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The map label for this gene is bioD

Identifier: 15602506

GI number: 15602506

Start: 742077

End: 742811

Strand: Reverse

Name: bioD

Synonym: PM0641

Alternate gene names: 15602506

Gene position: 742811-742077 (Counterclockwise)

Preceding gene: 15602507

Following gene: 15602504

Centisome position: 32.9

GC content: 37.69

Gene sequence:

>735_bases
ATGAGCAGTTTTTTTCTGACAGGCACGGATACTAATGTAGGTAAAACAGTCGCAAGTCGAGCCATTATACAAGCTTTACA
AAATCAAGGTATCCAAATTGTGGGCTATAAACCAGTTGCCTTTAGTCGAGAAGAATGTGTTTATACCGATATGGAAAATC
AACAAGCCGCAGAAAGTGATTACGATTCACAAAATAATAGTGATGTGCTAACACTGATGAAATCAACTCACGAAAAAGTA
AGTTATCAGGAAATCAATAGTTATACCTTTCGCCACAGCCTCCCCGTTTTTTCTGTTCAAGGTAAACATATTCGCATTGA
AAAAATGGATGCGGATTTAGCTCGTTTAAATCAAAAGTATCAATCTGTTTTAGTCGAAGGCAGCTATGGTTGGCTAACGC
CCATTAATAAAACGTATTGCTTTGCAGATTGGGCAAAATCACATCAAATGCCCGTTGTATTGGTCGTGGGAATTAAAGAG
GGGTGTCTTAACCATGCGTTATTAACAGTCGAATCTATACAACAGAAAGGGTTGCCATTATTAGGTTGGATTGCTAATCG
AATTAATCCCTGTTTAGGACATTATGCCGAGATTATTGATTTGCTCAGTGAAAAAATTGATGCGCCGTTATTGGGGCAAA
TTCCGTATTTACATAAGCCAGAAGAACAAGACTTAGCACGTTATATTCATAATCTCGATCGCTTAACCTATATGGAAACT
GTTTTAGCAGATTAG

Upstream 100 bases:

>100_bases
TAAAAGGGAATAATTTCTGAGAAAAAGTTGTGTTATCTCAACATTTTTTTTGCGTGATTGCTTTAAGATCTCGCATTAAG
AAATAACAAGGGGATAAACC

Downstream 100 bases:

>100_bases
TGCAACATTCAAGGCAAAAAAAGCGTTTTATCTTTCACAAAACGCTTTTTTTGATCGGAAAATGAACTTATTCCATATTC
ATTTTGGCTTTTTTATTCTT

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase 1; DTBS 1; Dethiobiotin synthase 1

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSSFFLTGTDTNVGKTVASRAIIQALQNQGIQIVGYKPVAFSREECVYTDMENQQAAESDYDSQNNSDVLTLMKSTHEKV
SYQEINSYTFRHSLPVFSVQGKHIRIEKMDADLARLNQKYQSVLVEGSYGWLTPINKTYCFADWAKSHQMPVVLVVGIKE
GCLNHALLTVESIQQKGLPLLGWIANRINPCLGHYAEIIDLLSEKIDAPLLGQIPYLHKPEEQDLARYIHNLDRLTYMET
VLAD

Sequences:

>Translated_244_residues
MSSFFLTGTDTNVGKTVASRAIIQALQNQGIQIVGYKPVAFSREECVYTDMENQQAAESDYDSQNNSDVLTLMKSTHEKV
SYQEINSYTFRHSLPVFSVQGKHIRIEKMDADLARLNQKYQSVLVEGSYGWLTPINKTYCFADWAKSHQMPVVLVVGIKE
GCLNHALLTVESIQQKGLPLLGWIANRINPCLGHYAEIIDLLSEKIDAPLLGQIPYLHKPEEQDLARYIHNLDRLTYMET
VLAD
>Mature_243_residues
SSFFLTGTDTNVGKTVASRAIIQALQNQGIQIVGYKPVAFSREECVYTDMENQQAAESDYDSQNNSDVLTLMKSTHEKVS
YQEINSYTFRHSLPVFSVQGKHIRIEKMDADLARLNQKYQSVLVEGSYGWLTPINKTYCFADWAKSHQMPVVLVVGIKEG
CLNHALLTVESIQQKGLPLLGWIANRINPCLGHYAEIIDLLSEKIDAPLLGQIPYLHKPEEQDLARYIHNLDRLTYMETV
LAD

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI87081944, Length=250, Percent_Identity=41.6, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786995, Length=231, Percent_Identity=42.8571428571429, Blast_Score=185, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD1_PASMU (Q9CN08)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245578.1
- ProteinModelPortal:   Q9CN08
- GeneID:   1243988
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0641
- NMPDR:   fig|272843.1.peg.641
- HOGENOM:   HBG650065
- OMA:   INPGLSH
- ProtClustDB:   PRK00090
- BioCyc:   PMUL272843:PM0641-MONOMER
- BRENDA:   6.3.3.3
- HAMAP:   MF_00336
- InterPro:   IPR004472
- InterPro:   IPR002586
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: PF01656 CbiA

EC number: =6.3.3.3

Molecular weight: Translated: 27582; Mature: 27451

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFFLTGTDTNVGKTVASRAIIQALQNQGIQIVGYKPVAFSREECVYTDMENQQAAESD
CCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEECCCCCHHHHCC
YDSQNNSDVLTLMKSTHEKVSYQEINSYTFRHSLPVFSVQGKHIRIEKMDADLARLNQKY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEECCCEEEEEECCHHHHHHHHHH
QSVLVEGSYGWLTPINKTYCFADWAKSHQMPVVLVVGIKEGCLNHALLTVESIQQKGLPL
HHHEECCCCCCCCCCCCCEEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCH
LGWIANRINPCLGHYAEIIDLLSEKIDAPLLGQIPYLHKPEEQDLARYIHNLDRLTYMET
HHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLAD
HHCC
>Mature Secondary Structure 
SSFFLTGTDTNVGKTVASRAIIQALQNQGIQIVGYKPVAFSREECVYTDMENQQAAESD
CCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEECCCCCHHHHCC
YDSQNNSDVLTLMKSTHEKVSYQEINSYTFRHSLPVFSVQGKHIRIEKMDADLARLNQKY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEECCCEEEEEECCHHHHHHHHHH
QSVLVEGSYGWLTPINKTYCFADWAKSHQMPVVLVVGIKEGCLNHALLTVESIQQKGLPL
HHHEECCCCCCCCCCCCCEEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCH
LGWIANRINPCLGHYAEIIDLLSEKIDAPLLGQIPYLHKPEEQDLARYIHNLDRLTYMET
HHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLAD
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100