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The map label for this gene is lysC [H]

Identifier: 15602802

GI number: 15602802

Start: 1105600

End: 1106952

Strand: Direct

Name: lysC [H]

Synonym: PM0937

Alternate gene names: 15602802

Gene position: 1105600-1106952 (Clockwise)

Preceding gene: 15602801

Following gene: 15602803

Centisome position: 48.97

GC content: 43.16

Gene sequence:

>1353_bases
ATGTCTCATCTTTCAATTGCCAAATTTGGAGGCACCAGTGTCGCTAATTATGCTGCCATGTCTGCCTCGGCAAAAATTGT
CGTGAATGATCCCAATACACGGGTTGTCGTACTTTCCGCTTCGGCAGGTGTCACTAACTTACTTGTTGCGTTGGCAAATG
GCTGTGACAACGAAGAACGCACTAAATTAATCAATGAAGTTCGCCAAATTCAAGAAAATATCCTTTCGGAATTAAAAGAT
GATAGCTTAGTACGCAATAAAGTGGAAAAGTTACTGGCGAATATAGAATCGCTTGCTGAAGCAGCAAGCCTAGCAACCTC
CCCAGCTCTCACAGATGAGCTGATTAGTCACGGGGAAATGATGTCTTCTCTGATCTTTGTTGAAATCTTACGCGAATTCA
ACACGCCATCCACTTGGATTGATGTGCGTAATATTATCGCGACTGATAGCCATTTTGGTAAAGCAGTACCAAACGATCAC
AAAACGCAAGAAAACAGTACACATATTTTAAAACCCTTAATTGATCGCGGTGAATTGATCATTACACAAGGTTTTATTGG
TCGTGATGAACAAGGCAAAACCACCACATTAGGTCGAGGTGGGAGTGATTATTCTGCGGCATTATTAGCCGAAGTACTCA
ATGCGGAAGATGTCTTGATCTGGACTGATGTCGCGGGCATTTATACCACTGATCCTCGTATCGTGCCGAATGCGAAACGT
ATTGATACCATGAGTTTTTCTGAAGCGGCTGAAATGGCAACCTTTGGTGCTAAAGTCTTACATCCCGCCACATTATTGCC
TGCAGTGCGCAGTAATATTCCTGTTTATGTTGGCTCCAGTAAAGCGCCAGAAGCAGGGGGCACTTGGGTAACACGCGATC
CTCAACACCGACCGATATTCCGAGCCATTGCTCTCCGTCGGGATCAAACGCTACTCACCCTCTCTAGCTTAAATATGTTA
CATGCGCAAGGCTTTCTCGCTAACGTCTTTACGATCTTAGCCAAACATAAAATTTCTGTGGACGTGGTCACAACCTCAGA
AGTCAGTATTGCACTCACATTAGATAAAACCGGTTCGGCATCTTCTGGTCTCAGTTTACTTTCAAGCGCACTGATTGACG
AATTAAGCCAACTTTGTAGTGTCAAAGTGGACAGCGATCTCGCTTTAGTCGCTTTAATCGGTAATGATTTGCATATTACC
TCAGGTATTGCCAAACGTATTTTTGATACATTAGCCCCTTATAATATCCGCTCAATCAGTTATGGTGCGAGTACGAATAA
TGTTTGTCTTCTAGTCACCAATGCACATGCTGATGCTGTTGTTTCCGCATTACATAAAAATCTCTTTGAGTAA

Upstream 100 bases:

>100_bases
GTTCACAAAATATGTTTGACAAGTTTTTTATAAATCGTTATTTGTTTTACCTCAAACACAACATACTGAAAATGAAAATA
ACTTAAACAGGAGCCAATCT

Downstream 100 bases:

>100_bases
CGCCTTGATAAAAAAGCGGTTAAGTCAAAAGATAAAGGTGCTTAACCGTTTTTTACCTTCTACAATTCATATAAATCCTC
AAATAAAAACGTAAATTACA

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSHLSIAKFGGTSVANYAAMSASAKIVVNDPNTRVVVLSASAGVTNLLVALANGCDNEERTKLINEVRQIQENILSELKD
DSLVRNKVEKLLANIESLAEAASLATSPALTDELISHGEMMSSLIFVEILREFNTPSTWIDVRNIIATDSHFGKAVPNDH
KTQENSTHILKPLIDRGELIITQGFIGRDEQGKTTTLGRGGSDYSAALLAEVLNAEDVLIWTDVAGIYTTDPRIVPNAKR
IDTMSFSEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEAGGTWVTRDPQHRPIFRAIALRRDQTLLTLSSLNML
HAQGFLANVFTILAKHKISVDVVTTSEVSIALTLDKTGSASSGLSLLSSALIDELSQLCSVKVDSDLALVALIGNDLHIT
SGIAKRIFDTLAPYNIRSISYGASTNNVCLLVTNAHADAVVSALHKNLFE

