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The map label for this gene is trpC

Identifier: 15602445

GI number: 15602445

Start: 668136

End: 669545

Strand: Reverse

Name: trpC

Synonym: PM0580

Alternate gene names: 15602445

Gene position: 669545-668136 (Counterclockwise)

Preceding gene: 15602446

Following gene: 15602444

Centisome position: 29.66

GC content: 41.21

Gene sequence:

>1410_bases
ATGACACAAGCGTTTCCCTCTATTCTGCAAAAAATCATTCAAGATAAAACCACTTGGATTGCAGAAAAACAAGCACAATT
GCCTTTAGCAAGCTTTCAAGATCAGCTAGAACGTAGTGATCGTGACTTTTATCAAGCGATGCAACAAGGCTCAAAACAAC
GCCCTTCATATATCTTAGAATGTAAAAAAGCCTCTCCCTCAAAAGGCTTAATTCGTGCAGCATTCGATTTAACCGAGATT
GCCGAGGTTTATCAACACTATGCTACGGTCATTTCCGTCTTAACCGATGAAAAATATTTTCAAGGGCATTTTGCTGATAT
TGCTCAAGTACGCCAACGCGTGACACAACCGATTTTATGTAAAGATTTTATCTTATCTGAATACCAAGTATATTTGGCAC
GATACGCACAAGCCGATGCTATTTTATTGATGCTTTCCGTTCTCAATGATGAACGCTATACACAATTAGCCACATTAGCA
CACCAATTAGGGATGGGCGTTTTAACTGAAACCAGTAATGAGGCAGAATTTGCGCGCGCATTAGCGTTAAAAGCGAAAGT
GATTGGTGTCAATAATCGGAATTTACATGATCTCAGTGTAGACATACAACGTGTTGCCCAGATCACTCAACACTATGCCG
ATCAGATTCCTCCTGAAACCAAAATTATCAGTGAATCTGGTATCTATCAACACCAACAAATTCGAGACTTACGCCATGTT
GCCGACGGTTTTTTAATTGGCAGTAGTTTAATGCAACACACAGATTTAAATCATGCGGTACGCTCACTTCTTTTTGGGGA
ACATAAAGTTTGTGGGCTCACCCGTCCACAAGATGTAAGAGCGGTTTACCAGCAAGGTGCACTTTACGGTGGACTGATTT
TTGTGACACACTCAAAACGTTGCATTAGCTTACGTCAAGCCCAAGAATTAGTCACACAAGCCCCATTGCGCTTTGTTGGG
GTATTTCAAGATCAATCCATAGCGTTTATCTGTCACCTTGCAACTCAATTAAGACTCCACGCCGTCCAATTACATGGCAA
CGAAAGCCACGAATTTATTCGCCAATTACGCGATGAATTGCCAGTGAATTGTGAAATTTGGCGCGCCATTTGCATTGAGA
GTAGTGGCACCAGTCCGTGTCAAATCGTGGAAAATAAAAATATTGATCGTTATATTTTTGACAGTAAAACGCATCAACAA
CGTGGCGGAACGGGGAAAACATTTGATTGGCAATTGATCCCTCATCACTTAAAACCAAAAAGTATGTTAGCTGGTGGTAT
TACACCAGAAAATATCCCTCTGGCGCTCGCTCAAGGCTGTTTAGGACTGGATTTAAATTCAGGGCTTGAAACTTATCCTG
GTGTAAAATCACACCAAAAAGTCGTTGCAGCTTTTGCTCAACTCCGCTAA

Upstream 100 bases:

>100_bases
GATTATGGATATTATCGCCACAGGCAAACCATTTGAGACCTTACAACAACTTACCCAATATTAATTCGTTTTGATGACTT
ATTATTAAGAGAACCTAACA

Downstream 100 bases:

>100_bases
GTTAAACAGTGTGATAACTTATACCTGAGGTAAAAATGAAAAAAATTGCACTAGTGACTGGTGCCACCGCCGGATTTGGC
ACCGCGATTTGTCGTACATT

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTQAFPSILQKIIQDKTTWIAEKQAQLPLASFQDQLERSDRDFYQAMQQGSKQRPSYILECKKASPSKGLIRAAFDLTEI
AEVYQHYATVISVLTDEKYFQGHFADIAQVRQRVTQPILCKDFILSEYQVYLARYAQADAILLMLSVLNDERYTQLATLA
HQLGMGVLTETSNEAEFARALALKAKVIGVNNRNLHDLSVDIQRVAQITQHYADQIPPETKIISESGIYQHQQIRDLRHV
ADGFLIGSSLMQHTDLNHAVRSLLFGEHKVCGLTRPQDVRAVYQQGALYGGLIFVTHSKRCISLRQAQELVTQAPLRFVG
VFQDQSIAFICHLATQLRLHAVQLHGNESHEFIRQLRDELPVNCEIWRAICIESSGTSPCQIVENKNIDRYIFDSKTHQQ
RGGTGKTFDWQLIPHHLKPKSMLAGGITPENIPLALAQGCLGLDLNSGLETYPGVKSHQKVVAAFAQLR

Sequences:

