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The map label for this gene is ttcA

Identifier: 15602471

GI number: 15602471

Start: 703250

End: 704194

Strand: Reverse

Name: ttcA

Synonym: PM0606

Alternate gene names: 15602471

Gene position: 704194-703250 (Counterclockwise)

Preceding gene: 15602480

Following gene: 15602470

Centisome position: 31.19

GC content: 37.67

Gene sequence:

>945_bases
TTGACGATGACTGATACAACTCAACAAGATAAAAAACACACTTATAATTTCAATAAGTTACAAAAACGCTTACGCCGTAA
TGTCGGCAATGCGATTGCCGATTTTAATATGATCGAAGAAGGCGATAAAGTCATGGTTTGTCTTTCTGGTGGAAAAGACA
GCTATACCCTATTAGATATTCTGTTAAATTTACGTCTTAACGCGCCAATCCATTTTGAGATTGTGGCGGTGAATTTAGAT
CAAAAACAACCGGGTTTCCCTGAACATATTCTGCCTGAATACTTGCAAAGTATCGGAGTGGATTACAAAATCGTGGAAGA
AAATACCTATGGCATCGTCAAAGAAAAAATTCCTGAAGGTAAAACGACCTGCTCACTTTGTTCACGTTTAAGACGTGGTA
TTTTATACCGGACCGCGACGGAATTAGGGGCAACCAAAATTGCACTTGGTCATCACCGTGATGATATGTTAGAAACCTTA
TTCTTAAATATGTTTTATGGCGGTAAACTAAAAAGTATGCCGCCAAAATTAATCAGTGATGACGGTAAACAGATCGTGAT
TCGTCCACTCGCCTATTGCAAAGAAAAAGACATTGAAAAATATGCTCAGGCAAAACATTTCCCGATTATTCCGTGCAATT
TGTGTGGTTCTCAACCCAATTTACAGCGCCAAGTGGTCAAAGAAATGTTGCAAAAATGGGATCGCCAATATCCCGGACGT
ATCGAAACTATGTTTAGTGCAATACAAAATATTGTGCCATCACATCTGTGTGATACGCATTTATTTAACTTTAAAGATCT
GCAACGTGGACAAATATTAGAAAACATTGAAGGTGATATTGCGTTCGATAAACCCGAATTTATTGCCACAAGTCCGATTG
ATGACGACGATGAACAACAAGATTTTCACCAAGTAGAACTGATAAATGTGAAAGAAATTCATTAA

Upstream 100 bases:

>100_bases
AATTTCACAAAAACTGACCGCACTTCATGAAAAGCACAATTTCTAATGGAAAAAATTGCAATTACCCCTTACTATACGCA
GATTTTAAGCAAAACAGAAA

Downstream 100 bases:

>100_bases
ACTCAAGCGAATAAACGATAAAAAAGGAAATCCTATGACACAACAAGCGATCTTTGCCGGCGGCTGTTTTTGGTGCGTTG
AGGCAGTATTTAATCAAATT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTMTDTTQQDKKHTYNFNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDILLNLRLNAPIHFEIVAVNLD
QKQPGFPEHILPEYLQSIGVDYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETL
FLNMFYGGKLKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAQAKHFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGR
IETMFSAIQNIVPSHLCDTHLFNFKDLQRGQILENIEGDIAFDKPEFIATSPIDDDDEQQDFHQVELINVKEIH

Sequences:

>Translated_314_residues
MTMTDTTQQDKKHTYNFNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDILLNLRLNAPIHFEIVAVNLD
QKQPGFPEHILPEYLQSIGVDYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETL
FLNMFYGGKLKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAQAKHFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGR
IETMFSAIQNIVPSHLCDTHLFNFKDLQRGQILENIEGDIAFDKPEFIATSPIDDDDEQQDFHQVELINVKEIH
>Mature_313_residues
TMTDTTQQDKKHTYNFNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDILLNLRLNAPIHFEIVAVNLDQ
KQPGFPEHILPEYLQSIGVDYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETLF
LNMFYGGKLKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAQAKHFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGRI
ETMFSAIQNIVPSHLCDTHLFNFKDLQRGQILENIEGDIAFDKPEFIATSPIDDDDEQQDFHQVELINVKEIH

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=313, Percent_Identity=73.1629392971246, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193211090, Length=259, Percent_Identity=32.8185328185328, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540090, Length=224, Percent_Identity=26.7857142857143, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24651972, Length=225, Percent_Identity=30.6666666666667, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_PASMU (Q9CN39)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245543.1
- ProteinModelPortal:   Q9CN39
- GeneID:   1243953
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0606
- NMPDR:   fig|272843.1.peg.606
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- BioCyc:   PMUL272843:PM0606-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 36081; Mature: 35950

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTDTTQQDKKHTYNFNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDI
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
LLNLRLNAPIHFEIVAVNLDQKQPGFPEHILPEYLQSIGVDYKIVEENTYGIVKEKIPEG
HHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCC
KTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETLFLNMFYGGKLKSMPPKLISD
CHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGKQIVIRPLAYCKEKDIEKYAQAKHFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGR
CCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCH
IETMFSAIQNIVPSHLCDTHLFNFKDLQRGQILENIEGDIAFDKPEFIATSPIDDDDEQQ
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHH
DFHQVELINVKEIH
HHHHEEEEEEEECC
>Mature Secondary Structure 
TMTDTTQQDKKHTYNFNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
LLNLRLNAPIHFEIVAVNLDQKQPGFPEHILPEYLQSIGVDYKIVEENTYGIVKEKIPEG
HHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCC
KTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETLFLNMFYGGKLKSMPPKLISD
CHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGKQIVIRPLAYCKEKDIEKYAQAKHFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGR
CCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCHHHHHHHHHHHHHHHCCCCH
IETMFSAIQNIVPSHLCDTHLFNFKDLQRGQILENIEGDIAFDKPEFIATSPIDDDDEQQ
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHH
DFHQVELINVKEIH
HHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100