The gene/protein map for NC_002663 is currently unavailable.
Definition Pasteurella multocida subsp. multocida str. Pm70, complete genome.
Accession NC_002663
Length 2,257,487

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The map label for this gene is gshAB

Identifier: 15602913

GI number: 15602913

Start: 1236075

End: 1238348

Strand: Reverse

Name: gshAB

Synonym: PM1048

Alternate gene names: 15602913

Gene position: 1238348-1236075 (Counterclockwise)

Preceding gene: 15602914

Following gene: 15602911

Centisome position: 54.86

GC content: 41.03

Gene sequence:

>2274_bases
ATGAAAATTCAACATATCATTCATGAAAACCAATTAGGATTATTGTTTCAACAAGGCTCATTCGGGTTAGAAAAAGAAAG
TCAGCGCGTGACTGCCGATGGTGCAATTGTAACGACTCCTCATCCTGCGGTGTTTGGTAATCGCCGTTATCATCCTTATA
TTCAAACAGATTTTGCTGAGAGCCAACTTGAGCTGATTACCCCGCCAACTAAAAAGTTAGAAGATACGTTTCGTTGGTTG
TCTGTTATTCATGAAGTGGTACAACGTTCGCTACCCGAAGAAGAATATATTTTCCCATTGAGTATGCCTGCGGGATTGCC
AGCAGAAGAGCAAATTCGTGTGGCACAATTAGATAACCCAGAAGACGTGGCTTATCGTGAATATTTAGTGAAAATATATG
GTAAAAACAAGCAGATGGTCAGTGGGATTCACTACAACTTTCAGCTTTCCCCCGACTTGATCACACGTTTATTCCGCTTG
CAGAATGAGTATCAAAGTGCGGTCGATTTTCAGAATGATTTATATCTGAAAATGGCAAAAAACTTCTTACGTTATCAATG
GATTTTGTTGTATCTATTAGCGGCAACACCAACGGTTGAATCCGCTTATTTTAAAGATGGATCCCCGTTAGCGAAAGGGC
AATTCGTGCGTAGTTTACGTTCAAGTCAATATGGTTATGTGAATGATCCCGAAATTAACGTTTCTTTTGATAGTGTCGAA
AAGTATGTTGAAAGCTTAGAGCATTGGGTATCAACGGGGAAATTGATTGCAGAAAAAGAATTTTATTCTAATGTGCGTTT
GCGTGGTGCAAAGAAAGCGCGCGAATTTTTGACAACGGGTATTCAATATCTGGAGTTCCGTTTATTTGACTTAAATCCGT
TTGAAATTTACGGGATTAGCCTAAAAGATGCGAAGTTTATCCACGTGTTCGCCTTATTCATGATTTGGATGGATCACACT
GCTGATCAAGAAGAAGTGGAATTAGGTAAAGCGCGTTTGGCAGAAGTGGCTTTTGAGCATCCATTAGAAAAAACCGCTTA
TGCCGTCGAAGGCGAATTGGTGCTCTTAGAATTATTGTCGATGCTAGAGCAAATTGGCGCAGAGCCGGAATTATTTGAGA
TTGTGAAAGAGAAATTAACTCAATTCACGGATCCAAGCAAAACAGTGGCAGGACGTTTAGTACGCGCGATTGAGCAAGCC
GGGAGCGATCAACAATTAGGTGCCCAGCTCGCACAGCAATATAAAGCCCAAGCCTTTGAACGTTTTTATGCCTTATCTGC
ATTCGATAACATGGAGCTTTCTACCCAAGCGTTGTTATTTGATGTGATTCAGAAAGGGATTCATACTGAGATTTTGGATG
AAAATGATCAATTCTTGTGCTTAAAATATGGAGATCATATTGAGTATGTGAAAAACGGCAATATGACCTCACACGACAGT
TATATTTCACCGCTAATTATGGAAAATAAAGTGGTGACCAAAAAAGTATTGCAAAAAGCGGGCTTTAATGTGCCACAAAG
TGTGGAGTTTACTTCTCTTGAGAAAGCGGTGGCAAGTTATGCACTTTTTGAAAACCGTGCGGTAGTGATTAAACCCAAAT
CCACGAATTATGGCTTGGGTATCACCATTTTCCAACAAGGCGTGCAAAACCGTGAGGATTTTGCTAAGGCGCTAGAAATT
GCTTTCCGTGAAGATAAAGAAGTAATGGTGGAAGATTATTTAGTCGGAACAGAATACCGCTTCTTTGTATTAGGTGATGA
AACATTGGCGGTATTATTGCGTGTACCAGCCAATGTCGTAGGAGACAGTGTGCATTCTGTGGCAGAACTTGTTGCCATGA
AAAATGATCATCCGCTACGAGGTGATGGTAGCCGTACACCATTGAAGAAAATTGCTTTAGGCGAAATTGAGCAGTTACAG
CTCAAGGAGCAAGGTTTAACCATTGATAGCATTCCCGCTAAAGATCAGCTTGTACAACTACGAGCCAATTCCAATATTAG
TACAGGTGGTGATTCCATTGATATGACGGATGAAATGCACGAGAGTTATAAACAACTGGCTGTCGGTATCACGAAAGCGA
TGGGCGCGGCGGTGTGTGGTGTGGATTTAATTATCCCTGACTTGAAGCAACCGGCTACGCCAAACTTAACTTCTTGGGGT
GTGATTGAAGCGAATTTTAATCCGATGATGATGATGCATATTTTCCCTTATGCGGGTAAATCTCGTCGTTTAACTCAGAA
TGTGATTAAGATGCTCTTTCCTGAACTGGAGTAA

