Click here to switch to the map view.

The map label for this gene is tesB [H]

Identifier: 15602435

GI number: 15602435

Start: 655221

End: 656099

Strand: Reverse

Name: tesB [H]

Synonym: PM0570

Alternate gene names: 15602435

Gene position: 656099-655221 (Counterclockwise)

Preceding gene: 15602436

Following gene: 15602434

Centisome position: 29.06

GC content: 43.0

Gene sequence:

>879_bases
ATGTCGAATGTCCTGAATAATTTAATTGCCTTATTACAACTTGAACGCCTCGATGATTTCCTTTTTCGTGGCAAAAGTGA
AGATTTAGGTTTACGCCAAGTATTTGGTGGTCAAGTCGTCGCACAAGCCTTATCCGCGGCAATACAGGTCGCCCCGCCGG
ATCGTGTTTTGCACTCTTGCCATGCTTATTTTCTTTCGCCGGGCGATAGTCAACATGGGATTATTTATGATGTGGAAACC
TTGCGCGAAGGACGTAATTTTACTGCTTTACGCGTCAAAGCGATTCAACACAATGAGCCGATTTGCCATATTACCGCCTC
TTTCCAAAAAGCAGAGCAAGGCTTTGATCATCAAAGTAAAATGCCGGATGTAGAATCCCCCGATCAATTGATCGCAGAAA
GTGCGATTATTCAAAAACTGGCACCTCATATTCCCGAAGCCATTCGTGCCAAATTCACCGCAGAGCGCCCTTTTGATATC
CGCACCAAATATATCAACAATCCCTTTCATGGCAGCCAACTACCCGCAGAACAATTTGCTTGGGTAAAAGCCAATGGTCA
TGCACCACAAGATCACAAAATCCAACAATGTTTACTGGCTTATTTTTCCGATTTTCATTGTTTATTAACCGCACTTCATC
CCCACCAAAAAGGCTTTTTACAACCGGGGATGAAAGTAGCCACAATTGATCATTCTATTTGGTTCCACCGTCCTTTTGAT
TTAAATGATTGGTTGCTCTATGCCATTGAAAGCAATAATGCTTTTGCTGCACGTGGTTTGGCACGAGGGCAAATTTTTGA
CCGCCAAGGTCGTTTAATTGCTACGACGCAACAAGAAGGCTTAATTCGTTATACGCCTGAAAAAGAAGGTGAAAAATGA

Upstream 100 bases:

>100_bases
GCGATTTCCGTGGGATTGCTTATATTTTATAACGTTTAGCGGTTTTCTAAACAAAAACCGTTCTCGTATTCTATACCCTA
TTCACCATAAGGAACAAAAT

Downstream 100 bases:

>100_bases
CCGCACTTTGGCATGCTATCACAGAAGCATTAACTGAAACACGCCCAGAAGAGAAATGTGCACTCGTCAATCATTTATAT
GATGAATTACTGCCTCAAGT

Product: TesB

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSNVLNNLIALLQLERLDDFLFRGKSEDLGLRQVFGGQVVAQALSAAIQVAPPDRVLHSCHAYFLSPGDSQHGIIYDVET
LREGRNFTALRVKAIQHNEPICHITASFQKAEQGFDHQSKMPDVESPDQLIAESAIIQKLAPHIPEAIRAKFTAERPFDI
RTKYINNPFHGSQLPAEQFAWVKANGHAPQDHKIQQCLLAYFSDFHCLLTALHPHQKGFLQPGMKVATIDHSIWFHRPFD
LNDWLLYAIESNNAFAARGLARGQIFDRQGRLIATTQQEGLIRYTPEKEGEK

Sequences:

>Translated_292_residues
MSNVLNNLIALLQLERLDDFLFRGKSEDLGLRQVFGGQVVAQALSAAIQVAPPDRVLHSCHAYFLSPGDSQHGIIYDVET
LREGRNFTALRVKAIQHNEPICHITASFQKAEQGFDHQSKMPDVESPDQLIAESAIIQKLAPHIPEAIRAKFTAERPFDI
RTKYINNPFHGSQLPAEQFAWVKANGHAPQDHKIQQCLLAYFSDFHCLLTALHPHQKGFLQPGMKVATIDHSIWFHRPFD
LNDWLLYAIESNNAFAARGLARGQIFDRQGRLIATTQQEGLIRYTPEKEGEK
>Mature_291_residues
SNVLNNLIALLQLERLDDFLFRGKSEDLGLRQVFGGQVVAQALSAAIQVAPPDRVLHSCHAYFLSPGDSQHGIIYDVETL
REGRNFTALRVKAIQHNEPICHITASFQKAEQGFDHQSKMPDVESPDQLIAESAIIQKLAPHIPEAIRAKFTAERPFDIR
TKYINNPFHGSQLPAEQFAWVKANGHAPQDHKIQQCLLAYFSDFHCLLTALHPHQKGFLQPGMKVATIDHSIWFHRPFDL
NDWLLYAIESNNAFAARGLARGQIFDRQGRLIATTQQEGLIRYTPEKEGEK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=296, Percent_Identity=37.5, Blast_Score=177, Evalue=7e-45,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=52.4163568773234, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71988741, Length=296, Percent_Identity=32.4324324324324, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17558508, Length=301, Percent_Identity=34.8837209302326, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI212645202, Length=286, Percent_Identity=34.6153846153846, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531889, Length=268, Percent_Identity=30.2238805970149, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115532456, Length=268, Percent_Identity=30.2238805970149, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17531885, Length=268, Percent_Identity=30.2238805970149, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982224, Length=286, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32978; Mature: 32847

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLNNLIALLQLERLDDFLFRGKSEDLGLRQVFGGQVVAQALSAAIQVAPPDRVLHSC
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHH
HAYFLSPGDSQHGIIYDVETLREGRNFTALRVKAIQHNEPICHITASFQKAEQGFDHQSK
HHHEECCCCCCCCEEEEHHHHHCCCCEEEEEEEEECCCCCEEEEEHHHHHHHCCCCCHHC
MPDVESPDQLIAESAIIQKLAPHIPEAIRAKFTAERPFDIRTKYINNPFHGSQLPAEQFA
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHEE
WVKANGHAPQDHKIQQCLLAYFSDFHCLLTALHPHQKGFLQPGMKVATIDHSIWFHRPFD
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEECCCC
LNDWLLYAIESNNAFAARGLARGQIFDRQGRLIATTQQEGLIRYTPEKEGEK
CCCEEEEEEECCCCEECCCCCCCCEECCCCCEEEEECCCCCEEECCCCCCCC
>Mature Secondary Structure 
SNVLNNLIALLQLERLDDFLFRGKSEDLGLRQVFGGQVVAQALSAAIQVAPPDRVLHSC
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHH
HAYFLSPGDSQHGIIYDVETLREGRNFTALRVKAIQHNEPICHITASFQKAEQGFDHQSK
HHHEECCCCCCCCEEEEHHHHHCCCCEEEEEEEEECCCCCEEEEEHHHHHHHCCCCCHHC
MPDVESPDQLIAESAIIQKLAPHIPEAIRAKFTAERPFDIRTKYINNPFHGSQLPAEQFA
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHEE
WVKANGHAPQDHKIQQCLLAYFSDFHCLLTALHPHQKGFLQPGMKVATIDHSIWFHRPFD
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEECCCC
LNDWLLYAIESNNAFAARGLARGQIFDRQGRLIATTQQEGLIRYTPEKEGEK
CCCEEEEEEECCCCEECCCCCCCCEECCCCCEEEEECCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]