>Translated_469_residues
MTQAFPSILQKIIQDKTTWIAEKQAQLPLASFQDQLERSDRDFYQAMQQGSKQRPSYILECKKASPSKGLIRAAFDLTEI
AEVYQHYATVISVLTDEKYFQGHFADIAQVRQRVTQPILCKDFILSEYQVYLARYAQADAILLMLSVLNDERYTQLATLA
HQLGMGVLTETSNEAEFARALALKAKVIGVNNRNLHDLSVDIQRVAQITQHYADQIPPETKIISESGIYQHQQIRDLRHV
ADGFLIGSSLMQHTDLNHAVRSLLFGEHKVCGLTRPQDVRAVYQQGALYGGLIFVTHSKRCISLRQAQELVTQAPLRFVG
VFQDQSIAFICHLATQLRLHAVQLHGNESHEFIRQLRDELPVNCEIWRAICIESSGTSPCQIVENKNIDRYIFDSKTHQQ
RGGTGKTFDWQLIPHHLKPKSMLAGGITPENIPLALAQGCLGLDLNSGLETYPGVKSHQKVVAAFAQLR
>Mature_468_residues
TQAFPSILQKIIQDKTTWIAEKQAQLPLASFQDQLERSDRDFYQAMQQGSKQRPSYILECKKASPSKGLIRAAFDLTEIA
EVYQHYATVISVLTDEKYFQGHFADIAQVRQRVTQPILCKDFILSEYQVYLARYAQADAILLMLSVLNDERYTQLATLAH
QLGMGVLTETSNEAEFARALALKAKVIGVNNRNLHDLSVDIQRVAQITQHYADQIPPETKIISESGIYQHQQIRDLRHVA
DGFLIGSSLMQHTDLNHAVRSLLFGEHKVCGLTRPQDVRAVYQQGALYGGLIFVTHSKRCISLRQAQELVTQAPLRFVGV
FQDQSIAFICHLATQLRLHAVQLHGNESHEFIRQLRDELPVNCEIWRAICIESSGTSPCQIVENKNIDRYIFDSKTHQQR
GGTGKTFDWQLIPHHLKPKSMLAGGITPENIPLALAQGCLGLDLNSGLETYPGVKSHQKVVAAFAQLR

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=463, Percent_Identity=51.1879049676026, Blast_Score=470, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322638, Length=274, Percent_Identity=33.5766423357664, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PASMU (P57855)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245517.1
- ProteinModelPortal:   P57855
- SMR:   P57855
- GeneID:   1243927
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0580
- NMPDR:   fig|272843.1.peg.580
- HOGENOM:   HBG296890
- OMA:   YILECKK
- ProtClustDB:   PRK09427
- BioCyc:   PMUL272843:PM0580-MONOMER
- BRENDA:   4.1.1.48
- BRENDA:   5.3.1.24
- HAMAP:   MF_00134_B
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48; =5.3.1.24

Molecular weight: Translated: 52852; Mature: 52721

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAFPSILQKIIQDKTTWIAEKQAQLPLASFQDQLERSDRDFYQAMQQGSKQRPSYILE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEE
CKKASPSKGLIRAAFDLTEIAEVYQHYATVISVLTDEKYFQGHFADIAQVRQRVTQPILC
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHH
KDFILSEYQVYLARYAQADAILLMLSVLNDERYTQLATLAHQLGMGVLTETSNEAEFARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHH
LALKAKVIGVNNRNLHDLSVDIQRVAQITQHYADQIPPETKIISESGIYQHQQIRDLRHV
HHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
ADGFLIGSSLMQHTDLNHAVRSLLFGEHKVCGLTRPQDVRAVYQQGALYGGLIFVTHSKR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCHH
CISLRQAQELVTQAPLRFVGVFQDQSIAFICHLATQLRLHAVQLHGNESHEFIRQLRDEL
HHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHC
PVNCEIWRAICIESSGTSPCQIVENKNIDRYIFDSKTHQQRGGTGKTFDWQLIPHHLKPK
CCCCEEHHHHEECCCCCCCEEEECCCCCCEEEECCCHHHHCCCCCCCEEEEECCCCCCCH
SMLAGGITPENIPLALAQGCLGLDLNSGLETYPGVKSHQKVVAAFAQLR
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQAFPSILQKIIQDKTTWIAEKQAQLPLASFQDQLERSDRDFYQAMQQGSKQRPSYILE
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEE
CKKASPSKGLIRAAFDLTEIAEVYQHYATVISVLTDEKYFQGHFADIAQVRQRVTQPILC
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHH
KDFILSEYQVYLARYAQADAILLMLSVLNDERYTQLATLAHQLGMGVLTETSNEAEFARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCHHHHHHH
LALKAKVIGVNNRNLHDLSVDIQRVAQITQHYADQIPPETKIISESGIYQHQQIRDLRHV
HHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
ADGFLIGSSLMQHTDLNHAVRSLLFGEHKVCGLTRPQDVRAVYQQGALYGGLIFVTHSKR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCHH
CISLRQAQELVTQAPLRFVGVFQDQSIAFICHLATQLRLHAVQLHGNESHEFIRQLRDEL
HHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHC
PVNCEIWRAICIESSGTSPCQIVENKNIDRYIFDSKTHQQRGGTGKTFDWQLIPHHLKPK
CCCCEEHHHHEECCCCCCCEEEECCCCCCEEEECCCHHHHCCCCCCCEEEEECCCCCCCH
SMLAGGITPENIPLALAQGCLGLDLNSGLETYPGVKSHQKVVAAFAQLR
HHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100