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The map label for this gene is dxs

Identifier: 15602397

GI number: 15602397

Start: 608496

End: 610340

Strand: Reverse

Name: dxs

Synonym: PM0532

Alternate gene names: 15602397

Gene position: 610340-608496 (Counterclockwise)

Preceding gene: 15602398

Following gene: 15602392

Centisome position: 27.04

GC content: 41.19

Gene sequence:

>1845_bases
ATGCAAAATTATCCTCTGTTATCATTAATTAATTCACCTGAAGATTTACGTTTATTAAGTAAAGAACAACTTCCCCAAAT
CTGTCAGGAATTACGTGCATATTTATTAGAGTCTGTTAGTCAAAGTAGTGGACATTTGGCATCAGGCTTGGGCACAGTAG
AATTAACCGTTGCCTTACACTATGTCTATAAAACCCCCTTTGATCAACTGATTTGGGATGTTGGTCATCAAGCCTATCCA
CATAAAATCTTAACCGGTCGTCGTGATCAAATGTCCACCATTCGTCAGAAAAATGGTATTCATCCTTTTCCATGGCGTGA
AGAAAGCGAATTTGATGTGTTAAGTGTTGGGCATTCTTCTACCTCAATTAGTGCAGGCTTAGGCATTGCCGTTGCCGCAC
AACGTGAAAATGCGGGACGTAAAACAGTTTGTGTGATTGGTGATGGCGCCATTACTGCAGGAATGGCGTTTGAAGCAATG
AATCATGCTGGTGCCTTGCATACCGATATGCTGGTGATTTTGAATGATAACGAAATGTCCATTTCAGAAAATGTCGGGGC
GCTCAACAATCATCTCGCCCGCTTATTAACGGGATCATTTTATTCTTCCATCCGTGAAGGGGGTAAAAAAATCCTCTCTG
GTATGCCACCGATTAAAGAATTTGTCAAAAAGACTGAAGAACATGTGAAAGGCTTTGTTTCTCCTGTGGGTACCATGTTC
GAGCAACTAGGGTTCAACTATATTGGTCCGATTGATGGTCATAACATTGAAGAACTTATCAGCACATTGAAAAATATGCG
CGCCTTAAAAGGTCCCCAATTTTTACATATCATGACCAAAAAAGGGAAAGGCTACGCTCCGGCAGAAAAAGACCCAATTG
GCTTTCATGGTGTACCTAAATTTGATCATTTAAGTGGTCAATTACCTAAATCAAATACAACGCCAACCTATTCAAAAATT
TTTGGTGATTGGCTGTGTGAAATGGCAGAAAACGATCCTAAACTGATCGGCATTACGCCGGCTATGCGTGAAGGCTCAGG
GATGGTCGAGTTTTCTAACCGTTTTCCACAACAATATTTTGATGTTGCCATTGCTGAACAACATGCCGTCACGTTTGCCG
CTGGCTTGGCGATTGGGGGTTATAAACCCGTAGTAGCAATTTATTCCACCTTTTTACAGCGTGCCTACGATCAAGTCATT
CATGACGTGGCTATTCAAAATCTGCCGGTTTTATTTGCTATTGATCGGGCTGGTGTGGTCGGTGCAGATGGTCAGACTCA
TCAAGGCGCTTTTGATATTAGCTTTCTGCGCTGTATCCCAAATATGGTGATCATGACACCTAGCGACGAAAATGAGTGTC
GTCAAATGCTTTATACTGGTTACAAACTCAATCAACCTGCTGCCGTACGTTATCCACGTGGTAATGCCATTGGTGTTGAA
CTCACCCCATTAACGATGTTAGCACTCGGTAAATCCAACCTGATTCGTGAGGGCGAAAAAATTGCGATTTTAAATTTTGG
CACTTTATTACCTACCGCCATCAACGTGGCAGAAAAATTAAATGCGACAGTAATCGATATGCGTTTTGTTAAACCTATTG
ATGTTGAGCGTATCCATCAAATTGCACAAACACACGACCTGATTGTGACTTTAGAAGAAAACGTCATTCAAGGTGGGGCT
GGCAGTGCCGTTGCCGAAGTCTTACATTCTCAACAACATCAAACAAAATTATTACAACTTGGTTTACCTGATTTCTTTAT
CCCACAAGGGACACAACAAGAAATTTTAGCGGACTTACATTTAGACGAAGCCGGTATCGAAACACAAATAAAAAATTTTT
TATAA

