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The map label for this gene is msrA

Identifier: 15602470

GI number: 15602470

Start: 702691

End: 703215

Strand: Reverse

Name: msrA

Synonym: PM0605

Alternate gene names: 15602470

Gene position: 703215-702691 (Counterclockwise)

Preceding gene: 15602471

Following gene: 15602461

Centisome position: 31.15

GC content: 39.43

Gene sequence:

>525_bases
ATGACACAACAAGCGATCTTTGCCGGCGGCTGTTTTTGGTGCGTTGAGGCAGTATTTAATCAAATTAAAGGCGTTGAAAA
AGCGACTTCAGGTTATATTAACGGGACGACTGAAAATCCAACTTACAAAGAAGTATGTACCGGTGAAACGGGTCATGCGG
AAGCGGTAAAAGTGGAATTCGATGCGACAGTGATTAGTTATGAAAAATTATTAGACATCTTCTTTTCTATCCATAATCCA
ACCCAATTAAATCACCAGGGCGAAGATGTGGGAACGCAATATCGCACAGGGATTTACTATTTAAATGATGAACAAGAACA
GCTGGCAAATAAGAAAATTGCAGAATTACAACCGCACTTTGCCGAAAAAATTGTCACTGAAGTGCTGCCAGCACAAACTT
TTTATCCCGCAGAAGATTATCACCAAGGCTATTTATTGCAGAACCCACAAAACAGCTACTGTAATTTAGTGGCAACGCCA
AAATTCTTAAAAGCCAAGGTGAAATTTGAGGAAATTTGGAAGTAA

Upstream 100 bases:

>100_bases
GATGACGACGATGAACAACAAGATTTTCACCAAGTAGAACTGATAAATGTGAAAGAAATTCATTAAACTCAAGCGAATAA
ACGATAAAAAAGGAAATCCT

Downstream 100 bases:

>100_bases
ACCATTTCTATCTCGAATATTGGTATAAAATCTCAATCATCATTCAGCGTGACTTTTTAAAAAACGTCACGCTTTTTTAT
ACTCTCAATGCCATATATAT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTQQAIFAGGCFWCVEAVFNQIKGVEKATSGYINGTTENPTYKEVCTGETGHAEAVKVEFDATVISYEKLLDIFFSIHNP
TQLNHQGEDVGTQYRTGIYYLNDEQEQLANKKIAELQPHFAEKIVTEVLPAQTFYPAEDYHQGYLLQNPQNSYCNLVATP
KFLKAKVKFEEIWK

Sequences:

>Translated_174_residues
MTQQAIFAGGCFWCVEAVFNQIKGVEKATSGYINGTTENPTYKEVCTGETGHAEAVKVEFDATVISYEKLLDIFFSIHNP
TQLNHQGEDVGTQYRTGIYYLNDEQEQLANKKIAELQPHFAEKIVTEVLPAQTFYPAEDYHQGYLLQNPQNSYCNLVATP
KFLKAKVKFEEIWK
>Mature_173_residues
TQQAIFAGGCFWCVEAVFNQIKGVEKATSGYINGTTENPTYKEVCTGETGHAEAVKVEFDATVISYEKLLDIFFSIHNPT
QLNHQGEDVGTQYRTGIYYLNDEQEQLANKKIAELQPHFAEKIVTEVLPAQTFYPAEDYHQGYLLQNPQNSYCNLVATPK
FLKAKVKFEEIWK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=46.2962962962963, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI208609995, Length=162, Percent_Identity=46.2962962962963, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=44.3478260869565, Blast_Score=90, Evalue=9e-19,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=50, Blast_Score=149, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=33.7837837837838, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.1025641025641, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24664627, Length=161, Percent_Identity=35.4037267080745, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45553131, Length=156, Percent_Identity=35.2564102564103, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24664631, Length=161, Percent_Identity=34.7826086956522, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_PASMU (Q9CN40)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245542.1
- ProteinModelPortal:   Q9CN40
- SMR:   Q9CN40
- GeneID:   1243952
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0605
- NMPDR:   fig|272843.1.peg.605
- HOGENOM:   HBG748152
- OMA:   LEILTLF
- BioCyc:   PMUL272843:PM0605-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19755; Mature: 19624

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: ACT_SITE 11-11

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQAIFAGGCFWCVEAVFNQIKGVEKATSGYINGTTENPTYKEVCTGETGHAEAVKVEF
CCCCCEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
DATVISYEKLLDIFFSIHNPTQLNHQGEDVGTQYRTGIYYLNDEQEQLANKKIAELQPHF
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHH
AEKIVTEVLPAQTFYPAEDYHQGYLLQNPQNSYCNLVATPKFLKAKVKFEEIWK
HHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCEEEEECCHHHHHCCHHHHHCC
>Mature Secondary Structure 
TQQAIFAGGCFWCVEAVFNQIKGVEKATSGYINGTTENPTYKEVCTGETGHAEAVKVEF
CCCCEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEE
DATVISYEKLLDIFFSIHNPTQLNHQGEDVGTQYRTGIYYLNDEQEQLANKKIAELQPHF
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHH
AEKIVTEVLPAQTFYPAEDYHQGYLLQNPQNSYCNLVATPKFLKAKVKFEEIWK
HHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCEEEEECCHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100