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The map label for this gene is dapA

Identifier: 15602916

GI number: 15602916

Start: 1240533

End: 1241429

Strand: Reverse

Name: dapA

Synonym: PM1051

Alternate gene names: 15602916

Gene position: 1241429-1240533 (Counterclockwise)

Preceding gene: 15602918

Following gene: 15602915

Centisome position: 54.99

GC content: 41.58

Gene sequence:

>897_bases
ATGTCAGCAAACAATTATCTCTTCTCGGGCAGTATCGTTGCTATCGTGACCCCAATGGACAGTTCTGGCGAAATTGATTT
TGTCAGATTGAAAAGTTTAGTTGAACATCATATCGCAGCGGGCACGGATGCGATTGTCTCAGTAGGTACAACCGGTGAAG
CTGCAACATTAAGCATTGATGAGAATGTTAAAACCATTTTAAAAACGGTCGAGTTTGCTGATGGACGTATTCCTGTGATT
GCGGGAGCCGGTGCTAATGCCACTAGCGAAGCCATTGTAATGACTAAACTCTTAAATGACAGTGGTGTAGCAGGCTGTCT
TTCTGTGGTGCCTTATTATAATAAGCCAACCCAAGAAGGTATGTATCAGCATTTTAAAGCCATTGCAGAATGTACAGATT
TGCCACAAATTTTATATAACGTACCAAGTCGTACTGGAAGCGATTTGTTGCCAGAAACAGTAGCCCGTTTGGCGAAAATC
AACAATATTGTTGCTATTAAAGAAGCAACCGGTGATCTTAGTCGTGTCGCCAAAATTAAAGAATTGGCGGGAGAGGATTT
CATTTTCTTAAGTGGTGATGATGCAACAGGGTTAGAGTCCATTAAATTAGGGGGGCAAGGTGTAATTTCTGTGACCAATA
ACGTGGCGGCCGCGGACATGGCAAAAATGTGTCATCTTGCACTAAATGGACAATTTGAGGAAGCTGAACAAATTAATCAG
CGCTTGATGGCATTACATAAAAATTTATTTGTCGAATCCAATCCAATTCCTGTGAAATGGGCAGCTTACCGTTTAGGTTT
GATTGATACACCGACTTTACGCTTACCGTTGACAACGCTGAGTGAACATTTACAACCTAAAGTCGAAGACGCATTAAAAA
TCGCGGGTTTGTTGTAA

Upstream 100 bases:

>100_bases
ATCTTAAATCGAAATTTACAAGCAAACTCAACATCAATATAGTGAATTCATTCTAAAAATGACAGCTATTTATAATTAAT
AAATATTTTCAGGAGGCTGT

Downstream 100 bases:

>100_bases
TAAGATACACTGAGGTTGTACAACAATAAGTCGAGTAAACTTTTGTTTCGCCTTATTGTCAAAGTGCGGTAGCGTTGAAA
AAAATTTATTATTAAGGAAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSANNYLFSGSIVAIVTPMDSSGEIDFVRLKSLVEHHIAAGTDAIVSVGTTGEAATLSIDENVKTILKTVEFADGRIPVI
AGAGANATSEAIVMTKLLNDSGVAGCLSVVPYYNKPTQEGMYQHFKAIAECTDLPQILYNVPSRTGSDLLPETVARLAKI
NNIVAIKEATGDLSRVAKIKELAGEDFIFLSGDDATGLESIKLGGQGVISVTNNVAAADMAKMCHLALNGQFEEAEQINQ
RLMALHKNLFVESNPIPVKWAAYRLGLIDTPTLRLPLTTLSEHLQPKVEDALKIAGLL

Sequences:

>Translated_298_residues
MSANNYLFSGSIVAIVTPMDSSGEIDFVRLKSLVEHHIAAGTDAIVSVGTTGEAATLSIDENVKTILKTVEFADGRIPVI
AGAGANATSEAIVMTKLLNDSGVAGCLSVVPYYNKPTQEGMYQHFKAIAECTDLPQILYNVPSRTGSDLLPETVARLAKI
NNIVAIKEATGDLSRVAKIKELAGEDFIFLSGDDATGLESIKLGGQGVISVTNNVAAADMAKMCHLALNGQFEEAEQINQ
RLMALHKNLFVESNPIPVKWAAYRLGLIDTPTLRLPLTTLSEHLQPKVEDALKIAGLL
>Mature_297_residues
SANNYLFSGSIVAIVTPMDSSGEIDFVRLKSLVEHHIAAGTDAIVSVGTTGEAATLSIDENVKTILKTVEFADGRIPVIA
GAGANATSEAIVMTKLLNDSGVAGCLSVVPYYNKPTQEGMYQHFKAIAECTDLPQILYNVPSRTGSDLLPETVARLAKIN
NIVAIKEATGDLSRVAKIKELAGEDFIFLSGDDATGLESIKLGGQGVISVTNNVAAADMAKMCHLALNGQFEEAEQINQR
LMALHKNLFVESNPIPVKWAAYRLGLIDTPTLRLPLTTLSEHLQPKVEDALKIAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=25.4355400696864, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI13540533, Length=239, Percent_Identity=26.7782426778243, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=65.7534246575342, Blast_Score=403, Evalue=1e-114,
Organism=Escherichia coli, GI87082415, Length=297, Percent_Identity=29.6296296296296, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786463, Length=246, Percent_Identity=28.4552845528455, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1789620, Length=283, Percent_Identity=24.0282685512367, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PASMU (Q9CLZ7)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245988.1
- ProteinModelPortal:   Q9CLZ7
- SMR:   Q9CLZ7
- GeneID:   1244398
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1051
- NMPDR:   fig|272843.1.peg.1051
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   PMUL272843:PM1051-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31759; Mature: 31628

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 167-167 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANNYLFSGSIVAIVTPMDSSGEIDFVRLKSLVEHHIAAGTDAIVSVGTTGEAATLSID
CCCCCEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEC
ENVKTILKTVEFADGRIPVIAGAGANATSEAIVMTKLLNDSGVAGCLSVVPYYNKPTQEG
HHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
MYQHFKAIAECTDLPQILYNVPSRTGSDLLPETVARLAKINNIVAIKEATGDLSRVAKIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHH
ELAGEDFIFLSGDDATGLESIKLGGQGVISVTNNVAAADMAKMCHLALNGQFEEAEQINQ
HHCCCCEEEEECCCCCCCHHEECCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHH
RLMALHKNLFVESNPIPVKWAAYRLGLIDTPTLRLPLTTLSEHLQPKVEDALKIAGLL
HHHHHHHHHEECCCCCCEEEHHEEECCCCCCCEEEEHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SANNYLFSGSIVAIVTPMDSSGEIDFVRLKSLVEHHIAAGTDAIVSVGTTGEAATLSID
CCCCEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEC
ENVKTILKTVEFADGRIPVIAGAGANATSEAIVMTKLLNDSGVAGCLSVVPYYNKPTQEG
HHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
MYQHFKAIAECTDLPQILYNVPSRTGSDLLPETVARLAKINNIVAIKEATGDLSRVAKIK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHH
ELAGEDFIFLSGDDATGLESIKLGGQGVISVTNNVAAADMAKMCHLALNGQFEEAEQINQ
HHCCCCEEEEECCCCCCCHHEECCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHH
RLMALHKNLFVESNPIPVKWAAYRLGLIDTPTLRLPLTTLSEHLQPKVEDALKIAGLL
HHHHHHHHHEECCCCCCEEEHHEEECCCCCCCEEEEHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100