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The map label for this gene is ponC [H]

Identifier: 15602509

GI number: 15602509

Start: 745946

End: 748303

Strand: Direct

Name: ponC [H]

Synonym: PM0644

Alternate gene names: 15602509

Gene position: 745946-748303 (Clockwise)

Preceding gene: 15602508

Following gene: 15602511

Centisome position: 33.04

GC content: 41.14

Gene sequence:

>2358_bases
ATGGCTCGCTTACGTAAAAACTGTATTTTATCGCTGCTTTATACCGCACTTTTACTTGCCTGCGTGGTGACCATTGTTCG
CCTTTTACCTTACTCCCCATTAAAAGATCATTTCCCCTATTCCAGCGCAGTTTATGACGAGCAACAAAATTTGTTACGCC
TCACCACCGCCAAAGATGAGAAATACCGTCTATGGACACCTCTCCATGATATCTCCCCGAAACTTGTTGATGCGGTGCTT
TTTCAGGAGGATGAATGGTTTTATTGGCATTTTGGTGTTAATCCTTACGGGCTATTGCGTGGGGCTTGGCAAACCTACAT
TTTAGGCAACTCACCACAAGGTGGATCAACGATTACTATGCAACTGGCTCGTGTCTTATGGGCTATTGACAGCCGAAGTC
TATTAGGCAAAACAGAACAAATCTTACGCGCAATCCAACTGGAAATACGTTACTCAAAAAAAGAGATTTTAGAGGCTTAT
TTGAATTTTGCCCCTTATGGCAGAAATATTGAAGGGGCGGGAACCGCCAGTTTAATCTACTTTAATAAAGCCAATCATAA
GATGAATTTGGCTGAAGCGCTTACCTTAGCGATTTTACCAAAGAATCCGAACAGCTATATTCGTCAAAACAATCAACAGC
TGAATTCTGCTTTATTCAAGGCACGTAACCAACTTTACCAACGTTGGATAGCACAATACCCTGCTGATCAACAATGGCAA
ACAGATTTTCAACTCAATTATCCACTGCGACCACTCGAAAAACTACCGTTTTTTGCACCGCATTTTGTTGATCAATTACT
ACAACAATATCCTGAACAAACGCATATTGTCAGTACGCTCAATAGCTCCCAACAGCGATTAATTGAGCGTATTACACGCC
GCTATTTATCCCAGCAATACACTAAAGGAATAGAAAATGTCGCAGTACTATTAGTGGATAATCGCGATATGGCAGTAAAA
GCCTTGATCGGTTCGGGTAACTATTTTAATCCAGCCATTTCGGGACAAATTAATGGTACTTTAGCTAACCGCTCTTATGG
TTCAACGTTAAAACCTTTTATTTACGCATTGGCGTTTGATCAAGGTTTAGCCCACGGCAAAACCGTTTTAAAAGATTTGC
CAACGACCTTTGGTGATTACCAGCCCGAAAATTACGAAGGCAATTTTTTAGGTCCCGTCAGTGTTACTCAGGCGTTATTA
CAAAGCCGCAATATTCCTGCTATTGATCTTGCCAAACAACTTAACCCCGATCTTTACGACTTTCTCCAACAAGCAGATAT
CAAACTACCCAAAAGTAAAAGCTATTATGGCTTATCTCTAGTATTAGGCGGTGCTGAATTAAATCTACAACAGTTAGCCA
GTTTATATGCGATGTTAGCCAATCAAGGGAGATGGCAACCGTTGAAATTCAACCAACGAGATAGTCTTCCTGCGCCTAAA
ACCGTATTAAGTCAAGAAAGTGCGGTCATGATTCATGATATTTTGCGGCAAAATTTTCGCACCGATATGCAAAATAAATC
GATTAAGACTGCATTACCGCTCTATTGGAAGACCGGCACGTCAAATGGGCTACGTGATGCGTGGACGGCAGGTTATTTTG
GACACTATACTCTTGTGGTTTGGTTTGGTAATTTTAACAATAAAAATAACCCGCATTTTATTGGGCGTGCTTTGGCTGCC
CCTTTGTTCTTACAACTGGCAGACAGTCTGATTGCTAGTGAGCCTCAAATGCGTGACATTGTCACTGAGAATATCAATCA
ACTCAATTTAAAAAATGTCCTCGTTTGTCAGGCGGACGGAAATCTACCGAATGCCTATTGCCAACAACAAGTCAACACCC
TGTTTATTCCCGGAAAATCGCCGATTACCATCAGCCAGCTTTATCAGCCTTTTATGGTACTCAAAAATAGCGACATGTTG
GCATGTTCAACACATGATAAAGCCGAAACGGAACAAAAAATTTATGAAATGTGGTCAAGTGATTTTCAACAGATTTTTGC
GCAAGCTGGCGTCATGAAAAGAATGCCGATCATAAATACGGCTTGCCCTTATGAACAACAACACCAAGCCTTACAAAATC
TACACCATAATAATCCGCAAATCGTTTCGCCATTAGCACAACGTCATTATTATATTGAACATGACAACCCAAAAAGCCCT
TTACTTCTGTCAGCTATTGCCGCGGGTGAAGTCAAAAAATTATACTGGTTTGTCAATAATAGTTTTATTGGTGAAGCCTT
GCCGCAGCAGCCCCTTTTTTGGCAACCTAGGTCAGCAGGCTATTATACGATCTCGGTGACAGATGATTACGGCAGAAGCA
CAAGCCTTTCCATTAATGTGCTACTGAAAGGATTTTAA

