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The map label for this gene is galR [H]

Identifier: 15602902

GI number: 15602902

Start: 1220029

End: 1221033

Strand: Direct

Name: galR [H]

Synonym: PM1037

Alternate gene names: 15602902

Gene position: 1220029-1221033 (Clockwise)

Preceding gene: 15602896

Following gene: 15602903

Centisome position: 54.04

GC content: 41.49

Gene sequence:

>1005_bases
ATGGTTACTATTCATGATGTTGCACAACATGCGGGTGTTTCTGTCGCTACGGTATCTCGCGTACTCAATAATCATCCTTC
TGCGAGTGAAAAAGCTCGCATCGCCGTCCAAGCTGCTATCGAAAAGCTTGGTTACCAACCCAATGCGAATGCACAAGCAC
TTGCCATGAAAAATACCGATACTATTGGAGTGGTGGTAACAGATGTTACCGACGCCTTTTTCGCGATCTTAGTGAAAGCT
GTCGATAAAGTGGCAGAAGAATACAAAAAAACCATTATCATTGGGATTGGCTATCATAATGCAGAAAAAGAAAAAGAAGC
GATCGATACACTATTACGCAAACGTTGTAGCTGTCTTGTGGTACATGCAAAGGCACTCAGTGATGAAGTCCTATGTCAAT
ATTTAGAAAAAGTGCCAGGTATGGTGATTATCAATCGTGTTGTGCAAGGGTATGAACATCGCTGTGTTAGCTTAGATAAT
GAAAAAGGGACTTTTATCGCGACAGAAACCTTAATTAAGCTCGGGCACAAGAAAATCGGCTATATTGGTTCAAACCATTA
TATTATGGATGAGATAGAAAGACATCGTGGTTATCTGGCGGCGTTAAAGCAATACCATATCCCCGTCATTGAACATGCGA
TTACGCACAGCTCACCCGATTTTGAAGGGGGAGAAGAAGCCATGATTAACCTACTCAGTTACAATTCCGATCTCACCGCG
GTGGTCGCTTATAATGATTCTATGGCAGCCGGTGCAATTTCTGTATTAAATGAAAATAACATTCGTGTTCCAGCCCAATG
TTCGATCATCGGCTTTGATGATATGCCAATTGCACGTTATTTGATTCCTAAACTCACTACAATCCGCTATCCCATCGATT
TAATGGCGAATTATGCGGCAAAGTTAGCGCTAAGCTTAGTGGATCAAGATGTGAAAAAACCTTCACACATTCAATTTAAT
CCTACATTAGTTAGACGTTTCTCAACCGAGCAGCATTCACAATGA

Upstream 100 bases:

>100_bases
TTGTGTATAAGGTGTCAGATTTAGTGCTAAACGTTTTCAAACCTAGCAAAATTTTATAGGATGAAAACAAGGGTTTCTCA
CAGGAAAGGTCATATTCGTT

Downstream 100 bases:

>100_bases
GCTAATGATGAAAACGTAAACATTTTCCATTAACAATACAAAAAACGTGGTTAAATTTGTGCAAATTTAGCCACGTTTTC
TTTTTTTTATAGTAAAAAAA

Product: GalR

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MVTIHDVAQHAGVSVATVSRVLNNHPSASEKARIAVQAAIEKLGYQPNANAQALAMKNTDTIGVVVTDVTDAFFAILVKA
VDKVAEEYKKTIIIGIGYHNAEKEKEAIDTLLRKRCSCLVVHAKALSDEVLCQYLEKVPGMVIINRVVQGYEHRCVSLDN
EKGTFIATETLIKLGHKKIGYIGSNHYIMDEIERHRGYLAALKQYHIPVIEHAITHSSPDFEGGEEAMINLLSYNSDLTA
VVAYNDSMAAGAISVLNENNIRVPAQCSIIGFDDMPIARYLIPKLTTIRYPIDLMANYAAKLALSLVDQDVKKPSHIQFN
PTLVRRFSTEQHSQ

Sequences:

>Translated_334_residues
MVTIHDVAQHAGVSVATVSRVLNNHPSASEKARIAVQAAIEKLGYQPNANAQALAMKNTDTIGVVVTDVTDAFFAILVKA
VDKVAEEYKKTIIIGIGYHNAEKEKEAIDTLLRKRCSCLVVHAKALSDEVLCQYLEKVPGMVIINRVVQGYEHRCVSLDN
EKGTFIATETLIKLGHKKIGYIGSNHYIMDEIERHRGYLAALKQYHIPVIEHAITHSSPDFEGGEEAMINLLSYNSDLTA
VVAYNDSMAAGAISVLNENNIRVPAQCSIIGFDDMPIARYLIPKLTTIRYPIDLMANYAAKLALSLVDQDVKKPSHIQFN
PTLVRRFSTEQHSQ
>Mature_334_residues
MVTIHDVAQHAGVSVATVSRVLNNHPSASEKARIAVQAAIEKLGYQPNANAQALAMKNTDTIGVVVTDVTDAFFAILVKA
VDKVAEEYKKTIIIGIGYHNAEKEKEAIDTLLRKRCSCLVVHAKALSDEVLCQYLEKVPGMVIINRVVQGYEHRCVSLDN
EKGTFIATETLIKLGHKKIGYIGSNHYIMDEIERHRGYLAALKQYHIPVIEHAITHSSPDFEGGEEAMINLLSYNSDLTA
VVAYNDSMAAGAISVLNENNIRVPAQCSIIGFDDMPIARYLIPKLTTIRYPIDLMANYAAKLALSLVDQDVKKPSHIQFN
PTLVRRFSTEQHSQ

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788474, Length=328, Percent_Identity=55.4878048780488, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=51.9519519519519, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1789068, Length=335, Percent_Identity=33.4328358208955, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=33.2326283987915, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790369, Length=289, Percent_Identity=32.5259515570934, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=30.2114803625378, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787906, Length=322, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786540, Length=342, Percent_Identity=29.5321637426901, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=29.8136645962733, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790715, Length=307, Percent_Identity=27.0358306188925, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994940, Length=327, Percent_Identity=25.0764525993884, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790689, Length=291, Percent_Identity=24.7422680412371, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789456, Length=319, Percent_Identity=24.4514106583072, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786268, Length=333, Percent_Identity=22.2222222222222, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36894; Mature: 36894

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIHDVAQHAGVSVATVSRVLNNHPSASEKARIAVQAAIEKLGYQPNANAQALAMKNTD
CEEHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
TIGVVVTDVTDAFFAILVKAVDKVAEEYKKTIIIGIGYHNAEKEKEAIDTLLRKRCSCLV
EEEEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHEEE
VHAKALSDEVLCQYLEKVPGMVIINRVVQGYEHRCVSLDNEKGTFIATETLIKLGHKKIG
EHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCEEHHHHHHHHCCHHEE
YIGSNHYIMDEIERHRGYLAALKQYHIPVIEHAITHSSPDFEGGEEAMINLLSYNSDLTA
EECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEE
VVAYNDSMAAGAISVLNENNIRVPAQCSIIGFDDMPIARYLIPKLTTIRYPIDLMANYAA
EEEECCCCHHHHHEEECCCCEECCCEEEEEECCCCCHHHHHHHHHHHEECCHHHHHHHHH
KLALSLVDQDVKKPSHIQFNPTLVRRFSTEQHSQ
HHHHHHHHHHCCCCCCEEECHHHHHHHCHHCCCC
>Mature Secondary Structure
MVTIHDVAQHAGVSVATVSRVLNNHPSASEKARIAVQAAIEKLGYQPNANAQALAMKNTD
CEEHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
TIGVVVTDVTDAFFAILVKAVDKVAEEYKKTIIIGIGYHNAEKEKEAIDTLLRKRCSCLV
EEEEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHEEE
VHAKALSDEVLCQYLEKVPGMVIINRVVQGYEHRCVSLDNEKGTFIATETLIKLGHKKIG
EHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCEEHHHHHHHHCCHHEE
YIGSNHYIMDEIERHRGYLAALKQYHIPVIEHAITHSSPDFEGGEEAMINLLSYNSDLTA
EECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEE
VVAYNDSMAAGAISVLNENNIRVPAQCSIIGFDDMPIARYLIPKLTTIRYPIDLMANYAA
EEEECCCCHHHHHEEECCCCEECCCEEEEEECCCCCHHHHHHHHHHHEECCHHHHHHHHH
KLALSLVDQDVKKPSHIQFNPTLVRRFSTEQHSQ
HHHHHHHHHHCCCCCCEEECHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1282642; 7542800 [H]