Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 15602484

GI number: 15602484

Start: 723156

End: 723656

Strand: Direct

Name: purE [H]

Synonym: PM0619

Alternate gene names: 15602484

Gene position: 723156-723656 (Clockwise)

Preceding gene: 15602479

Following gene: 15602485

Centisome position: 32.03

GC content: 45.11

Gene sequence:

>501_bases
ATGTCAAATTGCACACCTCAAATTGCGATTGTAATGGGCTCAAAAAGTGACTGGGCAACCATGCAAGAAGCAACCCATAT
TCTTGATGAATTACAAATTCCTTACCACGTTGAAGTGGTGTCTGCACATCGTACCCCAGATAAATTATTTACCTTTGCAG
AAACAGCGAGTGCGAAAGGTTACAAAGTGATTATTGCAGGTGCCGGCGGTGCTGCCCATTTACCGGGTATGATCGCGTCA
AAAACTTTAGTCCCTGTATTGGGCGTACCGGTCAAAAGTTCGATGTTAAGTGGCGTTGATAGTTTGTATTCGATTGTGCA
AATGCCTAAGGGGATTCCTGTCGGAACCTTAGCGATTGGTCCTGCAGGAGCGGCTAATGCAGGCTTATTAGCAGCTCAAA
TCTTAGCAGCCTTTGACACTTCGCTCCTGACAAGATTGACGGCATTTCGAGAAAAGCAAACAAATAGCGTACTAGAAAAT
CCAGATCCACGGATGCCATAG

Upstream 100 bases:

>100_bases
TCGTCTTTTCGTGTAGAAAAAACAAGGCAATCGTTTGCTTATTAATTATTGTATGCTATCCTAGCCACGCTTTAATTTTT
GAATAACATGAAGGAATGAC

Downstream 100 bases:

>100_bases
CATTTTAGGGCGGACAGATGTTCGCCCTCTCTCTTTTACTTTCTTTATATAATGGTTTGAATATGCAAAAAAGTGCTTTA
TATCCAACAGTGTATGTCCT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSNCTPQIAIVMGSKSDWATMQEATHILDELQIPYHVEVVSAHRTPDKLFTFAETASAKGYKVIIAGAGGAAHLPGMIAS
KTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFDTSLLTRLTAFREKQTNSVLEN
PDPRMP

Sequences:

>Translated_166_residues
MSNCTPQIAIVMGSKSDWATMQEATHILDELQIPYHVEVVSAHRTPDKLFTFAETASAKGYKVIIAGAGGAAHLPGMIAS
KTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFDTSLLTRLTAFREKQTNSVLEN
PDPRMP
>Mature_165_residues
SNCTPQIAIVMGSKSDWATMQEATHILDELQIPYHVEVVSAHRTPDKLFTFAETASAKGYKVIIAGAGGAAHLPGMIASK
TLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFDTSLLTRLTAFREKQTNSVLENP
DPRMP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=162, Percent_Identity=75.3086419753086, Blast_Score=213, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=52.9411764705882, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17353; Mature: 17222

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNCTPQIAIVMGSKSDWATMQEATHILDELQIPYHVEVVSAHRTPDKLFTFAETASAKG
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCC
YKVIIAGAGGAAHLPGMIASKTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIG
EEEEEEECCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PAGAANAGLLAAQILAAFDTSLLTRLTAFREKQTNSVLENPDPRMP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNCTPQIAIVMGSKSDWATMQEATHILDELQIPYHVEVVSAHRTPDKLFTFAETASAKG
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCC
YKVIIAGAGGAAHLPGMIASKTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIG
EEEEEEECCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
PAGAANAGLLAAQILAAFDTSLLTRLTAFREKQTNSVLENPDPRMP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 7997179 [H]