Upstream 100 bases:

>100_bases
GCTCGCTTGATTAGGCTACAATGCCAAACCAACCCTTTATTTCACTGATTAAGCTTCATCTGTTCAAGCCGGTTAACCGT
ATTTATTTGAAGGAAAGCAA

Downstream 100 bases:

>100_bases
GTGCATAAGTCATAATAAAGGCGAACCCTCAGTTCGCCTTTATTATATTTACGGCAATTGACGAAGAACACTCAAGATGC
CGTGACAGTAAGGCTTATCT

Product: bifunctional glutamate--cysteine ligase/glutathione synthetase

Products: NA

Alternate protein names: Gamma-GCS-GS; GCS-GS; Glutamate--cysteine ligase; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase; Glutathione synthetase; GSH synthetase; GS; GSH-S; GSHase; Glutathione synthase

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MKIQHIIHENQLGLLFQQGSFGLEKESQRVTADGAIVTTPHPAVFGNRRYHPYIQTDFAESQLELITPPTKKLEDTFRWL
SVIHEVVQRSLPEEEYIFPLSMPAGLPAEEQIRVAQLDNPEDVAYREYLVKIYGKNKQMVSGIHYNFQLSPDLITRLFRL
QNEYQSAVDFQNDLYLKMAKNFLRYQWILLYLLAATPTVESAYFKDGSPLAKGQFVRSLRSSQYGYVNDPEINVSFDSVE
KYVESLEHWVSTGKLIAEKEFYSNVRLRGAKKAREFLTTGIQYLEFRLFDLNPFEIYGISLKDAKFIHVFALFMIWMDHT
ADQEEVELGKARLAEVAFEHPLEKTAYAVEGELVLLELLSMLEQIGAEPELFEIVKEKLTQFTDPSKTVAGRLVRAIEQA
GSDQQLGAQLAQQYKAQAFERFYALSAFDNMELSTQALLFDVIQKGIHTEILDENDQFLCLKYGDHIEYVKNGNMTSHDS
YISPLIMENKVVTKKVLQKAGFNVPQSVEFTSLEKAVASYALFENRAVVIKPKSTNYGLGITIFQQGVQNREDFAKALEI
AFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVVGDSVHSVAELVAMKNDHPLRGDGSRTPLKKIALGEIEQLQ
LKEQGLTIDSIPAKDQLVQLRANSNISTGGDSIDMTDEMHESYKQLAVGITKAMGAAVCGVDLIIPDLKQPATPNLTSWG
VIEANFNPMMMMHIFPYAGKSRRLTQNVIKMLFPELE

Sequences:

>Translated_757_residues
MKIQHIIHENQLGLLFQQGSFGLEKESQRVTADGAIVTTPHPAVFGNRRYHPYIQTDFAESQLELITPPTKKLEDTFRWL
SVIHEVVQRSLPEEEYIFPLSMPAGLPAEEQIRVAQLDNPEDVAYREYLVKIYGKNKQMVSGIHYNFQLSPDLITRLFRL
QNEYQSAVDFQNDLYLKMAKNFLRYQWILLYLLAATPTVESAYFKDGSPLAKGQFVRSLRSSQYGYVNDPEINVSFDSVE
KYVESLEHWVSTGKLIAEKEFYSNVRLRGAKKAREFLTTGIQYLEFRLFDLNPFEIYGISLKDAKFIHVFALFMIWMDHT
ADQEEVELGKARLAEVAFEHPLEKTAYAVEGELVLLELLSMLEQIGAEPELFEIVKEKLTQFTDPSKTVAGRLVRAIEQA
GSDQQLGAQLAQQYKAQAFERFYALSAFDNMELSTQALLFDVIQKGIHTEILDENDQFLCLKYGDHIEYVKNGNMTSHDS
YISPLIMENKVVTKKVLQKAGFNVPQSVEFTSLEKAVASYALFENRAVVIKPKSTNYGLGITIFQQGVQNREDFAKALEI
AFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVVGDSVHSVAELVAMKNDHPLRGDGSRTPLKKIALGEIEQLQ
LKEQGLTIDSIPAKDQLVQLRANSNISTGGDSIDMTDEMHESYKQLAVGITKAMGAAVCGVDLIIPDLKQPATPNLTSWG
VIEANFNPMMMMHIFPYAGKSRRLTQNVIKMLFPELE
>Mature_757_residues
MKIQHIIHENQLGLLFQQGSFGLEKESQRVTADGAIVTTPHPAVFGNRRYHPYIQTDFAESQLELITPPTKKLEDTFRWL
SVIHEVVQRSLPEEEYIFPLSMPAGLPAEEQIRVAQLDNPEDVAYREYLVKIYGKNKQMVSGIHYNFQLSPDLITRLFRL
QNEYQSAVDFQNDLYLKMAKNFLRYQWILLYLLAATPTVESAYFKDGSPLAKGQFVRSLRSSQYGYVNDPEINVSFDSVE
KYVESLEHWVSTGKLIAEKEFYSNVRLRGAKKAREFLTTGIQYLEFRLFDLNPFEIYGISLKDAKFIHVFALFMIWMDHT
ADQEEVELGKARLAEVAFEHPLEKTAYAVEGELVLLELLSMLEQIGAEPELFEIVKEKLTQFTDPSKTVAGRLVRAIEQA
GSDQQLGAQLAQQYKAQAFERFYALSAFDNMELSTQALLFDVIQKGIHTEILDENDQFLCLKYGDHIEYVKNGNMTSHDS
YISPLIMENKVVTKKVLQKAGFNVPQSVEFTSLEKAVASYALFENRAVVIKPKSTNYGLGITIFQQGVQNREDFAKALEI
AFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVVGDSVHSVAELVAMKNDHPLRGDGSRTPLKKIALGEIEQLQ
LKEQGLTIDSIPAKDQLVQLRANSNISTGGDSIDMTDEMHESYKQLAVGITKAMGAAVCGVDLIIPDLKQPATPNLTSWG
VIEANFNPMMMMHIFPYAGKSRRLTQNVIKMLFPELE

Specific function: Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine

COG id: COG2918

COG function: function code H; Gamma-glutamylcysteine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1789044, Length=341, Percent_Identity=29.9120234604106, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSHAB_PASMU (Q9CM00)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245985.1
- ProteinModelPortal:   Q9CM00
- SMR:   Q9CM00
- GeneID:   1244395
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM1048
- NMPDR:   fig|272843.1.peg.1048
- HOGENOM:   HBG296652
- OMA:   PKSTNYG
- ProtClustDB:   PRK02471
- BioCyc:   PMUL272843:PM1048-MONOMER
- BRENDA:   6.3.2.2
- BRENDA:   6.3.2.3
- HAMAP:   MF_00782
- InterPro:   IPR011761
- InterPro:   IPR003806
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR007370
- InterPro:   IPR006335
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- TIGRFAMs:   TIGR01435