Upstream 100 bases:

>100_bases
GATCCCATTCCCACGTTCACCGCGTAATGCAAACTTCTAAACAAACTTAACACTGCTAATTCCCCTTATATTATTAAGGG
GAATTTTTTAGGTCACCTGA

Downstream 100 bases:

>100_bases
AAAGCCCCTGCGCATTTACTTGCTATGGGGCTTTTAGCTAGAACTTTAATTAAAATGCTCTAATCCATATTGATACAGCG
CATTTTTCTTATAACCATAG

Product: PonC

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MARLRKNCILSLLYTALLLACVVTIVRLLPYSPLKDHFPYSSAVYDEQQNLLRLTTAKDEKYRLWTPLHDISPKLVDAVL
FQEDEWFYWHFGVNPYGLLRGAWQTYILGNSPQGGSTITMQLARVLWAIDSRSLLGKTEQILRAIQLEIRYSKKEILEAY
LNFAPYGRNIEGAGTASLIYFNKANHKMNLAEALTLAILPKNPNSYIRQNNQQLNSALFKARNQLYQRWIAQYPADQQWQ
TDFQLNYPLRPLEKLPFFAPHFVDQLLQQYPEQTHIVSTLNSSQQRLIERITRRYLSQQYTKGIENVAVLLVDNRDMAVK
ALIGSGNYFNPAISGQINGTLANRSYGSTLKPFIYALAFDQGLAHGKTVLKDLPTTFGDYQPENYEGNFLGPVSVTQALL
QSRNIPAIDLAKQLNPDLYDFLQQADIKLPKSKSYYGLSLVLGGAELNLQQLASLYAMLANQGRWQPLKFNQRDSLPAPK
TVLSQESAVMIHDILRQNFRTDMQNKSIKTALPLYWKTGTSNGLRDAWTAGYFGHYTLVVWFGNFNNKNNPHFIGRALAA
PLFLQLADSLIASEPQMRDIVTENINQLNLKNVLVCQADGNLPNAYCQQQVNTLFIPGKSPITISQLYQPFMVLKNSDML
ACSTHDKAETEQKIYEMWSSDFQQIFAQAGVMKRMPIINTACPYEQQHQALQNLHHNNPQIVSPLAQRHYYIEHDNPKSP
LLLSAIAAGEVKKLYWFVNNSFIGEALPQQPLFWQPRSAGYYTISVTDDYGRSTSLSINVLLKGF

Sequences:

