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The map label for this gene is proA

Identifier: 15602801

GI number: 15602801

Start: 1104203

End: 1105465

Strand: Direct

Name: proA

Synonym: PM0936

Alternate gene names: 15602801

Gene position: 1104203-1105465 (Clockwise)

Preceding gene: 15602800

Following gene: 15602802

Centisome position: 48.91

GC content: 43.71

Gene sequence:

>1263_bases
ATGACCACAAATTTACAAGAAATGGGAAAACAGGCTAAACAAGCTGCCTTTGTACTCGCACAGCTCTCACAACAACAAAA
AAATCAAGCACTCGAAATCATTGCACAGCAGCTTGAAGCACAAAGCGATAAGATTTTAGCCGAAAACCAAAAAGACATCG
CACTGGCAAAACAGAATGGATTATCCGATGCCATCATTGATCGTCTTTTACTCACACCATCACGATTAAATGACATCGCT
AATGATGTTCACCATGTCATCTCCTTAGCCGATCCTGTTGGTCAACTCATTGATGGCGGCATACTTGATAGCGGTTTAAA
AATTGAGCGAGTCCGTGTTCCTCTTGGTGTCATTGGTACTATTTATGAGGCTCGCCCGAATGTCACTATTGATGTCGCAA
GCTTATGCCTAAAAACAGGCAACGCCGTCATCTTACGCGGTGGCAAAGAAACACAATATTCTAATAAAATTTTAGTCGAC
GTCGTGCAACATGCCTTAGTCCAAGCCGGACTACCGAAATATGCTATCCAAGCAATTACCGATCCTGATCGTCACTTAGT
GATGGAATTGCTGAAATTAGATCGTTATGTCGATATGATCATTCCTCGTGGTGGCGCAAGTTTACATGAGCTTTGTAAAC
AGCACTCGACTATTCCTGTTATTGTAGGCGGGATTGGTGTATGTCATCTATTTATCGAGCAAAGTGCCGATCTTGATAAA
GCCCTGCCTTTAATTGAAAACGCCAAAACACAACGTCCAAGTACCTGTAATACATTGGAAACACTGCTTGTCCAACGAGC
TATTGCTACGCAATTCTTACCCAAGTTGGCACAACACCTCTCCGCTAAGCACGTCAAATTTCACGCAGATCCGACCGCAC
TTGCTATCTTACAATCGGTACAAGCAGATGTTGAACCTGTTCAAGCACATCAGCTACGCCAAGAATGGCTTTCTTATGAT
TTAAATGTCGTGATTGTTGATGATATTGAACAAGCTATTGCACATATTCGTGAATATGGTAGCCAACATTCCGACGGTAT
TCTGACCGGCTCACAACGGTTGGCTCAACAATTTGTTGCACAGGTGGATTCGGCTGCGGTTTATGTGAATGCTAGCACAC
GTTTTACAGACGGAGGACAATTCGGACTCGGTGCTGAAGTCGCTGTCAGTACACAAAAACTGCATGCACGAGGTCCAATG
GGACTCGAAGCATTGACGACCTATAAATGGGTTTGTGTCGGCGACTATTGCGTAAGAAGCTAA

Upstream 100 bases:

>100_bases
CTACCTGTTTTTGACTATCAAGAGCAAGAAATGGCAAAGAAGAGTAATGATGACAAATTACCCAAAAAAGTAACATGGAA
AAAATAATCAGGAAAAAACA

Downstream 100 bases:

>100_bases
AGACGAGTCATTTGTGACAGCTTATCAACCCCATGTTCACAAAATATGTTTGACAAGTTTTTTATAAATCGTTATTTGTT
TTACCTCAAACACAACATAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTTNLQEMGKQAKQAAFVLAQLSQQQKNQALEIIAQQLEAQSDKILAENQKDIALAKQNGLSDAIIDRLLLTPSRLNDIA
NDVHHVISLADPVGQLIDGGILDSGLKIERVRVPLGVIGTIYEARPNVTIDVASLCLKTGNAVILRGGKETQYSNKILVD
VVQHALVQAGLPKYAIQAITDPDRHLVMELLKLDRYVDMIIPRGGASLHELCKQHSTIPVIVGGIGVCHLFIEQSADLDK
ALPLIENAKTQRPSTCNTLETLLVQRAIATQFLPKLAQHLSAKHVKFHADPTALAILQSVQADVEPVQAHQLRQEWLSYD
LNVVIVDDIEQAIAHIREYGSQHSDGILTGSQRLAQQFVAQVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPM
GLEALTTYKWVCVGDYCVRS

Sequences:

>Translated_420_residues
MTTNLQEMGKQAKQAAFVLAQLSQQQKNQALEIIAQQLEAQSDKILAENQKDIALAKQNGLSDAIIDRLLLTPSRLNDIA
NDVHHVISLADPVGQLIDGGILDSGLKIERVRVPLGVIGTIYEARPNVTIDVASLCLKTGNAVILRGGKETQYSNKILVD
VVQHALVQAGLPKYAIQAITDPDRHLVMELLKLDRYVDMIIPRGGASLHELCKQHSTIPVIVGGIGVCHLFIEQSADLDK
ALPLIENAKTQRPSTCNTLETLLVQRAIATQFLPKLAQHLSAKHVKFHADPTALAILQSVQADVEPVQAHQLRQEWLSYD
LNVVIVDDIEQAIAHIREYGSQHSDGILTGSQRLAQQFVAQVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPM
GLEALTTYKWVCVGDYCVRS
>Mature_419_residues
TTNLQEMGKQAKQAAFVLAQLSQQQKNQALEIIAQQLEAQSDKILAENQKDIALAKQNGLSDAIIDRLLLTPSRLNDIAN
DVHHVISLADPVGQLIDGGILDSGLKIERVRVPLGVIGTIYEARPNVTIDVASLCLKTGNAVILRGGKETQYSNKILVDV
VQHALVQAGLPKYAIQAITDPDRHLVMELLKLDRYVDMIIPRGGASLHELCKQHSTIPVIVGGIGVCHLFIEQSADLDKA
LPLIENAKTQRPSTCNTLETLLVQRAIATQFLPKLAQHLSAKHVKFHADPTALAILQSVQADVEPVQAHQLRQEWLSYDL
NVVIVDDIEQAIAHIREYGSQHSDGILTGSQRLAQQFVAQVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMG
LEALTTYKWVCVGDYCVRS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=37.6811594202899, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=37.6811594202899, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=65.3846153846154, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17569967, Length=418, Percent_Identity=36.8421052631579, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17569969, Length=418, Percent_Identity=36.8421052631579, Blast_Score=271, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=34.6420323325635, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21357643, Length=416, Percent_Identity=35.8173076923077, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PASMU (Q9CM98)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245873.1
- ProteinModelPortal:   Q9CM98
- GeneID:   1244283
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0936
- NMPDR:   fig|272843.1.peg.936
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   PMUL272843:PM0936-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45758; Mature: 45627

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNLQEMGKQAKQAAFVLAQLSQQQKNQALEIIAQQLEAQSDKILAENQKDIALAKQNG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCC
LSDAIIDRLLLTPSRLNDIANDVHHVISLADPVGQLIDGGILDSGLKIERVRVPLGVIGT
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHH
IYEARPNVTIDVASLCLKTGNAVILRGGKETQYSNKILVDVVQHALVQAGLPKYAIQAIT
HHHCCCCCEEHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCC
DPDRHLVMELLKLDRYVDMIIPRGGASLHELCKQHSTIPVIVGGIGVCHLFIEQSADLDK
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCHHH
ALPLIENAKTQRPSTCNTLETLLVQRAIATQFLPKLAQHLSAKHVKFHADPTALAILQSV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
QADVEPVQAHQLRQEWLSYDLNVVIVDDIEQAIAHIREYGSQHSDGILTGSQRLAQQFVA
HHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
QVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWVCVGDYCVRS
HHCCCEEEEECCCEECCCCCCCCCCHHEEHHHHHHCCCCCCHHHHHHEEEEEECHHHHCC
>Mature Secondary Structure 
TTNLQEMGKQAKQAAFVLAQLSQQQKNQALEIIAQQLEAQSDKILAENQKDIALAKQNG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCC
LSDAIIDRLLLTPSRLNDIANDVHHVISLADPVGQLIDGGILDSGLKIERVRVPLGVIGT
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHH
IYEARPNVTIDVASLCLKTGNAVILRGGKETQYSNKILVDVVQHALVQAGLPKYAIQAIT
HHHCCCCCEEHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCC
DPDRHLVMELLKLDRYVDMIIPRGGASLHELCKQHSTIPVIVGGIGVCHLFIEQSADLDK
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCHHH
ALPLIENAKTQRPSTCNTLETLLVQRAIATQFLPKLAQHLSAKHVKFHADPTALAILQSV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
QADVEPVQAHQLRQEWLSYDLNVVIVDDIEQAIAHIREYGSQHSDGILTGSQRLAQQFVA
HHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
QVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWVCVGDYCVRS
HHCCCEEEEECCCEECCCCCCCCCCHHEEHHHHHHCCCCCCHHHHHHEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100