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The map label for this gene is macA [H]

Identifier: 15602862

GI number: 15602862

Start: 1171993

End: 1173120

Strand: Reverse

Name: macA [H]

Synonym: PM0997

Alternate gene names: 15602862

Gene position: 1173120-1171993 (Counterclockwise)

Preceding gene: 15602863

Following gene: 15602861

Centisome position: 51.97

GC content: 39.8

Gene sequence:

>1128_bases
ATGAGGAAATACAGTAAATATGCCTTGCTTGTTTTATTACTCTGTCTCGTTACTTTTTACTATATAAGCGAAGAGGAAAA
TAGCAGCGATATTATTTTTCCAGCGATAAGAAGTGATATACAAAAAGTGATTACGGCAAGTGGTATTTTGCAAGCAAAAG
AAGAAGTTGAGATTGGTTCACAGGCCTCTGGTCAAGTGAAACAAATCGTGGTGCAAGAAGGGCAGCGTGTCAAGAAAGGG
GACTTATTAGCTCTTATTGATCCGCGTATTGCGGAAACCGAGTTGAAGCTTGCAAAAGCAGAGTTAGAAAGTGCTGAAGC
AAATTTAGAGGTAAAGCGAGCGAATTTAGTGTTATCTGAAGTGAATTTGGCACGCCATTATCAGTTGAATAAAAAAGAGG
CTACGACAAAAAAAGATATTGAGGAAGCCGAAAATAAGCGAATTATTGCAAGTGCAGAATTACGTATGGCGCAAAGCCAA
GTAGAAAGTGCCAAAGTCAAAGTGGAAAAAGCGAGCACAGAATTAGGTTATACTGAAATCCGTTCTCCGCTTGATGGTGT
AGTGATTTCCGTTGTGGCACAGAGTGGACAAACCTTAGCCGCGAGTCAACAAACACCGGTGTTAATGAAATTGGCTGTCA
TTGACACCATGAAAGTGAATGCCCGGGTTTCTGAAGCGGATGTGATTGATCTACAAGTGGGTGTACCAGTTCATTTTACT
TTATTAGGGGCACCACATGCACAATTTCATGCCAAATTAGCTGCAATTAAATTATCACCTGTGAAAGTGAGTGAGGCGAC
GTATTATTATGCAACTTTTGAGGTTCCTAATCCCGACCATAAACTACGTATCGCGATGACAGCAGAAGTGTCTATTTTAT
TAGATAAACGAGAAAATGTTGTGACGCTCCCGATTTCTGCATTAGGACAAATGCTCAAACCCAATCACTATTCTGTGACT
GTTTTAAATCAATCAGGTGAAAAAGAGCAGGTTATCGTGAAAACAGGCTTAAAAGATGGGGCAAGAATAGAAATTGTAGA
AGGTTTATCTGAAGGTGATAACGTTGTCCTGTCAGTAAATCCAGCTACCTCCTTGAATGACGAAGAAATATATGATCTTG
GATTATGA

Upstream 100 bases:

>100_bases
TATATGTTTTAATCTATCTTGAGGGAGGCAAAGTATGCCTCCCTTTTTATTCTTTTCTAGCATGATATTAAGTGAAATTG
ATAAAGGAGAGTGATTTTAC

Downstream 100 bases:

>100_bases
TGAATCAACCTTTAATTGAATTGAAAAATATTGTGCGTCGTTATGGTCATGGCGATACTGAAACGACAGTATTAAAGTCG
ATCAATCTTAAGATTTATGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MRKYSKYALLVLLLCLVTFYYISEEENSSDIIFPAIRSDIQKVITASGILQAKEEVEIGSQASGQVKQIVVQEGQRVKKG
DLLALIDPRIAETELKLAKAELESAEANLEVKRANLVLSEVNLARHYQLNKKEATTKKDIEEAENKRIIASAELRMAQSQ
VESAKVKVEKASTELGYTEIRSPLDGVVISVVAQSGQTLAASQQTPVLMKLAVIDTMKVNARVSEADVIDLQVGVPVHFT
LLGAPHAQFHAKLAAIKLSPVKVSEATYYYATFEVPNPDHKLRIAMTAEVSILLDKRENVVTLPISALGQMLKPNHYSVT
VLNQSGEKEQVIVKTGLKDGARIEIVEGLSEGDNVVLSVNPATSLNDEEIYDLGL

Sequences:

>Translated_375_residues
MRKYSKYALLVLLLCLVTFYYISEEENSSDIIFPAIRSDIQKVITASGILQAKEEVEIGSQASGQVKQIVVQEGQRVKKG
DLLALIDPRIAETELKLAKAELESAEANLEVKRANLVLSEVNLARHYQLNKKEATTKKDIEEAENKRIIASAELRMAQSQ
VESAKVKVEKASTELGYTEIRSPLDGVVISVVAQSGQTLAASQQTPVLMKLAVIDTMKVNARVSEADVIDLQVGVPVHFT
LLGAPHAQFHAKLAAIKLSPVKVSEATYYYATFEVPNPDHKLRIAMTAEVSILLDKRENVVTLPISALGQMLKPNHYSVT
VLNQSGEKEQVIVKTGLKDGARIEIVEGLSEGDNVVLSVNPATSLNDEEIYDLGL
>Mature_375_residues
MRKYSKYALLVLLLCLVTFYYISEEENSSDIIFPAIRSDIQKVITASGILQAKEEVEIGSQASGQVKQIVVQEGQRVKKG
DLLALIDPRIAETELKLAKAELESAEANLEVKRANLVLSEVNLARHYQLNKKEATTKKDIEEAENKRIIASAELRMAQSQ
VESAKVKVEKASTELGYTEIRSPLDGVVISVVAQSGQTLAASQQTPVLMKLAVIDTMKVNARVSEADVIDLQVGVPVHFT
LLGAPHAQFHAKLAAIKLSPVKVSEATYYYATFEVPNPDHKLRIAMTAEVSILLDKRENVVTLPISALGQMLKPNHYSVT
VLNQSGEKEQVIVKTGLKDGARIEIVEGLSEGDNVVLSVNPATSLNDEEIYDLGL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=351, Percent_Identity=35.8974358974359, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI87082036, Length=339, Percent_Identity=25.6637168141593, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789041, Length=221, Percent_Identity=25.7918552036199, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789929, Length=267, Percent_Identity=26.5917602996255, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790519, Length=283, Percent_Identity=25.4416961130742, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41042; Mature: 41042

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKYSKYALLVLLLCLVTFYYISEEENSSDIIFPAIRSDIQKVITASGILQAKEEVEIGS
CCCHHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
QASGQVKQIVVQEGQRVKKGDLLALIDPRIAETELKLAKAELESAEANLEVKRANLVLSE
CCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHEEEEEH
VNLARHYQLNKKEATTKKDIEEAENKRIIASAELRMAQSQVESAKVKVEKASTELGYTEI
HHHHHHEECCCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
RSPLDGVVISVVAQSGQTLAASQQTPVLMKLAVIDTMKVNARVSEADVIDLQVGVPVHFT
CCCHHHHHHEEECCCCCEEECCCCCCEEEEEEEEEEEEECCEECCCEEEEEEECCCEEEE
LLGAPHAQFHAKLAAIKLSPVKVSEATYYYATFEVPNPDHKLRIAMTAEVSILLDKRENV
EECCCCHHHHEEEEEEEECCEEEECCEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCCE
VTLPISALGQMLKPNHYSVTVLNQSGEKEQVIVKTGLKDGARIEIVEGLSEGDNVVLSVN
EEEEHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEC
PATSLNDEEIYDLGL
CCCCCCCCCEEECCC
>Mature Secondary Structure
MRKYSKYALLVLLLCLVTFYYISEEENSSDIIFPAIRSDIQKVITASGILQAKEEVEIGS
CCCHHHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
QASGQVKQIVVQEGQRVKKGDLLALIDPRIAETELKLAKAELESAEANLEVKRANLVLSE
CCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHEEEEEH
VNLARHYQLNKKEATTKKDIEEAENKRIIASAELRMAQSQVESAKVKVEKASTELGYTEI
HHHHHHEECCCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
RSPLDGVVISVVAQSGQTLAASQQTPVLMKLAVIDTMKVNARVSEADVIDLQVGVPVHFT
CCCHHHHHHEEECCCCCEEECCCCCCEEEEEEEEEEEEECCEECCCEEEEEEECCCEEEE
LLGAPHAQFHAKLAAIKLSPVKVSEATYYYATFEVPNPDHKLRIAMTAEVSILLDKRENV
EECCCCHHHHEEEEEEEECCEEEECCEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCCE
VTLPISALGQMLKPNHYSVTVLNQSGEKEQVIVKTGLKDGARIEIVEGLSEGDNVVLSVN
EEEEHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEC
PATSLNDEEIYDLGL
CCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]