Click here to switch to the map view.

The map label for this gene is vipA [H]

Identifier: 15602868

GI number: 15602868

Start: 1183307

End: 1184581

Strand: Direct

Name: vipA [H]

Synonym: PM1003

Alternate gene names: 15602868

Gene position: 1183307-1184581 (Clockwise)

Preceding gene: 15602867

Following gene: 15602869

Centisome position: 52.42

GC content: 37.25

Gene sequence:

>1275_bases
ATGAATATTGAAAAATTAAAAATTGGCATCATTGGTCTTGGTTACGTTGGACTACCTATCGCTGTGGAATTCGGTAAAAA
AGTCCCTACGGTGGGTTTTGATATTAATGAAAAACGTGTCAAATCACTGGCGTCAGGTAAAGATTACACATTAGAAGTGT
CTGAAGAGGAATTACAACATGCCTCCAAATTACGTTATACAAACCAAACCAAAGGGTTAGAAGAATGTAATTTCTTTATT
GTGACAGTTCCCACTCCGATCGATCATTACAAACAACCGGATCTTAACCCCCTGATAAAAGCCTCAGAAACTATCGCAGA
AGTATTGAAAAAAGGGGATGTCGTTGTATATGAATCGACAGTTTATCCAGGTGCGACTGAAGAAATTTGTGTGCCTGTAC
TTGAAAAAATGTCAGGTTTGAAATTTAACCATGACTTCTTTGTCGGTTATAGCCCCGAGCGGATTAATCCTGGTGATAAA
GAACATCGTGTTACGAATATTTTAAAAATTACATCCGGTTCAACTCCACTTGTCGCCAATTATATCGACTTCGTTTATAA
GCTCATTATAAAAGCGGGAACACATCAAGCCCCAAGCATCAAAGTGGCTGAAGCCGCTAAAGTAATTGAAAATACACAAC
GAGATGTCAATATCGCCCTGATTAATGAACTTGCCTTAATCTTCAACAAAATGGGGATTGATACCGAAGATGTGTTAAAC
GCGGCAGGAACGAAATGGAATTTTTTACCTTTTAAGCCCGGTTTAGTAGGCGGGCACTGTATTGGCGTAGATCCTTATTA
TTTAACACACAAAGCACAGTCACTGGGCTTACATCCCGAAATTATTCTTGCTGCACGCCGTTTAAATGACCGTATGGGAG
AATATGTCGCGACACAACTCATTAAAGAAATGGTGAAAAAAGACATTCCCGTGGTCAATTCTAAGATTTTAGTGATGGGC
TTGAGTTTCAAAGAAAATTGTCCAGATATACGTAATACCAAAATTATTGATCTCGTTAATTCATTAAAAGAATACGACAT
TGATATTGATATCTACGATCCTTGGGTAGATAAATACGAAGCAGAAGCAGAATATGGCTTAACACCAATCACAGAGATTC
ATTCACATAACTATGATGCCATTATTATCGCCGTTGCACATCAACAATTTAAGTGTATGACGGAAAAAGATTTTAAAGCA
TTAGGGAAAGAAAATTTTGTCCTTTATGACCTGAAATATGTGTTAGATCAATCTCAAGCCAATATTAGATTATGA

Upstream 100 bases:

>100_bases
TAATTAAATAAATTAAGTATTACGTTATATCCTCGTTAGTATTTTATTAAGTTATACCATCTGTCATTTTCATTTCTATT
TTTTCTTTAAGGGACAGAAT

Downstream 100 bases:

>100_bases
ATCTGAAATTATGTTAATACGAAATACGCTATTACTCACAATAAGCCATATGTTATCTCGAGGAAGCTTAATTTTTTCTT
CCGTGATCATATCAAGCTTA

Product: hypothetical protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNIEKLKIGIIGLGYVGLPIAVEFGKKVPTVGFDINEKRVKSLASGKDYTLEVSEEELQHASKLRYTNQTKGLEECNFFI
VTVPTPIDHYKQPDLNPLIKASETIAEVLKKGDVVVYESTVYPGATEEICVPVLEKMSGLKFNHDFFVGYSPERINPGDK
EHRVTNILKITSGSTPLVANYIDFVYKLIIKAGTHQAPSIKVAEAAKVIENTQRDVNIALINELALIFNKMGIDTEDVLN
AAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQSLGLHPEIILAARRLNDRMGEYVATQLIKEMVKKDIPVVNSKILVMG
LSFKENCPDIRNTKIIDLVNSLKEYDIDIDIYDPWVDKYEAEAEYGLTPITEIHSHNYDAIIIAVAHQQFKCMTEKDFKA
LGKENFVLYDLKYVLDQSQANIRL

Sequences:

>Translated_424_residues
MNIEKLKIGIIGLGYVGLPIAVEFGKKVPTVGFDINEKRVKSLASGKDYTLEVSEEELQHASKLRYTNQTKGLEECNFFI
VTVPTPIDHYKQPDLNPLIKASETIAEVLKKGDVVVYESTVYPGATEEICVPVLEKMSGLKFNHDFFVGYSPERINPGDK
EHRVTNILKITSGSTPLVANYIDFVYKLIIKAGTHQAPSIKVAEAAKVIENTQRDVNIALINELALIFNKMGIDTEDVLN
AAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQSLGLHPEIILAARRLNDRMGEYVATQLIKEMVKKDIPVVNSKILVMG
LSFKENCPDIRNTKIIDLVNSLKEYDIDIDIYDPWVDKYEAEAEYGLTPITEIHSHNYDAIIIAVAHQQFKCMTEKDFKA
LGKENFVLYDLKYVLDQSQANIRL
>Mature_424_residues
MNIEKLKIGIIGLGYVGLPIAVEFGKKVPTVGFDINEKRVKSLASGKDYTLEVSEEELQHASKLRYTNQTKGLEECNFFI
VTVPTPIDHYKQPDLNPLIKASETIAEVLKKGDVVVYESTVYPGATEEICVPVLEKMSGLKFNHDFFVGYSPERINPGDK
EHRVTNILKITSGSTPLVANYIDFVYKLIIKAGTHQAPSIKVAEAAKVIENTQRDVNIALINELALIFNKMGIDTEDVLN
AAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQSLGLHPEIILAARRLNDRMGEYVATQLIKEMVKKDIPVVNSKILVMG
LSFKENCPDIRNTKIIDLVNSLKEYDIDIDIYDPWVDKYEAEAEYGLTPITEIHSHNYDAIIIAVAHQQFKCMTEKDFKA
LGKENFVLYDLKYVLDQSQANIRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=402, Percent_Identity=28.8557213930348, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17560350, Length=384, Percent_Identity=25.78125, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136908, Length=412, Percent_Identity=24.5145631067961, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47575; Mature: 47575

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEKLKIGIIGLGYVGLPIAVEFGKKVPTVGFDINEKRVKSLASGKDYTLEVSEEELQH
CCCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHH
ASKLRYTNQTKGLEECNFFIVTVPTPIDHYKQPDLNPLIKASETIAEVLKKGDVVVYEST
HHHHCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
VYPGATEEICVPVLEKMSGLKFNHDFFVGYSPERINPGDKEHRVTNILKITSGSTPLVAN
CCCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCHHHHHEEEEEECCCCCCHHHH
YIDFVYKLIIKAGTHQAPSIKVAEAAKVIENTQRDVNIALINELALIFNKMGIDTEDVLN
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCHHHHHH
AAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQSLGLHPEIILAARRLNDRMGEYVATQL
CCCCCCCEECCCCCCCCCEEECCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IKEMVKKDIPVVNSKILVMGLSFKENCPDIRNTKIIDLVNSLKEYDIDIDIYDPWVDKYE
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHC
AEAEYGLTPITEIHSHNYDAIIIAVAHQQFKCMTEKDFKALGKENFVLYDLKYVLDQSQA
CCHHCCCCCHHHHHCCCCCEEEEEEECCHHHHCCHHHHHHCCCCCEEEEEHHHHHCCCCC
NIRL
CCCC
>Mature Secondary Structure
MNIEKLKIGIIGLGYVGLPIAVEFGKKVPTVGFDINEKRVKSLASGKDYTLEVSEEELQH
CCCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHH
ASKLRYTNQTKGLEECNFFIVTVPTPIDHYKQPDLNPLIKASETIAEVLKKGDVVVYEST
HHHHCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECC
VYPGATEEICVPVLEKMSGLKFNHDFFVGYSPERINPGDKEHRVTNILKITSGSTPLVAN
CCCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCHHHHHEEEEEECCCCCCHHHH
YIDFVYKLIIKAGTHQAPSIKVAEAAKVIENTQRDVNIALINELALIFNKMGIDTEDVLN
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCHHHHHH
AAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQSLGLHPEIILAARRLNDRMGEYVATQL
CCCCCCCEECCCCCCCCCEEECCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IKEMVKKDIPVVNSKILVMGLSFKENCPDIRNTKIIDLVNSLKEYDIDIDIYDPWVDKYE
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHC
AEAEYGLTPITEIHSHNYDAIIIAVAHQQFKCMTEKDFKALGKENFVLYDLKYVLDQSQA
CCHHCCCCCHHHHHCCCCCEEEEEEECCHHHHCCHHHHHHCCCCCEEEEEHHHHHCCCCC
NIRL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]