Upstream 100 bases:

>100_bases
TATCGCTGAATTTGTGGTAAATAGAAAAAGTTAAACCGCACAATATACCAAGATCAAAGTGCGGTCAGTTTTTTAATTAT
TTTGGAATTGACTAACAACT

Downstream 100 bases:

>100_bases
AAAATAAAACTTTTTCTGAACTATTTTAAAAATGCTCGGTCTTAGATAATGCTAGTGCACTGCAAATGCAGTCGTCTTTT
TAACTTTCTTATGTTAAGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MQNYPLLSLINSPEDLRLLSKEQLPQICQELRAYLLESVSQSSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGHQAYP
HKILTGRRDQMSTIRQKNGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAQRENAGRKTVCVIGDGAITAGMAFEAM
NHAGALHTDMLVILNDNEMSISENVGALNNHLARLLTGSFYSSIREGGKKILSGMPPIKEFVKKTEEHVKGFVSPVGTMF
EQLGFNYIGPIDGHNIEELISTLKNMRALKGPQFLHIMTKKGKGYAPAEKDPIGFHGVPKFDHLSGQLPKSNTTPTYSKI
FGDWLCEMAENDPKLIGITPAMREGSGMVEFSNRFPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVI
HDVAIQNLPVLFAIDRAGVVGADGQTHQGAFDISFLRCIPNMVIMTPSDENECRQMLYTGYKLNQPAAVRYPRGNAIGVE
LTPLTMLALGKSNLIREGEKIAILNFGTLLPTAINVAEKLNATVIDMRFVKPIDVERIHQIAQTHDLIVTLEENVIQGGA
GSAVAEVLHSQQHQTKLLQLGLPDFFIPQGTQQEILADLHLDEAGIETQIKNFL

Sequences:

>Translated_614_residues
MQNYPLLSLINSPEDLRLLSKEQLPQICQELRAYLLESVSQSSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGHQAYP
HKILTGRRDQMSTIRQKNGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAQRENAGRKTVCVIGDGAITAGMAFEAM
NHAGALHTDMLVILNDNEMSISENVGALNNHLARLLTGSFYSSIREGGKKILSGMPPIKEFVKKTEEHVKGFVSPVGTMF
EQLGFNYIGPIDGHNIEELISTLKNMRALKGPQFLHIMTKKGKGYAPAEKDPIGFHGVPKFDHLSGQLPKSNTTPTYSKI
FGDWLCEMAENDPKLIGITPAMREGSGMVEFSNRFPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVI
HDVAIQNLPVLFAIDRAGVVGADGQTHQGAFDISFLRCIPNMVIMTPSDENECRQMLYTGYKLNQPAAVRYPRGNAIGVE
LTPLTMLALGKSNLIREGEKIAILNFGTLLPTAINVAEKLNATVIDMRFVKPIDVERIHQIAQTHDLIVTLEENVIQGGA
GSAVAEVLHSQQHQTKLLQLGLPDFFIPQGTQQEILADLHLDEAGIETQIKNFL
>Mature_614_residues
MQNYPLLSLINSPEDLRLLSKEQLPQICQELRAYLLESVSQSSGHLASGLGTVELTVALHYVYKTPFDQLIWDVGHQAYP
HKILTGRRDQMSTIRQKNGIHPFPWREESEFDVLSVGHSSTSISAGLGIAVAAQRENAGRKTVCVIGDGAITAGMAFEAM
NHAGALHTDMLVILNDNEMSISENVGALNNHLARLLTGSFYSSIREGGKKILSGMPPIKEFVKKTEEHVKGFVSPVGTMF
EQLGFNYIGPIDGHNIEELISTLKNMRALKGPQFLHIMTKKGKGYAPAEKDPIGFHGVPKFDHLSGQLPKSNTTPTYSKI
FGDWLCEMAENDPKLIGITPAMREGSGMVEFSNRFPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVI
HDVAIQNLPVLFAIDRAGVVGADGQTHQGAFDISFLRCIPNMVIMTPSDENECRQMLYTGYKLNQPAAVRYPRGNAIGVE
LTPLTMLALGKSNLIREGEKIAILNFGTLLPTAINVAEKLNATVIDMRFVKPIDVERIHQIAQTHDLIVTLEENVIQGGA
GSAVAEVLHSQQHQTKLLQLGLPDFFIPQGTQQEILADLHLDEAGIETQIKNFL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=517, Percent_Identity=22.0502901353965, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4507521, Length=517, Percent_Identity=22.0502901353965, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637459, Length=531, Percent_Identity=22.7871939736347, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637463, Length=531, Percent_Identity=22.7871939736347, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637461, Length=531, Percent_Identity=22.7871939736347, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI133778974, Length=546, Percent_Identity=22.3443223443223, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=75.1623376623377, Blast_Score=975, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=551, Percent_Identity=23.049001814882, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24666278, Length=630, Percent_Identity=23.6507936507936, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45551847, Length=634, Percent_Identity=23.3438485804416, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45550715, Length=634, Percent_Identity=23.3438485804416, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24645119, Length=533, Percent_Identity=23.6397748592871, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PASMU (P57848)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245469.1
- ProteinModelPortal:   P57848
- SMR:   P57848
- GeneID:   1243879
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0532
- NMPDR:   fig|272843.1.peg.532
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   PMUL272843:PM0532-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67427; Mature: 67427

