLASMRDVLLVKDQAQIPELNAFQCGTYTEHSLAEAQQIAHNVLERGVSVNKNEDLL
LDEQLLSL
>Mature_167_residues
PLLDSFKVDHTRMKAPAVRIAKTMTTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGTEVEIIDISPM
GCRTGFYMSLIGTPNEQQVADAWLASMRDVLLVKDQAQIPELNAFQCGTYTEHSLAEAQQIAHNVLERGVSVNKNEDLLL
DEQLLSL

Specific function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is ca

COG id: COG1854

COG function: function code T; LuxS protein involved in autoinducer AI2 synthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the luxS family

Homologues:

Organism=Escherichia coli, GI1789043, Length=166, Percent_Identity=74.6987951807229, Blast_Score=269, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LUXS_PASMU (P57901)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245991.1
- ProteinModelPortal:   P57901
- SMR:   P57901
- GeneID:   1244401
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1054
- NMPDR:   fig|272843.1.peg.1054
- HOGENOM:   HBG347473
- OMA:   VRIAKTM
- ProtClustDB:   PRK02260
- BioCyc:   PMUL272843:PM1054-MONOMER
- BRENDA:   4.4.1.21
- HAMAP:   MF_00091
- InterPro:   IPR011249
- InterPro:   IPR003815
- Gene3D:   G3DSA:3.30.1360.80
- PIRSF:   PIRSF006160
- PRINTS:   PR01487
- ProDom:   PD013172

Pfam domain/function: PF02664 LuxS; SSF63411 Metalloenz_metal-bd

EC number: =4.4.1.21

Molecular weight: Translated: 18806; Mature: 18675

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLDSFKVDHTRMKAPAVRIAKTMTTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLF
CCCCCCCCCCHHHHHCHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHCCCCCHHHHHHHH
AGFMRDHLNGTEVEIIDISPMGCRTGFYMSLIGTPNEQQVADAWLASMRDVLLVKDQAQI
HHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCCC
PELNAFQCGTYTEHSLAEAQQIAHNVLERGVSVNKNEDLLLDEQLLSL
CCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCC
>Mature Secondary Structure 
PLLDSFKVDHTRMKAPAVRIAKTMTTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLF
CCCCCCCCCHHHHHCHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHCCCCCHHHHHHHH
AGFMRDHLNGTEVEIIDISPMGCRTGFYMSLIGTPNEQQVADAWLASMRDVLLVKDQAQI
HHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCCC
PELNAFQCGTYTEHSLAEAQQIAHNVLERGVSVNKNEDLLLDEQLLSL
CCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100