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The map label for this gene is ispA [H]

Identifier: 15602398

GI number: 15602398

Start: 610407

End: 611294

Strand: Reverse

Name: ispA [H]

Synonym: PM0533

Alternate gene names: 15602398

Gene position: 611294-610407 (Counterclockwise)

Preceding gene: 15602399

Following gene: 15602397

Centisome position: 27.08

GC content: 43.47

Gene sequence:

>888_bases
ATGTACCAACTTTCACAAGACTTACCCCAACTCCAACAACGTATTAATACTTTTTTAGCGCAACAATTGAATGTGGACAG
CAGCCCCTCTCCTCTTGCCGAAGCCATGCGTTACGGTGTGCTCCTTGGTGGTAAACGTATCCGTCCTTTCCTAGTGTATG
CAACAGGACGAATGCTCGGCGCAGACTTAAACCAACTCGATTATGCCGCGGCGAGTGTAGAAGCCGTTCATGCCTATTCA
TTAATTCACGACGATCTCCCTGCGATGGATGATGATCATTTACGTCGTGGACAACCAACTTGCCATATTGCTTTTGATCA
CGCCACCGCGATTTTAGCCGGTGACGCGTTGCAAGCCTTTGCTTTTGAAATATTAACTCAAGCACCTGCATTGCAAGCAG
AGCAAAAACTTGCGTTGGTACAAACGCTAAGTCAAGCAGCTGGTGTAAAAGGAATGTGTTTGGGGCAAAGTCTCGATCTG
ATTTCTGAGCAAAAACACATTAGCTTAATCGAATTAGAACAAATTCACCGCAATAAAACGGGGGCAATGCTTTCCGCAGC
GATTCAGCTTGGGCGAATTTGTTCTCCGCATTTTAAAAATGATACGCTAGCACAGCAATTACAACGGTATTCGGAAGCCA
TTGGCTTAGCCTTTCAAGTACAAGACGATATTTTAGATATTGAAGGCGAGAGTGACATTATTGGTAAAACCGTGGGTTCT
GATTTATTAGCAGATAAAAGCACCTACCCCAAATTATTAGGCTTAGCGGGTGCCAAACAAAAAGCGCAAGAACTGTATCA
AAACGCAATCGCGGAATTAGAAAGTATTCCTTTTGATACAAGTGCACTTCGTGCTATCGCTGAATTTGTGGTAAATAGAA
AAAGTTAA

Upstream 100 bases:

>100_bases
ACAACAAGCCGAACAACGCATTCAGATTTTATTACAAAAAAGTGACAGCGCGAAATTAAGCGATTACCAAGCGGAAGAAT
AACAACAATACGAGCATGTT

Downstream 100 bases:

>100_bases
ACCGCACAATATACCAAGATCAAAGTGCGGTCAGTTTTTTAATTATTTTGGAATTGACTAACAACTATGCAAAATTATCC
TCTGTTATCATTAATTAATT

Product: hypothetical protein

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MYQLSQDLPQLQQRINTFLAQQLNVDSSPSPLAEAMRYGVLLGGKRIRPFLVYATGRMLGADLNQLDYAAASVEAVHAYS
LIHDDLPAMDDDHLRRGQPTCHIAFDHATAILAGDALQAFAFEILTQAPALQAEQKLALVQTLSQAAGVKGMCLGQSLDL
ISEQKHISLIELEQIHRNKTGAMLSAAIQLGRICSPHFKNDTLAQQLQRYSEAIGLAFQVQDDILDIEGESDIIGKTVGS
DLLADKSTYPKLLGLAGAKQKAQELYQNAIAELESIPFDTSALRAIAEFVVNRKS

Sequences:

>Translated_295_residues
MYQLSQDLPQLQQRINTFLAQQLNVDSSPSPLAEAMRYGVLLGGKRIRPFLVYATGRMLGADLNQLDYAAASVEAVHAYS
LIHDDLPAMDDDHLRRGQPTCHIAFDHATAILAGDALQAFAFEILTQAPALQAEQKLALVQTLSQAAGVKGMCLGQSLDL
ISEQKHISLIELEQIHRNKTGAMLSAAIQLGRICSPHFKNDTLAQQLQRYSEAIGLAFQVQDDILDIEGESDIIGKTVGS
DLLADKSTYPKLLGLAGAKQKAQELYQNAIAELESIPFDTSALRAIAEFVVNRKS
>Mature_295_residues
MYQLSQDLPQLQQRINTFLAQQLNVDSSPSPLAEAMRYGVLLGGKRIRPFLVYATGRMLGADLNQLDYAAASVEAVHAYS
LIHDDLPAMDDDHLRRGQPTCHIAFDHATAILAGDALQAFAFEILTQAPALQAEQKLALVQTLSQAAGVKGMCLGQSLDL
ISEQKHISLIELEQIHRNKTGAMLSAAIQLGRICSPHFKNDTLAQQLQRYSEAIGLAFQVQDDILDIEGESDIIGKTVGS
DLLADKSTYPKLLGLAGAKQKAQELYQNAIAELESIPFDTSALRAIAEFVVNRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=50.5050505050505, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789578, Length=260, Percent_Identity=31.1538461538462, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325188, Length=282, Percent_Identity=22.6950354609929, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24651612, Length=220, Percent_Identity=26.8181818181818, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32152; Mature: 32152

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQLSQDLPQLQQRINTFLAQQLNVDSSPSPLAEAMRYGVLLGGKRIRPFLVYATGRMLG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHC
ADLNQLDYAAASVEAVHAYSLIHDDLPAMDDDHLRRGQPTCHIAFDHATAILAGDALQAF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHH
AFEILTQAPALQAEQKLALVQTLSQAAGVKGMCLGQSLDLISEQKHISLIELEQIHRNKT
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCHHHHHHHHHCCHH
GAMLSAAIQLGRICSPHFKNDTLAQQLQRYSEAIGLAFQVQDDILDIEGESDIIGKTVGS
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEECCEEECCCCCCHHHHHHCH
DLLADKSTYPKLLGLAGAKQKAQELYQNAIAELESIPFDTSALRAIAEFVVNRKS
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYQLSQDLPQLQQRINTFLAQQLNVDSSPSPLAEAMRYGVLLGGKRIRPFLVYATGRMLG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHC
ADLNQLDYAAASVEAVHAYSLIHDDLPAMDDDHLRRGQPTCHIAFDHATAILAGDALQAF
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHH
AFEILTQAPALQAEQKLALVQTLSQAAGVKGMCLGQSLDLISEQKHISLIELEQIHRNKT
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCHHHHHHHHHCCHH
GAMLSAAIQLGRICSPHFKNDTLAQQLQRYSEAIGLAFQVQDDILDIEGESDIIGKTVGS
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEECCEEECCCCCCHHHHHHCH
DLLADKSTYPKLLGLAGAKQKAQELYQNAIAELESIPFDTSALRAIAEFVVNRKS
HHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]