>Translated_785_residues
MARLRKNCILSLLYTALLLACVVTIVRLLPYSPLKDHFPYSSAVYDEQQNLLRLTTAKDEKYRLWTPLHDISPKLVDAVL
FQEDEWFYWHFGVNPYGLLRGAWQTYILGNSPQGGSTITMQLARVLWAIDSRSLLGKTEQILRAIQLEIRYSKKEILEAY
LNFAPYGRNIEGAGTASLIYFNKANHKMNLAEALTLAILPKNPNSYIRQNNQQLNSALFKARNQLYQRWIAQYPADQQWQ
TDFQLNYPLRPLEKLPFFAPHFVDQLLQQYPEQTHIVSTLNSSQQRLIERITRRYLSQQYTKGIENVAVLLVDNRDMAVK
ALIGSGNYFNPAISGQINGTLANRSYGSTLKPFIYALAFDQGLAHGKTVLKDLPTTFGDYQPENYEGNFLGPVSVTQALL
QSRNIPAIDLAKQLNPDLYDFLQQADIKLPKSKSYYGLSLVLGGAELNLQQLASLYAMLANQGRWQPLKFNQRDSLPAPK
TVLSQESAVMIHDILRQNFRTDMQNKSIKTALPLYWKTGTSNGLRDAWTAGYFGHYTLVVWFGNFNNKNNPHFIGRALAA
PLFLQLADSLIASEPQMRDIVTENINQLNLKNVLVCQADGNLPNAYCQQQVNTLFIPGKSPITISQLYQPFMVLKNSDML
ACSTHDKAETEQKIYEMWSSDFQQIFAQAGVMKRMPIINTACPYEQQHQALQNLHHNNPQIVSPLAQRHYYIEHDNPKSP
LLLSAIAAGEVKKLYWFVNNSFIGEALPQQPLFWQPRSAGYYTISVTDDYGRSTSLSINVLLKGF
>Mature_784_residues
ARLRKNCILSLLYTALLLACVVTIVRLLPYSPLKDHFPYSSAVYDEQQNLLRLTTAKDEKYRLWTPLHDISPKLVDAVLF
QEDEWFYWHFGVNPYGLLRGAWQTYILGNSPQGGSTITMQLARVLWAIDSRSLLGKTEQILRAIQLEIRYSKKEILEAYL
NFAPYGRNIEGAGTASLIYFNKANHKMNLAEALTLAILPKNPNSYIRQNNQQLNSALFKARNQLYQRWIAQYPADQQWQT
DFQLNYPLRPLEKLPFFAPHFVDQLLQQYPEQTHIVSTLNSSQQRLIERITRRYLSQQYTKGIENVAVLLVDNRDMAVKA
LIGSGNYFNPAISGQINGTLANRSYGSTLKPFIYALAFDQGLAHGKTVLKDLPTTFGDYQPENYEGNFLGPVSVTQALLQ
SRNIPAIDLAKQLNPDLYDFLQQADIKLPKSKSYYGLSLVLGGAELNLQQLASLYAMLANQGRWQPLKFNQRDSLPAPKT
VLSQESAVMIHDILRQNFRTDMQNKSIKTALPLYWKTGTSNGLRDAWTAGYFGHYTLVVWFGNFNNKNNPHFIGRALAAP
LFLQLADSLIASEPQMRDIVTENINQLNLKNVLVCQADGNLPNAYCQQQVNTLFIPGKSPITISQLYQPFMVLKNSDMLA
CSTHDKAETEQKIYEMWSSDFQQIFAQAGVMKRMPIINTACPYEQQHQALQNLHHNNPQIVSPLAQRHYYIEHDNPKSPL
LLSAIAAGEVKKLYWFVNNSFIGEALPQQPLFWQPRSAGYYTISVTDDYGRSTSLSINVLLKGF

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=795, Percent_Identity=28.9308176100629, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786343, Length=539, Percent_Identity=25.7884972170686, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082258, Length=248, Percent_Identity=30.6451612903226, Blast_Score=106, Evalue=7e-24,
Organism=Escherichia coli, GI1789601, Length=212, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 89317; Mature: 89186