Sequences:

>Translated_450_residues
MSHLSIAKFGGTSVANYAAMSASAKIVVNDPNTRVVVLSASAGVTNLLVALANGCDNEERTKLINEVRQIQENILSELKD
DSLVRNKVEKLLANIESLAEAASLATSPALTDELISHGEMMSSLIFVEILREFNTPSTWIDVRNIIATDSHFGKAVPNDH
KTQENSTHILKPLIDRGELIITQGFIGRDEQGKTTTLGRGGSDYSAALLAEVLNAEDVLIWTDVAGIYTTDPRIVPNAKR
IDTMSFSEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEAGGTWVTRDPQHRPIFRAIALRRDQTLLTLSSLNML
HAQGFLANVFTILAKHKISVDVVTTSEVSIALTLDKTGSASSGLSLLSSALIDELSQLCSVKVDSDLALVALIGNDLHIT
SGIAKRIFDTLAPYNIRSISYGASTNNVCLLVTNAHADAVVSALHKNLFE
>Mature_449_residues
SHLSIAKFGGTSVANYAAMSASAKIVVNDPNTRVVVLSASAGVTNLLVALANGCDNEERTKLINEVRQIQENILSELKDD
SLVRNKVEKLLANIESLAEAASLATSPALTDELISHGEMMSSLIFVEILREFNTPSTWIDVRNIIATDSHFGKAVPNDHK
TQENSTHILKPLIDRGELIITQGFIGRDEQGKTTTLGRGGSDYSAALLAEVLNAEDVLIWTDVAGIYTTDPRIVPNAKRI
DTMSFSEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEAGGTWVTRDPQHRPIFRAIALRRDQTLLTLSSLNMLH
AQGFLANVFTILAKHKISVDVVTTSEVSIALTLDKTGSASSGLSLLSSALIDELSQLCSVKVDSDLALVALIGNDLHITS
GIAKRIFDTLAPYNIRSISYGASTNNVCLLVTNAHADAVVSALHKNLFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=61.5555555555556, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1786183, Length=466, Percent_Identity=30.9012875536481, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1790376, Length=292, Percent_Identity=29.7945205479452, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320893, Length=508, Percent_Identity=27.9527559055118, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48247; Mature: 48115

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLSIAKFGGTSVANYAAMSASAKIVVNDPNTRVVVLSASAGVTNLLVALANGCDNEER
CCCCEEEECCCCCHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHH
TKLINEVRQIQENILSELKDDSLVRNKVEKLLANIESLAEAASLATSPALTDELISHGEM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MSSLIFVEILREFNTPSTWIDVRNIIATDSHFGKAVPNDHKTQENSTHILKPLIDRGELI
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
ITQGFIGRDEQGKTTTLGRGGSDYSAALLAEVLNAEDVLIWTDVAGIYTTDPRIVPNAKR
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCHH
IDTMSFSEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEAGGTWVTRDPQHRPIF
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHH
RAIALRRDQTLLTLSSLNMLHAQGFLANVFTILAKHKISVDVVTTSEVSIALTLDKTGSA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEECCCCCC
SSGLSLLSSALIDELSQLCSVKVDSDLALVALIGNDLHITSGIAKRIFDTLAPYNIRSIS
HHHHHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCCEEEEE
YGASTNNVCLLVTNAHADAVVSALHKNLFE
ECCCCCCEEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHLSIAKFGGTSVANYAAMSASAKIVVNDPNTRVVVLSASAGVTNLLVALANGCDNEER
CCCEEEECCCCCHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHH
TKLINEVRQIQENILSELKDDSLVRNKVEKLLANIESLAEAASLATSPALTDELISHGEM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MSSLIFVEILREFNTPSTWIDVRNIIATDSHFGKAVPNDHKTQENSTHILKPLIDRGELI
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
ITQGFIGRDEQGKTTTLGRGGSDYSAALLAEVLNAEDVLIWTDVAGIYTTDPRIVPNAKR
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCHH
IDTMSFSEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEAGGTWVTRDPQHRPIF
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHH
RAIALRRDQTLLTLSSLNMLHAQGFLANVFTILAKHKISVDVVTTSEVSIALTLDKTGSA
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEECCCCCC
SSGLSLLSSALIDELSQLCSVKVDSDLALVALIGNDLHITSGIAKRIFDTLAPYNIRSIS
HHHHHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCCEEEEE
YGASTNNVCLLVTNAHADAVVSALHKNLFE
ECCCCCCEEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]