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The map label for this gene is purK [H]

Identifier: 15602485

GI number: 15602485

Start: 723719

End: 724807

Strand: Direct

Name: purK [H]

Synonym: PM0620

Alternate gene names: 15602485

Gene position: 723719-724807 (Clockwise)

Preceding gene: 15602484

Following gene: 15602486

Centisome position: 32.06

GC content: 41.32

Gene sequence:

>1089_bases
ATGCAAAAAAGTGCTTTATATCCAACAGTGTATGTCCTCGGTAATGGACAGCTCGGGCGAATGTTACGTTATGCGGGTGC
CCCTTTAGATATTGATGTCCAACCGCTTGCTTTTAATACTCCACGCTTTGACTTAGCAGCGGACAGTATCATCACCGCAG
AAATTGAACGTTGGGAAAAAACACCTTTAACGGAAATGCTTGCTCATCACGCCAATTTTGTGAATCAAAGTGTGTTTGCC
AAATTAGCTGATCGGTTATCACAAAAAACTTTGCTTGATGCACTCCAGTTACCCACTTCCCCATGGTGCTTATTAAAAGA
CAAAAATCAATGGTCAACGGTATTCGATAGCATTGGCGAGAAAGTCGTCGTCAAACGTCGTATGGGGGGCTATGATGGTC
GAGGTCAGTGGATTGTTCAACAACAAAATACCGATGCCATTACCGACGATTTATACGGTGAAACCATTGCTGAAAAATTT
ATTCCTTTTGATTATGAAATTTCTCTTGTAGGCGCACGTTTTAAAAATGGTGAAACACGTTTCTATCCTGTCACGCACAA
TTTACAGCAAAATGGTATTTTGCGTTATAGCGTGGTCGATATAAATTTCCCACAGCAAGTACAACAGCAAGCCAGCGCTG
AAGCCATGCTAAGTAAAATTATGCACCAATTAAATTATGTTGGGGTGATGGCGATGGAATGTTTTGTGGTCGGTGATCAG
CTATTAATTAATGAATTGGCGCCTCGTGTTCATAACAGTGGACATTGGACACAACTAGGTTGTGCCATTAGTCAATTTGA
ATTGCATTTGCGTGCGTTATTGGATTTACCCACACCAACGCTTGGCACCTTTGCGCCGAGTGTGATGGTCAATCTGATTG
GAACAGAACACAATCCAGCTTGGTTAAATACGCCATTCAGCCAACTACATTGGTATGGCAAAGAAGTGCGTCTCGGACGT
AAAGTGGGACACATTAACTTTACACATATTGATAAAAAAGTATTGATCGCAAGCTTAACCACATTAGCACAGGCGTTACC
TGCGGATTATCAATCTGGTTTAAATTGGGCAATAGAAAAATTACAATAA

Upstream 100 bases:

>100_bases
ATAGCGTACTAGAAAATCCAGATCCACGGATGCCATAGCATTTTAGGGCGGACAGATGTTCGCCCTCTCTCTTTTACTTT
CTTTATATAATGGTTTGAAT

Downstream 100 bases:

>100_bases
TTCAATTTATTTGCTAATTTTTAAGAGATTATTCAAAAAATAGGATGAGTTTTTAAATTCCTTTAAAGCGGGCTTGATAA
TATTTGCCTCGTGCAGTATA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQKSALYPTVYVLGNGQLGRMLRYAGAPLDIDVQPLAFNTPRFDLAADSIITAEIERWEKTPLTEMLAHHANFVNQSVFA
KLADRLSQKTLLDALQLPTSPWCLLKDKNQWSTVFDSIGEKVVVKRRMGGYDGRGQWIVQQQNTDAITDDLYGETIAEKF
IPFDYEISLVGARFKNGETRFYPVTHNLQQNGILRYSVVDINFPQQVQQQASAEAMLSKIMHQLNYVGVMAMECFVVGDQ
LLINELAPRVHNSGHWTQLGCAISQFELHLRALLDLPTPTLGTFAPSVMVNLIGTEHNPAWLNTPFSQLHWYGKEVRLGR
KVGHINFTHIDKKVLIASLTTLAQALPADYQSGLNWAIEKLQ