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLRKNCILSLLYTALLLACVVTIVRLLPYSPLKDHFPYSSAVYDEQQNLLRLTTAKDE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCEEEEEECCCC
KYRLWTPLHDISPKLVDAVLFQEDEWFYWHFGVNPYGLLRGAWQTYILGNSPQGGSTITM
CEEEECCHHHCCHHHHHHHHEECCCEEEEEECCCHHHHHHHCEEEEEECCCCCCCCHHHH
QLARVLWAIDSRSLLGKTEQILRAIQLEIRYSKKEILEAYLNFAPYGRNIEGAGTASLIY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEE
FNKANHKMNLAEALTLAILPKNPNSYIRQNNQQLNSALFKARNQLYQRWIAQYPADQQWQ
EECCCCCCCHHHEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TDFQLNYPLRPLEKLPFFAPHFVDQLLQQYPEQTHIVSTLNSSQQRLIERITRRYLSQQY
CCEEECCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TKGIENVAVLLVDNRDMAVKALIGSGNYFNPAISGQINGTLANRSYGSTLKPFIYALAFD
HCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
QGLAHGKTVLKDLPTTFGDYQPENYEGNFLGPVSVTQALLQSRNIPAIDLAKQLNPDLYD
HCHHHHHHHHHHCCHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
FLQQADIKLPKSKSYYGLSLVLGGAELNLQQLASLYAMLANQGRWQPLKFNQRDSLPAPK
HHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
TVLSQESAVMIHDILRQNFRTDMQNKSIKTALPLYWKTGTSNGLRDAWTAGYFGHYTLVV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCCEEEEE
WFGNFNNKNNPHFIGRALAAPLFLQLADSLIASEPQMRDIVTENINQLNLKNVLVCQADG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCC
NLPNAYCQQQVNTLFIPGKSPITISQLYQPFMVLKNSDMLACSTHDKAETEQKIYEMWSS
CCCHHHHHHCCCEEEECCCCCEEHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHH
DFQQIFAQAGVMKRMPIINTACPYEQQHQALQNLHHNNPQIVSPLAQRHYYIEHDNPKSP
HHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCC
LLLSAIAAGEVKKLYWFVNNSFIGEALPQQPLFWQPRSAGYYTISVTDDYGRSTSLSINV
HHHHHHHHCCCEEEEEEECCCHHHCCCCCCCCEECCCCCCEEEEEEECCCCCCCEEEEEE
LLKGF
EEECC
>Mature Secondary Structure 
ARLRKNCILSLLYTALLLACVVTIVRLLPYSPLKDHFPYSSAVYDEQQNLLRLTTAKDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHCEEEEEECCCC
KYRLWTPLHDISPKLVDAVLFQEDEWFYWHFGVNPYGLLRGAWQTYILGNSPQGGSTITM
CEEEECCHHHCCHHHHHHHHEECCCEEEEEECCCHHHHHHHCEEEEEECCCCCCCCHHHH
QLARVLWAIDSRSLLGKTEQILRAIQLEIRYSKKEILEAYLNFAPYGRNIEGAGTASLIY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEE
FNKANHKMNLAEALTLAILPKNPNSYIRQNNQQLNSALFKARNQLYQRWIAQYPADQQWQ
EECCCCCCCHHHEEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TDFQLNYPLRPLEKLPFFAPHFVDQLLQQYPEQTHIVSTLNSSQQRLIERITRRYLSQQY
CCEEECCCCCHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TKGIENVAVLLVDNRDMAVKALIGSGNYFNPAISGQINGTLANRSYGSTLKPFIYALAFD
HCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
QGLAHGKTVLKDLPTTFGDYQPENYEGNFLGPVSVTQALLQSRNIPAIDLAKQLNPDLYD
HCHHHHHHHHHHCCHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
FLQQADIKLPKSKSYYGLSLVLGGAELNLQQLASLYAMLANQGRWQPLKFNQRDSLPAPK
HHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
TVLSQESAVMIHDILRQNFRTDMQNKSIKTALPLYWKTGTSNGLRDAWTAGYFGHYTLVV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCCEEEEE
WFGNFNNKNNPHFIGRALAAPLFLQLADSLIASEPQMRDIVTENINQLNLKNVLVCQADG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCC
NLPNAYCQQQVNTLFIPGKSPITISQLYQPFMVLKNSDMLACSTHDKAETEQKIYEMWSS
CCCHHHHHHCCCEEEECCCCCEEHHHHHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHH
DFQQIFAQAGVMKRMPIINTACPYEQQHQALQNLHHNNPQIVSPLAQRHYYIEHDNPKSP
HHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCEEEECCCCCCC
LLLSAIAAGEVKKLYWFVNNSFIGEALPQQPLFWQPRSAGYYTISVTDDYGRSTSLSINV
HHHHHHHHCCCEEEEEEECCCHHHCCCCCCCCEECCCCCCEEEEEEECCCCCCCEEEEEE
LLKGF
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]