Pfam domain/function: PF02655 ATP-grasp_3; PF04262 Glu_cys_ligase

EC number: =6.3.2.2; =6.3.2.3

Molecular weight: Translated: 85863; Mature: 85863

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQHIIHENQLGLLFQQGSFGLEKESQRVTADGAIVTTPHPAVFGNRRYHPYIQTDFAE
CCCHHHHCCCCEEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCEECCCCC
SQLELITPPTKKLEDTFRWLSVIHEVVQRSLPEEEYIFPLSMPAGLPAEEQIRVAQLDNP
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCEEEEECCCC
EDVAYREYLVKIYGKNKQMVSGIHYNFQLSPDLITRLFRLQNEYQSAVDFQNDLYLKMAK
HHHHHHHHHHHHHCCCCCEEECEEEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NFLRYQWILLYLLAATPTVESAYFKDGSPLAKGQFVRSLRSSQYGYVNDPEINVSFDSVE
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHH
KYVESLEHWVSTGKLIAEKEFYSNVRLRGAKKAREFLTTGIQYLEFRLFDLNPFEIYGIS
HHHHHHHHHHHHCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEE
LKDAKFIHVFALFMIWMDHTADQEEVELGKARLAEVAFEHPLEKTAYAVEGELVLLELLS
ECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHH
MLEQIGAEPELFEIVKEKLTQFTDPSKTVAGRLVRAIEQAGSDQQLGAQLAQQYKAQAFE
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RFYALSAFDNMELSTQALLFDVIQKGIHTEILDENDQFLCLKYGDHIEYVKNGNMTSHDS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCC
YISPLIMENKVVTKKVLQKAGFNVPQSVEFTSLEKAVASYALFENRAVVIKPKSTNYGLG
CCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
ITIFQQGVQNREDFAKALEIAFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVV
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHEEECCCEEEEEECCHHHHHHHHCCHHHH
GDSVHSVAELVAMKNDHPLRGDGSRTPLKKIALGEIEQLQLKEQGLTIDSIPAKDQLVQL
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCEECCCCCCCCEEEE
RANSNISTGGDSIDMTDEMHESYKQLAVGITKAMGAAVCGVDLIIPDLKQPATPNLTSWG
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
VIEANFNPMMMMHIFPYAGKSRRLTQNVIKMLFPELE
EEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIQHIIHENQLGLLFQQGSFGLEKESQRVTADGAIVTTPHPAVFGNRRYHPYIQTDFAE
CCCHHHHCCCCEEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCCCCCCCCCEECCCCC
SQLELITPPTKKLEDTFRWLSVIHEVVQRSLPEEEYIFPLSMPAGLPAEEQIRVAQLDNP
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCEEEEECCCC
EDVAYREYLVKIYGKNKQMVSGIHYNFQLSPDLITRLFRLQNEYQSAVDFQNDLYLKMAK
HHHHHHHHHHHHHCCCCCEEECEEEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NFLRYQWILLYLLAATPTVESAYFKDGSPLAKGQFVRSLRSSQYGYVNDPEINVSFDSVE
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHH
KYVESLEHWVSTGKLIAEKEFYSNVRLRGAKKAREFLTTGIQYLEFRLFDLNPFEIYGIS
HHHHHHHHHHHHCHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEE
LKDAKFIHVFALFMIWMDHTADQEEVELGKARLAEVAFEHPLEKTAYAVEGELVLLELLS
ECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHH
MLEQIGAEPELFEIVKEKLTQFTDPSKTVAGRLVRAIEQAGSDQQLGAQLAQQYKAQAFE
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RFYALSAFDNMELSTQALLFDVIQKGIHTEILDENDQFLCLKYGDHIEYVKNGNMTSHDS
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCC
YISPLIMENKVVTKKVLQKAGFNVPQSVEFTSLEKAVASYALFENRAVVIKPKSTNYGLG
CCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
ITIFQQGVQNREDFAKALEIAFREDKEVMVEDYLVGTEYRFFVLGDETLAVLLRVPANVV
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHEEECCCEEEEEECCHHHHHHHHCCHHHH
GDSVHSVAELVAMKNDHPLRGDGSRTPLKKIALGEIEQLQLKEQGLTIDSIPAKDQLVQL
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCEECCCCCCCCEEEE
RANSNISTGGDSIDMTDEMHESYKQLAVGITKAMGAAVCGVDLIIPDLKQPATPNLTSWG
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
VIEANFNPMMMMHIFPYAGKSRRLTQNVIKMLFPELE
EEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100