Sequences:

>Translated_362_residues
MQKSALYPTVYVLGNGQLGRMLRYAGAPLDIDVQPLAFNTPRFDLAADSIITAEIERWEKTPLTEMLAHHANFVNQSVFA
KLADRLSQKTLLDALQLPTSPWCLLKDKNQWSTVFDSIGEKVVVKRRMGGYDGRGQWIVQQQNTDAITDDLYGETIAEKF
IPFDYEISLVGARFKNGETRFYPVTHNLQQNGILRYSVVDINFPQQVQQQASAEAMLSKIMHQLNYVGVMAMECFVVGDQ
LLINELAPRVHNSGHWTQLGCAISQFELHLRALLDLPTPTLGTFAPSVMVNLIGTEHNPAWLNTPFSQLHWYGKEVRLGR
KVGHINFTHIDKKVLIASLTTLAQALPADYQSGLNWAIEKLQ
>Mature_362_residues
MQKSALYPTVYVLGNGQLGRMLRYAGAPLDIDVQPLAFNTPRFDLAADSIITAEIERWEKTPLTEMLAHHANFVNQSVFA
KLADRLSQKTLLDALQLPTSPWCLLKDKNQWSTVFDSIGEKVVVKRRMGGYDGRGQWIVQQQNTDAITDDLYGETIAEKF
IPFDYEISLVGARFKNGETRFYPVTHNLQQNGILRYSVVDINFPQQVQQQASAEAMLSKIMHQLNYVGVMAMECFVVGDQ
LLINELAPRVHNSGHWTQLGCAISQFELHLRALLDLPTPTLGTFAPSVMVNLIGTEHNPAWLNTPFSQLHWYGKEVRLGR
KVGHINFTHIDKKVLIASLTTLAQALPADYQSGLNWAIEKLQ

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=353, Percent_Identity=57.7903682719547, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788155, Length=377, Percent_Identity=26.790450928382, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=30.4347826086957, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40762; Mature: 40762

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSALYPTVYVLGNGQLGRMLRYAGAPLDIDVQPLAFNTPRFDLAADSIITAEIERWEK
CCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEECCCCCCHHHCHHHHHHHHHHCC
TPLTEMLAHHANFVNQSVFAKLADRLSQKTLLDALQLPTSPWCLLKDKNQWSTVFDSIGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCH
KVVVKRRMGGYDGRGQWIVQQQNTDAITDDLYGETIAEKFIPFDYEISLVGARFKNGETR
HEEHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEE
FYPVTHNLQQNGILRYSVVDINFPQQVQQQASAEAMLSKIMHQLNYVGVMAMECFVVGDQ
EEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLINELAPRVHNSGHWTQLGCAISQFELHLRALLDLPTPTLGTFAPSVMVNLIGTEHNPA
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
WLNTPFSQLHWYGKEVRLGRKVGHINFTHIDKKVLIASLTTLAQALPADYQSGLNWAIEK
CCCCCHHHHHHCCHHHHHCCEECCEEEEHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHH
LQ
CC
>Mature Secondary Structure
MQKSALYPTVYVLGNGQLGRMLRYAGAPLDIDVQPLAFNTPRFDLAADSIITAEIERWEK
CCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEECCCCCCHHHCHHHHHHHHHHCC
TPLTEMLAHHANFVNQSVFAKLADRLSQKTLLDALQLPTSPWCLLKDKNQWSTVFDSIGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCH
KVVVKRRMGGYDGRGQWIVQQQNTDAITDDLYGETIAEKFIPFDYEISLVGARFKNGETR
HEEHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEE
FYPVTHNLQQNGILRYSVVDINFPQQVQQQASAEAMLSKIMHQLNYVGVMAMECFVVGDQ
EEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLINELAPRVHNSGHWTQLGCAISQFELHLRALLDLPTPTLGTFAPSVMVNLIGTEHNPA
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
WLNTPFSQLHWYGKEVRLGRKVGHINFTHIDKKVLIASLTTLAQALPADYQSGLNWAIEK
CCCCCHHHHHHCCHHHHHCCEECCEEEEHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHH
LQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]