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNYPLLSLINSPEDLRLLSKEQLPQICQELRAYLLESVSQSSGHLASGLGTVELTVALH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHH
YVYKTPFDQLIWDVGHQAYPHKILTGRRDQMSTIRQKNGIHPFPWREESEFDVLSVGHSS
HHHHCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
TSISAGLGIAVAAQRENAGRKTVCVIGDGAITAGMAFEAMNHAGALHTDMLVILNDNEMS
CCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
ISENVGALNNHLARLLTGSFYSSIREGGKKILSGMPPIKEFVKKTEEHVKGFVSPVGTMF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQLGFNYIGPIDGHNIEELISTLKNMRALKGPQFLHIMTKKGKGYAPAEKDPIGFHGVPK
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
FDHLSGQLPKSNTTPTYSKIFGDWLCEMAENDPKLIGITPAMREGSGMVEFSNRFPQQYF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHHCCCHHHH
DVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQNLPVLFAIDRAGVV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEE
GADGQTHQGAFDISFLRCIPNMVIMTPSDENECRQMLYTGYKLNQPAAVRYPRGNAIGVE
CCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
LTPLTMLALGKSNLIREGEKIAILNFGTLLPTAINVAEKLNATVIDMRFVKPIDVERIHQ
ECCHHHHHHCCHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
IAQTHDLIVTLEENVIQGGAGSAVAEVLHSQQHQTKLLQLGLPDFFIPQGTQQEILADLH
HHHHCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
LDEAGIETQIKNFL
CCCCCHHHHHHHCC
>Mature Secondary Structure
MQNYPLLSLINSPEDLRLLSKEQLPQICQELRAYLLESVSQSSGHLASGLGTVELTVALH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHH
YVYKTPFDQLIWDVGHQAYPHKILTGRRDQMSTIRQKNGIHPFPWREESEFDVLSVGHSS
HHHHCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
TSISAGLGIAVAAQRENAGRKTVCVIGDGAITAGMAFEAMNHAGALHTDMLVILNDNEMS
CCCCCCCCEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
ISENVGALNNHLARLLTGSFYSSIREGGKKILSGMPPIKEFVKKTEEHVKGFVSPVGTMF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQLGFNYIGPIDGHNIEELISTLKNMRALKGPQFLHIMTKKGKGYAPAEKDPIGFHGVPK
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
FDHLSGQLPKSNTTPTYSKIFGDWLCEMAENDPKLIGITPAMREGSGMVEFSNRFPQQYF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHHCCCHHHH
DVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQNLPVLFAIDRAGVV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEE
GADGQTHQGAFDISFLRCIPNMVIMTPSDENECRQMLYTGYKLNQPAAVRYPRGNAIGVE
CCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
LTPLTMLALGKSNLIREGEKIAILNFGTLLPTAINVAEKLNATVIDMRFVKPIDVERIHQ
ECCHHHHHHCCHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
IAQTHDLIVTLEENVIQGGAGSAVAEVLHSQQHQTKLLQLGLPDFFIPQGTQQEILADLH
HHHHCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHC
LDEAGIETQIKNFL
CCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100